Activation of the contact system at the surface of Fusobacterium necrophorum represents a possible virulence mechanism in Lemièrre's syndrome

Infection and Immunity

Volumn 79, Issue 8, 2011, Pages 3284-3290

  Holm, Karin ^a   Frick, Inga Maria ^a   Björck, Lars ^a   Rasmussen, Magnus ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 11; BRADYKININ; HIGH MOLECULAR WEIGHT KININOGEN; IODINE 125; MEMBRANE PROTEIN; THROMBIN; TRYPSIN;

ARTICLE; BACTERIAL VIRULENCE; BINDING AFFINITY; CONTROLLED STUDY; FUSOBACTERIUM NECROPHORUM; INCUBATION TIME; ISOTOPE LABELING; LEMIERRE SYNDROME; NONHUMAN; PARTIAL THROMBOPLASTIN TIME; PRIORITY JOURNAL; PROTEIN BINDING; SUPERNATANT;

BLOOD COAGULATION; FACTOR XI; FUSOBACTERIUM NECROPHORUM; HUMANS; INFLAMMATION; KININOGENS; LEMIERRE SYNDROME; PROTEIN BINDING; VIRULENCE;

EID: 79961125621     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.05264-11     Document Type: Article

References (34)

1. Ben Nasr, A., et al. 1997. Absorption of kininogen from human plasma by Streptococcus pyogenes is followed by the release of bradykinin. Biochem. J. 326(Pt. 3):657-660.
2. Ben Nasr, A., A. Olsen, U. Sjöbring, W. Müller-Esterl, and L. Björck. 1996. Assembly of human contact phase proteins and release of bradykinin at the surface of curli-expressing Escherichia coli. Mol. Microbiol. 20:927-935.
3. Ben Nasr, A. B., H. Herwald, W. Müller-Esterl, and L. Björck. 1995. Human kininogens interact with M protein, a bacterial surface protein and virulence determinant. Biochem. J. 305(Pt. 1):173-180.
4. Brazier, J. S. 2006. Human infections with Fusobacterium necrophorum. Anaerobe 12:165-172.
5. Cheng, Q., et al. 2010. A role for factor XIIa-mediated factor XI activation in thrombus formation in vivo. Blood 116:3981-3989.
6. Colman, R. W., and A. H. Schmaier. 1997. Contact system: a vascular biology modulator with anticoagulant, profibrinolytic, antiadhesive, and proinflammatory attributes. Blood 90:3819-3843.
7. Coyle-Dennis, J. E., and L. H. Lauerman. 1979. Correlations between leukocidin production and virulence of two isolates of Fusobacterium necrophorum. Am. J. Vet. Res. 40:274-276.
8. Friberg, N., et al. 2008. Factor H binding as a complement evasion mechanism for an anaerobic pathogen, Fusobacterium necrophorum. J. Immunol. 181:8624-8632.
9. Frick, I. M., et al. 2006. The contact system-a novel branch of innate immunity generating antibacterial peptides. EMBO J. 25:5569-5578.
10. Hasan, A. A., D. B. Cines, H. Herwald, A. H. Schmaier, and W. Müller-Esterl. 1995. Mapping the cell binding site on high molecular weight kininogen domain 5. J. Biol. Chem. 270:19256-19261.
11. Hasan, A. A., D. B. Cines, J. Zhang, and A. H. Schmaier. 1994. The carboxyl terminus of bradykinin and amino terminus of the light chain of kininogens comprise an endothelial cell binding domain. J. Biol. Chem. 269:31822-31830.
12. Herwald, H., A. A. Hasan, J. Godovac-Zimmermann, A. H. Schmaier, and W. Müller-Esterl. 1995. Identification of an endothelial cell binding site on kininogen domain D3. J. Biol. Chem. 270:14634-14642.
13. Herwald, H., M. Mörgelin, and L. Björck. 2003. Contact activation by pathogenic bacteria: a virulence mechanism contributing to the pathophysiology of sepsis. Scand. J. Infect. Dis. 35:604-607.
14. Herwald, H., et al. 1998. Activation of the contact-phase system on bacterial surfaces-a clue to serious complications in infectious diseases. Nat. Med. 4:298-302.
15. Jensen, A., L. Hagelskjaer Kristensen, and J. Prag. 2007. Detection of Fusobacterium necrophorum subsp. funduliforme in tonsillitis in young adults by real-time PCR. Clin. Microbiol. Infect. 13:695-701.
16. Karkowska-Kuleta, J., A. Kozik, and M. Rapala-Kozik. 2010. Binding and activation of the human plasma kinin-forming system on the cell walls of Candida albicans and Candida tropicalis. Biol. Chem. 391:97-103.
17. Kettner, C., and E. Shaw. 1978. Synthesis of peptides of arginine chloromethyl ketone. Selective inactivation of human plasma kallikrein. Biochemistry 17:4778-4784.
18. Ludlam, H. A., et al. 2009. lktA-encoded leukotoxin is not a universal virulence factor in invasive Fusobacterium necrophorum infections in animals and man. J. Med. Microbiol. 58:529-530.
19. Mahdi, F., Z. Shariat-Madar, and A. H. Schmaier. 2003. The relative priority of prekallikrein and factors XI/XIa assembly on cultured endothelial cells. J. Biol. Chem. 278:43983-43990.
20. Mattsson, E., et al. 2001. Staphylococcus aureus induces release of bradykinin in human plasma. Infect. Immun. 69:3877-3882.
21. Motta, G., R. Rojkjaer, A. A. Hasan, D. B. Cines, and A. H. Schmaier. 1998. High molecular weight kininogen regulates prekallikrein assembly and activation on endothelial cells: a novel mechanism for contact activation. Blood 91:516-528.
22. Müller, F., et al. 2009. Platelet polyphosphates are proinflammatory and procoagulant mediators in vivo. Cell 139:1143-1156.
23. Müller-Esterl, W., D. A. Johnson, G. Salvesen, and A. J. Barrett. 1988. Human kininogens. Methods Enzymol. 163:240-256.
24. Oehmcke, S., and H. Herwald. 2010. Contact system activation in severe infectious diseases. J. Mol. Med. 88:121-126.
25. Oehmcke, S., et al. 2009. Treatment of invasive streptococcal infection with a peptide derived from human high-molecular weight kininogen. Blood 114:444-451.
26. Perkins, R., M. D. Ngo, F. Mahdi, and Z. Shariat-Madar. 2008. Identification of lipopolysaccharide binding site on high molecular weight kininogen. Biochem. Biophys. Res. Commun. 366:938-943.
27. Persson, K., et al. 2000. Severe lung lesions caused by Salmonella are prevented by inhibition of the contact system. J. Exp. Med. 192:1415-1424.
28. Persson, K., W. Russell, M. Mörgelin, and H. Herwald. 2003. The conversion of fibrinogen to fibrin at the surface of curliated Escherichia coli bacteria leads to the generation of proinflammatory fibrinopeptides. J. Biol. Chem. 278:31884-31890.
29. Rapala-Kozik, M., et al. 2011. Adsorption of components of the plasma kinin-forming system on the surface of Porphyromonas gingivalis involves gingipains as the major docking platforms. Infect. Immun. 79:797-805.
30. Rasmussen, M., H. P. Müller, and L. Björck. 1999. Protein GRAB of Streptococcus pyogenes regulates proteolysis at the bacterial surface by binding alpha2-macroglobulin. J. Biol. Chem. 274:15336-15344.
31. Riordan, T. 2007. Human infection with Fusobacterium necrophorum (necrobacillosis), with a focus on Lemierre's syndrome. Clin. Microbiol. Rev. 20: 622-659.
32. Schmaier, A. H. 2008. Assembly, activation, and physiologic influence of the plasma kallikrein/kinin system. Int. Immunopharmacol. 8:161-165.
33. Scott, C. F., L. D. Silver, A. D. Purdon, and R. W. Colman. 1985. Cleavage of human high molecular weight kininogen by factor XIa in vitro. Effect on structure and function. J. Biol. Chem. 260:10856-10863.
34. Tadepalli, S., G. C. Stewart, T. G. Nagaraja, and S. K. Narayanan. 2008. Human Fusobacterium necrophorum strains have a leukotoxin gene and exhibit leukotoxic activity. J. Med. Microbiol. 57:225-231.