Bacillus cereus G9241 makes anthrax toxin and capsule like highly virulent B. anthracis Ames but behaves like attenuated toxigenic nonencapsulated B. anthracis Sterne in rabbits and mice

Infection and Immunity

Volumn 79, Issue 8, 2011, Pages 3012-3019

  Wilson, Melissa K ^a,c   Vergis, James M ^a   Alem, Farhang ^a   Palmer, John R ^b   Keane Myers, Andrea M ^b   Brahmbhatt, Trupti N ^b   Ventura, Christy L ^a   O'Brien, Alison D ^a  

^a UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^b NAVAL MEDICAL RESEARCH CENTER   (United States)

^c BATTELLE MEMORIAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRAX TOXIN;

AMES TEST; ARTICLE; BACILLUS ANTHRACIS; BACILLUS CEREUS; BACTERIAL CELL; BACTERIAL MEMBRANE; BACTERIAL SPORE; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BACTERIUM ISOLATION; BLOOD; EXPERIMENTAL RABBIT; INOCULATION; LD 50; PLASMID; PRIORITY JOURNAL; RABBIT; SPLEEN; TOXICITY;

ADMINISTRATION, INHALATION; AEROSOLS; ANIMALS; ANTHRAX; ANTIGENS, BACTERIAL; BACILLUS ANTHRACIS; BACILLUS CEREUS; BACTERIAL CAPSULES; BACTERIAL TOXINS; DISEASE MODELS, ANIMAL; FEMALE; LETHAL DOSE 50; MICE; MICE, INBRED A; MICE, INBRED C57BL; PLASMIDS; RABBITS; RODENT DISEASES; VIRULENCE; VIRULENCE FACTORS;

EID: 79961115859     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.00205-11     Document Type: Article

References (43)

1. Akoachere, M., et al. 2007. Identification of an in vivo inhibitor of Bacillus anthracis spore germination. J. Biol. Chem. 282, 12112-12118.
2. Bottone, E. J. 2010. Bacillus cereus, a volatile human pathogen. Clin. Microbiol. Rev. 23, 382-398.
3. Brahmbhatt, T. N., et al. 2007. Recombinant exosporium protein BclA of Bacillus anthracis is effective as a booster for mice primed with suboptimal amounts of protective antigen. Infect. Immun. 75, 5240-5247.
4. Chand, H. S., et al. 2009. Discriminating virulence mechanisms among Bacillus anthracis strains by using a murine subcutaneous infection model. Infect. Immun. 77, 429-435.
5. Cybulski, R. J., Jr., et al. 2009. Four superoxide dismutases contribute to Bacillus anthracis virulence and provide spores with redundant protection from oxidative stress. Infect. Immun. 77, 274-285.
6. Cybulski, R. J., Jr., et al. 2008. Recombinant Bacillus anthracis spore proteins enhance protection of mice primed with suboptimal amounts of protective antigen. Vaccine 26, 4927-4939.
7. Drysdale, M., et al. 2005. Capsule synthesis by Bacillus anthracis is required for dissemination in murine inhalation anthrax. EMBO J. 24, 221-227.
8. Fieldhouse, R. J., Z. Turgeon, D. White, and A. R. Merrill. 2010. Choleraand anthrax-like toxins are among several new ADP-ribosyltransferases. PLoS Comput. Biol. 6, e1001029.
9. Frischknecht, F. 2003. The history of biological warfare. Human experimentation, modern nightmares and lone madmen in the twentieth century. EMBO Rep. 4, S47-S52.
10. Green, B. D., L. Battisti, T. M. Koehler, C. B. Thorne, and B. E. Ivins. 1985. Demonstration of a capsule plasmid in Bacillus anthracis. Infect. Immun. 49, 291-297.
11. Hernandez, E., F. Ramisse, J. P. Ducoureau, T. Cruel, and J. D. Cavallo. 1998. Bacillus thuringiensis subsp. konkukian (serotype H34) superinfection: case report and experimental evidence of pathogenicity in immunosuppressed mice. J. Clin. Microbiol. 36, 2138-2139.
12. Hoffmaster, A. R., et al. 2006. Characterization of Bacillus cereus isolates associated with fatal pneumonias, strains are closely related to Bacillus anthracis and harbor B. anthracis virulence genes. J. Clin. Microbiol. 44, 3352-3360.
13. Hoffmaster, A. R., and T. M. Koehler. 1999. Autogenous regulation of the Bacillus anthracis pag operon. J. Bacteriol. 181, 4485-4492.
14. Hoffmaster, A. R., et al. 2004. Identification of anthrax toxin genes in a Bacillus cereus associated with an illness resembling inhalation anthrax. Proc. Natl. Acad. Sci. U. S. A. 101, 8449-8454.
15. Ihde, D. C., and D. Armstrong. 1973. Clinical spectrum of infection due to Bacillus species. Am. J. Med. 55, 839-845.
16. Inglesby, T. V., et al. 2002. Anthrax as a biological weapon, 2002, updated recommendations for management. JAMA 287, 2236-2252.
17. Jernigan, J. A., et al. 2001. Bioterrorism-related inhalational anthrax, the first 10 cases reported in the United States. Emerg. Infect. Dis. 7, 933-944.
18. Klee, S. R., et al. 2010. The genome of a Bacillus isolate causing anthrax in chimpanzees combines chromosomal properties of B. cereus with B. anthracis virulence plasmids. PLoS One 5, e10986.
19. Knop, A. G., and V. A. Abalakin. 1986. Anthrax (Siberian plague), p. 100-109. Epidemic process as a socio-ecological system. Handbook of scientific works. Central Scientific Research Institute of Epidemiology, Moscow, Soviet Union.
20. Kuroki, R., et al. 2009. Nosocomial bacteremia caused by biofilm-forming Bacillus cereus and Bacillus thuringiensis. Intern. Med. 48, 791-796.
21. Lyons, C. R., et al. 2004. Murine model of pulmonary anthrax, kinetics of dissemination, histopathology, and mouse strain susceptibility. Infect. Immun. 72, 4801-4809.
22. Makino, S., I. Uchida, N. Terakado, C. Sasakawa, and M. Yoshikawa. 1989. Molecular characterization and protein analysis of the cap region, which is essential for encapsulation in Bacillus anthracis. J. Bacteriol. 171, 722-730.
23. McCormick, N. G. 1965. Kinetics of spore germination. J. Bacteriol. 89, 1180-1185.
24. McIntyre, L., K. Bernard, D. Beniac, J. L. Isaac-Renton, and D. C. Naseby. 2008. Identification of Bacillus cereus group species associated with food poisoning outbreaks in British Columbia, Canada. Appl. Environ. Microbiol. 74, 7451-7453.
25. Miller, J., et al. 1997. Fulminating bacteremia and pneumonia due to Bacillus cereus. J. Clin. Microbiol. 35, 504-507. (Erratum, 35:1294.).
26. Nicholson, W. L., and P. Setlow. 1990. Sporulation, germination, and outgrowth, p. 391-450. In C. R. Harwood and S. M. Cutting (ed.), Molecular biological methods for Bacillus. Wiley, Chichester, United Kingdom.
27. Oh, S. Y., J. M. Budzik, G. Garufi, and O. Schneewind. 2011. Two capsular polysaccharides enable Bacillus cereus G9241 to cause anthrax-like disease. Mol. Microbiol. 80, 455-470.
28. 2-bicarbonate and aerobic atmospheres. PLoS One 4, e4904.
29. Perego, M., and J. A. Hoch. 2008. Commingling regulatory systems following acquisition of virulence plasmids by Bacillus anthracis. Trends Microbiol. 16, 215-221.
30. Rasko, D. A., M. R. Altherr, C. S. Han, and J. Ravel. 2005. Genomics of the Bacillus cereus group of organisms. FEMS Microbiol. Rev. 29, 303-329.
31. Rasko, D. A., et al. 2007. Complete sequence analysis of novel plasmids from emetic and periodontal Bacillus cereus isolates reveals a common evolutionary history among the B. cereus-group plasmids, including Bacillus anthracis pXO1. J. Bacteriol. 189, 52-64.
32. Reed, L. J., and H. Muench. 1938. A simple method of estimating fifty percent endpoints. Am. J. Hyg. 27, 493-497.
33. Sanz, P., et al. 2008. Detection of Bacillus anthracis spore germination in vivo by bioluminescence imaging. Infect. Immun. 76, 1036-1047.
34. Shlyakhov, E. N., and E. Rubinstein. 1994. Human live anthrax vaccine in the former USSR. Vaccine 12, 727-730.
35. Sterne, M., J. Nicol, and M. C. Lambrechts. 1942. The effect of large scale active immunisation against anthrax. J. S. Afr. Med. Vet. Assoc. 13, 53.
36. Sue, D., A. R. Hoffmaster, T. Popovic, and P. P. Wilkins. 2006. Capsule production in Bacillus cereus strains associated with severe pneumonia. J. Clin. Microbiol. 44, 3426-3428.
37. Turnbull, P. C., K. Jorgensen, J. M. Kramer, R. J. Gilbert, and J. M. Parry. 1979. Severe clinical conditions associated with Bacillus cereus and the apparent involvement of exotoxins. J. Clin. Pathol. 32, 289-293.
38. Turnbull, P. C., and J. M. Kramer. 1983. Non-gastrointestinal Bacillus cereus infections, an analysis of exotoxin production by strains isolated over a two-year period. J. Clin. Pathol. 36, 1091-1096.
39. Uchida, I., J. M. Hornung, C. B. Thorne, K. R. Klimpel, and S. H. Leppla. 1993. Cloning and characterization of a gene whose product is a transactivator of anthrax toxin synthesis. J. Bacteriol. 175, 5329-5338.
40. Uchida, I., S. Makino, T. Sekizaki, and N. Terakado. 1997. Cross-talk to the genes for Bacillus anthracis capsule synthesis by atxA, the gene encoding the trans-activator of anthrax toxin synthesis. Mol. Microbiol. 23, 1229-1240.
41. Welkos, S. L., T. J. Keener, and P. H. Gibbs. 1986. Differences in susceptibility of inbred mice to Bacillus anthracis. Infect. Immun. 51, 795-800.
42. Welkos, S. L., N. J. Vietri, and P. H. Gibbs. 1993. Non-toxigenic derivatives of the Ames strain of Bacillus anthracis are fully virulent for mice, role of plasmid pX02 and chromosome in strain-dependent virulence. Microb. Pathog. 14, 381-388.
43. Zaucha, G. M., L. M. Pitt, J. Estep, B. E. Ivins, and A. M. Friedlander. 1998. The pathology of experimental anthrax in rabbits exposed by inhalation and subcutaneous inoculation. Arch. Pathol. Lab. Med. 122, 982-992.