Epidermal barrier treatments based on vernix caseosa

Skin Pharmacology and Physiology

Volumn 24, Issue 6, 2011, Pages 322-329

  Visscher, Marty O ^a   Barai, Namrata ^b   LaRuffa, Angela A ^a   Pickens, William L ^a   Narendran, Vivek ^a   Hoath, Steven B ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b UNIVERSITY OF CINCINNATI   (United States)

Author keywords

Barrier repair; Premature infant; Stratum corneum; Transepidermal water loss; Vernix caseosa; Wound healing

Indexed keywords

PETROLATUM; WATER OIL CREAM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOACCUMULATION; CONTROLLED STUDY; CONVALESCENCE; CREAM; DERMIS; DRY SKIN; EPIDERMIS; ERYTHEMA; FEMALE; FILM; HUMAN; HYDRATION; INFANT; KERATINOCYTE; MATURATION; MINIPIG; MOISTURE; MOTHER; NEWBORN; NONHUMAN; PREMATURITY; PRIORITY JOURNAL; SKIN PERMEABILITY; SKIN SURFACE; SKIN WATER LOSS; VERNIX CASEOSA; WATER VAPOR; WOUND HEALING;

ANIMALS; BODY WATER; EPIDERMIS; FEMALE; HUMANS; INFANT, NEWBORN; OINTMENTS; SWINE; SWINE, MINIATURE; VERNIX CASEOSA; WOUND HEALING;

EID: 79961110117     PISSN: 16605527     EISSN: 16605535     Source Type: Journal    
DOI: 10.1159/000328744     Document Type: Article

References (56)

1. Pickens W, Warner R, Boissy R, Hoath S: Characterization of human vernix: water content morphology and elemental analysis. J Invest Dermatol 2000;115:875-881.
2. Visscher MO, Narendran V, Pickens WL, LaRuffa AA, Meinzen-Derr J, Allen K, Hoath SB: Vernix caseosa in neonatal adaptation. J Perinatol 2005;25:440-446. (Pubitemid 40975593)
3. Youssef W, Wickett RR, Hoath SB: Surface free energy characterization of vernix caseo - sa: potential role in waterproofing the newborn infant. Skin Res Technol 2001;7:10-17. (Pubitemid 32060994)
4. Bautista M, Pickens W, Visscher M, Hoath S: Characterization of vernix caseosa as a natural biofilm: comparison to standard oilbased ointments. Pediatr Dermatol 2000;17:253-260.
5. Visscher MO, Utturkar R, Picken WL, LaRuffa AA, Robinson M, Wickett RR, Narendran V, Hoath SB: Neonatal skin maturation - vernix caseosa and free amino acids. Pediatr Dermatol 2011;28:122-132.
6. Visscher MO, Chatterjee R, Munson KA, Pickens WL, Hoath SB: Changes in diapered and nondiapered infant skin over the first month of life. Pediatr Dermatol 2000;17:45-51. (Pubitemid 30198241)
7. Akinbi HT, Narendran V, Pass AK, Markart P, Hoath SB: Host defense proteins in vernix caseosa and amniotic fluid. Am J Obstet Gynecol 2004;191:2090-2096. (Pubitemid 39601518)
8. Marchini G, Lindow S, Brismar H, Stabi B, Berggren V, Ulfgren AK, Lonne-Rahm S, Agerberth B, Gudmundsson GH: The newborn infa nt is protected by an innate antimicrobial barrier: peptide antibiotics are present in the skin and vernix caseosa. Br J Dermatol 2002;147:1127-1134. (Pubitemid 36963018)
9. Yoshio H, Tollin M, Gudmundsson GH, Lagercrantz H, Jornvall H, Marchini G, Agerberth B: Antimicrobial polypeptides of human vernix caseosa and amniotic fluid: implications for newborn innate defense. Pediatr Res 2003;53:211-216. (Pubitemid 36177115)
10. Tollin M, Bergsson G, Kai-Larsen Y, Lengqvist J, Sjovall J, Griffiths W, Skuladottir GV, Haraldsson A, Jornvall H, Gudmundsson GH, Agerberth B: Vernix caseosa as a multi-component defence system based on polypeptides, lipids and their interactions. Cell Mol Life Sci 2005;62:2390-2399. (Pubitemid 41500555)
11. Tansirikongkol A, Wickett RR, Visscher MO, Hoath SB: Effect of vernix caseosa on the penetration of chymotryptic enzyme: potential role in epidermal barrier development. Pediatr Res 2007;62:49-53. (Pubitemid 46985849)
12. Oudshoorn MH, Rissmann R, van der Coelen D, Hennink WE, Ponec M, Bouwstra JA: Development of a murine model to evaluate the effect of vernix caseosa on skin barrier recovery. Exp Dermatol 2009;18:178-184.
13. Zhukov BN, Neverova EI, Nikitin KE, Kostiaev VE, Myshentsev PN: A comparative evaluation of the use of vernix caseosa and solcoseryl in treating patients with trophic ulcers of the lower extremities (in Russian). Vestn Khir Im I I Grek 1992;148:339-341.
14. Hoath SB, Pickens WL, Visscher MO: The biology of vernix caseosa. Int J Cosmet Sci 2006;28:319-333. (Pubitemid 44423008)
15. Hoath S, Narendran V: Adhesives and emollients in newborn care. Sem Neonatol 2000;5:289-296.
16. Rutter N: The immature skin. Eur J Pediatr 1996;155(suppl 2): S18-S20.
17. Darmstadt GL, Dinulos JG: Neonatal skin care. Pediatr Clin North Am 2000;47:757-782. (Pubitemid 30480388)
18. Agren J, Sjors G, Sedin G: Transepidermal water loss in infants born at 24 and 25 weeks of gestation. Acta Paediatr 1998;87:1185-1190. (Pubitemid 28538430)
19. Harpin VA, Rutter N: Barrier properties of the newborn infant's skin. J Pediatr 1983;102:419-425. (Pubitemid 13149473)
20. Kalia YN, Nonato LB, Lund CH, Guy RH: Development of skin barrier function in pre - mature infants. J Invest Dermatol 1998;111:320-326. (Pubitemid 28354723)
21. Nonato LB, Lund CH, Kalia YN, Guy RH: Transepidermal water loss in 24 and 25 weeks gestational age infants. Acta Paediatr 2000;89:747-748. (Pubitemid 30624930)
22. Nikolovski J, Stamatas GN, Kollias N, Wiegand BC: Barrier function and water-holding and transport properties of infant stratum corneum are different from adult and continue to develop through the first year of life. J Invest Dermatol 2008;128:1728-1736. (Pubitemid 351863594)
23. Edwards WH, Conner JM, Soll RF: The effect of prophylactic ointment therapy on nosocomial sepsis rates and skin integrity in infants with birth weights of 501 to 1, 000 g. Pediatrics 2004;113:1195-1203. (Pubitemid 38580680)
24. Nopper AJ, Horii KA, Sookdeo-Drost S, Wang TH, Mancini AJ, Lane AT: Topical ointment therapy benefits premature infants. J Pediatr 1996;128:660-669. (Pubitemid 26137725)
25. Pabst RC, Starr KP, Qaiyumi S, Schwalbe RS, Gewolb IH: The effect of application of Aquaphor on skin condition, fluid requirements, and bacterial colonization in very low birth weight infants. J Perinatol 1999;19:278-283.
26. Visscher M, Hoath SB, Conroy E, Wickett RR: Effect of semipermeable membranes on skin barrier repair following tape stripping. Arch Dermatol Res 2001;293:491-499.
27. Bock M, Damer K, Wulfhorst B, John SM: Semipermeable glove membranes - effects on skin barrier repair following SLS irritation. Contact Dermatitis 2009;61:276-280.
28. Mancini AJ, Sookdeo-Drost S, Madison KC, Smoller BR, Lane AT: Semipermeable dressings improve epidermal barrier function in premature infants. Pediatr Res 1994;36:306-314. (Pubitemid 24256777)
29. Vernon HJ, Lane AT, Wischerath LJ, Davis JM, Menegus MA: Semipermeable dressing and transepidermal water loss in premature infants. Pediatrics 1990;86:357-362. (Pubitemid 20334966)
30. Gunt H: Water Handling Properties of Vernix Caseosa: Pharmacy. Cincinnati, University of Cincinnati, 2002.
31. Tansirikongkol A, Visscher MO, Wickett RR: Water-handling properties of vernix caseosa and a synthetic analogue. J Cosmet Sci 2007;58:651-662.
32. Visscher M, Narendran V, Joseph W, Gunt H, Hoath S: Development of topical eqidermal barriers for preterm infant skin: comparison of Aquaphor and vernix caseosa. Pediatr Acad Soc Annu Meet, Baltimore, 2002.
33. Schunck M, Neumann C, Proksch E: Artificial barrier repair in wounds by semi-occlusive foils reduced wound contraction and enhanced cell migration and reepithelization in mouse skin. J Invest Dermatol 2005;125:1063-1071.
34. 2 and erbium laser resur facing. Aesthet Surg J 2003;23:20-27. (Pubitemid 36748318)
35. Sterilization of health care products. Requirements for validation and routine control - radiation sterilization. Arlington, Association for the Advancement of Medical Instrumentation, 1995.
36. Jemac GB, Serup J: Epidermal hydration and skin mechanics: the relationship between electrical capacitance and the mechanical proper ties of human skin in vivo. Acta Derm Venereol (Stockh) 1990;70:245-247. (Pubitemid 20172430)
37. Treffel P, Gabard B: Stratum corneum dynamic function measurements after moisturizer or irritant application. Arch Dermatol Res 1995;287:474-479.
38. Sedin G, Hammarlund K, Stromberg B: Transepidermal water loss in full-term and pre-term infants. Acta Paediatr Scand Suppl 1983;305:27-31. (Pubitemid 13064445)
39. Visscher M, Robinson M, Wickett R: Stratum corneum free amino acids following barrier perturbation and repair. Int J Cosmet Sci 2011;33:80-89.
40. Visscher M, Robinson M, Wickett R: Stratum corneum free amino acids following barrier perturbation and repair. Int J Cosmet Sci 2011;33:80-89.
41. Breternitz M, Flach M, Prassler J, Elsner P, Fluhr JW: Acute barrier disruption by adhesive tapes is influenced by pressure, time and anatomical location: integrity and cohesion assessed by sequential tape stripping. A randomized, controlled study. Br J Dermatol 2007;156:231-240. (Pubitemid 46095949)
42. Harding CR, Watkinson A, Rawlings AV, Scott IR: Dry skin, moisturization and corneodesmolysis. Int J Cosmet Sci 2000;22:21-52. (Pubitemid 30166882)
43. Agren J, Sjors G, Sedin G: Transepidermal water loss in infants born at 24 and 25 weeks of gestation. Acta Paediatr 1998;87:1185-1190. (Pubitemid 28538430)
44. Agren J, Sjors G, Sedin G: Ambient humidity influences the rate of skin barrier maturation in extremely preterm infants. J Pediatr 2006;148:613-617. (Pubitemid 43776886)
45. Narendran V, Visscher MO, Abril I, Hendrix SW, Hoath SB: Biomarkers of epidermal innate immunity in premature and full-term infants. Pediatr Res 2010;67:382-386.
46. Visscher MO, Said D, Wickett R: Stratum corneum cytokines, structural proteins, and transepidermal water loss: effect of hand hygiene. Skin Res Technol 2010;16:229-236.
47. Okah FA, Wickett RR, Pickens WL, Hoath SB: Surface electrical capacitance as a noninvasive bedside measure of epidermal barrier maturation in the newborn infant. Pediatrics 1995;96:688-692.
48. Denda M, Sato J, Masuda Y, Tsuchiya T, Koyama J, Kuramoto M, Elias PM, Feingold KR: Exposure to a dry environment enhances epidermal permeability barrier function. J Invest Dermatol 1998;111:858-863. (Pubitemid 28509330)
49. Lane AT, Drost SS: Effects of repeated application of emollient cream to premature neonates' skin. Pediatrics 1993;92:415-419. (Pubitemid 23264639)
50. Conner JM, Soll RF, Edwards WH: Topical ointment for preventing infection in preterm infants. Cochrane Database Syst Rev 2004;1: CD001150.
51. Rissmann R, Groenink HW, Weerheim AM, Hoath SB, Ponec M, Bouwstra JA: New insights into ultrastructure, lipid composition and organization of vernix caseosa. J Invest Dermatol 2006;126:1823-1833. (Pubitemid 44086517)
52. Darmstadt GL, Mao-Qiang M, Chi E, Saha SK, Ziboh VA, Black RE, Santosham M, Elias PM: Impact of topical oils on the skin barrier: possible implications for neonatal health in developing countries. Acta Paediatr 2002;91:546-554. (Pubitemid 34620642)
53. Yang L, Mao-Qiang M, Taljebini M, Elias PM, Feingold KR: Topical stratum corneum lipids accelerate barrier repair after tape stripping, solvent treatment and some but not all types of detergent treatment. Br J Dermatol 1995;133:679-685.
54. Kessner D, Ruettinger A, Kiselev MA, Wartewig S, Neubert RH: Properties of ceramides and their impact on the stratum corneum structure. 2. Stratum corneum lipid model systems. Skin Pharmacol Physiol 2008;21:58-74. (Pubitemid 351440524)
55. Elias PM, Mao-Qiang M, Thornfeldt CR, Feingold KR: The epidermal permeability barrier: effects of physiologic and nonphysiologic lipids; in Hoppe U (ed): The Lanolin Book. Hamburg, Beiersdorf AG, 1999, pp 253-279.
56. Man MM, Feingold KR, Thornfeldt CR, Elias PM: Optimization of physiological lipid mixtures for barrier repair. J Invest Dermatol 1996;106:1096-1101. (Pubitemid 26153514)