Immune amplification of murine CD8 + suppressor T cells induced via an immune-privileged site: Quantifying suppressor T cells functionally

PLoS ONE

Volumn 6, Issue 8, 2011, Pages

  Sharafieh, Roshanak ^a   Lemire, Yen ^a   Powell, Sabrina ^a   O'Rourke, James ^a   Cone, Robert E ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; ANTIGEN;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTERIOR EYE CHAMBER; ANTIGEN EXPRESSION; ANTIGEN SPECIFICITY; ARTICLE; CD8+ T LYMPHOCYTE; CELL EXPANSION; CELLULAR IMMUNITY; CONTROLLED STUDY; DELAYED HYPERSENSITIVITY; FEMALE; FOOT PAD; LYMPHOCYTE COUNT; LYMPHOCYTE FUNCTION; MALE; MOUSE; NONHUMAN; SPLEEN CELL; SUPPRESSOR CELL; T LYMPHOCYTE SUBPOPULATION; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; CYTOLOGY; IMMUNOLOGY; SPLEEN;

MURINAE; MUS;

ADOPTIVE TRANSFER; ANIMALS; ANTERIOR CHAMBER; ANTIGENS; CD8-POSITIVE T-LYMPHOCYTES; FEMALE; HYPERSENSITIVITY, DELAYED; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; SPLEEN;

EID: 79961092756     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0022496     Document Type: Article

References (28)

1. Jiang H, Chess L, (2004) An integrated model of immunoregulation mediated by regulatory T cell subsets. Adv in Immunol 83: 253-88.
2. Tang X, Maric I, Kumar V, (2007) TCR antibody treatment activates a novel population of CD8 αα+,TCR α,β+ regulatory T cells and prevents experimental autoimmune encelphalomyelitis. Jour Immunol 178: 6043-6050.
3. Jiang H, Braunstein NS, Yu B, Winchester R, Chess L, (2001) CD8+ T cells control the TH phenotype of MBP-reactive CD4+ T cells in EAE mice. Proc Nat Acad Sci (USA) 98: 6301-6306.
4. Bhowmick S, Clark RB, Brocke S, Cone RE, (2011) Antigen-specific splenic CD4+ and CD8+ regulatory T cells generated via the eye, suppress Experimental Autoimmune Encephalomyelitis either at the priming or at the effector phase. Int Immunol 2011 23: 119-12.
5. Jiang H, Chess L, (2000) The specific regulation of immune responses by CD8+ T cells restricted by the MHC Class IB molecule, Qa-1. Annu Rev Immunol 18: 185-216.
6. Sarantopoulos S, Lu L, Cantor H, (2004) Qa-1 restriction of CD8+ suppressor T cells. Jour Clin Invest 114: 1218-21.
7. Hao H, Peizeng Y, Liquiong JJ, Unfeng Z, Xiomin L, et al. (2008) Upregulation of CD94 on CD8+ T cells in anterior chamber-associated immune deviation. Biomed Central Immunology 9: 53-64.
8. Jiang H, Braunstein NS, Yu B, Winchester R, Chess L, (2001) CD8+ T cells control the TH phenotype of the MBP-reactive CD4+ T cells in EAE mice. Proc Nat Acad Sci USA 98: 6301-6306.
9. Cone RE, Chattopadhyay S, Sharafieh R, Lemire Y, O'Rourke J, (2009) The suppression of hypersensitivity by ocular-induced CD8+ regulatory T cells requires compatibility in the Qa-1'haplotype. Immunology and Cell Biology 87: 241-248.
10. Kapp JA, Honjo K, Kapp LM, Xu XY, Cozier A, et al. (2006) TCR transgenic CD8+ T cells activated in the presence of TGFβ express FoxP3 and mediate linked suppression of primary immune responses and cardiac allograft rejection. Int Immunol 18: 1549-1562.
11. Kezuka T, Streilein JW, (2000) In vitro generation of regulatory CD8+ T cells similar to those found in mice with anterior chamber-associated immune deviation. Investigative Ophthalmology and Visual Science 41: 1803-11.
12. Cantor H, (2004) Reviving suppression? Nat Immunol 5: 347-8.
13. Cone RE, Chattopadhyay S, Pais R, Bhowmick S, Sharafieh R, et al. (2010) The induction of circulating, ACAID-inducing monocytes requires CCR2/CCL2-dependent migration of circulating F4/80+ cells into the anterior chamber. Ophthalmology and Eye Diseases 2: 57-68.
14. Wilbanks GA, Streilein JW, (1990) Macrophages capable of inducing anterior chamber associated immune deviation demonstrate spleen-seeking migratory properties. Reg Immunol 4: 130-7.
15. Wang Y, Goldschneider I, O'Rourke J, Cone RE, (2001) Blood mononuclear cells induce regulatory NK thymocytes in anterior chamber-associated immune deviation. J Leukoc Biol 69: 741-6.
16. Li X, Shen S, Urso D, Kalique S, Park S-H, et al. (2006) Phenotypic and immunoregulatory characteristics of monocytic iris cells. Immunology 117: 566-75.
17. Niederkorn JY, (2002) Immune privilege in the anterior chamber of the eye. Crit Rev Immunol 11: 13-46.
18. Wilbanks GA, Mammolenti M, Streilein JW, (1991) Studies on the induction of anterior chamber-associated immune deviation (ACAID) II. Eye-derived cells participate in generating blood-borne signals that induce ACAID. J Immunol 146: 3018-24.
19. D'Orazio TJ, Niederkorn JY, (1998) A novel role for TGF-beta and IL-10 in the induction of immune privilege. Jour of Immunol 160: 2089-98.
20. Faunce DE, Sonoda K-H, Stein-Streilein J, (2001) MIP-2 mediated recruitment of NKT cells to the spleen during tolerance induction. J Immunol 166:313: 954-958.
21. Cone RE, Chattopadhyay S, Sharafieh R, Lemire Y, O'Rourke J, et al. (2009) T ell sensitivity to TGF-beta is required for the effector function but not the generation of splenic CD8+ regulatory T cells induced via the injection of antigen into the anterior chamber. Intern Immunol 21: 567-74.
22. Keino H, Takeuchi M, Kezuka T, Hattori T, Usui M, et al. (2006) Induction of eye-derived tolerance does not depend on naturally occurring CD4+CD25+ T regulatory cells. Invest Ophthalmol Vis Sci 47: 1047-55.
23. Li X, Wang Y, Urso D, O'Rourke J, Cone RE, (2006) Thymocytes induced by antigen injection into the anterior chamber activate splenic CD8+ suppressor cells and enhance the antigen-induced production of immunoglobulin G1 antibodies. Immunology 113: 44-56.
24. Jiang L, He H, Yang P, Lin X, Zhou H, et al. (2009) Splenic CD8+ T cells secrete TGF-β1 to exert suppression in mice with anterior chamber-associated immune deviation. Graefes Arch Clin Exp Ophthalmol 247: 87-9227.
25. Marchal G, Seman M, Milon G, Truffa-Bachi P, Zilberfarb V, (1982) Local adoptive transfer of skin delayed-type hypersensitivity initiated by a single T lymphocyte. Jour Immunol 129: 954-958.
26. Cone RE, Li X, Sharafieh R, O'Rourke J, Vella AT, (2006) The suppression of delayed-type hypersensitivity by CD8+regulatory T cells requires interferon-γ. Immunology 120: 12-119.
27. Myers L, Croft B, Kwon BS, Mittler RS, Vella AT, (2003) Peptide-specific CD8 regulatory cells use IFN- to elaborate TGFβ suppression. J Immunol 174: 7625-32.
28. Bhowmick S, Singh A, Flavell RA, Clark RB, O'Rourke J, et al. (2009) The sympathetic nervous system modulates CD4 FoxP3 regulatory T cells via a TGF-β dependent mechanism. Jour Leuk Biol 86: 1275-1283.