A phosphodegron controls nutrient-induced proteasomal activation of the signaling protease Ssy5

Molecular Biology of the Cell

Volumn 22, Issue 15, 2011, Pages 2754-2765

  Omnus, Deike J ^a   Pfirrmann, Thorsten ^a   Andréasson, Claes ^a   Ljungdahl, Per O ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CASEIN KINASE I; CASEIN KINASE II; CULLIN; F BOX PROTEIN; LYSINE; PROTEASOME; PROTEINASE; SSY5 PROTEASE; UBIQUITIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME DEGRADATION; ENZYME PHOSPHORYLATION; ENZYME SUBSTRATE; NONHUMAN; PHOSPHODEGRON; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN PROCESSING; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; UBIQUITINATION;

AMINO ACID SEQUENCE; AMINO ACIDS; BLOTTING, WESTERN; CASEIN KINASE I; CELL MEMBRANE; CYTOPLASM; DNA-BINDING PROTEINS; ENZYME ACTIVATION; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN STRUCTURE, TERTIARY; RNA-BINDING PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SERINE PROTEASES; SIGNAL TRANSDUCTION; SKP CULLIN F-BOX PROTEIN LIGASES; TRANSCRIPTION FACTORS; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 79961058510     PISSN: 10591524     EISSN: 19394586     Source Type: Journal    
DOI: 10.1091/mbc.E11-04-0282     Document Type: Article

References (46)

1. Abdel-Sater F, El Bakkoury M, Urrestarazu A, Vissers S, André B (2004). Amino acid signaling in yeast: casein kinase I and the Ssy5 endoprotease are key determinants of endoproteolytic activation of the membrane-bound Stp1 transcription factor. Mol Cell Biol 24, 9771-9785. (Pubitemid 39458806)
2. Abdel-Sater F, Jean C, Merhi A, Vissers S, André B (2011). Amino-acid signalling in yeast: activation of the Ssy5 protease is associated with its phosphorylation-induced ubiquitylation. J Biol Chem 286, 12006-12015.
3. Andréasson C, Heessen S, Ljungdahl PO (2006). Regulation of transcription factor latency by receptor-activated proteolysis. Genes Dev 20, 1563-1568. (Pubitemid 43901095)
4. Andréasson C, Ljungdahl PO (2002). Receptor-mediated endoproteolytic activation of two transcription factors in yeast. Genes Dev 16, 3158-3172. (Pubitemid 36025970)
5. Andréasson C, Ljungdahl PO (2004). The N-terminal regulatory domain of Stp1p is modular and, fused to an artificial transcription factor, confers full Ssy1p-Ptr3p-Ssy5p sensor control. Mol Cell Biol 24, 7503-7513. (Pubitemid 39121478)
6. 2+-ATPase homologue, PMR1, is required for normal Golgi function and localizes in a novel Golgi-like distribution. Mol Biol Cell 3, 633-654.
7. Grr1 ubiquitin ligase complex are involved in the signalling pathway activated by external amino acids in Saccharomyces cerevisiae. FEBS Lett 496, 81-85.
8. Boatright KM, Salvesen GS (2003). Mechanisms of caspase activation. Curr Opin Cell Biol 15, 725-731. (Pubitemid 37492933)
9. Brivanlou AH, Darnell JE, Jr (2002). Signal transduction and the control of gene expression. Science 295, 813-818. (Pubitemid 34118354)
10. Ciosk R, Zachariae W, Michaelis C, Shevchenko A, Mann M, Nasmyth K (1998). An ESP1/PDS1 complex regulates loss of sister chromatid cohesion at the metaphase to anaphase transition in yeast. Cell 93, 1067-1076. (Pubitemid 28280799)
11. Eckert-Boulet N, Larsson K, Wu B, Poulsen P, Regenberg B, Nielsen J, Kielland-Brandt MC (2006). Deletion of RTS1, encoding a regulatory subunit of protein phosphatase 2A, results in constitutive amino acid signaling via increased Stp1p processing. Eukaryot Cell 5, 174-179. (Pubitemid 43113463)
12. Flick KM, Spielewoy N, Kalashnikova TI, Guaderrama M, Zhu Q, Chang HC, Wittenberg C (2003). Grr1-dependent inactivation of Mth1 mediates glucose-induced dissociation of Rgt1 from HXT gene promoters. Mol Biol Cell 14, 3230-3241. (Pubitemid 37013123)
13. Flotow H, Graves PR, Wang AQ, Fiol CJ, Roeske RW, Roach PJ (1990). Phosphate groups as substrate determinants for casein kinase I action. J Biol Chem 265, 14264-14269.
14. Forsberg H, Ljungdahl PO (2001). Genetic and biochemical analysis of the yeast plasma membrane Ssy1p-Ptr3p-Ssy5p sensor of extracellular amino acids. Mol Cell Biol 21, 814-826. (Pubitemid 32104730)
15. Ghislain M, Udvardy A, Mann C (1993). S. cerevisiae 26S protease mutants arrest cell division in G2/metaphase. Nature 366, 358-362. (Pubitemid 23349365)
16. Gross SD, Anderson RA (1998). Casein kinase I: spatial organization and positioning of a multifunctional protein kinase family. Cell Signal 10, 699-711. (Pubitemid 28520022)
17. Gyuris J, Golemis E, Chertkov H, Brent R (1993). Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2. Cell 75, 791-803. (Pubitemid 23346376)
18. Hoppe T, Matuschewski K, Rape M, Schlenker S, Ulrich HD, Jentsch S (2000). Activation of a membrane-bound transcription factor by regulated ubiquitin/proteasome-dependent processing. Cell 102, 577-586.
19. Iglesias N, Tutucci E, Gwizdek C, Vinciguerra P, Von Dach E, Corbett AH, Dargemont C, Stutz F (2010). Ubiquitin-mediated mRNP dynamics and surveillance prior to budding yeast mRNA export. Genes Dev 24, 1927-1938.
20. Ingrell CR, Miller ML, Jensen ON, Blom N (2007). NetPhosYeast: prediction of protein phosphorylation sites in yeast. Bioinformatics 23, 895-897. (Pubitemid 47049925)
21. Iraqui I, Vissers S, Bernard F, de Craene JO, Boles E, Urrestarazu A, André B (1999). Amino acid signaling in Saccharomyces cerevisiae: a permease-like sensor of external amino acids and F-Box protein Grr1p are required for transcriptional induction of the AGP1 gene, which encodes a broad-specificity amino acid permease. Mol Cell Biol 19, 989-1001. (Pubitemid 29046843)
22. Johnston M, Kim JH (2005). Glucose as a hormone: receptor-mediated glucose sensing in the yeast Saccharomyces cerevisiae. Biochem Soc Trans 33, 247-252. (Pubitemid 40313813)
23. Jonkers W, Rep M (2009). Lessons from fungal F-box proteins. Eukaryot Cell 8, 677-695.
24. Jørgensen MU, Bruun MB, Didion T, Kielland-Brandt MC (1998). Mutations in five loci affecting GAP1-independent uptake of neutral amino acids in yeast. Yeast 14, 103-114. (Pubitemid 28062862)
25. Klasson H, Fink GR, Ljungdahl PO (1999). Ssy1p and Ptr3p are plasma membrane components of a yeast system that senses extracellular amino acids. Mol Cell Biol 19, 5405-5416. (Pubitemid 29339899)
26. Knippschild U, Gocht A, Wolff S, Huber N, Lohler J, Stoter M (2005). The casein kinase 1 family: participation in multiple cellular processes in eukaryotes. Cell Signal 17, 675-689. (Pubitemid 40250168)
27. Lakshmanan J, Mosley AL, Özcan S (2003). Repression of transcription by Rgt1 in the absence of glucose requires Std1 and Mth1. Curr Genet 44, 19-25. (Pubitemid 37265827)
28. Liu Z, Thornton J, Spirek M, Butow RA (2008). Activation of the SPS amino acid-sensing pathway in Saccharomyces cerevisiae correlates with the phosphorylation state of a sensor component, Ptr3. Mol Cell Biol 28, 551-563.
29. Moriya H, Johnston M (2004). Glucose sensing and signaling in Saccharomyces cerevisiae through the Rgt2 glucose sensor and casein kinase I. Proc Natl Acad Sci USA 101, 1572-1577. (Pubitemid 38234195)
30. Nasmyth K (2002). Segregating sister genomes: the molecular biology of chromosome separation. Science 297, 559-565.
31. Nasmyth K (2005). How do so few control so many?. Cell 120, 739-746.
32. Page MJ, Macgillivray RT, Di Cera E (2005). Determinants of specificity in coagulation proteases. J Thromb Haemost 3, 2401-2408. (Pubitemid 41727155)
33. Pfirrmann T, Heessen S, Omnus DJ, Andréasson C, Ljungdahl PO (2010). The prodomain of Ssy5 protease controls receptor-activated proteolysis of transcription factor Stp1. Mol Cell Biol 30, 3299-3309.
34. Poulsen P, Lo Leggio L, Kielland-Brandt MC (2006). Mapping of an internal protease cleavage site in the Ssy5p component of the amino acid sensor of Saccharomyces cerevisiae and functional characterization of the resulting pro- and protease domains by gain-of-function genetics. Eukaryot Cell 5, 601-608.
35. Silve S, Volland C, Garnier C, Jund R, Chevallier MR, Haguenauer-Tsapis R (1991). Membrane insertion of uracil permease, a polytopic yeast plasma membrane protein. Mol Cell Biol 11, 1114-1124. (Pubitemid 21895463)
36. Grr1 targets in the glucose and amino acid signaling pathways. Mol Cell Biol 24, 8994-9005.
37. Spielewoy N, Guaderrama M, Wohlschlegel JA, Ashe M, Yates JR, 3rd, Wittenberg C (2010). Npr2, yeast homolog of the human tumor suppressor NPRL2, is a target of Grr1 required for adaptation to growth on diverse nitrogen sources. Eukaryot Cell 9, 592-601.
38. Stroud RM, Kossiakoff AA, Chambers JL (1977). Mechanisms of zymogen activation. Annu Rev Biophys Bioeng 6, 177-193.
39. Tumusiime S, Zhang C, Overstreet MS, Liu Z (2011). Differential regulation of transcription factors Stp1 and Stp2 in the Ssy1-Ptr3-Ssy5 amino acid sensing pathway. J Biol Chem 286, 4620-4631.
40. Uhlmann F, Lottspeich F, Nasmyth K (1999). Sister-chromatid separation at anaphase onset is promoted by cleavage of the cohesin subunit Scc1. Nature 400, 37-42. (Pubitemid 29315102)
41. Vancura A, Sessler A, Leichus B, Kuret J (1994). A prenylation motif is required for plasma membrane localization and biochemical function of casein kinase I in budding yeast. J Biol Chem 269, 19271-19278. (Pubitemid 24233444)
42. Wang PC, Vancura A, Mitcheson TG, Kuret J (1992). Two genes in Saccharomyces cerevisiae encode a membrane-bound form of casein kinase-1. Mol Biol Cell 3, 275-286. (Pubitemid 23095964)
43. Wielemans K, Jean C, Vissers S, Andre B (2010). Amino acid signaling in yeast: post-genome duplication divergence of the Stp1 and Stp2 transcription factors. J Biol Chem 285, 855-865.
44. Willems AR, Schwab M, Tyers M (2004). A hitchhiker's guide to the cullin ubiquitin ligases: SCF and its kin. Biochim Biophys Acta 1695, 133-170. (Pubitemid 39574971)
45. Wolf DH (2004). From lysosome to proteasome: the power of yeast in the dissection of proteinase function in cellular regulation and waste disposal. Cell Mol Life Sci 61, 1601-1614.
46. Wu B, Ottow K, Poulsen P, Gaber RF, Albers E, Kielland-Brandt MC (2006). Competitive intra- and extracellular nutrient sensing by the transporter homologue Ssy1p. J Cell Biol 173, 327-331.