Novel modular DNA aptamer for human thrombin with high anticoagulant activity

Current Medicinal Chemistry

Volumn 18, Issue 22, 2011, Pages 3343-3350

  Zavyalova, E ^a   Golovin, A ^a,b   Reshetnikov, R ^a,b   Mudrik, N ^b   Panteleyev, D ^b,c   Pavlova, G ^b,c   Kopylov, A ^a,b  

^a MOSCOW STATE UNIVERSITY   (Russian Federation)

^b Apto Pharm Ltd   (Russian Federation)

^c INSTITUTE OF GENE BIOLOGY   (Russian Federation)

Author keywords

Anticoagulant; Coagulation; G quadruplex; Hemostasis; Molecular dynamic simulation; Pharmacodynamics; Pharmacokinetics; Thrombin; Thrombin binding DNA aptamer; Thrombin inhibitor; Turbidimetry

Indexed keywords

ANTICOAGULANT AGENT; APTAMER; DNA APTAMER RA 36; GUANINE QUADRUPLEX; POTASSIUM ION; THROMBIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTICOAGULATION; BLOOD CLOTTING TEST; COMBINATORIAL CHEMISTRY; COMBINATORIAL LIBRARY; COMPETITIVE INHIBITION; CONFERENCE PAPER; CONTROLLED STUDY; DNA STRUCTURE; DRUG CONFORMATION; DRUG DESIGN; DRUG EXCRETION; DRUG MECHANISM; HUMAN; MOLECULAR DYNAMICS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PROTEIN DNA BINDING; RAT; SIMULATION; SPECIES DIFFERENCE; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTICOAGULANTS; APTAMERS, NUCLEOTIDE; BLOOD COAGULATION TESTS; GENE LIBRARY; HUMANS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; SPECIES SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBIN;

EID: 79961053711     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/092986711796504727     Document Type: Conference Paper

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