Adenosine negative feedback on A2A adenosine receptors mediates hyporesponsiveness in chronically septic mice

Shock

Volumn 35, Issue 4, 2011, Pages 382-387

  Belikoff, Bryan ^a   Hatfield, Stephen ^b   Sitkovsky, Michail ^b   Remick, Daniel G ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NORTHEASTERN UNIVERSITY   (United States)

Author keywords

Bacterial overgrowth; Compensatory anti inflammatory response syndrome; Cytokines; Immune suppression; Inflammation; Systemic inflammatory response syndrome

Indexed keywords

ADENOSINE; ADENOSINE A2A RECEPTOR; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MACROPHAGE INFLAMMATORY PROTEIN 2; TUMOR NECROSIS FACTOR ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBIOTIC THERAPY; ARTICLE; BACTERIAL OVERGROWTH; BACTERIAL PERITONITIS; BLOOD LEVEL; CONTROLLED STUDY; CYTOKINE RELEASE; IMMUNE RESPONSE; MALE; MORTALITY; MOUSE; NEGATIVE FEEDBACK; NONHUMAN; PROTEIN DEFECT; SPLEEN; ANIMAL; C57BL MOUSE; CECUM; GENETICS; IMMUNOASSAY; INJURY; METABOLISM; MICROBIOLOGY; MOUSE MUTANT; PERITONITIS; PUNCTURE; SEPSIS;

ADENOSINE; ANIMALS; CECUM; CHEMOKINE CCL2; IMMUNOASSAY; INTERLEUKIN-10; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PERITONITIS; PUNCTURES; RECEPTOR, ADENOSINE A2A; SEPSIS;

EID: 79961042393     PISSN: 10732322     EISSN: 15400514     Source Type: Journal    
DOI: 10.1097/SHK.0b013e3182085f12     Document Type: Article

References (31)

1. Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR: Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 29:1303-1310, 2001.
2. Osuchowski MF, Welch K, Yang H, Siddiqui J, Remick DG: Chronic sepsis mortality characterized by an individualized inflammatory response. J Immunol 179:623-630, 2007.
3. Wang H, Bloom O, Zhang M, Vishnubhakat JM, Ombrellino M, Che J, Frazier A, Yang H, Ivanova S, Borovikova L, et al.: HMG-1 as a late mediator of endotoxin lethality in mice. Science 285:248-251, 1999.
4. Inoue S, Unsinger J, Davis CG, Muenzer JT, Ferguson TA, Chang K, Osborne DF, Clark AT, Coopersmith CM, McDunn JE, Hotchkiss RS: IL-15 prevents apoptosis, reverses innate and adaptive immune dysfunction, and improves survival in sepsis. J Immunol 184:1401-1409, 2010.
5. Remick DG: Pathophysiology of sepsis. Am J Pathol 170:1435-1444, 2007.
6. Hotchkiss RS, Nicholson DW: Apoptosis and caspases regulate death and inflammation in sepsis. Nat Rev Immunol 6:813-822, 2006.
7. Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, Schein RM, Sibbald WJ: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 101:1644-1655, 1992.
8. Ellaban E, Bolgos G, Remick D: Selective macrophage suppression during sepsis. Cell Immunol 231:103-111, 2004.
9. Ohta A, Sitkovsky M: Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage. Nature 414:916-920, 2001.
10. Ohta A, Gorelik E, Prasad SJ, Ronchese F, Lukashev D, Wong MK, Huang X, Caldwell S, Liu K, Smith P, et al.: A2A adenosine receptor protects tumors from antitumor T cells. Proc Natl Acad Sci U S A 103:13132-13137, 2006.
11. Bingham TC, Fisher EA, Parathath S, Reiss AB, Chan ES, Cronstein BN: A2A adenosine receptor stimulation decreases foam cell formation by enhancing ABCA1-dependent cholesterol efflux. J Leukoc Biol 87:683-690, 2010.
12. Lukashev D, Ohta A, Apasov S, Chen JF, Sitkovsky M: Cutting edge: physiologic attenuation of proinflammatory transcription by the Gs protein-coupled A2A adenosine receptor in vivo. J Immunol 173:21-24, 2004.
13. Csoka B, Nemeth ZH, Virag L, Gergely P, Leibovich SJ, Pacher P, Sun CX, Blackburn MR, Vizi ES, Deitch EA, et al.: A2A adenosine receptors and C/EBPbeta are crucially required for IL-10 production by macrophages exposed to Escherichia coli. Blood 110:2685-2695, 2007.
14. Nemeth ZH, Csoka B, Wilmanski J, Xu D, Lu Q, Ledent C, Deitch EA, Pacher P, Spolarics Z, Hasko G: Adenosine A2A receptor inactivation increases survival in polymicrobial sepsis. J Immunol 176:5616-5626, 2006.
15. Kaufmann I, Hoelzl A, Schliephake F, Hummel T, Chouker A, Lysenko L, Peter K, Thiel M: Effects of adenosine on functions of polymorphonuclear leukocytes from patients with septic shock. Shock 27:25-31, 2007.
16. Wichterman KA, Baue AE, Chaudry IH: Sepsis and septic shockVa review of laboratory models and a proposal. J Surg Res 29:189-201, 1980.
17. Knight PR, Sreekumar A, Siddiqui J, Laxman B, Copeland S, Chinnaiyan A, Remick DG: Development of a sensitive microarray immunoassay and comparison with standard enzyme-linked immunoassay for cytokine analysis. Shock 21:26-30, 2004.
18. Vianna RC, Gomes RN, Bozza FA, Amancio RT, Bozza PT, David CM, Castro-Faria-Neto HC: Antibiotic treatment in a murine model of sepsis: impact on cytokines and endotoxin release. Shock 21:115-120, 2004.
19. Xiao H, Siddiqui J, Remick DG: Mechanisms of mortality in early and late sepsis. Infect Immun 74:5227-5235, 2006.
20. Hotchkiss RS, Karl IE: The pathophysiology and treatment of sepsis. N Engl J Med 348:138-150, 2003.
21. Hotchkiss RS, Strasser A, McDunn JE, Swanson PE: Cell death. N Engl J Med 361:1570-1583, 2009.
22. Kasten KR, Tschop J, Adediran SG, Hildeman DA, Caldwell CC: T cells are potent early mediators of the host response to sepsis. Shock 34:327-336, 2010.
23. Sitkovsky MV, Lukashev D, Apasov S, Kojima H, Koshiba M, Caldwell C, Ohta A, Thiel M: Physiological control of immune response and inflammatory tissue damage by hypoxia-inducible factors and adenosine A2A receptors. Annu Rev Immunol 22:657-682, 2004.
24. Synnestvedt K, Furuta GT, Comerford KM, Louis N, Karhausen J, Eltzschig HK, Hansen KR, Thompson LF, Colgan SP: Ecto-5'-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia. J Clin Invest 110:993-1002, 2002.
25. Hatfield S, Belikoff B, Lukashev D, Sitkovsky M, Ohta A: The antihypoxia-adenosinergic pathogenesis as a result of collateral damage by overactive immune cells. J Leukoc Biol 86:545-548, 2009.
26. Thammavongsa V, Kern JW, Missiakas DM, Schneewind O: Staphylococcus aureus synthesizes adenosine to escape host immune responses. J Exp Med 206:2417-2427, 2009.
27. Remick DG, Ward PA: Evaluation of endotoxin models for the study of sepsis. Shock 1:7-11(24 Suppl), 2005.
28. + helper T cells and regulates Helicobacter-induced gastritis and bacterial persistence. Mucosal Immunol 2:232-242, 2009.
29. Remick DG, Bolgos GR, Siddiqui J, Shin J, Nemzek JA: Six at six: interleukin-6 measured 6 h after the initiation of sepsis predicts mortality over 3 days. Shock 17:463-467, 2002.
30. Osuchowski MF, Connett J, Welch K, Granger J, Remick DG: Stratification is the key: inflammatory biomarkers accurately direct immunomodulatory therapy in experimental sepsis. Crit Care Med 37:1567-1573, 2009.
31. Buras JA, Holt D, Orlow D, Belikoff B, Pavlides S, Reenstra WR: Hyperbaric oxygen protects from sepsis mortality via an interleukin-10-dependent mechanism. Crit Care Med 34:2624-2629, 2006.