Vasopressors and intestinal mucosal perfusion after cardiac surgery: Norepinephrine vs. phenylephrine

Critical Care Medicine

Volumn 34, Issue 3, 2006, Pages 722-729

  Nygren, Andreas ^a   Thorén, Anders ^a   Ricksten, Sven Erik ^a  

^a SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Intestinal mucosa; Laser Doppler; Microcirculation; Norepinephrine; Phenylephrine

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR STIMULATING AGENT; ATENOLOL; BETA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; BETA 1 ADRENERGIC RECEPTOR STIMULATING AGENT; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; HYPERTENSIVE FACTOR; LACTIC ACID; METOPROLOL; NORADRENALIN; PHENYLEPHRINE; PROPOFOL;

ADULT; AGED; ARTERIAL PRESSURE; ARTICLE; ARTIFICIAL VENTILATION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY BYPASS SURGERY; CORONARY ARTERY DISEASE; DRUG EFFECT; DRUG INFUSION; ERYTHROCYTE; FEMALE; HEART SURGERY; HEMATOCRIT; HUMAN; INTENSIVE CARE UNIT; INTESTINE MUCOSA; INTESTINE PERFUSION; JEJUNUM MUCOSA; LASER DOPPLER FLOWMETRY; MALE; MEAN ARTERIAL PRESSURE; OXYGEN CONSUMPTION; OXYGEN SATURATION; OXYGEN SUPPLY; POSTOPERATIVE COMPLICATION; PRESSURE GRADIENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SEDATION; SPLANCHNIC BLOOD FLOW; STATISTICAL SIGNIFICANCE; TONOMETRY; VASOCONSTRICTION; VASODILATATION;

AGED; ANALYSIS OF VARIANCE; CARDIAC SURGICAL PROCEDURES; CROSS-OVER STUDIES; FEMALE; GASTRIC MUCOSA; HEMODYNAMIC PROCESSES; HUMANS; INTESTINAL MUCOSA; JEJUNUM; LASER-DOPPLER FLOWMETRY; MALE; MICROCIRCULATION; MIDDLE AGED; NOREPINEPHRINE; PHENYLEPHRINE; SHOCK, SURGICAL; SPLANCHNIC CIRCULATION; VASOCONSTRICTOR AGENTS;

EID: 33644591741     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000201879.20281.C6     Document Type: Article

References (39)

1. Task Force of the American College of Critical Care Medicine, SoCCM: Practice parameters for hemodynamic support of sepsis in adult patients in sepsis. Crit Care Med 1999; 27:639-660
2. Dunser MW, Mayr AJ, Ulmer H, et al: The effects of vasopressin on systemic hemodynamics in catecholamine-resistant septic and postcardiotomy shock: A retrospective analysis. Anesth Analg 2001; 93:7-13
3. Landry DW, Oliver, JA: The pathogenesis of vasodilatory shock. N Engl J Med 2001; 345:588-595
4. Ruokonen E, Takala J, Kari A, et al: Regional blood flow and oxygen transport in septic shock. Crit Care Med 1993; 21:1296-1303
5. Sakka SG, Meier-Hellmann A, Reinhart K: Do fluid administration and reduction in norepinephrine dose improve global and splanchnic haemodynamics? Br J Anaesth 2000; 84:758-762
6. Meier-Hellmann A, Specht M, Hannemann L, et al: Splanchnic blood flow is greater in septic shock treated with norepinephrine than in severe sepsis. Intensive Care Med 1996; 22:1354-1359
7. Thoren A, Jakob SM, Pradl R, et al: Jejunal and gastric mucosal perfusion versus splanchnic blood flow and metabolism: An observational study on postcardiac surgical patients. Crit Care Med 2000; 28:3649-3654
8. Cain S: Gut oxygenation after reduced oxygen delivery. Yearbook of Intensive Care and Emergency Medicine. Vincent J (Ed). Berlin-Heidelberg, Springer-Verlag, 1996, pp 219-226
9. Nygren A, Thoren A, Ricksten SE: Effects of norepinephrine alone and norepinephrine plus dopamine on human intestinal mucosal perfusion. Intensive Care Med 2003; 29:1322-1328
10. Thoren A, Elam M, Ricksten SE: Jejunal mucosal perfusion is well maintained during mild hypothermic cardiopulmonary bypass in humans. Anesth Analg 2001; 92:5-11
11. Thoren A, Ricksten SE, Lundin S, et al: Baroreceptor-mediated reduction of jejunal mucosal perfusion, evaluated with endoluminal laser Doppler flowmetry in conscious humans. J Auton Nerv Syst 1998; 68:157-163
12. Hudetz AG, Wood JD, Biswal BB, et al: Effect of hemodilution on RBC velocity, supply rate, and hematocrit in the cerebral capillary network. J Appl Physiol 1999; 87:505-509
13. Colantuouni A, Bertuglia S: Correlation between laser Doppler perfusion monitoring and hematocrit in hamster cheek pouch microcirculation. Int J Microcirc 1997; 17:33-40
14. Haffner CA, Kendall MJ: Metabolic effects of beta 2-agonists. J Clin Pharm Ther 1992; 17:155-164
15. Ensinger H, Geisser W, Brinkmann A, et al: Metabolic effects of norepinephrine and dobutamine in healthy volunteers. Shock 2002; 18:495-500
16. Reinelt H, Radermacher P, Kiefer P, et al: Impact of exogenous beta-adrenergic receptor stimulation on hepatosplanchnic oxygen kinetics and metabolic activity in septic shock. Crit Care Med 1999; 27:325-331
17. Guzman JA, Rosado AE, Kruse JA: Vasopressin vs. norepinephrine in endotoxic shock: Systemic, renal, and splanchnic hemodynamic and oxygen transport effects. J Appl Physiol 2003; 95:803-809
18. Schwarz B, Hofstotter H, Salak N, et al: Effects of norepinephrine and phenylephrine on intestinal oxygen supply and mucosal tissue oxygen tension. Intensive Care Med 2001; 27:593-601
19. Sautner T, Wessely C, Riegler M, et al: Early effects of catecholamine therapy on mucosal integrity, intestinal blood flow, and oxygen metabolism in porcine endotoxin shock. Ann Surg 1998; 228:239-248
20. Trager K, Radermacher P, Rieger KM, et al: Norepinephrine and N(G)-monomethyl-L-arginine in hyperdynamic septic shock in pigs: Effects on intestinal oxygen exchange and energy balance. Crit Care Med 2000; 28:2007-2014
21. Revelly JP, Liaudet L, Frascarolo P, et al: Effects of norepinephrine on the distribution of intestinal blood flow and tissue adenosine triphosphate content in endotoxic shock. Crit Care Med 2000; 28:2500-2506
22. Guth PH, Smith E: Escape from vasoconstriction in the gastric microcirculation. Am J Physiol 1975; 228:1880-1886
23. Greenway CV, Scott GD, Zink J: Sites of autoregulatory escape of blood flow in the mesenteric vascular bed. J Physiol 1976; 259:1-12
24. Hulten L, Lindhagen J, Lundgren O: Sympathetic nervous control of intramural blood flow in the feline and human intestines. Gastroenterology 1977; 72:41-48
25. Shepherd AP, Riedel GL: Intramural distribution of intestinal blood flow during sympathetic stimulation. Am J Physiol 1988; 255:H1091-H1095
26. Lautt WW, Legare DJ, Lockhart LK: Vascular escape from vasoconstriction and post-stimulatory hyperemia in the superior mesenteric artery of the cat. Can J Physiol Pharmacol 1988; 66:1174-1180
27. Ming Z, Han C, Lautt WW: Nitric oxide mediates hepatic arterial vascular escape from norepinephrine-induced constriction. Am J Physiol 1999; 277:G1200-G1206
28. Remak G, Hottenstein OD, Jacobson ED: Adrenergic, purinergic, and endothelial mediators and modulators of norepinephrine-induced mesenteric autoregulatory escape. Dig Dis Sci 1994; 39:1655-1664
29. Crissinger KD, Kvietys PR, Granger DN: Autoregulatory escape from norepinephrine infusion: Roles of adenosine and histamine. Am J Physiol 1988; 254:G560-G565
30. Guth PH, Ross G, Smith E: Changes in intestinal vascular diameter during norepinephrine vasoconstrictor escape. Am J Physiol 1976; 230:1466-1468
31. Remak G, Hottenstein OD, Jacobson ED: Multifactorial mediation of post norepinephrine induced intestinal hyperemia. J Physiol Pharmacol 1994; 45:241-257
32. Uusaro A, Russell JA, Walley KR, et al: Gastric-arterial PCO2 gradient does not reflect systemic and splanchnic hemodynamics or oxygen transport after cardiac surgery. Shock 2000; 14:13-17
33. Thoren A, Elam M, Ricksten SE: Differential effects of dopamine, dopexamine, and dobutamine on jejunal mucosal perfusion early after cardiac surgery. Crit Care Med 2000; 28:2338-2343
34. Thollander M, Hellstrom PM, Svensson TH, et al: Haemodynamic changes in the small intestine correlate to migrating motor complex in humans. Eur J Gastroenterol Hepatol 1996; 8:777-785
35. Ahn H, Lindhagen J, Nilsson GE, et al: Assessment of blood flow in the small intestine with laser Doppler flowmetry. Scand J Gastroenterol 1986; 21:863-870
36. Ahn H, Lindhagen J, Nilsson GE, et al: Evaluation of laser Doppler flowmetry in the assessment of intestinal blood flow in cat. Gastroenterology 1985; 88:951-957
37. Kvietys PR, Shepherd AP, Granger DN: Laser-Doppler, H2 clearance, and microsphere estimates of mucosal blood flow. Am J Physiol 1985; 249:G221-G227
38. DiNardo JA, Bert A, Schwartz MJ, et al: Effects of vasoactive drugs on flows through left internal mammary artery and saphenous vein grafts in man. J Thorac Cardiovasc Surg 1991; 102:730-735
39. Morimatsu H, Uchino S, Chung J, et al: Norepinephrine for hypotensive vasodilatation after cardiac surgery: Impact on renal function. Intensive Care Med 2003; 29:1106-1112