How to use mTOR inhibitors? the search goes on

American Journal of Transplantation

Volumn 11, Issue 8, 2011, Pages 1551-1552

  Budde, K ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Clinical trial; mTOR inhibitors; mycophenolate; sirolimus; tacrolimus

Indexed keywords

CALCINEURIN INHIBITOR; CORTICOSTEROID; DACLIZUMAB; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; RAPAMYCIN; TACROLIMUS;

ANEMIA; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; EDEMA; EDITORIAL; GRAFT SURVIVAL; HUMAN; HYPERLIPIDEMIA; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY BIOPSY; KIDNEY FUNCTION; KIDNEY TRANSPLANTATION; LYMPHOCELE; PRACTICE GUIDELINE; PRIORITY JOURNAL; PROTEINURIA; STATISTICAL SIGNIFICANCE; WOUND HEALING IMPAIRMENT;

FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KIDNEY NEOPLASMS; MALE; MYCOPHENOLIC ACID; SIROLIMUS; TACROLIMUS;

EID: 79961023382     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2011.03574.x     Document Type: Editorial

References (5)

1. Flechner S, Glyda M, Cockfield S, et al,. The ORION Study: Comparison of two sirolimus-based regimens vs tacrolimus and mycophenolate mofetil in renal allograft recipients. Am J Transplant, 2011, in press.
2. Ekberg H, Tedesco-Silva H, Demirbas A, et al,.; ELITE-Symphony Study. Reduced exposure to calcineurin inhibitors in renal transplantation. N Engl J Med 2007; 357: 2562-2575. (Pubitemid 350294223)
3. Oberbauer R, Segoloni G, Campistol JM, et al,. Early cyclosporine withdrawal from a sirolimus-based regimen results in better renal allograft survival and renal function at 48 months after transplantation. Transpl Int 2011; 79: 897-907.
4. Budde K, Becker T, Arns W, et al,. Everolimus-based, calcineurin- inhibitor-free regimen in recipients of de-novo kidney transplants: an open-label, randomised, controlled trial. Lancet 2011; 377: 837-847.
5. Weir MR, Mulgaonkar S, Chan L, et al,. Mycophenolate mofetil-based immunosuppression with sirolimus in renal transplantation: a randomized, controlled Spare-the-Nephron trial. Kidney Int 2010 [Epub ahead of print].