L-3-Phosphoserine phosphatase (PSPH) regulates cutaneous squamous cell carcinoma proliferation independent of l-serine biosynthesis

Journal of Dermatological Science

Volumn 63, Issue 3, 2011, Pages 164-172

  Bachelor, Michael A ^a   Lu, Yan ^a   Owens, David M ^a  

^a Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain   (United States)

Author keywords

Epidermis; Keratinocyte; PSPH; Serine metabolism; Squamous cell carcinoma

Indexed keywords

CYCLIN D1; CYTOPLASM PROTEIN; LEVO 3 PHOSPHOSERINE PHOSPHATASE; SERINE; UNCLASSIFIED DRUG;

AMINO ACID SYNTHESIS; ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME LOCALIZATION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SKIN CARCINOGENESIS; SKIN CARCINOMA; SQUAMOUS CELL CARCINOMA;

ANIMALS; APOPTOSIS; BASE SEQUENCE; CARCINOMA, SQUAMOUS CELL; CELL PROLIFERATION; DIMERIZATION; DNA PRIMERS; ENDOSOMES; FEMALE; GENE EXPRESSION; GENE KNOCKDOWN TECHNIQUES; HUMANS; KERATINOCYTES; MALE; MICE; MUTATION; PHOSPHORIC MONOESTER HYDROLASES; SERINE; SKIN NEOPLASMS;

EID: 79961022279     PISSN: 09231811     EISSN: 1873569X     Source Type: Journal    
DOI: 10.1016/j.jdermsci.2011.06.001     Document Type: Article

References (27)

1. Borkenhagen L.F., Kennedy E.P. The enzymic equilibration of l-serine with O-phospho-l-serine. Biochim Biophys Acta 1958, 28:222-223.
2. Neuhaus F.C., Byrne W.L. O-Phosphoserine phosphatase. Biochim Biophys Acta 1958, 28:223-224.
3. Collet J.F., Gerin I., Rider M.H., Veiga-da-Cunha M., Van Schaftingen E. Human l-3-phosphoserine phosphatase: sequence, expression and evidence for a phosphoenzyme intermediate. FEBS Lett 1997, 411:251-254.
4. Collet J.F., Stroobant V., Pirard M., Delpierre G., Van Schaftingen E. A new class of phosphotransferases phosphorylated on an aspartate residue in an amino-terminal DXDX(T/V) motif. J Biol Chem 1998, 273:14107-14112.
5. Collet J.F., Stroobant V., Van Schaftingen E. Mechanistic studies of phosphoserine phosphatase, an enzyme related to P-type ATPases. J Biol Chem 1999, 274:33985-33990.
6. de Koning T.J., Snell K., Duran M., Berger R., Poll-The B.T., Surtees R. l-Serine in disease and development. Biochem J 2003, 371:653-661.
7. Tabatabaie L., Klomp L.W., Berger R., de Koning T.J. l-Serine synthesis in the central nervous system: a review on serine deficiency disorders. Mol Gen Metab 2010, 99:256-262.
8. Pollari S., Kakonen S.M., Edgren H., Wolf M., Kohonen P., Sara H., et al. Enhanced serine production by bone metastatic breast cancer cells stimulates osteoclastogenesis. Breast Cancer Res Treat 2011, 125:421-430.
9. Tan E.H., Ramlau R., Pluzanska A., Kuo H.P., Reck M., Milanowski J., et al. A multicentre phase II gene expression profiling study of putative relationships between tumour biomarkers and clinical response with erlontinib in non-small-cell lung cancer. Ann Oncol 2010, 21:217-222.
10. Greengard O., Head J.F., Chahinian A.P., Goldberg S.L. Enzyme pathology of human mesotheliomas. J Natl Cancer Inst 1987, 78:617-622.
11. Shimomura K., Sakakura C., Takemura M., Takagi T., Fukuda K., Kin S., et al. Combination of l-3-phosphoserine phosphatase and CEA using real-time RT-PCR improves accuracy in detection of peritoneal micrometastasis of gastric cancer. Anticancer Res 2004, 24:1113-1120.
12. Hemmati H.D., Nakano I., Lazareff J.A., Masterman-Smith M., Geschwind D.H., Bronner-Fraser M., et al. Cancerous stem cells can arise from pediatric brain tumors. Proc Natl Acad Sci U S A 2003, 100:15178-15183.
13. Owens D.M., Romero R.M., Gardner C., Watt F.M. Suprabasal α6β4 integrin expression in epidermis results in enhanced tumorigenesis and disruption of TGFβ signaling. J Cell Sci 2003, 116:3783-3791.
14. Stumpfova M., Ratner D., Desciak E.B., Eliezri Y.D., Owens D.M. The immunosuppressive surface ligand CD200 augments the metastatic capacity of squamous cell carcinoma. Cancer Res 2010, 70:2962-2972.
15. Jensen U.B., Yan X., Triel C., Woo S.H., Christensen R., Owens D.M. A distinct population of clonogenic and multipotent murine follicular keratinocytes residing in the upper isthmus. J Cell Sci 2008, 121:609-617.
16. Rheinwald J.G., Green H. Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells. Cell 1975, 6:317-330.
17. Morgenstern J.P., Land H. Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line. Nucleic Acids Res 1990, 18:3587-3596.
18. Levy L., Broad S., Zhu A.J., Carroll J.M., Khazaal I., Peault B., et al. Optimised retroviral infection of human epidermal keratinocytes: long-term expression of transduced integrin gene following grafting on to SCID mice. Gene Ther 1998, 5:913-922.
19. Kurihara T., Esaki N. Bacterial hydrolytic dehalogenases and related enzymes: occurrences, reaction mechanisms, and applications. Chem Rec 2008, 8:67-74.
20. Gohla A., Birkenfeld J., Bokoch G.M. Chronophin, a novel HAD-type serine protein phosphatase, regulates cofilin-dependent actin dynamics. Nat Cell Biol 2005, 7:21-29.
21. Newman J.W., Morisseau C., Harris T.R., Hammock B.D. The soluble epoxide hydrolase encoded by EPXH2 is a bifunctional enzyme with novel lipid phosphate phosphatase activity. Proc Natl Acad Sci U S A 2003, 100:1558-1563.
22. Roberts S.J., Stewart A.J., Sadler P.J., Farquharson C. Human PHOSPHO1 exhibits high specific phosphoethanolamine and phosphocholine phosphatase activities. Biochem J 2004, 382:59-65.
23. Terskikh A.V., Easterday M.C., Li L., Hood L., Kornblum H.I., Geschwind D.H., et al. From hematopoiesis to neuropoiesis: evidence of overlapping genetic programs. Proc Natl Acad Sci U S A 2001, 98:7934-7939.
24. Geschwind D.H., Ou J., Easterday M.C., Dougherty J.D., Jackson R.L., Chen Z., et al. A genetic analysis of neural progenitor differentiation. Neuron 2001, 29:325-339.
25. Nakano I., Dougherty J.D., Kim K., Klement I., Geschwind D.H., Kornblum H.I. Phosphoserine phosphatase is expressed in the neural stem cell niche and regulates neural stem and progenitor cell proliferation. Stem Cells 2007, 25:1975-1984.
26. Asha H., Nagy I., Kovacs G., Stetson D., Ando I., Dearolf C.R. Analysis of Ras-induced overproliferation in Drosophila hemocytes. Genetics 2003, 163:203-215.
27. Egger B., Leemans R., Loop T., Kammermeier L., Fan Y., Radimerski T., et al. Gliogenesis in Drosophila: genome-wide analysis of downstream genes of glial cells missing in the embryonic nervous system. Development 2002, 129:3295-3309.