메뉴 건너뛰기




Volumn 38, Issue 4, 2011, Pages 521-532

From chemotherapy to targeted therapy in adjuvant treatment for stage III colon cancer

Author keywords

[No Author keywords available]

Indexed keywords

BEVACIZUMAB; CAPECITABINE; CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; FLUOROPYRIMIDINE; FLUOROURACIL; FOLINIC ACID; IRINOTECAN; LEVAMISOLE; MOLECULAR MARKER; OXALIPLATIN; VASCULOTROPIN;

EID: 79961016292     PISSN: 00937754     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.seminoncol.2011.05.006     Document Type: Article
Times cited : (36)

References (74)
  • 1
    • 79960972952 scopus 로고    scopus 로고
    • http://globocan.iarc.fr/summary-table-pop.asp?selection=219900&title= World&sex=0&type=0&window=1&sort=0&submit=%A0Execute%A0.
  • 2
    • 67650410937 scopus 로고    scopus 로고
    • Atlanta: American Cancer Society; Available at
    • American Cancer Society. Cancer facts & figures 2009. Atlanta: American Cancer Society; 2009. Available at: www.cancer.org/downloads/STT/ 500809web.pdf.
    • (2009) Cancer Facts & Figures 2009
  • 3
    • 2542615200 scopus 로고    scopus 로고
    • Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer
    • The Multicenter International Study of Oxaliplatin/5- Fluorouracil/Leucovorin in the Adjuvant Treatment of Colon Cancer (MOSAIC) Investigators
    • André T, Boni C, Mounedji-Boudiaf L, et al. Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer. The Multicenter International Study of Oxaliplatin/5- Fluorouracil/Leucovorin in the Adjuvant Treatment of Colon Cancer (MOSAIC) Investigators. N Engl J Med. 2004;350:2343-51.
    • (2004) N Engl J Med , vol.350 , pp. 2343-2351
    • André, T.1    Boni, C.2    Mounedji-Boudiaf, L.3
  • 5
    • 77952867243 scopus 로고    scopus 로고
    • Clinical and pathologic factors that predict lymph node yield from surgical specimens in colorectal cancer: A population-based study
    • Chou JF, Row D, Gonen M, Liu YH, Schrag D, Weiser MR. Clinical and pathologic factors that predict lymph node yield from surgical specimens in colorectal cancer: a population-based study. Cancer. 2010;116:2560-70.
    • (2010) Cancer , vol.116 , pp. 2560-2570
    • Chou, J.F.1    Row, D.2    Gonen, M.3    Liu, Y.H.4    Schrag, D.5    Weiser, M.R.6
  • 6
    • 64249099411 scopus 로고    scopus 로고
    • American Joint Committee on Cancer. 7th edition. New York: Springer
    • American Joint Committee on Cancer. AJCC cancer staging manual. 7th edition. New York: Springer; 2010.
    • (2010) AJCC Cancer Staging Manual
  • 8
    • 0029644482 scopus 로고
    • Efficacy of adjuvant fluorouracil and folinic acid in colon cancer
    • International Multicentre Pooled Analysis of Colorectal Cancer Trials (IMPACT)
    • International Multicentre Pooled Analysis of Colorectal Cancer Trials (IMPACT). Efficacy of adjuvant fluorouracil and folinic acid in colon cancer. Lancet. 1995;345:939-44.
    • (1995) Lancet , vol.345 , pp. 939-944
  • 9
    • 0032729240 scopus 로고    scopus 로고
    • Clinical trial to assess the relative efficacy of fluorouracil and leucovorin, fluorouracil and levamisole, and fluorouracil, leucovorin, and levamisole in patients with Dukes' B and C carcinoma of the colon: Results from National Surgical Adjuvant Breast and Bowel Project C-04
    • Wolmark N, Rockette H, Mamounas E, et al. Clinical trial to assess the relative efficacy of fluorouracil and leucovorin, fluorouracil and levamisole, and fluorouracil, leucovorin, and levamisole in patients with Dukes' B and C carcinoma of the colon: results from National Surgical Adjuvant Breast and Bowel Project C-04. J Clin Oncol. 1999;17:3553-9. (Pubitemid 29517927)
    • (1999) Journal of Clinical Oncology , vol.17 , Issue.11 , pp. 3553-3559
    • Wolmark, N.1    Rockette, H.2    Mamounas, E.3    Jones, J.4    Wieand, S.5    Wickerham, D.L.6    Bear, H.D.7    Atkins, J.N.8    Dimitrov, N.V.9    Glass, A.G.10    Fisher, E.R.11    Fisher, B.12
  • 12
    • 0035846320 scopus 로고    scopus 로고
    • A pooled analysis of adjuvant chemotherapy for resected colon cancer in elderly patients
    • Sargent DJ, Goldberg RM, Jacobson SD, et al. A pooled analysis of adjuvant chemotherapy for resected colon cancer in elderly patients. N Engl J Med. 2001;345: 1091-7.
    • (2001) N Engl J Med , vol.345 , pp. 1091-1097
    • Sargent, D.J.1    Goldberg, R.M.2    Jacobson, S.D.3
  • 16
    • 1442265952 scopus 로고    scopus 로고
    • Efficacy of oral adjuvant therapy after resection of colorectal cancer: 5-Year results from three randomized trials
    • DOI 10.1200/JCO.2004.04.065
    • Sakamoto J, Ohashi Y, Hamada C, Buyse M, Burzykowski T, Piedbois P. Efficacy of oral adjuvant therapy after resection of colorectal cancer: 5-year results from three randomized trials. J Clin Oncol. 2004;22:484-92. (Pubitemid 41079778)
    • (2004) Journal of Clinical Oncology , vol.22 , Issue.3 , pp. 484-492
    • Sakamoto, J.1
  • 19
    • 0034727063 scopus 로고    scopus 로고
    • Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer
    • Saltz LB, Cox JV, Blanke C, et al. Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. N Engl J Med. 2000;343:905-14.
    • (2000) N Engl J Med , vol.343 , pp. 905-914
    • Saltz, L.B.1    Cox, J.V.2    Blanke, C.3
  • 21
    • 77953574743 scopus 로고    scopus 로고
    • Efficacy findings from a randomized phase III trial of capecitabine plus oxaliplatin versus bolus 5-FU/LV for stage III colon cancer (NO16968): No impact of age on disease-free survival (DFS)
    • abstract 284
    • Haller DG, Cassidy J, Tabernero J, et al. Efficacy findings from a randomized phase III trial of capecitabine plus oxaliplatin versus bolus 5-FU/LV for stage III colon cancer (NO16968): no impact of age on disease-free survival (DFS) [abstract 284]. 2010 Gastrointestinal Cancers Symposium. Orlando, FL; January 22-24, 2010.
    • 2010 Gastrointestinal Cancers Symposium. Orlando, FL; January 22-24, 2010
    • Haller, D.G.1    Cassidy, J.2    Tabernero, J.3
  • 22
    • 67650315187 scopus 로고    scopus 로고
    • Improved overall survival with oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment in stage II or III colon cancer in the MOSAIC trial
    • André T, Boni C, Navarro M, et al. Improved overall survival with oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment in stage II or III colon cancer in the MOSAIC trial. J Clin Oncol. 2009;27:3109-16.
    • (2009) J Clin Oncol , vol.27 , pp. 3109-3116
    • André, T.1    Boni, C.2    Navarro, M.3
  • 24
    • 34548160680 scopus 로고    scopus 로고
    • Irinotecan fluorouracil plus leucovorin is not superior to fluorouracil plus leucovorin alone as adjuvant treatment for stage III colon cancer: Results of CALGB 89803
    • DOI 10.1200/JCO.2007.11.2144
    • Saltz LB, Niedzwiecki D, Hollis D, et al. Irinotecan fluorouracil plus leucovorin is not superior to fluorouracil plus leucovorin alone as adjuvant treatment for stage III colon cancer: results of CALGB 89803. J Clin Oncol. 2007;25:3456-61. (Pubitemid 47310883)
    • (2007) Journal of Clinical Oncology , vol.25 , Issue.23 , pp. 3456-3461
    • Saltz, L.B.1    Niedzwiecki, D.2    Hollis, D.3    Goldberg, R.M.4    Hantel, A.5    Thomas, J.P.6    Fields, A.L.A.7    Mayer, R.J.8
  • 25
    • 70449105423 scopus 로고    scopus 로고
    • A randomized phase III study comparing adjuvant 5-fluorouracil/ folinic acid with FOLFIRI in patients following complete resection of liver metastases from colorectal cancer
    • Ychou M, Hohenberger W, Thezenas S, et al. A randomized phase III study comparing adjuvant 5-fluorouracil/ folinic acid with FOLFIRI in patients following complete resection of liver metastases from colorectal cancer. Ann Oncol. 2009;20:1964-70.
    • (2009) Ann Oncol , vol.20 , pp. 1964-1970
    • Ychou, M.1    Hohenberger, W.2    Thezenas, S.3
  • 26
    • 67650290547 scopus 로고    scopus 로고
    • Randomized phase III trial comparing biweekly infusional fluorouracil/ leucovorin alone or with irinotecan in the adjuvant treatment of stage III colon cancer: PETACC-3
    • Van Cutsem, Labianca R, Bodoky G, et al. Randomized phase III trial comparing biweekly infusional fluorouracil/ leucovorin alone or with irinotecan in the adjuvant treatment of stage III colon cancer: PETACC-3. J Clin Oncol. 2009;27:3117-25.
    • (2009) J Clin Oncol , vol.27 , pp. 3117-3125
    • Van Cutsem1    Labianca, R.2    Bodoky, G.3
  • 28
    • 20544478429 scopus 로고    scopus 로고
    • Addition of bevacizumab to bolus fluorouracil and leucovorin in firstline metastatic colorectal cancer. Results of a randomized phase II trial
    • Kabbinavar FF, Schulz J, McCleod M, et al. Addition of bevacizumab to bolus fluorouracil and leucovorin in firstline metastatic colorectal cancer. Results of a randomized phase II trial. J Clin Oncol. 2005;23:3697-705.
    • (2005) J Clin Oncol , vol.23 , pp. 3697-3705
    • Kabbinavar, F.F.1    Schulz, J.2    McCleod, M.3
  • 29
    • 34248173883 scopus 로고    scopus 로고
    • Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: Results from the Eastern Cooperative Oncology Group Study E3200
    • DOI 10.1200/JCO.2006.09.6305
    • Giantonio BJ, Catalano PJ, Meropol NJ, et al. Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group study E3200. J Clin Oncol. 2007;25: 1539-44. (Pubitemid 46733080)
    • (2007) Journal of Clinical Oncology , vol.25 , Issue.12 , pp. 1539-1544
    • Giantonio, B.J.1    Catalano, P.J.2    Meropol, N.J.3    O'Dwyer, P.J.4    Mitchell, E.P.5    Alberts, S.R.6    Schwartz, M.A.7    Benson III, A.B.8
  • 30
    • 42949149159 scopus 로고    scopus 로고
    • Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: A randomized phase III study
    • Saltz LB, Clarke S, Diaz-Rubio E, et al. Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: a randomized phase III study. J Clin Oncol. 2008;26:2013-9.
    • (2008) J Clin Oncol , vol.26 , pp. 2013-2019
    • Saltz, L.B.1    Clarke, S.2    Diaz-Rubio, E.3
  • 31
    • 0024549349 scopus 로고
    • Induction of angiogenesis during the transition from hyperplasia to neoplasia
    • DOI 10.1038/339058a0
    • Folkman J, Watson K, Ingber D, Hanahan D. Induction of angiogenesis during the transition from hyperplasia to neoplasia. Nature. 1989;339:58-61. (Pubitemid 19115892)
    • (1989) Nature , vol.339 , Issue.6219 , pp. 58-61
    • Folkman, J.1    Watson, K.2    Ingber, D.3    Hanahan, D.4
  • 32
    • 66149147757 scopus 로고    scopus 로고
    • Initial safety report of NSABP C-08: A randomized phase III study of modified FOLFOX6 with or without bevacizumab for the adjuvant treatment of patients with stage II or III colon cancer
    • Allegra C, Yothers G, O'Connell M, et al. Initial safety report of NSABP C-08: a randomized phase III study of modified FOLFOX6 with or without bevacizumab for the adjuvant treatment of patients with stage II or III colon cancer. J Clin Oncol. 2009;27:3385-90.
    • (2009) J Clin Oncol , vol.27 , pp. 3385-3390
    • Allegra, C.1    Yothers, G.2    O'Connell, M.3
  • 33
    • 69549147378 scopus 로고    scopus 로고
    • A phase III trial comparing mFOLFOX6 to mFOLFOX6 plus bevacizumab in stage II or III carcinoma of the colon: Results of NSABP protocol C-08
    • abstract LBA-4
    • Wolmark N, Yothers G, O'Connell MJ, et al. A phase III trial comparing mFOLFOX6 to mFOLFOX6 plus bevacizumab in stage II or III carcinoma of the colon: results of NSABP protocol C-08 [abstract LBA-4]. J Clin Oncol. 2009;27 18s:793s.
    • (2009) J Clin Oncol , vol.27 , Issue.18 S
    • Wolmark, N.1    Yothers, G.2    O'Connell, M.J.3
  • 34
    • 60649116477 scopus 로고    scopus 로고
    • Silencing or fueling metastasis with VEGF inhibitors: Antiangiogenesis revisited
    • Loges S, Mazzone M, Hohensinner P, et al. Silencing or fueling metastasis with VEGF inhibitors: antiangiogenesis revisited. Cancer Cell. 2009;15:167-70.
    • (2009) Cancer Cell , vol.15 , pp. 167-170
    • Loges, S.1    Mazzone, M.2    Hohensinner, P.3
  • 35
    • 60649087564 scopus 로고    scopus 로고
    • Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis
    • Ebos JM, Lee CR, Cruz-Munoz W, et al. Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis. Cancer Cell. 2009;15: 232-9.
    • (2009) Cancer Cell , vol.15 , pp. 232-239
    • Ebos, J.M.1    Lee, C.R.2    Cruz-Munoz, W.3
  • 36
    • 60649106195 scopus 로고    scopus 로고
    • Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis
    • Paez-Ribes M, Allen E, Hudock J, et al. Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell. 2009;15:220-31.
    • (2009) Cancer Cell , vol.15 , pp. 220-231
    • Paez-Ribes, M.1    Allen, E.2    Hudock, J.3
  • 37
    • 75649102390 scopus 로고    scopus 로고
    • A three-arm phase III randomized trial of FOLFOX-4 vs. FOLFOX-4 plus bevacizumab vs. XELOX plus bevacizumab in the adjuvant treatment of patients with stage III or high-risk stage II colon cancer: Results of the interim safety analysis of the AVANT trial
    • Hoff P, Clarke S, Cunnigham D, et al. A three-arm phase III randomized trial of FOLFOX-4 vs. FOLFOX-4 plus bevacizumab vs. XELOX plus bevacizumab in the adjuvant treatment of patients with stage III or high-risk stage II colon cancer: results of the interim safety analysis of the AVANT trial. Eur J Cancer Suppl. 2009;7:324.
    • (2009) Eur J Cancer Suppl , vol.7 , pp. 324
    • Hoff, P.1    Clarke, S.2    Cunnigham, D.3
  • 38
    • 79960987617 scopus 로고    scopus 로고
    • http://www.roche.com/investors/ir-update/inv-update-2010-09-18b.html.
  • 40
    • 63849088630 scopus 로고    scopus 로고
    • Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer
    • Van Cutsem E, Kohne CH, Hitre E, et al. Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N Engl J Med. 2009;360:1408-17.
    • (2009) N Engl J Med , vol.360 , pp. 1408-1417
    • Van Cutsem, E.1    Kohne, C.H.2    Hitre, E.3
  • 41
    • 59949091448 scopus 로고    scopus 로고
    • Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer
    • Bokemeyer C, Bondarenko I, Hartmann J, et al. Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer. J Clin Oncol. 2008;27:663-71.
    • (2008) J Clin Oncol , vol.27 , pp. 663-671
    • Bokemeyer, C.1    Bondarenko, I.2    Hartmann, J.3
  • 42
    • 79959571031 scopus 로고    scopus 로고
    • Intermittent versus continuous oxaliplatin and fluoropyrimidine combination chemotherapy for first-line treatment of advanced colorectal cancer: Results of the randomised phase 3 MRC COIN trial
    • Jun 3. [Epub ahead of print]
    • Adams RA, Meade AM, Seymour MT, et al. Intermittent versus continuous oxaliplatin and fluoropyrimidine combination chemotherapy for first-line treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial. Lancet Oncol. 2011, Jun 3. [Epub ahead of print].
    • (2011) Lancet Oncol
    • Adams, R.A.1    Meade, A.M.2    Seymour, M.T.3
  • 43
    • 77956653023 scopus 로고    scopus 로고
    • Adjuvant mFOLFOX6 with or without cetuximab in KRAS wild-type patients with resected stage III colon cancer: Results from NCCTG intergroup phase III trial NO147
    • Alberts SR, Sargent DJ, Smyrrk TC, et al. Adjuvant mFOLFOX6 with or without cetuximab in KRAS wild-type patients with resected stage III colon cancer: results from NCCTG intergroup phase III trial NO147. J Clin Oncol. 2010:28 18S:959s.
    • (2010) J Clin Oncol , vol.28 , Issue.18 S
    • Alberts, S.R.1    Sargent, D.J.2    Smyrrk, T.C.3
  • 44
    • 77956689048 scopus 로고    scopus 로고
    • Adjuvant mFOLFOX6 plus or minus cetuximab in patients with KRAS mutant resected stage III colon cancer: NCCTG intergroup phase III trial NO147
    • Goldberg RM, Sargent DJ, Thibodeau N, et al. Adjuvant mFOLFOX6 plus or minus cetuximab in patients with KRAS mutant resected stage III colon cancer: NCCTG intergroup phase III trial NO147. J Clin Oncol. 2010:28 15S:262s.
    • (2010) J Clin Oncol , vol.28 , Issue.15 S
    • Goldberg, R.M.1    Sargent, D.J.2    Thibodeau, N.3
  • 46
    • 33747051508 scopus 로고    scopus 로고
    • Increasing negative lymph node count is independently associated with improved long-term survival in stage IIIB and IIIC colon cancer
    • DOI 10.1200/JCO.2006.06.8866
    • Johnson PM, Porter GA, Ricciardi R, Baxter NN. Increasing negative lymph node count is independently associated with improved long-term survival in stage IIIB and IIIC colon cancer. J Clin Oncol. 2006;24:3570-5. (Pubitemid 46630528)
    • (2006) Journal of Clinical Oncology , vol.24 , Issue.22 , pp. 3570-3575
    • Johnson, P.M.1    Porter, G.A.2    Ricciardi, R.3    Baxter, N.N.4
  • 48
    • 77949274921 scopus 로고    scopus 로고
    • Molecular markers in colon cancer have a stage specific prognostic value. Results of the translational study on the PETACC 3-EORTC 40993-SAKK 60-00 trial
    • Roth AD, Tejpar S, Yan P, et al. Molecular markers in colon cancer have a stage specific prognostic value. Results of the translational study on the PETACC 3-EORTC 40993-SAKK 60-00 trial. J Clin Oncol. 2009;27 15S:4002.
    • (2009) J Clin Oncol , vol.27 , Issue.15 S , pp. 4002
    • Roth, A.D.1    Tejpar, S.2    Yan, P.3
  • 49
    • 75749102647 scopus 로고    scopus 로고
    • Prognostic role of KRAS and BRAF in stage II and III resected colon cancer: Results of the translational study on the PETACC-3, EORTC 40993, SAKK 60-00 trial
    • Roth AD, Tejpar S, Delorenzi M, et al, Prognostic role of KRAS and BRAF in stage II and III resected colon cancer: results of the translational study on the PETACC-3, EORTC 40993, SAKK 60-00 trial. J Clin Oncol. 2010:28: 466-74.
    • (2010) J Clin Oncol , vol.28 , pp. 466-474
    • Roth, A.D.1    Tejpar, S.2    Delorenzi, M.3
  • 51
    • 77951967408 scopus 로고    scopus 로고
    • Impact of p53 expression and microsatellite instability on stage III colon cancer disease-free survival in patients treated by 5-fluorouracil and leucovorin with or without oxaliplatin
    • Zaanan A, Cuilliere-Dartigues P, Guilloux A, et al. Impact of p53 expression and microsatellite instability on stage III colon cancer disease-free survival in patients treated by 5-fluorouracil and leucovorin with or without oxaliplatin. Ann Oncol. 2010;21:772-80.
    • (2010) Ann Oncol , vol.21 , pp. 772-780
    • Zaanan, A.1    Cuilliere-Dartigues, P.2    Guilloux, A.3
  • 52
    • 77953587132 scopus 로고    scopus 로고
    • Molecular markers to individualize adjuvant therapy for colon cancer
    • Gangadhar T, Schilsky R. Molecular markers to individualize adjuvant therapy for colon cancer. Nat Rev Clin Oncol. 2010;7:318-25.
    • (2010) Nat Rev Clin Oncol , vol.7 , pp. 318-325
    • Gangadhar, T.1    Schilsky, R.2
  • 53
    • 77956103532 scopus 로고    scopus 로고
    • A review of the most promising biomarkers in colorectal cancer: One step closer to targeted therapy
    • Deschoolmeester V, Baay M, Specenier O, Lardon F, Vermorken JB. A review of the most promising biomarkers in colorectal cancer: one step closer to targeted therapy. Oncologist. 2010;15:699-731.
    • (2010) Oncologist , vol.15 , pp. 699-731
    • Deschoolmeester, V.1    Baay, M.2    Specenier, O.3    Lardon, F.4    Vermorken, J.B.5
  • 54
    • 77955715212 scopus 로고    scopus 로고
    • The loss of the CBX7 gene expression represents an adverse prognostic marker for survival of colon carcinoma patients
    • Pallante PL, Terracciano L, Carafa V, et al. The loss of the CBX7 gene expression represents an adverse prognostic marker for survival of colon carcinoma patients. Eur J Cancer. 2010;46:2304-13.
    • (2010) Eur J Cancer , vol.46 , pp. 2304-2313
    • Pallante, P.L.1    Terracciano, L.2    Carafa, V.3
  • 55
    • 77749251731 scopus 로고    scopus 로고
    • A quantitative multi-gene RT-PCR assay for prediction of recurrence in stage II colon cancer: Selection of the genes in 4 large studies and results of the independent, prospectively-designed QUASAR validation study
    • Kerr D, Gray R, Quirke P, et al. A quantitative multi-gene RT-PCR assay for prediction of recurrence in stage II colon cancer: selection of the genes in 4 large studies and results of the independent, prospectively-designed QUASAR validation study. J Clin Oncol. 2009;27 15S: 4000.
    • (2009) J Clin Oncol , vol.27 , Issue.15 S , pp. 4000
    • Kerr, D.1    Gray, R.2    Quirke, P.3
  • 57
    • 79960984370 scopus 로고    scopus 로고
    • http://data.un.org/Data.aspx?d=GenderStat&f=inID%3A36.
  • 59
    • 70350177864 scopus 로고    scopus 로고
    • Impact of older age on the efficacy of newer adjuvant therapies in >12500 patients with stage II/III colon cancer: Findings from the ACCENT database
    • Jackson McCleary NA, Meyerhardt J, Green E, et al. Impact of older age on the efficacy of newer adjuvant therapies in >12500 patients with stage II/III colon cancer: findings from the ACCENT database. J Clin Oncol. 2009;27 15S:4010.
    • (2009) J Clin Oncol , vol.27 , Issue.15 S , pp. 4010
    • Jackson McCleary, N.A.1    Meyerhardt, J.2    Green, E.3
  • 60
    • 79960979396 scopus 로고    scopus 로고
    • FOLFOX4 as adjuvant therapy in elderly patients with colon cancer: Subgroup analysis of the MOSAIC trial
    • Tournigand C, André T, Bacher JB, et al. FOLFOX4 as adjuvant therapy in elderly patients with colon cancer: subgroup analysis of the MOSAIC trial. J Clin Oncol. 2010;28 15S:266s.
    • (2010) J Clin Oncol , vol.28 , Issue.15 S
    • Tournigand, C.1    André, T.2    Bacher, J.B.3
  • 62
    • 27944456879 scopus 로고    scopus 로고
    • Investigating the potential of bevacizumab in other indications: Metastatic renal cell, non-small cell lung, pancreatic and breast cancer
    • de Gramont A, Van Cutsem E. Investigating the potential of bevacizumab in other indications: metastatic renal cell, non-small cell lung, pancreatic and breast cancer. Oncology. 2005;69 suppl 3:46-56.
    • (2005) Oncology , vol.69 , Issue.SUPPL. 3 , pp. 46-56
    • De Gramont, A.1    Van Cutsem, E.2
  • 64
    • 77950239573 scopus 로고    scopus 로고
    • HER kinase axis receptor dimer partner switching occurs in response to EGFR tyrosine kinase inhibition despite failure to block cellular proliferation
    • Jain A, Penuel E, Mink S, et al. HER kinase axis receptor dimer partner switching occurs in response to EGFR tyrosine kinase inhibition despite failure to block cellular proliferation. Cancer Res. 2010;70:1989-99.
    • (2010) Cancer Res , vol.70 , pp. 1989-1999
    • Jain, A.1    Penuel, E.2    Mink, S.3
  • 65
    • 47949099628 scopus 로고    scopus 로고
    • Modes of resistance to anti-angiogenic therapy
    • Bergers G, Hanahan D. Modes of resistance to anti-angiogenic therapy. Nat Rev Cancer. 2008;8:592-603.
    • (2008) Nat Rev Cancer , vol.8 , pp. 592-603
    • Bergers, G.1    Hanahan, D.2
  • 66
    • 60649116477 scopus 로고    scopus 로고
    • Silencing or fueling metastasis with VEGF inhibitors: Antiangiogenesis revisited
    • Loges S, Mazzone M, Hohensinner P, Carmeliet P. Silencing or fueling metastasis with VEGF inhibitors: antiangiogenesis revisited. Cancer Cell. 2009;15:167-70.
    • (2009) Cancer Cell , vol.15 , pp. 167-170
    • Loges, S.1    Mazzone, M.2    Hohensinner, P.3    Carmeliet, P.4
  • 67
    • 50849089255 scopus 로고    scopus 로고
    • Reversible tumor growth acceleration following bevacizumab interruption in metastatic colorectal cancer patients scheduled for surgery
    • Cacheux W, Boisserie T, Staudacher L, et al. Reversible tumor growth acceleration following bevacizumab interruption in metastatic colorectal cancer patients scheduled for surgery. Ann Oncol. 2008;19:1659-61.
    • (2008) Ann Oncol , vol.19 , pp. 1659-1661
    • Cacheux, W.1    Boisserie, T.2    Staudacher, L.3
  • 68
    • 0344394180 scopus 로고    scopus 로고
    • Mechanisms of resistance to topoisomerase I-targeting drugs
    • DOI 10.1038/sj.onc.1206935, Drug Resistance
    • Rasheed ZA, Rubin EH. Mechanisms of resistance to topoisomerase I-targeting drugs. Oncogene. 2003;22: 7296-304. (Pubitemid 37487161)
    • (2003) Oncogene , vol.22 , Issue.47 REV. ISS. 6 , pp. 7296-7304
    • Rasheed, Z.A.1    Rubin, E.H.2
  • 69
    • 48249116801 scopus 로고    scopus 로고
    • Proapoptotic Bad and Bid protein expression predict survival in stage II and III colon cancers
    • Sinicrope FA, Rego RL, Foster NR, et al. Proapoptotic Bad and Bid protein expression predict survival in stage II and III colon cancers. Clin Cancer Res. 2008;14:4128-33.
    • (2008) Clin Cancer Res , vol.14 , pp. 4128-4133
    • Sinicrope, F.A.1    Rego, R.L.2    Foster, N.R.3
  • 70
    • 79952737508 scopus 로고    scopus 로고
    • Ongoing colorectal cancer adjuvant trials in Japan
    • Watanabe T. Ongoing colorectal cancer adjuvant trials in Japan. Curr Colorectal Cancer Rep. 2010;6:168-174.
    • (2010) Curr Colorectal Cancer Rep , vol.6 , pp. 168-174
    • Watanabe, T.1
  • 71
    • 36849068465 scopus 로고    scopus 로고
    • Evolvable signaling networks of receptor tyrosine kinases: Relevance of robustness to malignancy and to cancer therapy
    • Amit I, Wides R, Yarden Y. Evolvable signaling networks of receptor tyrosine kinases: relevance of robustness to malignancy and to cancer therapy. Mol Syst Biol. 2007; 3:151.
    • (2007) Mol Syst Biol , vol.3 , pp. 151
    • Amit, I.1    Wides, R.2    Yarden, Y.3
  • 73
    • 79961010960 scopus 로고    scopus 로고
    • http://www.adjuvantonline.com/index.jsp.
  • 74
    • 58149102560 scopus 로고    scopus 로고
    • How well do we communicate with patients concerning adjuvant systemic therapy? A survey of 150 colorectal cancer survivors
    • Love N, Bylynd C, Meropol NJ, et al. How well do we communicate with patients concerning adjuvant systemic therapy? A survey of 150 colorectal cancer survivors. J Clin Oncol. 2007;25 18S:168s.
    • (2007) J Clin Oncol , vol.25 , Issue.18 S
    • Love, N.1    Bylynd, C.2    Meropol, N.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.