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Volumn 15, Issue 4, 2011, Pages 523-528

Natural product drug discovery: The successful optimization of ISP-1 and halichondrin B

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN A; ERIBULIN; FINGOLIMOD; HALICHONDRIN B; ISP 1; NATURAL PRODUCT; UNCLASSIFIED DRUG;

EID: 79961010756     PISSN: 13675931     EISSN: 18790402     Source Type: Journal    
DOI: 10.1016/j.cbpa.2011.05.019     Document Type: Article
Times cited : (20)

References (25)
  • 1
    • 40649122843 scopus 로고    scopus 로고
    • FTY720 story. Its discovery and the following accelerated development of sphingosine 1-phosphate receptor agonists as immunomodulators based on reverse pharmacology
    • Adachi K., Chiba K. FTY720 story. Its discovery and the following accelerated development of sphingosine 1-phosphate receptor agonists as immunomodulators based on reverse pharmacology. Perspect Med Chem 2007, 1:11-23.
    • (2007) Perspect Med Chem , vol.1 , pp. 11-23
    • Adachi, K.1    Chiba, K.2
  • 3
    • 0017750562 scopus 로고
    • Effects of the new anti-lymphocytic peptide cyclosporin A in animals
    • Borel J.F., Feurer C., Magnée C., Stähelin H. Effects of the new anti-lymphocytic peptide cyclosporin A in animals. Immunology 1977, 32:1017-1025.
    • (1977) Immunology , vol.32 , pp. 1017-1025
    • Borel, J.F.1    Feurer, C.2    Magnée, C.3    Stähelin, H.4
  • 6
    • 0028943870 scopus 로고
    • Design, synthesis, and structure-activity relationships of 2-substituted-2-amino-1,3 propanediols: discovery of a novel immunosuppressant, FTY720
    • Adachi K., Kohara T., Nakao N., Arita M., Chiba K., Mishina T., Sasaki S., Fujita T. Design, synthesis, and structure-activity relationships of 2-substituted-2-amino-1,3 propanediols: discovery of a novel immunosuppressant, FTY720. Bioorg Med Chem Lett 1995, 5:853-856.
    • (1995) Bioorg Med Chem Lett , vol.5 , pp. 853-856
    • Adachi, K.1    Kohara, T.2    Nakao, N.3    Arita, M.4    Chiba, K.5    Mishina, T.6    Sasaki, S.7    Fujita, T.8
  • 7
    • 33645283403 scopus 로고    scopus 로고
    • FTY720, sphingosine 1-phosphate receptor modulator, ameliorates experimental autoimmune encephalomyelitis by inhibition of T cell infiltration
    • Kataoka H., Sugahara K., Shimano K., Teshima K., Koyama M., Fukunari A., Chiba K. FTY720, sphingosine 1-phosphate receptor modulator, ameliorates experimental autoimmune encephalomyelitis by inhibition of T cell infiltration. Cell Mol Immunol 2005, 2:439-448.
    • (2005) Cell Mol Immunol , vol.2 , pp. 439-448
    • Kataoka, H.1    Sugahara, K.2    Shimano, K.3    Teshima, K.4    Koyama, M.5    Fukunari, A.6    Chiba, K.7
  • 8
    • 0029075192 scopus 로고
    • Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1/myriocin
    • Miyake Y., Kozutsumi Y., Nakamura S., Fujita T., Kawasaki T. Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1/myriocin. Biochem Biophys Res Commun 1995, 211:396-403.
    • (1995) Biochem Biophys Res Commun , vol.211 , pp. 396-403
    • Miyake, Y.1    Kozutsumi, Y.2    Nakamura, S.3    Fujita, T.4    Kawasaki, T.5
  • 12
    • 0142215631 scopus 로고    scopus 로고
    • The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2
    • Paugh S.W., Payne S.G., Barbour S.E., Milstien S., Spiegel S. The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2. FEBS Lett 2003, 554:189-193.
    • (2003) FEBS Lett , vol.554 , pp. 189-193
    • Paugh, S.W.1    Payne, S.G.2    Barbour, S.E.3    Milstien, S.4    Spiegel, S.5
  • 13
    • 0036773971 scopus 로고    scopus 로고
    • FTY720: targeting G-proteincoupled receptors for sphingosine 1 phosphate in transplantation and autoimmunity
    • Brinkmann V., Lynch K.R. FTY720: targeting G-proteincoupled receptors for sphingosine 1 phosphate in transplantation and autoimmunity. Curr Opin Immunol 2002, 14:569-575.
    • (2002) Curr Opin Immunol , vol.14 , pp. 569-575
    • Brinkmann, V.1    Lynch, K.R.2
  • 14
    • 23444460121 scopus 로고    scopus 로고
    • Novel immunomodulator FTY720 is phosphorylated in rats and humans to form a single stereoisomer. Identification, chemical proof, and biological characterization of the biologically active species and its enantiomer
    • Albert R., Hinterding K., Brinkmann V., Guerini D., Müller-Hartwieg C., Knecht H., Simeon C., Streiff M., Wagner T., Welzenbach K., et al. Novel immunomodulator FTY720 is phosphorylated in rats and humans to form a single stereoisomer. Identification, chemical proof, and biological characterization of the biologically active species and its enantiomer. J Med Chem 2005, 48:5373-5377.
    • (2005) J Med Chem , vol.48 , pp. 5373-5377
    • Albert, R.1    Hinterding, K.2    Brinkmann, V.3    Guerini, D.4    Müller-Hartwieg, C.5    Knecht, H.6    Simeon, C.7    Streiff, M.8    Wagner, T.9    Welzenbach, K.10
  • 16
    • 0022709534 scopus 로고
    • Halichondrins-antitumor polyether macrolides from a marine sponge
    • Hirata Y., Uemura D. Halichondrins-antitumor polyether macrolides from a marine sponge. Pure Appl Chem 1986, 58:701-7190.
    • (1986) Pure Appl Chem , vol.58 , pp. 701-7190
    • Hirata, Y.1    Uemura, D.2
  • 17
    • 0026069885 scopus 로고
    • Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin
    • Bai R., Paull K.D., Herald C.L., Malspeis L., Pettit G.R., Hamel E. Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. J Biol Chem 1991, 266:15882-15889.
    • (1991) J Biol Chem , vol.266 , pp. 15882-15889
    • Bai, R.1    Paull, K.D.2    Herald, C.L.3    Malspeis, L.4    Pettit, G.R.5    Hamel, E.6
  • 23
  • 24
    • 35648962108 scopus 로고    scopus 로고
    • E7389, a synthetic analog of halichondrin B, suppresses microtubule dynamics in living MCF7 cells by a novel mechanism
    • Abs LM-43
    • Kamath K., Okouneva T., Miller H., Davis C., Littlefield B.A., Wilson L., Jordan M.A. E7389, a synthetic analog of halichondrin B, suppresses microtubule dynamics in living MCF7 cells by a novel mechanism. Proc Am Assoc Cancer Res 2003, 44. Abs LM-43.
    • (2003) Proc Am Assoc Cancer Res , vol.44
    • Kamath, K.1    Okouneva, T.2    Miller, H.3    Davis, C.4    Littlefield, B.A.5    Wilson, L.6    Jordan, M.A.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.