Effect of weight loss on serum pigment epithelium-derived factor levels

European Journal of Clinical Investigation

Volumn 41, Issue 9, 2011, Pages 937-942

  Tschoner, Alexander ^a   Sturm, Wolfgang ^a   Ress, Claudia ^a   Engl, Julia ^a   Kaser, Susanne ^a   Laimer, Markus ^a   Laimer, Elisabeth ^a   Klaus, Alexander ^a   Tilg, Herbert ^b   Patsch, Josef R ^a   Ebenbichler, Christoph F ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b Academic Teaching Hospital   (Austria)

Author keywords

Bariatric surgery; Metabolism; Obesity; Pigment epithelium derived factor; Weight loss

Indexed keywords

C REACTIVE PROTEIN; INSULIN; INTERLEUKIN 6; LEPTIN; LIPID; PIGMENT EPITHELIUM DERIVED FACTOR; TUMOR NECROSIS FACTOR ALPHA;

ABDOMINAL FAT; ABDOMINAL OBESITY; ADULT; ARTICLE; BARIATRIC SURGERY; BODY FAT DISTRIBUTION; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; ECHOGRAPHY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GLUCOSE HOMEOSTASIS; HUMAN; INSULIN RESISTANCE; LIPID ANALYSIS; MALE; METABOLIC PARAMETERS; OBESITY; PIGMENT EPITHELIUM; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SMOKING; STANDARD; WEIGHT REDUCTION;

ADULT; BARIATRIC SURGERY; BODY COMPOSITION; BODY MASS INDEX; EYE PROTEINS; FEMALE; HUMANS; MALE; MIDDLE AGED; NERVE GROWTH FACTORS; OBESITY; REGRESSION ANALYSIS; SERPINS; TIME FACTORS; WEIGHT LOSS; YOUNG ADULT;

EID: 79961008429     PISSN: 00142972     EISSN: 13652362     Source Type: Journal    
DOI: 10.1111/j.1365-2362.2011.02482.x     Document Type: Article

References (24)

1. Rosen ED, Spiegelman BM. Adipocytes as regulators of energy balance and glucose homeostasis. Nature 2006;444:847-53.
2. Tombran-Tink J, Barnstable CJ. PEDF: a multifaceted neurotrophic factor. Nat Rev Neurosci 2003;4:628-36.
3. Dawson DW, Volpert OV, Gillis P, Crawford SE, Xu H, Benedict W et al. Pigment epithelium-derived factor: a potent inhibitor of angiogenesis. Science 1999;285:245-8.
4. Zvonic S, Lefevre M, Kilroy G, Floyd ZE, DeLany JP, Kheterpal I et al. Secretome of primary cultures of human adipose-derived stem cells: modulation of serpins by adipogenesis. Mol Cell Proteomics 2007;6:18-28.
5. Sabater M, Moreno-Navarrete JM, Ortega FJ, Pardo G, Salvador J, Ricart W et al. Circulating pigment epithelium-derived factor levels are associated with insulin resistance and decrease after weight loss. J Clin Endocrinol Metab 2010;95:4720-8.
6. Nakamura K, Yamagishi S, Adachi H, Kurita-Nakamura Y, Matsui T, Inoue H. Serum levels of pigment epithelium-derived factor (PEDF) are positively associated with visceral adiposity in Japanese patients with type 2 diabetes. Diabetes Metab Res Rev 2009;25:52-6.
7. Yamagishi S, Adachi H, Abe A, Yashiro T, Enomoto M, Furuki K et al. Elevated serum levels of pigment epithelium-derived factor in the metabolic syndrome. J Clin Endocrinol Metab 2006;91:2447-50.
8. Jenkins A, Zhang SX, Gosmanova A, Aston C, Dashti A, Baker MZ et al. Increased serum pigment epithelium derived factor levels in Type 2 diabetes patients. Diabetes Res Clin Pract 2008;82:e5-7.
9. Jenkins AJ, Zhang SX, Rowley KG, Karschimkus CS, Nelson CL, Chung JS et al. Increased serum pigment epithelium-derived factor is associated with microvascular complications, vascular stiffness and inflammation in Type 1 diabetes. Diabet Med 2007;24:1345-51.
10. Yamagishi S, Matsui T, Nakamura K, Ueda S, Noda Y, Imaizumi T. Pigment epithelium-derived factor (PEDF): its potential therapeutic implication in diabetic vascular complications. Curr Drug Targets 2008;9:1025-9.
11. Famulla S, Lamers D, Hartwig S, Passlack W, Horrighs A, Cramer A et al. Pigment epithelium-derived factor is one of the most abundant proteins secreted by human adipocytes and induces insulin resistance and inflammatory signaling in muscle and fat cells. Int J Obes (Lond) 2010; [Epub ahead of print].
12. Buchwald H, Avidor Y, Braunwald E, Jensen MD, Pories W, Fahrbach K et al. Bariatric surgery: a systematic review and meta-analysis. JAMA 2004;292:1724-37.
13. Sjostrom L, Lindroos AK, Peltonen M, Torgerson J, Bouchard C, Carlsson B et al. Lifestyle, diabetes, and cardiovascular risk factors 10years after bariatric surgery. N Engl J Med 2004;351:2683-93.
14. Sjostrom L, Narbro K, Sjostrom CD, Karason K, Larsson B, Wedel H et al. Effects of bariatric surgery on mortality in Swedish obese subjects. N Engl J Med 2007;357:741-52.
15. Adams TD, Gress RE, Smith SC, Halverson RC, Simper SC, Rosamond WD et al. Long-term mortality after gastric bypass surgery. N Engl J Med 2007;357:753-61.
16. Nehoda H, Weiss H, Labeck B, Hourmont K, Lanthaler M, Oberwalder M et al. Results and complications after adjustable gastric banding in a series of 250 patients. Am J Surg 2001;181:12-5.
17. Pontiroli AE, Pizzocri P, Giacomelli M, Marchi M, Vedani P, Cucchi E et al. Ultrasound measurement of visceral and subcutaneous fat in morbidly obese patients before and after laparoscopic adjustable gastric banding: comparison with computerized tomography and with anthropometric measurements. Obes Surg 2002;12:648-51.
18. Crowe S, Wu LE, Economou C, Turpin SM, Matzaris M, Hoehn KL et al. Pigment epithelium-derived factor contributes to insulin resistance in obesity. Cell Metab 2009;10:40-7.
19. Ogata N, Matsuoka M, Matsuyama K, Shima C, Tajika A, Nishiyama T et al. Plasma concentration of pigment epithelium-derived factor in patients with diabetic retinopathy. J Clin Endocrinol Metab 2007;92:1176-9.
20. Fernandez-Veledo S, Vila-Bedmar R, Nieto-Vazquez I, Lorenzo M. c-Jun N-terminal kinase 1/2 activation by tumor necrosis factor-alpha induces insulin resistance in human visceral but not subcutaneous adipocytes: reversal by liver X receptor agonists. J Clin Endocrinol Metab 2009;94:3583-93.
21. Tilg H, Moschen AR. Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol 2006;6:772-83.
22. Forsythe LK, Wallace JM, Livingstone MB. Obesity and inflammation: the effects of weight loss. Nutr Res Rev 2008;21:117-33.
23. Steinberg GR, Kemp BE, Watt MJ. Adipocyte triglyceride lipase expression in human obesity. Am J Physiol Endocrinol Metab 2007;293:E958-64.
24. Notari L, Baladron V, Aroca-Aguilar JD, Balko N, Heredia R, Meyer C et al. Identification of a lipase-linked cell membrane receptor for pigment epithelium-derived factor. J Biol Chem 2006;281:38022-37.