Decreased gene expression of LC3 in peripheral leucocytes of patients with coronary artery disease

European Journal of Clinical Investigation

Volumn 41, Issue 9, 2011, Pages 958-963

  Wu, Guanghua ^a,b   Wei, Guanghe ^a,c   Huang, Jian ^a   Pang, Shuchao ^a   Liu, Lixin ^a,c   Yan, Bo ^a  

^a Shandong Provincial Key Laboratory of Cardiac Disease Diagnosis   (China)

^b Divisions of Cardiac Surgery   (China)

^c JINING MEDICAL UNIVERSITY   (China)

Author keywords

Atherosclerosis; Autophagy; Coronary artery disease; LC3; Leucocytes

Indexed keywords

LC3 II PROTEIN; LC3 PROTEIN; MEMBRANE PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; ATHEROSCLEROSIS; AUTOLYSOSOME; AUTOPHAGOSOME; AUTOPHAGY; CELL ORGANELLE; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DISEASE ASSOCIATION; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; LYMPHOCYTE; MAJOR CLINICAL STUDY; MONOCYTE; NEUTROPHIL; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

AGED; ATHEROSCLEROSIS; AUTOPHAGY; BIOLOGICAL MARKERS; BLOTTING, WESTERN; CASE-CONTROL STUDIES; CHINA; CORONARY ARTERY DISEASE; FEMALE; GENE EXPRESSION; HUMANS; LEUKOCYTES; MALE; MICROTUBULE-ASSOCIATED PROTEINS; MIDDLE AGED; MULTIVARIATE ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 79960993362     PISSN: 00142972     EISSN: 13652362     Source Type: Journal    
DOI: 10.1111/j.1365-2362.2011.02486.x     Document Type: Article

References (37)

1. Mayer B, Erdmann J, Schunkert H. Genetics and heritability of coronary artery disease and myocardial infarction. Clin Res Cardiol 2007;96:1-7.
2. Teslovich TM, Musunuru K, Smith AV, Edmondson AC, Stylianou IM, Koseki M et al. Biological, clinical and population relevance of 95 loci for blood lipids. Nature 2010;466:707-13.
3. Hansson GK. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med 2005;352:1685-95.
4. Rocha VZ, Libby P. Obesity, inflammation, and atherosclerosis. Nat Rev Cardiol 2009;6:399-409.
5. Baetta R, Corsini A. Role of polymorphonuclear neutrophils in atherosclerosis: current state and future perspectives. Atherosclerosis 2010;210:1-13.
6. Weber C, Zernecke A, Libby P. The multifaceted contributions of leukocyte subsets to atherosclerosis: lessons from mouse models. Nat Rev Immunol 2008;8:802-15.
7. Soehnlein O, Drechsler M, Hristov M, Weber C. Functional alterations of myeloid cell subsets in hyperlipidaemia: relevance for atherosclerosis. J Cell Mol Med 2009;13:4293-303.
8. Levine B, Klionsky DJ. Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell 2004;6:463-77.
9. Lum JJ, DeBerardinis RJ, Thompson CB. Autophagy in metazoans: cell survival in the land of plenty. Nat Rev Mol Cell Biol 2005;6:439-48.
10. De Meyer GR, Martinet W. Autophagy in the cardiovascular system. Biochim Biophys Acta 2009;1793:1485-95.
11. Levine B, Deretic V. Unveiling the roles of autophagy in innate and adaptive immunity. Nat Rev Immunol 2007;7:767-77.
12. Levine B, Kroemer G. Autophagy in the pathogenesis of disease. Cell 2008;132:27-42.
13. Terman A, Brunk UT. Autophagy in cardiac myocyte homeostasis, aging, and pathology. Cardiovasc Res 2005;68:355-65.
14. Klionsky DJ, Cuervo AM, Seglen PO. Methods for monitoring autophagy from yeast to human. Autophagy 2007;3:181-206.
15. Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, Noda T et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 2000;19:5720-8.
16. Klionsky DJ, Abeliovich H, Agostinis P, Agrawal DK, Aliev G, Askew DS et al. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 2008;4:1-24.
17. Tanida I, Ueno T, Kominami E. LC3 conjugation system in mammalian autophagy. Int J Biochem Cell Biol 2004;36:2503-25018.
18. Mizushima N. Autophagy: process and function. Genes Dev 2007;21:2861-73.
19. Gustafsson AB, Gottlieb RA. Recycle or die: the role of autophagy in cardioprotection. J Mol Cell Cardiol 2008;44:654-61.
20. Taneike M, Yamaguchi O, Nakai A, Hikoso S, Takeda T, Mizote I et al. Inhibition of autophagy in the heart induces age-related cardiomyopathy. Autophagy 2010;6:600-6.
21. Martinet W, De Meyer GR. Autophagy in atherosclerosis: a cell survival and death phenomenon with therapeutic potential. Circ Res 2009;104:304-17.
22. Simera I, Moher D, Hoey J, Schulz KF, Altman DG. A catalogue of reporting guidelines for health research. Eur J Clin Invest 2010;40:35-53.
23. Schrijvers DM, De Meyer GR, Herman AG, Martinet W. Phagocytosis in atherosclerosis: molecular mechanisms and implications for plaque progression and stability. Cardiovasc Res 2007;73:470-80.
24. Paulsson J, Dadfar E, Held C, Jacobson SH, Lundahl J. Activation of peripheral and in vivo transmigrated neutrophils in patients with stable coronary artery disease. Atherosclerosis 2007;192:328-34.
25. Naruko T, Ueda M, Haze K, van der Wal AC, van der Loos CM, Itoh A et al. Neutrophil infiltration of culprit lesions in acute coronary syndromes. Circulation 2002;106:2894-900.
26. Rotzius P, Thams S, Soehnlein O, Kenne E, Tseng CN, Björkström NK et al. Distinct Infiltration of Neutrophils in Lesion Shoulders in ApoE-/- Mice. Am J Pathol 2010;177:493-500.
27. Zernecke A, Bot I, Djalali-Talab Y, Shagdarsuren E, Bidzhekov K, Meiler S et al. Protective role of CXC receptor 4/CXC ligand 12 unveils the importance of neutrophils in atherosclerosis. Circ Res 2008;102:209-17.
28. Avanzas P, Arroyo-Espliguero R, Cosín-Sales J, Quiles J, Zouridakis E, Kaski JC. Multiple complex stenoses, high neutrophil count and C-reactive protein levels in patients with chronic stable angina. Atherosclerosis 2004;175:151-7.
29. Kostis JB, Turkevich D, Sharp J. Association between leukocyte count and the presence and extent of coronary atherosclerosis as determined by coronary arteriography. Am J Cardiol 1984;53:997-9.
30. Kassiotis C, Ballal K, Wellnitz K, Vela D, Gong M, Salazar R et al. Markers of autophagy are downregulated in failing human heart after mechanical unloading. Circulation 2009;120(Suppl.):S191-7.
31. Miracco C, Cevenini G, Franchi A, Luzi P, Cosci E, Mourmouras V et al. Beclin 1 and LC3 autophagic gene expression in cutaneous melanocytic lesions. Hum Pathol 2010;41:503-12.
32. Yoshioka A, Miyata H, Doki Y, Yamasaki M, Sohma I, Gotoh K et al. LC3, an autophagosome marker, is highly expressed in gastrointestinal cancers. Int J Oncol 2008;33:461-8.
33. Pan M, Maitin V, Parathath S, Andreo U, Lin SX, St Germain C et al. Presecretory oxidation, aggregation, and autophagic destruction of apoprotein-B: a pathway for late-stage quality control. Proc Natl Acad Sci USA 2008;105:5862-7.
34. Zhang YL, Cao YJ, Zhang X, Liu HH, Tong T, Xiao GD et al. The autophagy-lysosome pathway: a novel mechanism involved in the processing of oxidized LDL in human vascular endothelial cells. Biochem Biophys Res Commun 2010;394:377-82.
35. Shibata M, Yoshimura K, Tamura H, Ueno T, Nishimura T, Inoue T et al. LC3, a microtubule-associated protein1A/B light chain3, is involved in cytoplasmic lipid droplet formation. Biochem Biophys Res Commun 2010;393:274-9.
36. Singh R, Kaushik S, Wang Y, Xiang Y, Novak I, Komatsu M et al. Autophagy regulates lipid metabolism. Nature 2009;458:1131-5.
37. Schadt EE. Molecular networks as sensors and drivers of common human diseases. Nature 2009;461:218-23.