Keeping ahead of the flow: Can the next generation of flow chemistry and biology platforms be fully integrated to transform the efficiency of small-molecule drug discovery for pharmaceutical industry?

Drug Discovery World

Volumn 12, Issue 3, 2011, Pages 25-29

  Treherne, J Mark ^a,b,c,d,e   Parry, David M ^g   Selway, Christopher N ^f  

^a Board of NeuroDiscovery Limited   (United Kingdom)

^b Board of Domain Pharmaceuticals SA   (United Kingdom)

^c Board of Population Genetics Technologies Limited   (United Kingdom)

^d Board of Senexis Limited   (United Kingdom)

^e Xention Limited   (United Kingdom)

^f UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^g NONE

Author keywords

[No Author keywords available]

Indexed keywords

MONOCLONAL ANTIBODY;

AUTOMATION; COMBINATORIAL CHEMISTRY; DRUG INDUSTRY; DRUG MANUFACTURE; DRUG RESEARCH; HIGH THROUGHPUT SCREENING; PROCESS OPTIMIZATION; SHORT SURVEY; TECHNOLOGY;

EID: 79960990669     PISSN: 14694344     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Short Survey

References (13)

1. See for example: Kymouse platform (www.kymab.com);
2. UCB Selective Lymphocyte Antibody Method (http://www.ucb.com/rd/science/ innovative-proprietary/ucbslam).
3. Wong-Hawkes, SYF, Matteo, JC, Warrington, BH and White, JD. Microreactors as new tools for drug discovery and development. Ernst Schering Found Symp Proc. 2006;(3):39-55.
4. For a recent review see Wiles, Charlotte and Watts, Paul. Recent advances in micro reaction technology Chem Commun. 2011, 47, 6512-6535.
5. DuBois, D.An apparatus for the study of rapid chemical reactions J Biol Chem 137(1): 123-137 (1941).
6. deBoer, AR, Lingeman, H, Niessen, WM, Irth, H. Mass spectrometry-based biochemical assays for enzyme-inhibitor screening.
7. Hadd, Andrew G, Raymond, Daniel E, Halliwell, John W, Jacobson, Stephen C and Ramsey, J Michael. Microchip Device for Performing Enzyme Assays Anal chem. 1997, 69, 3407-3412.
8. Hadd, Andrew G, Jacobson, Stephen C and Ramsey, J. Michael. Microfluidic assays of acetylcholinesterase inhibitors Anal Chem 1999 71 5206-5212.
9. Huber, Walter. SPR-Based Direct Binding Assays in Drug Discovery. Label-Free Technologies for Drug Discovery, Editors: Matthew Cooper, Lorenz M. Mayr. Wiley 2011.
10. Lipinski, CA, Lombardo, F, Dominy, BW, Feeney, PJ. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug Delivery Rev. 23, 1997, 3-25.
11. For example Labview from National Instruments.
12. For example Knime (www.knime.org)
13. and Pipeline Pilot (www.accelrys.com/products/pipeline-pilot).