Signal Transduction by G Proteins: Basic Principles, Molecular Diversity, and Structural Basis of Their Actions

Handbook of Cell Signaling, Second Edition

Volumn 2, Issue , 2009, Pages 1597-1614

  Birnbaumer, Lutz ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 79960983193     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-374145-5.00197-2     Document Type: Chapter

References (49)

1. H Lodish, A Berk, CA Kaiser, M Krieger, MP Scott, A Bretshcer, H Ploeg and P Matsudaira (2008) Molecular cell biology. 6th ed. New York, NY: H. Freeman and Co p. 623–712.
2. M Rodbell, L Birnbaumer, SL Pohl and HMJ Krans (1970) Properties of the adenyl cyclase systems in liver and adipose cells: the mode of action of hormones. Acta Diabetol Lat 7(Suppl. 1), 9-57.
3. SH Kim, GG Priveé and MV Milburn (1993) Conformational switch and structural basis offor oncogenic mutations of Ras proteins. B Dickey, L Birnbaumer (Eds) Handbook of experimental pharmacology, vol. 108/I, GTPases in biology Heidelberg: Springer Verlag 177-193.
4. B Dickey and L Birnbaumer (Eds) (1993) Handbook of experimental pharmacology, vol. 108/I, GTPases in biology Heidelberg: Springer Verlag
5. LA Feig (1993) Dominant inhibitory Ras mutants: tools for eucidading Ras function. B Dickey, L Birnbaumer (Eds) Handbook of experimental pharmacology, vol. 108/I, GTPases in biology Heidelberg, Germany: Springer Verlag 289-298.
6. JP Noel, HE Hamm and PB Sigler (1993) The 2.2-Å crystal structure of transducin a GTPγS. Nature 366 654-663.
7. DE Coleman, AM Berghuis, E Lee, ME Lindner, AG Gilman and SR Sprang (1994) Structures of active conformations of Giα1 and the mechanism of GTP hydrolysis. Science 265 1405-1412.
8. T Higashijima, KM Ferguson, PC Sternweis, MD Smigel and AG Gilman (1987) Effects of Mg2+ and the βγ subunit complex on the interactions of guanine nucleotides with G proteins. J Biol Chem 262 762-766.
9. JJ Tesmer, RK Sunahara, AG Gilman and SR Sprang (1997) Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsα. GTPγS. Science 278 1907-1916.
10. DG Lambright, JP Noel, HE Hamm and PB Sigler (1994) Structral determinants for the activation of the a subunit of a heterotrimeric G protein. Nature 239 621-628.
11. MA Wall, DE Coleman, E Lee, JA IniguezLluhi, BA Posner, AG Gilman and SR Sprang (1995) The structure of the G protein heterotrimer Giα1 β1 γ2. Cell 83 1047-1058.
12. PJ Casey (1995) Protein lipidation in cell signaling. Science 268 221-225.
13. L Birnbaumer (2007) The discovery of signal transduction by G proteins. A personal account and an overview of the initial findings and contributions that led to our present understanding. Biochim Biophys Acta Biomembranes 1768 756-771.
14. L Birnbaumer (2007) Expansion of signal transduction by G proteins from 3 to 16 a subunits plus βγ dimers. The second 15 years or so. Biochim Biophys Acta Biomembranes 1768 772-793.
15. T Gerachshenko, T Blackmer, EJ Yoon, C Bartleson, HE Hamm and S Alford (2005) Gβγ acts at the C terminus of SNAP-25 to mediate presynaptic inhibition. Nat Neurosci 8 597-605.
16. Yoon EJ, Hamm HE, Currie KP. G protein βγ subunits modulate the number and nature of exocytotic fusion events in adrenal chromaffin cells independent of calcium entry. J Neurophysiol 2008. 14 September, epub ahead of print.
17. AS Raw, DE Coleman, AG Gilman and SR Sprang (1997) Structural and biochemical characterization of the GTPγS-, GDP.Pi-, and GDP-bound forms of a GTPase-deficient Gly42 → Val mutant of Giα1. Biochemistry 36 15,660-15,669.
18. J John, H Rensland, I Schlichting, I Vetter, GD Borasio, RS Goody and A Wittinghofer (1993) Kinetic and structural analysis of the Mg2+-binding site of the guanine nucleotide-binding protein p21H-ras. J Biol Chem 268 923-929.
19. HR Bourne (1995) How receptors talk to trimeric G proteins. Curr Opin Cell Biol 9 134-142.
20. J Wess (1998) Molecular basis of receptor/G protein coupling selectivity. Pharmacol Ther 80 231-264.
21. G Grishina and CH Berlot (2000) A surface exposed region of Gsα in which substitutions decrease receptor mediated activation and increase receptor affinity. Mol Pharmacol 57 1081-1092.
22. CH Berlot (2002) A highly effective dominant negative as constuct containing mutations that affect distinct functions inhibits multiple Gs-coupled receptor signalling pathways. J Biol Chem 277 21,080-21,085.
23. BR Conklin, Z Farfel, KD Lustig, D Julius and HR Bourne (1993) Substitution of three amino acids switches receptor specificity of Gqα to that of Giα. Nature 363 274-276.
24. HE Hamm (2002) How activated receptors couple to G propteins. Proc Natl Acad Sci USA 98 4819-4821.
25. K Palczewski (2006) G protein-coupled receptor rhodopsin. Annu Rev Biochem 75 743-767.
26. JH Park, P Scheerer, KP Hofmann, HW Choe and OP Ernst (2008) Crystal structure of the ligand-free G-protein-coupled receptor opsin. Nature 454 183-187.
27. P Scheerer, JH Park, PW Hildebrand, YJ Kim, N Krauss, HW Choe, KP Hofmann and OP Ernst (2008) Crystal structure of opsin in its G-protein-interacting conformation. Nature 455 497-502.
28. N Van Eps, WM Oldham, HE Hamm and WL Hubbell (2006) Structural and dynamical changes in an alpha-subunit of a heterotrimeric G protein along the activation pathway. Proc Natl Acad Sci USA 103 16,194-16,199.
29. WM Oldham, N Van Eps, AM Preininger, WL Hubbell and HE Hamm (2007) Mapping allosteric connections from the receptor to the nucleotide-binding pocket of heterotrimeric G proteins. Proc Natl Acad Sci USA 104 7927-7932.
30. TW Schwartz and WL Hubbell (2008) Structural biology: a moving story of receptors. Nature 455 473-474.
31. T Iiri, P Herzmark, JM Nakamoto, C van Dop and HR Bourne (1994) Rapid GDP release from Gs alpha in patients with gain and loss of endocrine function. Nature 371 164-168.
32. C Kleuss, J Hescheler, C Ewel, W Rosenthal, G Schultz and B Wittig (1991) Assignment of G-protein subtypes to specific receptors inducing inhibition of calcium currents. Nature 353 43-48.
33. C Chen and IJ Clarke (1996) Go2 Protein mediates the reduction in Ca2+ current by somatostatin in cultured ovine somatotrophs. J Physiol 491 21-29.
34. C Kleuss, H Scherübl, J Hescheler, G Schultz and B Wittig (1992) Different β-subunits determine G protein interaction with transmembrane receptors. Nature 358 424-426.
35. C Kleuss, H Scherübl, J Hescheler, G Schultz and B Wittig (1993) Selectivity in signal transduction determined by γ subunits of heterotrimeric G proteins. Science 259 832-834.
36. L DeVries, B Zheng, T Fischer, E Elenko and MG Farquhar (2000) The regulator of G protein signaling family. Annu Rev Pharmacol Toxicol 40 235-271.
37. CK Chen, ME Burns, W He, TG Wensel, DA Baylor and MI Simon (2000) Slowed recovery of rod photoresponse in mice lacking the GTPase accelerating protein RGS9-1. Nature 403 557-560.
38. MJ Cismowski, A Takesono, ML Bernard, E Duzic and SM Lanier (2001) Receptor-independent activators of heterotrimeric G proteins. Life Sci 68 2301-2308.
39. RJ Kimple, FS Willard and DR Siderovski (2002) The GoLoco motif: heralding a new tango between G protein signaling and cell division. Mol Interventions 2 88-100.
40. MJ Lohse (2006) G protein-coupled receptors: too many dimers? Nat Methods 3 972-973.
41. Birnbaumer L. Martin Rodbell (1925 1998) In memoriam. Science 283 1999;1656.
42. TK Bjarnadóttir, DE Gloriam, SH Hellstrand, H Kristiansson, R Fredriksson and HB Schiöth (2006) Comprehensive repertoire and phylogenetic analysis of the G protein-coupled receptors in human and mouse. Genomics 88 263-273.
43. TM Wilkie, DJ Gilbert, AS Olsen, XN Chen, TT Amatruda, JR Korenberg, BJ Trask, P de Jong, RR Reed, MI Simon, NA Jenkins and NG Copeland (1992) Chromosomal evolution of the G protein a subunit multigene family. Nat Genet 1 85-91.
44. R Taussig, WJ Tang, JR Hepler and AG Gilman (1994) Distinct patterns of bidirectional regulation of mammalian adenylyl cyclases. J Biol Chem 269 6093-6100.
45. RA Cerione (2004) Cdc42: new roads to travel. Trends Cell Biol 14 127-132.
46. S Tsukada, MI Simon, ON Witte and A Katz (1994) Binding of βγ subunits of heterotrimeric G proteins to the PH domain of Bruton tyrosine kinase. Proc Natl Acad Sci USA 91 11,256-11,260.
47. SA Langhans-Rajasekaran, Y Wan and XY Huang (1995) Activation of Tsk and Btk tyrosine kinases by G protein βγ subunits. Proc Natl Acad Sci USA 92 8601-8605.
48. Y Jiang, W Ma, Y Wan, T Kozasa, S Hattori and XY Huang (1998) The G protein G121α stimulates Bruton’s tyrosine kinase and a rasGAP through a conserved PH/BM domain. Nature 395 808-813.
49. R Iyengar and L Birnbaumer (1982) Hormone receptor modulates the regulatory component of adenylyl cyclases by reducing its requirement for Mg ion and enhancing its extent of activation by guanine nucleotides. Proc Natl Acad Sci USA 79 5179-5183.