-
1
-
-
0033973070
-
Phase I clinical trial design in cancer drug development
-
Eisenhauer EA, O'Dwyer PJ, Christian M, Humphrey JS. Phase I clinical trial design in cancer drug development. J Clin Oncol 2000;18:684-92. (Pubitemid 30078550)
-
(2000)
Journal of Clinical Oncology
, vol.18
, Issue.3
, pp. 684-692
-
-
Eisenhauer, E.A.1
O'Dwyer, P.J.2
Christian, M.3
Humphrey, J.S.4
-
2
-
-
66749124176
-
Prospective validation of a prognostic score to improve patient selection for oncology phase I trials
-
Arkenau HT, Barriuso J, Olmos D, Ang JE, de Bono J, Judson I, et al. Prospective validation of a prognostic score to improve patient selection for oncology phase I trials. J Clin Oncol 2009;27:2692-6.
-
(2009)
J Clin Oncol
, vol.27
, pp. 2692-2696
-
-
Arkenau, H.T.1
Barriuso, J.2
Olmos, D.3
Ang, J.E.4
De Bono, J.5
Judson, I.6
-
3
-
-
40849111655
-
Clinical outcome and prognostic factors for patients treated within the context of a phase I study: The Royal Marsden Hospital experience
-
DOI 10.1038/sj.bjc.6604218, PII 6604218
-
Arkenau HT, Olmos D, Ang JE, de Bono J, Judson I, Kaye S. Clinical outcome and prognostic factors for patients treated within the context of a phase I study: the Royal Marsden Hospital experience. Br J Cancer 2008;98:1029-33. (Pubitemid 351399798)
-
(2008)
British Journal of Cancer
, vol.98
, Issue.6
, pp. 1029-1033
-
-
Arkenau, H.-T.1
Olmos, D.2
Ang, J.E.3
De Bono, J.4
Judson, I.5
Kaye, S.6
-
4
-
-
0034013999
-
Multivariable analysis of prognostic factors for toxicity and survival for patients enrolled in phase I clinical trials
-
DOI 10.1023/A:1008368319526
-
Bachelot T, Ray-Coquard I, Catimel G, Ardiet C, Guastalla JP, Dumortier A, et al. Multivariable analysis of prognostic factors for toxicity and survival for patients enrolled in phase I clinical trials. Ann Oncol 2000;11:151-6. (Pubitemid 30148727)
-
(2000)
Annals of Oncology
, vol.11
, Issue.2
, pp. 151-156
-
-
Bachelot, T.1
Ray-Coquard, I.2
Catimel, G.3
Ardiet, C.4
Guastalla, J.P.5
Dumortier, A.6
Chauvin, F.7
Droz, J.P.8
Philip, T.9
Clavel, M.10
-
5
-
-
0242266499
-
Comparison of prognostic factors in patients in phase I trials of cytotoxic drugs vs new noncytotoxic agents
-
DOI 10.1038/sj.bjc.6601218
-
Han C, Braybrooke JP, Deplanque G, Taylor M, Mackintosh D, Kaur K, et al. Comparison of prognostic factors in patients in phase I trials of cytotoxic drugs vs new noncytotoxic agents. Br J Cancer 2003;89:1166-71. (Pubitemid 37363397)
-
(2003)
British Journal of Cancer
, vol.89
, Issue.7
, pp. 1166-1171
-
-
Han, C.1
Braybrooke, J.P.2
Deplanque, G.3
Taylor, M.4
Mackintosh, D.5
Kaur, K.6
Samouri, K.7
Ganesan, T.S.8
Harris, A.L.9
Talbot, D.C.10
-
6
-
-
14544284502
-
Risks and benefits of phase 1 oncology trials, 1991 through 2002
-
DOI 10.1056/NEJMsa042220
-
Horstmann E, McCabe MS, Grochow L, Yamamoto S, Rubinstein L, Budd T, et al. Risks and benefits of phase 1 oncology trials, 1991 through 2002. N Engl J Med 2005;352:895-904. (Pubitemid 40300298)
-
(2005)
New England Journal of Medicine
, vol.352
, Issue.9
, pp. 895-904
-
-
Horstmann, E.1
McCabe, M.S.2
Grochow, L.3
Yamamoto, S.4
Rubinstein, L.5
Budd, T.6
Shoemaker, D.7
Emanuel, E.J.8
Grady, C.9
-
7
-
-
41549095568
-
Treatment outcome and survival in participants of phase I oncology trials carried out from 2003 to 2006 at Institut Gustave Roussy
-
DOI 10.1093/annonc/mdm548
-
Italiano A, Massard C, Bahleda R, Vataire AL, Deutsch E, Magne N, et al. Treatment outcome and survival in participants of phase I oncology trials carried out from 2003 to 2006 at Institut Gustave Roussy. Ann Oncol 2008;19:787-92. (Pubitemid 351467383)
-
(2008)
Annals of Oncology
, vol.19
, Issue.4
, pp. 787-792
-
-
Italiano, A.1
Massard, C.2
Bahleda, R.3
Vataire, A.-L.4
Deutsch, E.5
Magne, N.6
Pignon, J.-P.7
Vassal, G.8
Armand, J.-P.9
Soria, J.-C.10
-
8
-
-
0027998512
-
Prognostic factors for survival in patients treated in Phase I clinical trials
-
DOI 10.1002/1097-0142(19941001)74:7<1965::AID-CNCR2820740723>3.0. CO;2-1
-
Janisch L, Mick R, Schilsky RL, Vogelzang NJ, O'Brien S, Kut M, et al. Prognostic factors for survival in patients treated in phase I clinical trials. Cancer 1994;74:1965-73. (Pubitemid 24301862)
-
(1994)
Cancer
, vol.74
, Issue.7
, pp. 1965-1973
-
-
Janisch, L.1
Mick, R.2
Schilsky, R.L.3
Vogelzang, N.J.4
O'Brien, S.5
Kut, M.6
Ratain, M.J.7
-
9
-
-
38149057329
-
Prognostic factors among cancer patients with good performance status screened for phase I trials
-
Penel N, Vanseymortier M, Bonneterre ME, Clisant S, Dansin E, Vendel Y, et al. Prognostic factors among cancer patients with good performance status screened for phase I trials. Invest New Drugs 2008;26:53-8.
-
(2008)
Invest New Drugs
, vol.26
, pp. 53-58
-
-
Penel, N.1
Vanseymortier, M.2
Bonneterre, M.E.3
Clisant, S.4
Dansin, E.5
Vendel, Y.6
-
10
-
-
7244243743
-
Trends in the risk and benefits to patients with cancer participating in phase 1 clinical trials
-
DOI 10.1001/jama.292.17.2130
-
Roberts TG, Jr., Goulart BH, Squitieri L, Stallings SC, Halpern EF, Chabner BA, et al. Trends in the risks and benefits to patients with cancer participating in phase 1 clinical trials. JAMA 2004;292:2130-40. (Pubitemid 39435104)
-
(2004)
Journal of the American Medical Association
, vol.292
, Issue.17
, pp. 2130-2140
-
-
Roberts Jr., T.G.1
Goulart, B.H.2
Squitieri, L.3
Stallings, S.C.4
Halpern, E.F.5
Chabner, B.A.6
Gazelle, G.S.7
Finkelstein, S.N.8
Clark, J.W.9
-
11
-
-
61449180271
-
Survival of patients in a phase I Clinic: The M. D. Anderson Cancer Center experience
-
Wheler J, Tsimberidou AM, Hong D, Naing A, Jackson T, Liu S, et al. Survival of patients in a phase I Clinic: the M. D. Anderson Cancer Center experience. Cancer 2009;115:1091-9.
-
(2009)
Cancer
, vol.115
, pp. 1091-1099
-
-
Wheler, J.1
Tsimberidou, A.M.2
Hong, D.3
Naing, A.4
Jackson, T.5
Liu, S.6
-
12
-
-
49249130844
-
Relationship of circulating tumor cells to tumor response, progression-free survival, and overall survival in patients with metastatic colorectal cancer
-
Cohen SJ, Punt CJ, Iannotti N, Saidman BH, Sabbath KD, Gabrail NY, et al. Relationship of circulating tumor cells to tumor response, progression-free survival, and overall survival in patients with metastatic colorectal cancer. J Clin Oncol 2008;26:3213-21.
-
(2008)
J Clin Oncol
, vol.26
, pp. 3213-3221
-
-
Cohen, S.J.1
Punt, C.J.2
Iannotti, N.3
Saidman, B.H.4
Sabbath, K.D.5
Gabrail, N.Y.6
-
13
-
-
4143094988
-
Circulating tumor cells, disease progression, and survival in metastatic breast cancer
-
DOI 10.1056/NEJMoa040766
-
Cristofanilli M, Budd GT, Ellis MJ, Stopeck A, Matera J, Miller MC, et al. Circulating tumor cells, disease progression, and survival in metastatic breast cancer. N Engl J Med 2004;351:781-91. (Pubitemid 39095313)
-
(2004)
New England Journal of Medicine
, vol.351
, Issue.8
, pp. 781-791
-
-
Cristofanilli, M.1
Budd, G.T.2
Ellis, M.J.3
Stopeck, A.4
Matera, J.5
Miller, M.C.6
Reuben, J.M.7
Doyle, G.V.8
Allard, W.J.9
Terstappen, L.W.M.M.10
Hayes, D.F.11
-
14
-
-
58149165081
-
Circulating tumor cells predict survival benefit from treatment in metastatic castration-resistant prostate cancer
-
de Bono JS, Scher HI, Montgomery RB, Parker C, Miller MC, Tissing H, et al. Circulating tumor cells predict survival benefit from treatment in metastatic castration-resistant prostate cancer. Clin Cancer Res 2008;14:6302-9.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 6302-6309
-
-
De Bono, J.S.1
Scher, H.I.2
Montgomery, R.B.3
Parker, C.4
Miller, M.C.5
Tissing, H.6
-
15
-
-
6044259206
-
Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with nonmalignant diseases
-
DOI 10.1158/1078-0432.CCR-04-0378
-
Allard WJ, Matera J, Miller MC, Repollet M, Connelly MC, Rao C, et al. Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with nonmalignant diseases. Clin Cancer Res 2004;10:6897-904. (Pubitemid 39383039)
-
(2004)
Clinical Cancer Research
, vol.10
, Issue.20
, pp. 6897-6904
-
-
Allard, W.J.1
Matera, J.2
Miller, M.C.3
Repollet, M.4
Connelly, M.C.5
Rao, C.6
Tibbe, A.G.J.7
Uhr, J.W.8
Terstappen, L.W.M.M.9
-
16
-
-
17144426134
-
Circulating tumor cells predict survival in patients with metastatic prostate cancer
-
DOI 10.1016/j.urology.2004.11.006
-
Moreno JG, Miller MC, Gross S, Allard WJ, Gomella LG, Terstappen LW. Circulating tumor cells predict survival in patients with metastatic prostate cancer. Urology 2005;65:713-8. (Pubitemid 40523005)
-
(2005)
Urology
, vol.65
, Issue.4
, pp. 713-718
-
-
Moreno, J.G.1
Miller, M.C.2
Gross, S.3
Allard, W.J.4
Gomella, L.G.5
Terstappen, L.W.M.M.6
-
17
-
-
58949088650
-
Circulating tumour cell (CTC) counts as intermediate end points in castration-resistant prostate cancer (CRPC): A single-centre experience
-
Olmos D, Arkenau HT, Ang JE, Ledaki I, Attard G, Carden CP, et al. Circulating tumour cell (CTC) counts as intermediate end points in castration-resistant prostate cancer (CRPC): a single-centre experience. Ann Oncol 2009;20:27-33.
-
(2009)
Ann Oncol
, vol.20
, pp. 27-33
-
-
Olmos, D.1
Arkenau, H.T.2
Ang, J.E.3
Ledaki, I.4
Attard, G.5
Carden, C.P.6
-
18
-
-
20144385756
-
Circulating tumor cells: A novel prognostic factor for newly diagnosed metastatic breast cancer
-
Cristofanilli M, Hayes DF, Budd GT, Ellis MJ, Stopeck A, Reuben JM, et al. Circulating tumor cells: a novel prognostic factor for newly diagnosed metastatic breast cancer. J Clin Oncol 2005;23:1420-30.
-
(2005)
J Clin Oncol
, vol.23
, pp. 1420-1430
-
-
Cristofanilli, M.1
Hayes, D.F.2
Budd, G.T.3
Ellis, M.J.4
Stopeck, A.5
Reuben, J.M.6
-
19
-
-
33846814619
-
Circulating tumor cells at each follow-up time point during therapy of metastatic breast cancer patients predict progression-free and overall survival
-
Hayes DF, Cristofanilli M, Budd GT, Ellis MJ, Stopeck A, Miller MC, et al. Circulating tumor cells at each follow-up time point during therapy of metastatic breast cancer patients predict progression-free and overall survival. Clin Cancer Res 2006;12:4218-24.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 4218-4224
-
-
Hayes, D.F.1
Cristofanilli, M.2
Budd, G.T.3
Ellis, M.J.4
Stopeck, A.5
Miller, M.C.6
-
20
-
-
33751272999
-
Circulating tumor cells versus imaging - Predicting overall survival in metastatic breast cancer
-
DOI 10.1158/1078-0432.CCR-05-1769
-
Budd GT, Cristofanilli M, Ellis MJ, Stopeck A, Borden E, Miller MC, et al. Circulating tumor cells versus imaging - predicting overall survival in metastatic breast cancer. Clin Cancer Res 2006;12:6403-9. (Pubitemid 44799711)
-
(2006)
Clinical Cancer Research
, vol.12
, Issue.21
, pp. 6403-6409
-
-
Budd, G.T.1
Cristofanilli, M.2
Ellis, M.J.3
Stopeck, A.4
Borden, E.5
Miller, M.C.6
Matera, J.7
Repollet, M.8
Doyle, G.V.9
Terstappen, L.W.M.M.10
Hayes, D.F.11
-
21
-
-
79953885749
-
Phase I trial of a selective c-MET inhibitor ARQ 197 incorporating proof of mechanism pharmacodynamic studies
-
Yap TA, Olmos D, Brunetto AT, Tunariu N, Barriuso J, Riisnaes R, et al. Phase I trial of a selective c-MET inhibitor ARQ 197 incorporating proof of mechanism pharmacodynamic studies. J Clin Oncol 2011;29:1271-9.
-
(2011)
J Clin Oncol
, vol.29
, pp. 1271-1279
-
-
Yap, T.A.1
Olmos, D.2
Brunetto, A.T.3
Tunariu, N.4
Barriuso, J.5
Riisnaes, R.6
-
22
-
-
0034594628
-
New guidelines to evaluate the response to treatment in solid tumors
-
European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada
-
Therasse P, Arbuck SG, Eisenhauer EA, Wanders J, Kaplan RS, Rubinstein L, et al. New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst 2000;92:205-16.
-
(2000)
J Natl Cancer Inst
, vol.92
, pp. 205-216
-
-
Therasse, P.1
Arbuck, S.G.2
Eisenhauer, E.A.3
Wanders, J.4
Kaplan, R.S.5
Rubinstein, L.6
-
23
-
-
0032747375
-
Eligibility and response guidelines for phase II clinical trials in androgen-independent prostate cancer: Recommendations from the prostate- Specific antigen working group
-
Bubley GJ, Carducci M, Dahut W, Dawson N, Daliani D, Eisenberger M, et al. Eligibility and response guidelines for phase II clinical trials in androgen-independent prostate cancer: recommendations from the Prostate-Specific Antigen Working Group. J Clin Oncol 1999;17:3461-7. (Pubitemid 29517916)
-
(1999)
Journal of Clinical Oncology
, vol.17
, Issue.11
, pp. 3461-3467
-
-
Bubley, G.J.1
Carducci, M.2
Dahut, W.3
Dawson, N.4
Daliani, D.5
Eisenberger, M.6
Figg, W.D.7
Freidlin, B.8
Halabi, S.9
Hudes, G.10
Hussain, M.11
Kaplan, R.12
Myers, C.13
Oh, W.14
Petrylak, D.P.15
Reed, E.16
Roth, B.17
Sartor, O.18
Scher, H.19
Simons, J.20
Sinibaldi, V.21
Small, E.J.22
Smith, M.R.23
Trump, D.L.24
Vollmer, R.25
Wilding, G.26
more..
-
24
-
-
74149089423
-
Development and validation of a model that predicts early death among cancer patients participating in phase I clinical trials investigating cytotoxics
-
Penel N, Delord JP, Bonneterre ME, Bachelot T, Ray-Coquard I, Blay JY, et al. Development and validation of a model that predicts early death among cancer patients participating in phase I clinical trials investigating cytotoxics. Invest New Drugs 2010;28:76-82.
-
(2010)
Invest New Drugs
, vol.28
, pp. 76-82
-
-
Penel, N.1
Delord, J.P.2
Bonneterre, M.E.3
Bachelot, T.4
Ray-Coquard, I.5
Blay, J.Y.6
-
25
-
-
0023710206
-
Comparing the areas under two or more correlated receiver operating characteristic curves: A nonparametric approach
-
DeLong E, DeLong D, Clarke-Pearson D. Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics 1988;44:837-45.
-
(1988)
Biometrics
, vol.44
, pp. 837-845
-
-
DeLong, E.1
DeLong, D.2
Clarke-Pearson, D.3
-
26
-
-
46049119818
-
StAR: A simple tool for the statistical comparison of ROC curves
-
Vergara I, Norambuena T, Ferrada E, Slater A, Melo F. StAR: a simple tool for the statistical comparison of ROC curves. BMC Bioinformat 2008;9:265.
-
(2008)
BMC Bioinformat
, vol.9
, pp. 265
-
-
Vergara, I.1
Norambuena, T.2
Ferrada, E.3
Slater, A.4
Melo, F.5
-
27
-
-
46049110497
-
90-Days mortality rate in patients treated within the context of a phase-I trial: How should we identify patients who should not go on trial?
-
Arkenau HT, Olmos D, Ang JE, Barriuso J, Karavasilis V, Ashley S, et al. 90-Days mortality rate in patients treated within the context of a phase-I trial: how should we identify patients who should not go on trial? Eur J Cancer 2008;44:1536-40.
-
(2008)
Eur J Cancer
, vol.44
, pp. 1536-1540
-
-
Arkenau, H.T.1
Olmos, D.2
Ang, J.E.3
Barriuso, J.4
Karavasilis, V.5
Ashley, S.6
-
28
-
-
7244231121
-
Risks and benefits of phase 1 clinical trials evaluating new anticancer agents: A case for more innovation
-
DOI 10.1001/jama.292.17.2150
-
Chen EX, Tannock IF. Risks and benefits of phase 1 clinical trials evaluating new anticancer agents: a case for more innovation. JAMA 2004;292:2150-1. (Pubitemid 39435106)
-
(2004)
Journal of the American Medical Association
, vol.292
, Issue.17
, pp. 2150-2151
-
-
Chen, E.X.1
Tannock, I.F.2
-
29
-
-
0033208598
-
Survival and prognostic factors in lung cancer patients treated in phase I trials: Japanese experience
-
Yamamoto N, Tamura T, Fukuoka M, Saijo N. Survival and prognostic factors in lung cancer patients treated in phase I trials: Japanese experience. Int J Oncol 1999;15:737-41.
-
(1999)
Int J Oncol
, vol.15
, pp. 737-741
-
-
Yamamoto, N.1
Tamura, T.2
Fukuoka, M.3
Saijo, N.4
-
30
-
-
77957189024
-
A study of the pattern of hospital admissions in a specialist phase I oncology trials unit: Unplanned admissions as an early indicator of patient attrition
-
Brunetto AT, Ang JE, Olmos D, Tan D, Barriuso J, Arkenau HT, et al. A study of the pattern of hospital admissions in a specialist phase I oncology trials unit: unplanned admissions as an early indicator of patient attrition. Eur J Cancer 2010;46:2739-45.
-
(2010)
Eur J Cancer
, vol.46
, pp. 2739-2745
-
-
Brunetto, A.T.1
Ang, J.E.2
Olmos, D.3
Tan, D.4
Barriuso, J.5
Arkenau, H.T.6
-
31
-
-
75149155679
-
Circulating tumor cells in solid tumor in metastatic and localized stages
-
Maestro LM, Sastre J, Rafael SB, Veganzones SB, Vidaurreta M, Martin M, et al. Circulating tumor cells in solid tumor in metastatic and localized stages. Anticancer Res 2009;29:4839-43.
-
(2009)
Anticancer Res
, vol.29
, pp. 4839-4843
-
-
Maestro, L.M.1
Sastre, J.2
Rafael, S.B.3
Veganzones, S.B.4
Vidaurreta, M.5
Martin, M.6
-
32
-
-
77957364747
-
Translating cancer research into targeted therapeutics
-
de Bono JS, Ashworth A. Translating cancer research into targeted therapeutics. Nature 2010;467:543-9.
-
(2010)
Nature
, vol.467
, pp. 543-549
-
-
De Bono, J.S.1
Ashworth, A.2
-
33
-
-
33749555957
-
Reproducibility of a semiquantitative measurement of circulating DNA in plasma from neoplastic patients
-
author reply 4-5
-
Frattini M, Balestra D, Verderio P, Gallino G, Leo E, Sozzi G, et al. Reproducibility of a semiquantitative measurement of circulating DNA in plasma from neoplastic patients. J Clin Oncol 2005;23:3163-4; author reply 4-5.
-
(2005)
J Clin Oncol
, vol.23
, pp. 3163-3164
-
-
Frattini, M.1
Balestra, D.2
Verderio, P.3
Gallino, G.4
Leo, E.5
Sozzi, G.6
-
34
-
-
48749122914
-
Circulating microRNAs as stable blood-based markers for cancer detection
-
Mitchell PS, Parkin RK, Kroh EM, Fritz BR, Wyman SK, Pogosova-Agadjanyan EL, et al. Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci U S A 2008;105:10513-8.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 10513-10518
-
-
Mitchell, P.S.1
Parkin, R.K.2
Kroh, E.M.3
Fritz, B.R.4
Wyman, S.K.5
Pogosova-Agadjanyan, E.L.6
-
35
-
-
66149098947
-
Characterization of ERG, AR and PTEN gene status in circulating tumor cells from patients with castration-resistant prostate cancer
-
Attard G, Swennenhuis JF, Olmos D, Reid AH, Vickers E, A'Hern R, et al. Characterization of ERG, AR and PTEN gene status in circulating tumor cells from patients with castration-resistant prostate cancer. Cancer Res 2009;69:2912-8.
-
(2009)
Cancer Res
, vol.69
, pp. 2912-2918
-
-
Attard, G.1
Swennenhuis, J.F.2
Olmos, D.3
Reid, A.H.4
Vickers, E.5
A'Hern, R.6
-
36
-
-
34250783291
-
Potential applications for circulating tumor cells expressing the insulin-like growth factor-I receptor
-
DOI 10.1158/1078-0432.CCR-07-0268
-
de Bono JS, Attard G, Adjei A, Pollak MN, Fong PC, Haluska P, et al. Potential applications for circulating tumor cells expressing the insulin-like growth factor-I receptor. Clin Cancer Res 2007;13:3611-6. (Pubitemid 46955123)
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.12
, pp. 3611-3616
-
-
De Bono, J.S.1
Attard, G.2
Adjei, A.3
Pollak, M.N.4
Fong, P.C.5
Haluska, P.6
Roberts, L.7
Melvin, C.8
Repollet, M.9
Chianese, D.10
Connely, M.11
Terstappen, L.W.M.M.12
Gualberto, A.13
|