Varied association of prothrombin G20210A polymorphism with coronary artery disease susceptibility in different ethnic groups: Evidence from 15,041 cases and 21,507 controls

Molecular Biology Reports

Volumn 38, Issue 4, 2011, Pages 2371-2376

  Jin, Bo ^a   Li, Yong ^a   Ge Shang, Qu Zhen ^b   Ni, Huan Chun ^a   Shi, Hai Ming ^a   Shen, Wei ^a  

^a FUDAN UNIVERSITY   (China)

^b TIBET UNIVERSITY   (China)

Author keywords

Coronary artery diseases; G20210A; Gene polymorphism; Meta analysis; Prothrombin

Indexed keywords

PROTHROMBIN;

ALLELE; AMERICAN; ARTICLE; ASIAN; CASE CONTROL STUDY; CAUCASIAN; CORONARY ARTERY DISEASE; CORONARY RISK; DISEASE PREDISPOSITION; ETHNIC GROUP; ETHNICITY; EUROPEAN; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; HEART INFARCTION; HUMAN; PATHOGENESIS; SENSITIVITY ANALYSIS; COMPARATIVE STUDY; ETHNOLOGY; FEMALE; GENETIC PREDISPOSITION; GENETICS; MALE; META ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM;

ASIAN CONTINENTAL ANCESTRY GROUP; CORONARY ARTERY DISEASE; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTHROMBIN;

EID: 79960967095     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-010-0370-1     Document Type: Article

References (50)

1. Roberts R (2008) Genetics of premature myocardial infarction. Curr Atheroscler Rep 10:186-193
2. Ng MC, Wang Y, So WY, Cheng S, Visvikis S, Zee RY, Fernandez-Cruz A, Lindpaintner K, Chan JC (2004) Ethnic differences in the linkage disequilibrium and distribution of single-nucleotide polymorphisms in 35 candidate genes for cardiovascular diseases. Genomics 83:559-565
3. Tanaka KA, Key NS, Levy JH (2009) Blood coagulation: hemostasis and thrombin regulation. Anesth Analg 108:1433-1446
4. Poort SR, Rosendaal FR, Reitsma PH, Bertina RM (1996) A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 88:3698-3703
5. Abu-Amero KK, Wyngaard CA, Kambouris M, Dzimiri N (2002) Prevalence of the 20210 G → A prothrombin variant and its association with coronary artery disease in a Middle Eastern Arab population. Arch Pathol Lab Med 126:1087-1090
6. Almawi WY, Ameen G, Tamim H, Finan RR, Irani-Hakime N (2004) Factor V G1691A, prothrombin G20210A, and methylenetetrahydrofolate reductase [MTHFR] C677T gene polymorphism in angiographically documented coronary artery disease. J Thromb Thrombolysis 17:199-205
7. Angeline T, Bentley HA, Hawk AB, Manners RJ, Mokashi HA, Jeyaraj N, Tsongalis GJ (2005) Prevalence of the Factor V G1691A and the Factor II/prothrombin G20210A gene polymorphisms among Tamilians. Exp Mol Pathol 79:9-13
8. Araújo F, Santos A, Araújo V, Henriques I, Monteiro F, Meireles E, Moreira I, David D, Maciel MJ, Cunha-Ribeiro LM (1999) Genetic risk factors in acute coronary disease. Haemostasis 29:212-218
9. Ardissino D, Mannucci PM, Merlini PA, Duca F, Fetiveau R, Tagliabue L, Tubaro M, Galvani M, Ottani F, Ferrario M, Corral J, Margaglione M (1999) Prothrombotic genetic risk factors in young survivors of myocardial infarction. Blood 94:46-51
10. Arruda VR, Siquiera LH, Chiaparini LC, Coelho OR, Mansur AP, Ramires A, Annichino-Bizzacchi JM (1998) Prevalence of the prothrombin gene variant 20210 G → A among patients with myocardial infarction. Cardiovasc Res 37:42-45
11. Burzotta F, Paciaroni K, De Stefano V, Chiusolo P, Manzoli A, Casorelli I, Leone AM, Rossi E, Leone G, Maseri A, Andreotti F (2002) Increased prevalence of the G20210A prothrombin gene variant in acute coronary syndromes without metabolic or acquired risk factors or with limited extent of disease. Eur Heart J 23:26-30
12. Butt C, Zheng H, Randell E, Robb D, Parfrey P, Xie YG (2003) Combined carrier status of prothrombin 20210A and factor XIIIA Leu34 alleles as a strong risk factor for myocardial infarction: evidence of a gene-gene interaction. Blood 101:3037-3041
13. Celik M, Altintas A, Celik Y, Karabulut A, Ayyildiz O (2008) Thrombophilia in young patients with acute myocardial infarction. Saudi Med J 29:48-54
14. Corral J, Gonzalez-Conejero R, Lozano ML, Rivera J, Heras I, Vicente V (1997) The venous thrombosis risk factor 20210 A allele of the prothrombin gene is not a major risk factor for arterial thrombotic disease. Br J Haematol 99:304-307
15. Coulet F, Godard V, Verdy E, Soubrier F (2000) Lack of association of the prothrombin gene variant G20210A with myocardial infarction in Caucasian males. Thromb Haemost 83:796-797
16. Croft SA, Daly ME, Steeds RP, Channer KS, Samani NJ, Hampton KK (1999) The prothrombin 20210A allele and its association with myocardial infarction. Thromb Haemost 81:861-864
17. Doggen CJ, Cats VM, Bertina RM, Rosendaal FR (1998) Interaction of coagulation defects and cardiovascular risk factors: increased risk of myocardial infarction associated with factor V Leiden or prothrombin 20210A. Circulation 97:1037-1041
18. Eikelboom JW, Baker RI, Parsons R, Taylor RR, van Bockxmeer FM (1998) No association between the 20210 G/A prothrombin gene mutation and premature coronary artery disease. Thromb Haemost 80:878-880
19. Ercan B, Tamer L, Sucu N, Pekdemir H, Camsari A, Atik U (2008) Factor V Leiden and prothrombin G20210A gene polymorphisms in patients with coronary artery disease. Yonsei Med J 49:237-243
20. Feng YJ, Draghi A, Linfert DR, Wu AH, Tsongalis GJ (1999) Polymorphisms in the genes for coagulation factors II, V, and VII in patients with ischemic heart disease. Arch Pathol Lab Med 123:1230-1235
21. Ferraresi P, Marchetti G, Legnani C, Cavallari E, Castoldi E, Mascoli F, Ardissino D, Palareti G, Bernardi F (1997) The heterozygous 20210 G/A prothrombin genotype is associated with early venous thrombosis in inherited thrombophilias and is not increased in frequency in artery disease. Arterioscler Thromb Vasc Biol 17:2418-2422
22. Franco RF, Trip MD, ten Cate H, van den Ende A, Prins MH, Kastelein JJ, Reitsma PH (1999) The 20210 G → A mutation in the 3'-untranslated region of the prothrombin gene and the risk for arterial thrombotic disease. Br J Haematol 104:50-54
23. Gardemann A, Arsic T, Katz N, Tillmanns H, Hehrlein FW, Haberbosch W (1999) The factor II G20210A and factor V G1691A gene transitions and coronary heart disease. Thromb Haemost 81:208-213
24. Gundogdu F, Gurlertop Y, Pirim I, Arslan S, Ikbal M, Islamoglu Y, Aksoy H, Senocak H (2007) G20210A Prothrombin gene variant in Turkish patients with angiographically documented coronary artery disease. J Thromb Thrombolysis 24:255-259
25. Gupta N, Khan F, Tripathi M, Singh VP, Tewari S, Ramesh V, Sinha N, Agrawal S (2003) Absence of factor V Leiden (G1691A) mutation, FII G20210A allele in coronary artery disease in North India. Indian J Med Sci 57:535-542
26. Hindorff LA, Psaty BM, Carlson CS, Heckbert SR, Lumley T, Smith NL, Lemaitre RN, Rieder MJ, Nickerson DA, Reiner AP (2006) Common genetic variation in the prothrombin gene, hormone therapy, and incident nonfatal myocardial infarction in postmenopausal women. Am J Epidemiol 163:600-607
27. Inbal A, Freimark D, Modan B, Chetrit A, Matetzky S, Rosenberg N, Dardik R, Baron Z, Seligsohn U (1999) Synergistic effects of prothrombotic polymorphisms and atherogenic factors on the risk of myocardial infarction in young males. Blood 93:2186-2190
28. Atherosclerosis, Thrombosis, and Vascular Biology Italian Study Group (2003) No evidence of association between prothrombotic gene polymorphisms and the development of acute myocardial infarction at a young age. Circulation 107:1117-1122
29. Marcucci R, Brogi D, Sofi F, Giglioli C, Valente S, Liotta AA, Lenti M, Gori AM, Prisco D, Abbate R, Gensini GF (2006) PAI-1 and homocysteine, but not lipoprotein (a) and thrombophilic polymorphisms, are independently associated with the occurrence of major adverse cardiac events after successful coronary stenting. Heart 92:377-381
30. Martinelli N, Trabetti E, Pinotti M, Olivieri O, Sandri M, Friso S, Pizzolo F, Bozzini C, Caruso PP, Cavallari U, Cheng S, Pignatti PF, Bernardi F, Corrocher R, Girelli D (2008) Combined effect of hemostatic gene polymorphisms and the risk of myocardial infarction in patients with advanced coronary atherosclerosis. PLoS ONE 3:e1523
31. Motovska Z, Kvasnicka J, Widimsky P, Petr R, Hajkova J, Bobcikova P, Osmancik P, Odvodyova D, Katina S (2010) Platelet glycoprotein GP VI 13254C allele is an independent risk factor of premature myocardial infarction. Thromb Res 125:e61-e64
32. Prohaska W, Schmidt M, Mannebach H, Gleichmann U, Kleesiek K (1999) The prevalence of the prothrombin 20210 G → A mutation is not increased in angiographically confirmed coronary artery disease. Thromb Haemost 81:161-162
33. Rahimi Z, Nomani H, Mozafari H, Vaisi-Raygani A, Madani H, Malek-Khosravi S, Parsian A (2009) Factor V G1691A, prothrombin G20210A and methylenetetrahydrofolate reductase polymorphism C677T are not associated with coronary artery disease and type 2 diabetes mellitus in western Iran. Blood Coagul Fibrinolysis 20:252-256
34. Ranjith N, Pegoraro RJ, Rom L (2003) Haemostatic gene polymorphisms in young Indian Asian subjects with acute myocardial infarction. Med Sci Monit 9:CR417-CR421
35. Redondo M, Watzke HH, Stucki B, Sulzer I, Biasiutti FD, Binder BR, Furlan M, Lämmle B, Wuillemin WA (1999) Coagulation factors II, V, VII, and X, prothrombin gene 20210G → A transition, and factor V Leiden in coronary artery disease: high factor V clotting activity is an independent risk factor for myocardial infarction. Arterioscler Thromb Vasc Biol 19:1020-1025
36. Ridker PM, Hennekens CH, Miletich JP (1999) G20210A mutation in prothrombin gene and risk of myocardial infarction, stroke, and venous thrombosis in a large cohort of US men. Circulation 99:999-1004
37. Roldán V, González-Conejero R, Marín F, Pineda J, Vicente V, Corral J (2005) Five prothrombotic polymorphisms and the prevalence of premature myocardial infarction. Haematologica 90:421-423
38. Rosendaal FR, Siscovick DS, Schwartz SM, Psaty BM, Raghunathan TE, Vos HL (1997) A common prothrombin variant (20210 G to A) increases the risk of myocardial infarction in young women. Blood 90:1747-1750
39. Russo C, Girelli D, Olivieri O, Guarini P, Manzato F, Pizzolo F, Zaia B, Mazzucco A, Corrocher R (2001) G20210A prothrombin gene polymorphism and prothrombin activity in subjects with or without angiographically documented coronary artery disease. Circulation 103:2436-2440
40. Taymaz H, Erarslan S, Oner ET, Alkan T, Aǧirbaşli M, Kirdar B (2007) Sequence variations within the genes related to hemostatic imbalance and their impact on coronary artery disease in Turkish population. Thromb Res 119:55-62
41. Tütün U, Aksöyek A, Ulus AT, Misirlioǧlu M, Ciçekçioǧlu F, Ozişik K, Ihsan Parlar A, Baran Budak A, Gedik S, Katircioǧlu SF (2006) Gene polymorphisms in patients below 35 years of age who underwent coronary artery bypass surgery. Coron Artery Dis 17:35-39
42. Var A, Utük O, Akçali S, Sanlidaǧ T, Uyanik BS, Dinç G (2009) Impact of hemostatic gene single point mutations in patients with non-diabetic coronary artery disease. Mol Biol Rep 36:2235-2243
43. Vargas M, Soto I, Pinto CR, Urgelles MF, Batalla A, Rodriguez-Reguero J, Cortina A, Alvarez V, Coto E (1999) The prothrombin 20210A allele and the factor V Leiden are associated with venous thrombosis but not with early coronary artery disease. Blood Coagul Fibrinolysis 10:39-41
44. Watzke HH, Schüttrumpf J, Graf S, Huber K, Panzer S (1997) Increased prevalence of a polymorphism in the gene coding for human prothrombin in patients with coronary heart disease. Thromb Res 87:521-526
45. Weischer M, Juul K, Zacho J, Jensen GB, Steffensen R, Schroeder TV, Tybjaerg-Hansen A, Nordestgaard BG (2010) Prothrombin and risk of venous thromboembolism, ischemic heart disease and ischemic cerebrovascular disease in the general population. Atherosclerosis 208:480-483
46. Xu G, Jin GD, Fu GS, Ma JI, Shan J, Wang JA (2003) Polymorphisms in the genes for coagulation factor II, V, VII in patients undergoing coronary angiography. JZUS 4:369-373
47. Higgins JP, Thompson SG (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21:1539-1558
48. Hirschhorn JN, Lohmueller K, Byrne E (2002) A comprehensive review of genetic association studies. Genet Med 4:45-61
49. Wacholder S, Chanock S, Garcia-Closas M (2004) Assessing the probability that a positive report is false: an approach for molecular epidemiology studies. J Natl Cancer Inst 96:434-442
50. Villar J, Piaggio G (2005) Large trials or meta-analysis? That is not the question. Best Pract Res Clin Obstet Gynaecol 19:27-35