Sedation in neurocritical patients: Is it useful?

Minerva Anestesiologica

Volumn 77, Issue 8, 2011, Pages 828-834

  Beretta, L ^a   de Vitis, A ^a   Grandi, E ^a  

^a SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

Deep sedation; Hypnotics and sedatives; Physiology; Standards

Indexed keywords

DIAZEPAM; FENTANYL; MIDAZOLAM; MORPHINE; OPIATE; PROPOFOL; REMIFENTANIL; SEDATIVE AGENT;

ADVERSE OUTCOME; ALGORITHM; ANESTHESIA; BRAIN BLOOD FLOW; BRAIN DAMAGE; BRAIN OXYGEN CONSUMPTION; CRITICALLY ILL PATIENT; DEEP SEDATION; DOSE RESPONSE; DRUG BINDING; DRUG CHOICE; DRUG CLEARANCE; DRUG EFFECT; DRUG HALF LIFE; DRUG MEGADOSE; DRUG METABOLISM; DRUG SAFETY; DRUG USE; HUMAN; HYPOTENSION; INTENSIVE CARE UNIT; INTRACRANIAL HYPERTENSION; INTRACRANIAL PRESSURE; LOW DRUG DOSE; NEUROLOGIC DISEASE; PAIN; PERFUSION PRESSURE; PROPOFOL INFUSION SYNDROME; REVIEW; SEDATION; SIDE EFFECT; SYSTOLIC BLOOD PRESSURE; TRAUMATIC BRAIN INJURY; TREATMENT INDICATION;

ALGORITHMS; BRAIN; CRITICAL CARE; DEEP SEDATION; HUMANS; HYPNOTICS AND SEDATIVES; NERVOUS SYSTEM DISEASES;

EID: 79960962799     PISSN: 03759393     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (38)

1. Kollef MH, Levy NT, Ahrens TS, Schaiff R, Prentice D, Sherman G. The use of continuous i.v. sedation is associated with prolongation of mechanical ventilation. Chest 1998;114:541-8.
2. Girard TD, Kress JP, Fuchs BD, Thompson JW, Schweickert WD, Pun BT et al. Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial. Lancet 2008;371:126-34.
3. Kress JP, Pohlman AS, O'Connor MF, Hall JB. Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation. N Engl J Med 2009;342:1471-7.
4. Strøm T, Martinussen T, Toft P. A protocol of no sedation for critically ill patients receiving mechanical ventilation: a randomised trial. Lancet 2010;375:475-80.
5. Beretta L, Citerio G, Stocchetti N, Procaccio F, D'Avella D, Brambilla GL et al. Recommendations for the treatment of serious adult head injury. II. Medical treatment criteria. Minerva Anestesiol 1999;65:159-68.
6. Citerio G, Stocchetti N, Cormio M, Beretta L. Neuro- Link, a computer-assisted database for head injury in intensive care. Acta Neurochir (Wien) 2000;142:769-76.
7. Brain Trauma Foundation, American Association of Neurological Surgeons. Guidelines for the management of severe traumatic brain injury. J Neurotrauma 2007;24:S1-106.
8. Kelly DF, Goodale DB, Williams J, Herr DL, Chappel ET, Rosner MJ et al. Propofol in the treatment of moderate and severe head injury: a randomized, prospective, doubleblinded pilot trial. J Neurosurg 1999;90:1042-52.
9. Van Hemelrijck J, Fitch W, Mattheussen M, Van Aken H, Plets C, Lauwers T. Effect of propofol on cerebral circulation and autoregulation in the baboon. Anesth Analg 1990;71:49-54.
10. Stephan H, Sonntag H, Schenk HD, Kohlhausen S. Effect of diprivan (propofol) on the circulation and oxygen consumption of the brain and CO2 reactivity of brain vessels in the human. Anaesthesist 1987;36:60-5.
11. Bladin CF, Alexandrov AV, Bellavance A, Bornstein N, Chambers B, Coté R et al. Seizure after stroke: a prospective multicenter study. Arch Neurol 2000;57:1617-22.
12. Vespa PM, Nuwer MR, Nenov V, Ronne-Engstrom E, Hovda DA, Bergsneider M. Increased incidence and impact of nonconvulsive and convulsive seizures after traumatic brain injury as detected by continuous electroencephalographic monitoring. J Neurosurg 1999;91:750-60.
13. Beretta L, Aldrovandi V, Grandi E, Citerio G, Stocchetti N. Improving the quality of data entry in a low-budget head injury database. Acta Neurochir (Wien) 2007;149:903-9.
14. Engel J, Kuhl DE, Phelps ME. Patterns of human local cerebral glucose metabolism during epileptic seizures. Science 1982;218:64-6.
15. Delgado-Escueta AV, Wasterlain C, Treiman DM, Porter RJ. Current concepts in neurology: management of status epilepticus. N Engl J Med 1982;306:1337-40.
16. Stecker MM, Kramer TH, Raps EC, O'Meeghan R, Dulaney E, Skaar DJ. Treatment of refractory status epilepticus with propofol: clinical and pharmacokinetic findings. Epilepsia 2005;39:18-26.
17. Stocchetti N, Pagan F, Calappi E, Canavesi K, Beretta L, Citerio G et al. Inaccurate early assessment of neurological severity in head injury. J Neurotrauma 2004;9:1131-40.
18. Morrison G, Gibbons E, Whitehouse WP. High-dose midazolam therapy for refractory status epilepticus in children Intensive Care Med 2006;32:1935-6.
19. Altan A, Turgut N, Yildiz F, Türkmen A, Ustün H. Effects of magnesium sulphate and clonidine on propofol consumption, haemodynamics and postoperative recovery. Br J Anaesth 2005;94:438-41.
20. Pavlin DJ, Coda B, Shen DD, Tschanz J, Nguyen Q, Schaffer R et al. Effects of combining propofol and alfentanil on ventilation, analgesia, sedation, and emesis in human volunteers. Anesthesiology 1996;84:23-37.
21. Vuyk J, Engbers FHM, Burm AGL, Vletter AA, Griever GE, Olofsen E et al. Pharmacodynamic interaction between propofol and alfentanil when given for induction of anesthesia. Anesthesiology 1996;84:288-99.
22. Egerod I, Jensen MB, Herling SF, Welling KL. Effect of an analgo-sedation protocol for neurointensive patients: a two phase interventional non-randomized pilot study. Crit Care 2010;14:R71.
23. Jacobi J, Fraser GL, Coursin DB, Riker RR, Fontaine D, Wittbrodt ET et al. Clinical practice guidelines for the sustained use of sedatives and analgesics in the critically ill adult. Crit Care Med 2002;30:119-41.
24. Ouchi T, Ochiai R, Takeda J, Tsukada H, Kakiuchi T. Combined effects of propofol and mild hypothermia on cerebral metabolism and blood flow in rhesus monkey: a positron emission tomography study. J Anesth 2006;20:208-14.
25. Cremer OL, Moons KGM, Bouman EAC, Kruijswijk JE, de Smet AM, Kalkman CJ. Long-term propofol infusion and cardiac failure in adult head-injured patients. Lancet 2001;357:117-8.
26. Vasile B, Rasulo F, Candiani A, Latronico N. The pathophysiology of propofol infusion syndrome: a simple name for a complex syndrome. Intensive Care Med 2003;29:1417-25.
27. Fudickar A, Bein B. Propofol infusion syndrome: update of clinical manifestation and pathophysiology. Minerva Anestesiol 2009;75:339-44.
28. Kelbel I, Weiss M. Anaesthetics and immune function. Curr Opin Anaesthesiol 2001;14:685-91.
29. Heller A, Heller S, Blecken S, Urbaschenk R, Koch T. Effects of intravenous anaesthetics on bacterial elimination in human blood in vitro. Acta Anaesthesiol Scand 1998;42:518-26.
30. Krumhholz W, Endrass J, Hempelmann G. Propofol inhibits phagocytosis and killing of Staphylococcus aureus and Escherichia coli by polymorphonuclear leukocytes in vitro. Can J Anaesth 1994;41:446-9.
31. Chen RM, Wu CH, Chang HC, Wu GJ, Lin YL, Sheu JR et al. Propofol suppresses macrophage functions and modulates mitochondrial membrane potential and cellular adenosine triphosphate synthesis. Anesthesiology 2003;98:1178-85.
32. Sanders RD, Hussell T, Maze M. Sedation and immunomodulation. Crit Care Clin 2009;25:551-70.
33. Nugent M, Artru AA, Michenfelder JD. Cerebral effects of midazolam and diazepam. Anesthesiology 1980;53:5-8.
34. Sanchez-Izquierdo Riera JA, Caballero-Cubedo RE, Perez-Vela JL, Ambros-Checa A, Cantalapiedra-Santiago JA, Alfred Lopez E. Propofol versus midazolam: safety and efficacy for sedating the severe trauma patient. Anesth Analg 1998;86:1219-24.
35. Noriyasu F, Mayuki A, Toyohisa T, Keisuke S, Shushi M. Biphasic concentration change during continuous midazolam administration in brain-injury patients undergoing therapeutic moderate hypotermia. Resuscitation 2004;60:225-30.
36. Short TG, Chui PT. Propofol and midazolam act synergistically in combination. Br J Anaesth 1991;67:539-45.
37. Karabinis A, Mandragos K, Stergiopoulos S, Komnos A, Soukup J, Speelberg B et al. Safety and efficacy of analgesia- based sedation using remifentanil versus standard hypnotic- based regimens in intensive care unit patients with brain injuries: a randomised, controlled trial. Crit Care 2004;8:R268-R80.
38. Engelhard K, Reeker W, Kochs E, Werner C. Effect of remifentanil on intracranial pressure and cerebral blood flow velocity in patients with head trauma. Acta Anaesthesiol Scand 2004;48:396-9.