Bioavailability of dexmedetomidine after intranasal administration

European Journal of Clinical Pharmacology

Volumn 67, Issue 8, 2011, Pages 825-831

  Iirola, Timo ^a   Vilo, Sanna ^a   Manner, Tuula ^a   Aantaa, Riku ^a   Lahtinen, Maria ^b   Scheinin, Mika ^b   Olkkola, Klaus T ^a  

^a TURKU UNIVERSITY HOSPITAL   (Finland)

^b UNIVERSITY OF TURKU   (Finland)

Author keywords

Administration; Dexmedetomidine; Intranasal

Indexed keywords

ADRENALIN; DEXDOMITOR; DEXMEDETOMIDINE; NORADRENALIN; UNCLASSIFIED DRUG;

ADRENALIN BLOOD LEVEL; AREA UNDER THE CURVE; ARTICLE; BIOEQUIVALENCE; BLOOD PRESSURE MEASUREMENT; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG EFFECT; HEART RATE VARIABILITY; HUMAN; HUMAN EXPERIMENT; MALE; MAXIMUM PLASMA CONCENTRATION; NORADRENALIN BLOOD LEVEL; NORMAL HUMAN; PHARMACODYNAMICS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SEDATION; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADMINISTRATION, INTRANASAL; ADRENERGIC ALPHA-2 RECEPTOR AGONISTS; ADULT; BIOLOGICAL AVAILABILITY; BLOOD PRESSURE; CONSCIOUS SEDATION; CONSCIOUSNESS; CROSS-OVER STUDIES; DEXMEDETOMIDINE; EPINEPHRINE; HALF-LIFE; HEART RATE; HUMANS; HYPNOTICS AND SEDATIVES; INJECTIONS, INTRAVENOUS; MALE; METABOLIC CLEARANCE RATE; NASAL MUCOSA; NOREPINEPHRINE; SLEEP STAGES;

EID: 79960959377     PISSN: 00316970     EISSN: 14321041     Source Type: Journal    
DOI: 10.1007/s00228-011-1002-y     Document Type: Article

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