A comparison of intranasal dexmedetomidine and oral midazolam for premedication in pediatric anesthesia: A double-blinded randomized controlled trial

Anesthesia and Analgesia

Volumn 106, Issue 6, 2008, Pages 1715-1721

  Yuen, Vivian M ^a   Hui, Theresa W ^a   Irwin, Michael G ^a   Yuen, Man K ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

DEXMEDETOMIDINE; MIDAZOLAM; PARACETAMOL; PLACEBO; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; HYPNOTIC SEDATIVE AGENT;

ANESTHESIA INDUCTION; ARTICLE; BEHAVIOR; BLOOD PRESSURE; CHILD; CLINICAL EVALUATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CONVALESCENCE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; ELECTIVE SURGERY; FEMALE; HEART RATE; HUMAN; MAJOR CLINICAL STUDY; MALE; MINOR SURGERY; OXYGEN SATURATION; PARENT; PEDIATRIC ANESTHESIA; PREMEDICATION; PRESCHOOL CHILD; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SCHOOL CHILD; SCORING SYSTEM; SEDATION; SEPARATION ANXIETY; SYRUP; WAKEFULNESS; BREATHING; CHILD BEHAVIOR; COMPARATIVE STUDY; CONSCIOUSNESS; DRUG EFFECT; HEMODYNAMICS; INTRANASAL DRUG ADMINISTRATION; METHODOLOGY; ORAL DRUG ADMINISTRATION; PATIENT COMPLIANCE; TIME; TREATMENT OUTCOME;

ADMINISTRATION, INTRANASAL; ADMINISTRATION, ORAL; ADRENERGIC ALPHA-AGONISTS; ANXIETY, SEPARATION; CHILD; CHILD BEHAVIOR; CHILD, PRESCHOOL; CONSCIOUSNESS; DEXMEDETOMIDINE; DOUBLE-BLIND METHOD; FEMALE; HEMODYNAMICS; HUMANS; HYPNOTICS AND SEDATIVES; MALE; MIDAZOLAM; PATIENT COMPLIANCE; PREANESTHETIC MEDICATION; PROSPECTIVE STUDIES; RESEARCH DESIGN; RESPIRATION; TIME FACTORS; TREATMENT OUTCOME;

EID: 44649137953     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/ane.0b013e31816c8929     Document Type: Article

References (37)

1. Kain ZN, Caldwell-Andrews AA, Krivutza DM, Weinberg ME, Wang S-M, Gaal D. Trends in the practice of parental presence during induction of anesthesia and the use of preoperative sedative premedication in the United States, 1995-2002: results of a follow-up national survey. Anesth Analg 2004;98:1252-9
2. Kain ZN, Mayes L, Bell C, Weisman S, Hofstadter M, Rimar S. Premedication in the United States: a status report. Anesth Analg 1997;84:427-32
3. Kain ZN, Mayes LC, Wang SM, Caramico LA, Hofstadter MB. Parental presence during induction of anesthesia versus sedative premedication: which intervention is more effective? Anesthesiology 1998;89:1147-56
4. Kain ZN, Hofstadter MB, Mayes LC, Krivutza DM, Alexander G, Wang SM, Reznick JS. Midazolam: effects on amnesia and anxiety in children. Anesthesiology 2000;93:676-84
5. Cote CJ, Cohen IT, Suresh S, Rabb M, Rose JB, Weldon C, Davis PJ, Bikhazi GB, Karl HW, Hummer KA, Hannallah RS, Khoo KC, Collins P. A comparison of three doses of commercially prepared oral midazolam syrup in children. Anesth Analg 2002;94:37-43
6. Kogan A, Katz J, Efrat R, Eidelman LA. Premedication with midazolam in young children: a comparison of four routes of administration. Paediatr Anaesth 2002;12:685-9
7. Splinter WM, MacNeill HB, Menard EA, Rhine EJ, Roberts DJ, Gould MH. Midazolam reduces vomiting after tonsillectomy in children. Can J Anaesth 1995;42:201-3
8. Buffett-Jerrott SE, Stewart SH, Finley GA, Loughlan HL. Effects of benzodiazepines on explicit memory in a paediatric surgery setting. Psychopharmacology (Berl) 2003;168:377-86
9. Marshall J, Rodarte A, Blumer J, Khoo KC, Akbari B, Kearns G. Pediatric pharmacodynamics of midazolam oral syrup. Pediatric Pharmacology Research Unit Network. J Clin Pharmacol 2000;40:578-89
10. Cox RG, Nemish U, Ewen A, Crowe M-J. Evidence-based clinical update: does premedication with oral midazolam lead to improved behavioural outcomes in children? Can J Anaesth 2006;53:1213-19
11. Khalil S, Vije H, Kee S. A paediatric trial comparing midazolam/syrpalta mixture with premixed midazolam syrup (Roche). Paediatr Anaesth 2003;13:205-9
12. Lonnqvist PA, Habre W. Midazolam as premedication: is the emperor naked or just half-dressed? Paediatr Anaesth 2005;15: 263-5
13. Kanegaye JT, Favela JL, Acosta M, Bank DE. High-dose rectal midazolam for pediatric procedures: a randomized trial of sedative efficacy and agitation. Pediatr Emerg Care 2003;19:329-36
14. McGraw T, Kendrick A. Oral midazolam premedication and postoperative behaviour in children. Paediatr Anaesth 1998; 8:117-21
15. Watson AT, Visram A. Children's preoperative anxiety and postoperative behaviour. Paediatr Anaesth 2003;13:188-204
16. Bergendahl H, Lonnqvist P-A, Eksborg S. Clonidine in paediatric anaesthesia: a review of the literature and comparison with benzodiazepines for premedication. Acta Anaesthesiol Scand 2006;50:135-43
17. Schmidt AP, Valinetti EA, Banderira D, Bertacchi MF, Simoes CM, JOSE OTAVIO C Auler, JR. Effects of preanesthetic administration of midazolam, clonidine, or dexmedetomidine on postoperative pain and anxiety in children. Paediatr Anaesth 2007;17:667-74
18. Mikawa K, Maekawa N, Nishina K, Takao Y, Yaku H, Obara H. Efficacy of oral clonidine premedication in children. Anesthesiology 1993;79:926-31
19. Ramesh VJ, Bhardwaj N, Batra YK. Comparative study of oral clonidine and diazepam as premedicants in children. Int J Clin Pharmacol Ther 1997;35:218-21
20. Tazeroualti N, De Groote F, De Hert S, De Ville A, Dierick A, Van der Linden P. Oral clonidine vs midazolam in the prevention of sevoflurane-induced agitation in children. A prospective, randomized, controlled trial. Br J Anaesth 2007;98:667-71
21. Anttila M, Penttila J, Helminen A, Vuorilehto L, Scheinin H. Bioavailability of dexmedetomidine after extravascular doses in healthy subjects. Br J Clin Pharmacol 2003;56:691-3
22. Yuen VM, Hui TW, Yuen MK, Irwin MG. A double blind crossover assessment of the sedative and analgesic effects of intranasal dexmedetomidine. Anesth Analg 2007;105:374-80
23. Weber F, Wulf H, el Saeidi G. Premedication with nasal s-ketamine and midazolam provides good conditions for induction of anesthesia in preschool children. Can J Anaesth 2003;50:470-5
24. Galinkin JL, Fazi LM, Cuy RM, Chiavacci RM, Kurth CD, Shah UK, Jacobs IN, Watcha MF. Use of intranasal fentanyl in children undergoing myringotomy and tube placement during halothane and sevoflurane anesthesia. Anesthesiology 2000;93: 1378-83
25. Almenrader N, Passariello M, Coccetti B, Haiberger R, Pietropaoli P. Steal-induction after clonidine premedication: a comparison of the oral and nasal route. Paediatr Anaesth 2007;17:230-4
26. Khan ZP, Ferguson CN, Jones RM. alpha-2 and imidazoline receptor agonists. Their pharmacology and therapeutic role. Anaesthesia 1999;54:146-65
27. Ghai B, Grandhe RP, Kumar A, Chari P. Comparative evaluation of midazolam and ketamine with midazolam alone as oral premedication. Paediatr Anaesth 2005;15:554-9
28. Darlong V, Shende D, Subramanyam MS, Sunder R, Naik A. Oral ketamine or midazolam or low dose combination for premedication in children. Anaesth Intensive Care 2004;32:246-9
29. Horiuchi T, Kawaguchi M, Kurehara K, Kawaraguchi Y, Sasaoka N, Furuya H. Evaluation of relatively low dose of oral transmucosal ketamine premedication in children: a comparison with oral midazolam. Paediatr Anaesth 2005;15:643-7
30. McMillan CO, Spahr-Schopfer IA, Sikich N, Hartley E, Lerman J. Premedication of children with oral midazolam. Can J Anaesth 1992;39:545-50
31. Feld LH, Negus JB, White PF. Oral midazolam preanesthetic medication in pediatric outpatients. Anesthesiology 1990;73:831-4
32. Samarkandi A, Naguib M, Riad W, Thalaj A, Alotibi W, Aldammas F, Albassam A. Melatonin vs. midazolam premedication in children: a double-blind, placebo-controlled study. Eur J Anaesthesiol 2005;22:189-96
33. Kain ZN, Mayes LC, Cicchetti DV, Bagnall AL, Finley JD, Hofstadter MB. The Yale Preoperative Anxiety Scale: how does it compare with a "gold standard"? Anesth Analg 1997;85:783-8
34. Bloor B, Ward D, Belleville J, Maze M. Effects of intravenous dexmedetomidine in humans. II. Hemodynamic changes. Anesthesiology 1992;77:1134-42
35. Petroz GC, Sikich N, James M, van Dyk H, Shafer SL, Schily M, Lerman J. A phase I, two-center study of the pharmacokinetics and pharmacodynamics of dexmedetomidine in children. Anesthesiology 2006;105:1098-110
36. Munro HM, Tirotta CF, Felix DE, Lagueruela RG, Madril DR, Zahn EM, Nykanen DG. Initial experience with dexmedetomidine for diagnostic and interventional cardiac catheterization in children. Paediatr Anaesth 2007;17:109-12
37. Finley GA, Stewart SH, Buffett-Jerrott S, Wright KD, Millington D. High levels of impulsivity may contraindicate midazolam premedication in children. Can J Anaesth 2006;53:73-8