Effects of corticotropin-releasing hormone and its antagonist on the gene expression of gonadotrophin-releasing hormone (GnRH) and GnRH receptor in the hypothalamus and anterior pituitary gland of follicular phase ewes

Reproduction, Fertility and Development

Volumn 23, Issue 6, 2011, Pages 780-787

  Ciechanowska, Magdalena ^a,b   Łapot, Magdalena ^a   Malewski, Tadeusz ^c   Mateusiak, Krystyna ^a   Misztal, Tomasz ^a   Przekop, Franciszek ^a  

^a KIELANOWSKI INSTITUTE OF ANIMAL PHYSIOLOGY AND NUTRITION   (Poland)

^b MILITARY INSTITUTE OF HYGIENE AND EPIDEMIOLOGY   (Poland)

^c MUSEUM AND INSTITUTE OF ZOOLOGY   (Poland)

Author keywords

LH

Indexed keywords

CORTICOTROPIN RELEASING FACTOR; CORTICOTROPIN RELEASING FACTOR RECEPTOR; CORTICOTROPIN RELEASING FACTOR[9-41]; GONADORELIN; GONADORELIN RECEPTOR; LUTEINIZING HORMONE; MESSENGER RNA;

ADENOHYPOPHYSIS; ANIMAL EXPERIMENT; ARTICLE; BRAIN THIRD VENTRICLE; CONTROLLED STUDY; FEMALE; FOLLICULAR PHASE; GENE EXPRESSION; HYPOTHALAMUS; LUTEINIZING HORMONE BLOOD LEVEL; LUTEINIZING HORMONE RELEASE; MEDIAN EMINENCE; NONHUMAN; PREOPTIC AREA; SHEEP;

ANALYSIS OF VARIANCE; ANIMALS; CORTICOTROPIN-RELEASING HORMONE; DNA PRIMERS; FEMALE; FOLLICULAR PHASE; GENE EXPRESSION REGULATION; GONADOTROPIN-RELEASING HORMONE; HYPOTHALAMUS; LUTEINIZING HORMONE; PEPTIDE FRAGMENTS; PITUITARY GLAND, ANTERIOR; RADIOIMMUNOASSAY; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, LHRH; SHEEP;

EID: 79960958066     PISSN: 10313613     EISSN: 14485990     Source Type: Journal    
DOI: 10.1071/RD10341     Document Type: Article

References (63)

1. Adams, B. M., Sukarai, H., and Adams, T. E. (1996).Concentration of gonadotropin-releasing hormone (GnRH) receptor messenger ribonucleic acid in pituitary tissue of orchidectomized sheep: effect of estradiol and GnRH. Biol. Reprod. 54, 407-412. doi:10.1095/BIOLRE PROD54.2.407 (Pubitemid 26031410)
2. Breen, K. M., Davis, T. L., Doro, L. T., Nett, T. M., Oakley, A. E., Podmanabhan, V., Ripoli, L. A., Wagenmaker, E. R., and Karsch, F. J. (2008).Insight into the neuroendocrine site and cellular mechanism by which cortisol suppress pituitary responsiveness to gonadotropin-releasing hormone. Endocrinology 149, 767-773. doi:10.1210/EN.2007-0773 (Pubitemid 351159351)
3. Brooks, J., andMc Neilly, A. S. (1994).Regulation of gonadotropin- releasing hormone receptor mRNA expression in the sheep. J. Endocrinol. 143, 175-182. doi:10.1677/JOE.0.1430175 (Pubitemid 24306528)
4. Caraty, A., Miller, D. W., Delaleu, B., and Martin, B. (1997).Stimulation of LH secretion in sheep by central administration of corticotropin-releasing hormone. J. Reprod. Fertil. 111, 249-257. doi:10.1530/JRF.0.1110249
5. Cheng,K.W.,Ngan,E. S.W.,Kang, S.K.,Chow,B.K. C., and Leung, P.C. K. (2000).Transcriptional down-regulation of human gonadotropin-releasing hormone (GnRH) receptor gene by GnRH role of protein kinase C and activating protein 1. Endocrinology 141, 3611-3622. doi:10.1210/EN.141. 10.3611
6. Ciechanowska, M., Lapot, M., Malewski, T., Misztal, T., Mateusiak, K., and Przekop, F. (2007).Effect of stress on the expression of GnRH and GnRH receptor (GnRH-R) genes in the preoptic area-hypothalamus and GnRH-R gene in the stalk/median eminence and anterior pituitary gland in ewes during follicular phase of the estrous cycle. Acta Neurobiol. Exp. (Wars) 67, 1-12. (Pubitemid 46631831)
7. Ciechanowska, M., Łapot, M., Malewski, T., Mateusiak, K., Misztal, T., and Przekop, F. (2008a).The central effect of b-endorphin and naloxone on the expression of GnRH gene and GnRH receptor (GnRH-R) gene in the hypothalamus, and on GnRH-R gene in the anterior pituitary gland in follicular phase ewes. Exp. Clin. Endocrinol. Diabetes 116, 40-46. doi:10.1055/S-2007-990299 (Pubitemid 351270907)
8. Ciechanowska, M., Łapot, M., Malewski, T., Misztal, T., Mateusiak, K., and Przekop, F. (2008b).Implication of dopaminergic systems on GnRH and GnRHR genes expression in the hypothalamus and GnRH-R gene expression in the anterior pituitary gland of anestrous ewes. Exp. Clin. Endocrinol. Diabetes 116, 357-362. doi:10.1055/S-2008-1042406 (Pubitemid 351947867)
9. Ciechanowska, M., Łapot, M., Malewski, T., Misztal, T., Mateusiak, K., and Przekop, F. (2009).Effects of GABAA receptor modulation on the expression of GnRH gene and GnRH receptor (GnRH-R) gene in the hypothalamus and GnRH-R gene in the anterior pituitary gland of follicular-phase ewes. Anim. Reprod. Sci. 111, 235-248. doi:10.1016/J.ANIREPROSCI.2008.03.006
10. Clarke, I. J., Horton, R. J. E., and Doughton, B. (1990).Investigation of the mechanismby which insulin induced hypoglycaemia decreases luteinizing hormone secretion on ovariectomized ewes. Endocrinology 127, 1470-1476. doi:10.1210/ENDO-127-3-1470 (Pubitemid 20277635)
11. De Paolo, L. V., King, R. A., and Carrollo, A. J. (1987).In vivo and in vitro examination of an autoregulatory mechanism for luteinizing hormonereleasing hormone. Endocrinology 120, 273-279.
12. Dobson, H., Ghuman, S., Prabhakar, S., and Smith, R. (2003).A conceptual model of the influence of stress on female reproduction. Reproduction 125, 151-163. doi:10.1530/REP.0.1250151 (Pubitemid 36284887)
13. Donald, R. A., Redekopp, C., Cameron, V., Nicholls, M. G., Bolton, J., Liversey, J., Espiner, E. A., Rivier, J., and Vale, W. (1983).Thehormonal actions of corticotropin-releasing factor in sheep: effects of intravenous and intracerebroventricular injection. Endocrinology 113, 866-870. doi:10.1210/ENDO-113-3-866 (Pubitemid 13051924)
14. Dunn, A. J., and Berridge, C. W. (1990).Physiological and behavioral responses to corticotropin-releasing factor administration: is CRF a mediator of anxiety of stress responses? Brain Rev. 15, 71-100. doi:10.1016/0165-0173(90) 90012-D
15. Emoto, H., Yokoo, H., Yoshida, M., and Tanaka, M. (1993). Corticotropinreleasing factor enhances noradrenaline release in the rat hypothalamus assessed by intracerebral microdialysis. Brain Res. 601, 286-288. doi:10.1016/0006-8993(93)91722-5 (Pubitemid 23047693)
16. Fueshko, S. M., Key, S., and Wray, S. (1998).Luteinizing hormonereleasing hormone (LHRH) neurons maintained in nasal explants decrease LHRH messenger ribonucleic acid levels after activation of GABAA receptors. Endocrinology 139, 2734-2740. doi:10.1210/EN.139.6.2734 (Pubitemid 28512381)
17. Gajewska, A., Kochman, K., Leranth, Y., Kochman, H., and Cunis, R. (2000).Modulation of luteinizing hormone subunit gene expression by intracerebroventricular microinjection of gonadotropin-releasing hormone or b-endorphin in female rats. Biochim. Biophys. Acta 1523, 217-224.
18. Gambacciani, M., Yen, S. S. C., and Rasmussen, D. D. (1986).GnRH release from the mediobasal hypothalamus: in vitro inhibition by corticotropinreleasing factor. Neuroendocrinology 43, 533-536. doi:10.1159/ 000124578 (Pubitemid 16058026)
19. Gore, A. C., and Roberts, J. L. (1997).Regulation of gonadotropin- releasing hormone gene expression in vivo and in vitro. Front. Neuroendocrinol. 18, 209-245. doi:10.1006/FRNE.1996.0149 (Pubitemid 27172847)
20. Harris, T. G., Robinson, J. E., Evans, N. P., Skinner, D. C., and Herbison, A. E. (1998).Gonadotropin-releasing hormone messenger ribonucleic acid expression changes prior to onset of the LH surge in the ewe. Endocrinology 139, 57-64. doi:10.1210/EN.139.1.57 (Pubitemid 28166291)
21. Herbison, A. E. (1998).Multimodal influence of estrogen upon gonadotropinreleasing hormone neurons. Endocr. Rev. 19, 302-330. doi:10.1210/ ER.19.3.302 (Pubitemid 29117818)
22. Jennes, L., McShane, T., Brame, B., and Centers, A. (1996).Dynamic changes in gonadotropin releasing hormone receptor mRNA content in the mediobasal hypothalamus during the rat estrous cycle. J. Neuroendocrinol. 8, 275-281. doi:10.1046/J.1365-2826.1996.04544.X (Pubitemid 26119370)
23. Kaiser, U. B., Jakubowiak, A., Steinberger, A., and Chin, W. W. (1997). Differential effect of gonadotropin-releasing hormone (GnRH) pulse frequency on gonadotropin subunit and GnRH receptor messenger ribonucleic acid levels in vitro. Endocrinology 138, 1224-1231. doi:10.1210/ EN.138.3.1224 (Pubitemid 27089781)
24. Kang, S. M., Seong, J. Y., Cho, S., Cho, H., and Kim, K. (1995).Acute increases of GABAergic neurotransmission exerts a stimulatory effect on GnRH gene expression in the preoptic/anterior hypothalamus area of ovariectomized, estrogen and progesterone treated adult female rats. Neuroendocrinology 61, 486-492. doi:10.1159/000126871
25. Kim, K., Lim, I. S., Cho, B. N., Kang, S. S., Lee, B. J., Choi, K. H., Chung, C. H., Lee, C. C., Cho, W. K., and Wuttke, W. (1993).Apartial blockade of catecholaminergic neurotransmission with 6-hydroxydopamine decreases mRNA level of gonadotropin releasing hormone in the male rat hypothalamus. Neuroendocrinology 58, 146-152. doi:10.1159/000126524 (Pubitemid 23279084)
26. Kim, K., Lee, B. J., Cho, B. N., Kang, S. S., Choi, W. S., Park, S. D., Lee, C.C.,Cho,W.K., andWuttke,W. (1994).Blockade of noradrenergic neurotransmition with diethyldithiocarbonic acid decreases the mRNA level of gonadotropin-releasing hormone in the hypothalamus of ovariectomized, steroid treated prepubertal rats. Neuroendocrinology 59, 539-544. doi:10.1159/000126703
27. Kirkpatrick, B. L., Esquivel, E., Moss, G. E., Hamernik, D. L., and Wise, M. E. (1998).Estradiol and gonadotropin-releasing hormone (GnRH) interact to increase GnRH receptor expression in ovariectomized ewes after hypothalamic-pituitary disconnection. Endocrine 8, 225-229. doi:10.1385/ENDO:8: 3:225 (Pubitemid 28350811)
28. Łapot, M., Ciechanowska, M., Malewski, T., Mateusiak, K., Misztal, T., and Przekop, F. (2008)Changes in the GnRH mRNA and GnRH receptor (GnRH-R) mRNA levels in the hypothalamic-anterior pituitary unit of anestrous ewes after infusion of GnRH into the third cerebral ventricle. Reprod. Biol. 8,149-161
29. Leonhardt, S., Seong, J. Y., Kim, K., Thorun, J., and Wuttke, W. (1995). Activation of central GABAA but not GABAB receptors rapidly reduces pituitary LH release and GnRH gene expression in the preoptic/anterior hypothalamic area of ovariectomized rats. Neuroendocrinology 61, 655-662. doi:10.1159/000126892
30. Li, S., and Pelletier, G. (1993).Chronic administration of muscimol and pentobarbital decreases gonadotropin-releasing hormone mRNA levels in the male rat hypothalamus determined by quantitative in situ hybridization. Neuroendocrinology 58, 136-139. doi:10.1159/000126522 (Pubitemid 23279082)
31. Livak, K. J., and Smittgen, T. D. (2001).Analysis of relative gene expression data using real-time quantitative PCR and 2-DDCT method. Methods 25, 402-408. doi:10.1006/METH.2001.1262 (Pubitemid 34164012)
32. MacLusky, N. J., Naftolin, F., and Leranth, C. (1988).Immunocytochemical evidence for direct synaptic connections between corticotropin-releasing factor (CRF) and gonadotropin-releasing hormone (GnRH)-containing neurons in the preoptic area of the rat. Brain Res. 439, 391-395. doi:10.1016/0006-8993(88) 91501-6 (Pubitemid 18065730)
33. Maeda, K. I., Cagampang, F. R. A., Coen, C. W., and Tsukamura, H. (1994). Involvement of the catecholaminergic input to the paraventricular nucleus and corticotropin-releasing hormone in the fasting-induced suppression of luteinizing hormone in female rats. Endocrinology 134, 1718-1722. doi:10.1210/EN.134.4.1718 (Pubitemid 24110728)
34. Marriam, G. R., and Wachter, W. (1982).Algorithm for the study of episodic hormone secretion. Am. J. Physiol. 243, E310-E318.
35. Mitchell, J. C., Li, X. F., Breen, L., Thalabard, J. C., and O'Byrne, K. T. (2005).The role of the locus coeruleus in corticotropin-releasing hormone and stress-induced suppression of pulsatile luteinizing hormone secretion in the female rat. Endocrinology 146, 323-331. doi:10.1210/EN.2004-1053 (Pubitemid 40051755)
36. Naylor, A. M., Porter, D. W. F., and Lincoln, D. W. (1990).Central administration of corticotrophin-releasing factor in the sheep: effects on secretion of gonadotropins, prolactin and cortisol. J. Endocrinol. 124, 117-125. doi:10.1677/JOE.0.1240117 (Pubitemid 20032571)
37. Nikolarakis, K. E., Almeida, O. F. X., and Herz, A. (1986).Corticotropin releasing factor (CRF) inhibits gonadotropin-releasing hormone (GnRH) release from superfused rat hypothalami in vitro. Brain Res. 377, 388-390. doi:10.1016/0006-8993(86)90887-5 (Pubitemid 16041297)
38. Oakley, A. E., Breen, K. M., Clarke, I. J., Karsch, F. J., Wagenmaker, E. R., and Tilbrook, A. J. (2009).Cortisol reduces gonadotropin-releasing hormone pulse frequency in follicular phase ewes: influence off ovarian steroids. Endocrinology 150, 341-349. doi:10.1210/EN.2008-0587
39. Parrott, R. F., Robinson, J. E., and Thornton, S. N. (1988).No change in LH pulse frequency or plasma oxytocin in castrated rams treated with corticotropin-releasing hormone (CRF).J. Endocrinol. 119 (Suppl.), 130.
40. Polkowska, J., and Przekop, F. (1997).The effect of corticotropin- releasing factor (CRF) on the gonadotropin hormone releasing hormone (GnRH) hypothalamic neuronal system during preovulatory period in the ewe. Acta Neurobiol. Exp. 57, 91-99. (Pubitemid 27265019)
41. Price, M. L., Curtis, A. L., Kirby, L. G., Valentino, R. J., and Lucki, I. (1998). Effect of corticotropin-releasing factor on brain serotoninergic activity. Neuropsychopharmacology 18, 492-502. doi:10.1016/S0893-133X(97) 00197-8 (Pubitemid 28202356)
42. Rivest, S., and Rivier, C. (1995).The role of corticotropin-releasing factor and interleukin-1 in the regulations of neurons controlling reproductive functions. Endocr. Rev. 16, 177-199.
43. Rivier, C., and Rivest, S. (1991).Effect of stress on the activity of hypothalamic-pituitary-gonadal axis: peripheral and central mechanisms. Biol. Reprod. 45, 523-532. doi:10.1095/BIOLREPROD45.4.523
44. Rivier, C., Rivier, J., and Vale, W. (1986).Stress-induced inhibition of reproductive functions: role of endogenous corticotropin-releasing factor. Science 231, 607-609. doi:10.1126/SCIENCE.3003907 (Pubitemid 16088944)
45. Robinson, J. E., Healey, A. E., Harris, T. G., Messent, E. A., Skinner, D. C., Taylor, J. A., and Evans, N. P. (2000).The negative feedback action of progesterone on luteinizing hormone release is not associated with changes in GnRHmRNA expression in the ewe. J. Neuroendocrinol. 12, 121-129. doi:10.1046/J.1365-2826.2000.00426.X (Pubitemid 30098893)
46. Roth,C., Jung,K.,Kim,K.,Arias, P.,Moguilevsky, J., Jarry,H., Leonhardt, S., and Wuttke, W. (1997).Involvement of gamma amino butyric acid (GABA) in the postnatal function of the GnRH pulse generator as gene expression in the hypothalamus and pituitary. Exp. Clin. Endocrinol. Diabetes 105, 353-358. doi:10.1055/S-0029-1211778 (Pubitemid 27523691)
47. Sarkar, D. K. (1987).In vivo secretion of LHRH in ovariectomized rats is regulated by a possible autofeedback mechanism. Neuroendocrinology 45, 510-513. doi:10.1159/000124783 (Pubitemid 17076628)
48. Seong, J.Y., Jarry,H.,Kühnemuth, S., Leonhardt, S.,Wuttke,W., andKim,K. (1995).Effect of GABA-ergic compounds on gonadotropin-releasing hormone receptor gene expression in the rat. Endocrinology 136, 2587-2593. doi:10.1210/EN.136.6.2587
49. Seong, J. Y., Kang, S. S., Kam, K., Han, Y.-G., Kwon, H. B., Ryu, K., and Kim, K. (1998).Different regulation of gonadotropin-releasing hormone (GnRH) receptor expression in the posterior mediobasal hypothalamus by steroid hormones implication of GnRH neuronal activity. Brain Res. Mol. Brain Res. 53, 226-235. doi:10.1016/S0169-328X(97)00297-0 (Pubitemid 28085458)
50. Shoemaker, J. K., Garland, C. W., and Steinfeld, J. I. (Eds) (1974).Experiments in physical chemistry. In 'Chemistry, Physical and Theoretical; Laboratory Manuals, 3rd edn'. pp. 34-39. (McGraw-Hill: New York.)
51. Stupnicki, R., and Madej, A. (1976).Radioimmunoassay of LH in the blood plasma of farm animals. Endokrinologie 68, 6-13.
52. Tellam, D. J., Perone, M. J., Dunn, I. C., Radovick, S., Brennand, J., Rivier, J. E.,Castro,M.G., and Lovejoy,D.A. (1998).Direct regulation ofGnRH transcription by CRF-like peptides in an immortalized neuronal cell line. Neuroreport 9, 3135-3140. doi:10.1097/00001756-199810050-00003 (Pubitemid 28522325)
53. Tellam, D. J., Mohammad, Y. N., and Lovejoy, D. A. (2000).Molecular integration of hypothalamo-pituitary-adrenal axis-related neurohormones on the GnRH neuron. Biochem. Cell Biol. 78, 205-216. doi:10.1139/ O00-060
54. Thanky, N. R., Slater, R., and Herbison, A. E. (2003).Sex differences in estrogen-dependent transcription of gonadotropin releasing hormone (GnRH) gene revealed in GnRH transgenic mice. Endocrinology 144, 3351-3358. doi:10.1210/EN.2001-211342 (Pubitemid 36904410)
55. Tilbrook,A. J., Canng, B. J., Stewart,B. J., Serapiglia,M.D., and Clowke, I. J. (1999).Central administration of corticotrophin releasing hormone but not arginine vasopressin stimulates the secretion of luteinizing hormone in rams in the presence and absence of testosterone. J. Endocrinol. 162, 301-311. doi:10.1677/JOE.0.1620301 (Pubitemid 29369178)
56. Tomaszewska, D., Mateusiak, K., and Przekop, F. (1997).Extracellular monoamines and their metabolites in the mediobasal hypothalamus- median eminence of anestrous ewes during CRF treatment. Exp. Clin. Endocrinol. Diabetes 105, 175-181. doi:10.1055/S-0029-1211748 (Pubitemid 27289433)
57. Traczyk, W., and Przekop, F. (1963).Methods of investigation of the function of hypothalamus and hypophysis in chronic experiments in sheep. Acta Physiol. Pol. 14, 217-226.
58. Turzillo, A.M., Juengel, J. L., and Nett, T.M. (1995).Pulsatile gonadotropinreleasing hormone (GnRH) increases concentrations of GnRH receptor messenger ribonucleic acid and numbers of GnRH receptors during luteolysis in the ewe. Biol. Reprod. 53, 418-423. doi:10.1095/BIOLRE PROD53.2.418
59. Turzillo, A. M., Nolan, T. E., and Nett, T. M. (1998).Regulation of gonadotropin-releasing hormone (GnRH) receptor gene expression in sheep: interaction of GnRH and estradiol. Endocrinology 139, 4890-4894. doi:10.1210/EN.139.12.4890 (Pubitemid 28533434)
60. Viguie, C., Caraty, A., Locatelli, A., and Malpoux, B. (1995).Regulation of luteinizing hormone-releasing hormone (LHRH) secretion by melatonin in the ewe. Simultaneous delayed increase in LHRH and luteinizing hormone pulsatile secretion. Biol. Reprod. 52, 1114-1120. doi:10.1095/ BIOLREPROD52.5.1114
61. Vizcarra, J. A., Wettemann, R. P., Braden, T. D., Turzillo, A. M., and Nett, T. M. (1997).Effect of gonadotropin-releasing hormone (GnRH) pulse frequency on serum and pituitary concentrations of luteinizing hormone and follicle stimulating hormone, GnRH receptors, and messenger ribonucleic acid for gonadotropin subunits in cows. Endocrinology 138, 594-601. doi:10.1210/EN.138. 2.594 (Pubitemid 27110907)
62. Wagenmaker, E. R., Breen, K. M., Oacley, A. E., Tilbrook, A. J., and Karsch, F. J. (2009).Psychological stress inhibits amplitude of gonadotropinreleasing hormone pulses independent of cortisol action on the Type II glucocorticoid receptor. Endocrinology 150, 762-769. doi:10.1210/ EN.2008-0757
63. Welento, J., Szteyn, S., and Milart, Z. (1969).Observations on the stereotaxic configuration of the hypothalamus nuclei in the sheep. Anat. Anz. 124, 1-27.