Mitochondrial dependent apoptosis: Ameliorative effect of flunarizine on ischemia-reperfusion of celiac artery-induced gastric lesions in the rat

Digestive Diseases and Sciences

Volumn 56, Issue 8, 2011, Pages 2244-2251

  Muthuraman, Arunachalam ^a,d   Ramesh, Muthusamy ^b   Chauhan, Ashish ^a,c  

^a Rayat Institute of Pharmacy   (India)

^b NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

^c LOVELY PROFESSIONAL UNIVERSITY   (India)

^d PUNJABI UNIVERSITY   (India)

Author keywords

Apoptosis; Cyclosporine A; Flunarizine; Free radical; Ischemia reperfusion

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM; CYCLOSPORIN A; DNA; FLUNARIZINE; GLUTATHIONE; MYELOPEROXIDASE; OMEPRAZOLE; PROTEIN; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELIAC ARTERY; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA FRAGMENTATION; DRUG EFFICACY; DRUG MECHANISM; ISCHEMIA; MALE; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; RAT; REPERFUSION INJURY; STOMACH LESION; STOMACH PROTECTION;

ANIMALS; ANTI-ULCER AGENTS; APOPTOSIS; CALCIUM; CELIAC ARTERY; CYCLOSPORINE; FLUNARIZINE; GLUTATHIONE; IMMUNOSUPPRESSIVE AGENTS; MALE; MITOCHONDRIA; OMEPRAZOLE; PEROXIDASE; RATS; RATS, WISTAR; REPERFUSION INJURY; STOMACH; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCES; VASODILATOR AGENTS;

EID: 79960949157     PISSN: 01632116     EISSN: 15732568     Source Type: Journal    
DOI: 10.1007/s10620-011-1607-0     Document Type: Article

References (56)

1. Bagdatoglu OT, Polat G, Bagdatoglu C, et al. Effects of peripheral nerve ischemia-reperfusion model on serum cytokine levels. Turk Neurosurg. 2008;18:149-156.
2. Muthuraman A, Ramesh M, Sood S. Development of animal model for vasculatic neuropathy: Induction by ischemic-reperfusion in the rat femoral artery. J Neurosci Methods. 2010;186:215-221.
3. Muthuraman A, Sood S. Antisecretary, antioxidative and antiapoptotic effects of montelukast on pyloric ligation and water immersion stress induced peptic ulcer in rat. Prostaglandins Leukot Essent. Fatty Acids. 2010;83:55-60.
4. Kwiecien S, Brzozowski T, Konturek SJ. Effects of reactive oxygen species action on gastric mucosa in various models of mucosal injury. J Physiol Pharmacol. 2002;53:39-50. (Pubitemid 34266310)
5. Rugge M, de Boni M, Pennelli G, et al. Gastritis OLGA-staging and gastric cancer risk: a twelve year clinico-pathological follow-up study. Aliment Pharmacol Ther. 2010;31:1104-1111.
6. Wada K, Montalto MC, Stahl GL. Inhibition of complement C5 reduces local and remote organ injury after intestinal ischemia/reperfusion in the rat. Gastroenterology. 2001;120:126-133. (Pubitemid 32061876)
7. Stevens CE, Leblond CP. Renewal of the mucous cells in the gastric mucosa of the rat. Anat Rec. 2005;115:231-245.
8. Droge W. Free radicals in the physiological control of cell function. Physiol Rev. 2002;82:47-95. (Pubitemid 34654215)
9. Muthuraman A, Jaggi AS, Singh N, et al. Ameliorative effects of amiloride and pralidoxime in chronic constriction injury and vincristine induced painful neuropathy in rats. Eur J Pharmacol. 2008;587:104-111.
10. Evans SM, Whittle BJR. Role of bacteria and inducible nitric oxide synthase activity in the systemic inflammatory microvascular response provoked by indomethacin in the rat. Eur J Pharmacol. 2003;461:63-71. (Pubitemid 36144266)
11. Olivares D, Gisbert JP, Pajares JM. Helicobacter pylori infection and gastric mucosal epithelial cell apoptosis. Rev Esp Enferm Dig. 2005;97:505-520. (Pubitemid 41474590)
12. Fukuyama K, Iwakiri R, Noda T, et al. Apoptosis induced by ischemia-reperfusion and fasting in gastric mucosa compared to small intestinal mucosa in rats. Dig Dis Sci. 2001;46:545-549. (Pubitemid 32299808)
13. Wada K, Nakajima A, Takahashi H, et al. Protective effect of endogenous PPARgamma against acute gastric mucosal lesions associated with ischemia-reperfusion. Am J Physiol Gastrointest Liver Physiol. 2004;287:G452-G458. (Pubitemid 38955266)
14. 2+ trigger site. Arch Biochem Biophys 1979;195:460-467.
15. Zoratti M, Szabo I. The mitochondrial permeability transition. Biochim Biophys Acta. 1995;1241:139-176.
16. Lemasters JJ, Theruvath TP, Zhong Z, et al. Mitochondrial calcium and the permeability transition in cell death. Biochim Biophys Acta. 2009;1787:1395-1401.
17. Zhou XY, Du DS, Ma XB, et al. The protective mechanism of N-acetylcysteine against ischemia/reperfusion induced gastric injury in rats. Sheng Li Xue Bao. 2010;62:69-72.
18. Biswas K, Bandyopadhyay U, Chattopadhyay I, et al. A novel antioxidant and antiapoptotic role of omeprazole to block gastric ulcer through scavenging of hydroxyl radical. J Biol Chem. 2003;278:10993-11001. (Pubitemid 36792647)
19. Muthuraman A, Sood S. Antisecretory, antioxidative and antiapoptotic effects of montelukast on pyloric ligation and water immersion stress induced peptic ulcer in rat. Prostaglandins Leukot Essent Fatty Acids. 2010;83:55-60.
20. Armstrong JS. The role of the mitochondrial permeability transition in cell death. Mitochondrion. 2006;6:225-234. (Pubitemid 44567384)
21. Kim JS, He L, Lemasters JJ. Mitochondrial permeability transition: a common pathway to necrosis and apoptosis. Biochem Biophys Res Commun. 2003;304:463-470. (Pubitemid 36506518)
22. Santi CM, Cayabyab FS, Sutton KG, et al. Differential inhibition of T-type calcium channels by neuroleptics. J Neurosci. 2002;22:396-403. (Pubitemid 34049077)
23. Spierings EL. Clinical and experimental evidence for a role of calcium entry blockers in the treatment of migraine. Ann N Y Acad Sci. 1988;522:676-689.
24. 2+ channel modulating drugs. Brain Res. 1987;410:143-146.
25. Murai K, Tyler RS, Harker LA, et al. Review of pharmacologic treatment of tinnitus. Am J Otol. 1992;13:454-464.
26. Konrad T, Bloechle C, Haller G, et al. Verapamil and flunarizine protect the isolated perfused rat liver against warm ischemia and reperfusion injury. Res Exp Med. 1995;195:61-68.
27. Elimadi A, Bouillot L, Sapena R, et al. Dose-related inversion of cinnarizine and flunarizine effects on mitochondrial permeability transition. Eur J Pharmacol. 1998;348:115-121. (Pubitemid 28266760)
28. Takei M, Hiramatsu M, Mori A. Inhibitory effects of calcium antagonists on mitochondrial swelling induced by lipid peroxidation or arachidonic acid in the rat brain in vitro. Neurochem Res. 1994;19:1199-1206. (Pubitemid 24284797)
29. So HS, Park C, Kim HJ, et al. Protective effect of T-type calcium channel blocker flunarizine on cisplatin-induced death of auditory cells. Hear Res. 2005;204:127-139. (Pubitemid 40733210)
30. Ali BH, Al-Moundhri M, Eldin MT, et al. Amelioration of cisplatin-induced nephrotoxicity in rats by tetramethylpyrazine, a major constituent of the chinese herb Ligusticum wallichi. Exp Biol Med. 2008;233:891-896.
31. Armstrong JS. The role of the mitochondrial permeability transition in cell death. Mitochondrion. 2006;6:225-234. (Pubitemid 44567384)
32. Ciancarelli I, Tozzi-Ciancarelli MG, Di Massimo C, et al. Urinary nitric oxide metabolites and lipid peroxidation by products in migraine. Cephalalgia. 2003;23:39-42. (Pubitemid 36356803)
33. Muthuraman A, Singla SK, Rana A, et al. Reno-protective role of flunarizine (mitochondrial permeability transition pore inactivator) against gentamicin induced nephrotoxicity in rats. Yakugaku Zasshi. 2010 (in press).
34. Wada K, Kamisaki Y, Kitano M, et al. A new gastric ulcer model induced by ischemia-reperfusion in the rat: role of leukocytes on ulceration in rat stomach. Life Sci. 1996;59:PL295-PL301.
35. Shay H, Sun DCY, Gruenstein R. A quantitative method for measuring spontaneous gastric secretion in the rat. Gastroenterology. 1954;26:906-1013.
36. Okhawa H, Ohishi N, Yagi K. Assay for lipid peroxidation in animal tissue by thiobarbituric acid reaction. Analyt Biochem. 1979;95:351-358. (Pubitemid 9194347)
37. Ellman GL. Tissue sulfhydryl groups. Arch Biochem Biophys. 1959;82:70-77.
38. Krawisz JE, Sharon P, Stenson WF. Quantitative assay for acute intestinal inflammation based on myeloperoxidease activity: assessment of inflammation in rat and hamster models. Gastroenterology. 1984;87:1344-1350. (Pubitemid 15201434)
39. Hillegass LM, Griswold DE, Brickson B, et al. Assessment of myeloperoxidase activity in whole rat kidney. J Pharmacol Meth. 1990;24:285-295.
40. Qiu BS, Pfeiffer CJ, Wu W, et al. Tungstic acid reduced gastric ulceration in stressed rats. J Gastroenterol Hepatol. 1997;12:19-23. (Pubitemid 27100160)
41. Severinghaus JW, Ferrebee JW. Calcium determination by flame photometry; methods for serum, urine, and other fluids. J Biol Chem. 1950;187:621-630.
42. Lowry OH, Rosenbrough NJ, Farr AL, et al. Protein measurement with folin phenol reagent. J Biol Chem. 1951;193:265-275.
43. Paroni R, de Vecchi E, Lubatti L, et al. Influence of the 21-aminosteroid U74389F on ischemia-reperfusion injury in the rat. Eur J Pharmacol. 1995;294:737-742. (Pubitemid 26013252)
44. Vecchi ED, Lubatti L, Beretta C, et al. Protection from renal ischemia-reperfusion injury by the 2-methylaminochroman U83836E. Kidney Int. 1998;54:857-863. (Pubitemid 28397403)
45. Moore DD. In Current protocols in molecular biology. In: Ausubel FM, eds. New York: Wiley, 1998:2.1.1-2.1.2.
46. Huang T, Cheng AG, Stupak H, et al. Oxidative stress-induced apoptosis of cochlear sensory cells: otoprotective strategies. Int J Dev Neurosci. 2000;18:259-270. (Pubitemid 30129199)
47. Jiang M, Wei Q, Pabla N, et al. Effects of hydroxyl radical scavenging on cisplatin-induced p53 activation, tubular cell apoptosis and nephrotoxicity. Biochem Pharmacol. 2007;73:1499-1510. (Pubitemid 46452592)
48. Xia HH, Talley NJ. Apoptosis in gastric epithelium induced by Helicobacter pylori infection: implications in gastric carcinogenesis. Am J Gastroenterol. 2001;96:16-26. (Pubitemid 32104802)
49. Sood S, Muthuraman A. Activity of tacrolimus: an immunosuppressant, in pyloric ligation-induced peptic ulcer in the rat. Yakugaku Zasshi. 2009;129:1523-1528.
50. Zhang JF, Zhang YM, Yan CD, et al. Neuroregulation mechanism of hypothalamic paraventricular nucleus on gastric-reperfusion injury in rats. Life Sci. 2002;71:1501-1510.
51. Zhang Z, Yuan Y, Gao H, et al. Apoptosis, proliferation and p53 gene expression of H. pylori associated gastric epithelial lesions. World J Gastroenterol. 2001;7:779-782. (Pubitemid 34051492)
52. Naito Y, Mizushima K, Yoshikawa T. Global analysis of gene expression in gastric ischemia-reperfusion: a future therapeutic direction for mucosal protective drugs. Dig Dis Sci. 2005;50:S45-S55. (Pubitemid 41380798)
53. Sahin E, Gumuslu S. Immobilization stress in rat tissues: alterations in protein oxidation, lipid peroxidation and antioxidant defense system. Comp Biochem Physiol C Toxicol Pharmacol. 2007;144:342-347. (Pubitemid 46177769)
54. Qiao WL, Wang L, Zhang JF, et al. Effects of gastric ischemia-reperfusion on gastric mucosal cellular apoptosis and proliferation in rats. Sheng Li Xue Bao. 2006;58:237-243.
55. Wang RF, Gagliuso DJ, Podos SM. Effect of flunarizine, a calcium channel blocker, on intraocular pressure and aqueous humor dynamics in monkeys. J Glaucoma. 2008;17:73-78. (Pubitemid 351321482)
56. So HS, Kim HJ, Lee JH, et al. Flunarizine induces Nrf2-mediated transcriptional activation of heme oxygenase-1 in protection of auditory cells from cisplatin. Cell Death Differ. 2006;13:1763-1775.