Lean Mass Predicts Hip Geometry in Men and Women With Non-Insulin-Requiring Type 2 Diabetes Mellitus

Journal of Clinical Densitometry

Volumn 14, Issue 3, 2011, Pages 332-339

  Moseley, Kendall F ^a   Dobrosielski, Devon A ^b   Stewart, Kerry J ^b   Sellmeyer, Deborah E ^b   Jan De Beur, Suzanne M ^b  

^a JOHNS HOPKINS HOSPITAL   (United States)

^b JOHNS HOPKINS BAYVIEW MEDICAL CENTER   (United States)

Author keywords

Body composition; Bone density; Hip geometry; Type 2 diabetes

Indexed keywords

HEMOGLOBIN A1C;

ABDOMINAL FAT; ADULT; AGED; ARTICLE; BODY COMPOSITION; BODY MASS; BONE DENSITY; BONE STRENGTH; DIABETIC PATIENT; DUAL ENERGY X RAY ABSORPTIOMETRY; EXERCISE; FEMALE; GEOMETRY; HIGH RISK PATIENT; HIP; HIP FRACTURE; HUMAN; LEAN BODY WEIGHT; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; YOUNG MODULUS;

ABSORPTIOMETRY, PHOTON; ADIPOSITY; ADULT; AGED; BODY COMPOSITION; BODY MASS INDEX; BONE DENSITY; DIABETES MELLITUS, TYPE 2; FEMALE; HIP JOINT; HUMANS; MALE; MIDDLE AGED;

EID: 79960923448     PISSN: 10946950     EISSN: 15590747     Source Type: Journal    
DOI: 10.1016/j.jocd.2011.04.007     Document Type: Article

References (48)

1. Strotmeyer E.S., Cauley J.A. Diabetes mellitus, bone mineral density, and fracture risk. Curr Opin Endocrinol Diabetes Obes 2007, 14(6):429-435.
2. Schwartz A.V., Sellmeyer D.E. Women, type 2 diabetes, and fracture risk. Curr Diab Rep 2004, 4(5):364-369.
3. Vestergaard P. Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes-a meta-analysis. Osteoporos Int 2007, 18(4):427-444.
4. Schwartz A.V., Sellmeyer D.E. Diabetes, fracture, and bone fragility. Curr Osteoporos Rep 2007, 5(3):105-111.
5. de Liefde, van der Klift M., de Laet C.E., et al. Bone mineral density and fracture risk in type-2 diabetes mellitus: the Rotterdam Study. Osteoporos Int 2005, 16(12):1713-1720.
6. Bonnick S.L. HSA: beyond BMD with DXA. Bone 2007, 41(1 Suppl 1):S9-S12.
7. Beck T.J., Ruff C.B., Warden K.E., et al. Predicting femoral neck strength from bone mineral data. A structural approach. Invest Radiol 1990, 25(1):6-18.
8. Strotmeyer E.S., Cauley J.A., Schwartz A.V., et al. Diabetes is associated independently of body composition with BMD and bone volume in older white and black men and women: the Health, Aging, and Body Composition Study. J Bone Miner Res 2004, 19(7):1084-1091.
9. Yamaguchi T., Kanazawa I., Yamamoto M., et al. Associations between components of the metabolic syndrome versus bone mineral density and vertebral fractures in patients with type 2 diabetes. Bone 2009, 45(2):174-179.
10. Ozcivici E., Luu Y.K., Adler B., et al. Mechanical signals as anabolic agents in bone. Nat Rev Rheumatol 2010, 6(1):50-59.
11. Cornish J., Callon K.E., Bava U., et al. Leptin directly regulates bone cell function in vitro and reduces bone fragility in vivo. J Endocrinol 2002, 175(2):405-415.
12. Rosen C.J. Bone: serotonin, leptin and the central control of bone remodeling. Nat Rev Rheumatol 2009, 5(12):657-658.
13. Luo X.H., Guo L.J., Xie H., et al. Adiponectin stimulates RANKL and inhibits OPG expression in human osteoblasts through the MAPK signaling pathway. J Bone Miner Res 2006, 21(10):1648-1656.
14. Lenchik L., Register T.C., Hsu F.C., et al. Adiponectin as a novel determinant of bone mineral density and visceral fat. Bone 2003, 33(4):646-651.
15. Beck T.J., Oreskovic T.L., Stone K.L., et al. Structural adaptation to changing skeletal load in the progression toward hip fragility: the study of osteoporotic fractures. J Bone Miner Res 2001, 16(6):1108-1119.
16. Travison T.G., Araujo A.B., Esche G.R., et al. Lean mass and not fat mass is associated with male proximal femur strength. J Bone Miner Res 2008, 23(2):189-198.
17. Chobanian A.V., Bakris G.L., Black H.R., et al. The seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA 2003, 289(19):2560-2572.
18. American Diabetes Association: clinical practice recommendations 1997. Diabetes Care 1997, 20(Suppl 1):S1-S70.
19. Munzer T., Harman S.M., Hees P., et al. Effects of GH and/or sex steroid administration on abdominal subcutaneous and visceral fat in healthy aged women and men. J Clin Endocrinol Metab 2001, 86(8):3604-3610.
20. Beck T.J., Ruff C.B., Scott W.W., et al. Sex differences in geometry of the femoral neck with aging: a structural analysis of bone mineral data. Calcif Tissue Int 1992, 50(1):24-29.
21. Stewart K.J., Deregis J.R., Turner K.L., et al. Fitness, fatness and activity as predictors of bone mineral density in older persons. J Intern Med 2002, 252(5):381-388.
22. Hrebicek J., Janout V., Malincikova J., et al. Detection of insulin resistance by simple quantitative insulin sensitivity check index QUICKI for epidemiological assessment and prevention. J Clin Endocrinol Metab 2002, 87(1):144-147.
23. Looker A.C., Dawson-Hughes B., Tosteson A.N., et al. Hip fracture risk in older US adults by treatment eligibility status based on new national osteoporosis foundation guidance. Osteoporos Int 2011, 22(2):541-549.
24. Holick M.F. Vitamin D deficiency. N Engl J Med 2007, 357(3):266-281.
25. Ross A.C., Manson J.E., Abrams S.A., et al. The 2011 report on dietary reference intakes for calcium and vitamin D from the institute of medicine: what clinicians need to know. J Clin Endocrinol Metab 2011, 96(1):53-58.
26. Gruntmanis U., Fordan S., Ghayee H.K., et al. The peroxisome proliferator-activated receptor-gamma agonist rosiglitazone increases bone resorption in women with type 2 diabetes: a randomized, controlled trial. Calcif Tissue Int 2010, 86(5):343-349.
27. Vestergaard P. Bone metabolism in type 2 diabetes and role of thiazolidinediones. Curr Opin Endocrinol Diabetes Obes 2009, 16(2):125-131.
28. Schwartz A.V., Sellmeyer D.E., Vittinghoff E., et al. Thiazolidinedione use and bone loss in older diabetic adults. J Clin Endocrinol Metab 2006, 91(9):3349-3354.
29. Moseley K.F., Dobrosieski D.A., Stewart K.J., et al. Lean mass and fat mass predict bone mineral density in middle-aged individuals with non-insulin-requiring type 2 diabetes mellitus. Clin Endocrinol (Oxf) 2011, 74(5):565-571.
30. Vogt M.T., Cauley J.A., Kuller L.H., Nevitt M.C. Bone mineral density and blood flow to the lower extremities: the study of osteoporotic fractures. J Bone Miner Res 1997, 12(2):283-289.
31. Schwartz A.V., Vittinghoff E., Sellmeyer D.E., et al. Diabetes-related complications, glycemic control, and falls in older adults. Diabetes Care 2008, 31(3):391-396.
32. Petit M.A., Paudel M.L., Taylor B.C., et al. Bone mass and strength in older men with type 2 diabetes: the Osteoporotic Fractures in Men Study. J Bone Miner Res 2010, 25(2):285-291.
33. Beck T.J., Petit M.A., Wu G., et al. Does obesity really make the femur stronger? BMD, geometry, and fracture incidence in the women's health initiative-observational study. J Bone Miner Res 2009, 24(8):1369-1379.
34. El Hage R., Moussa E., Jacob C. Femoral neck geometry in overweight and normal weight adolescent girls. J Bone Miner Metab 2010, 28(5):595-600.
35. Goulding A., Gold E., Cannan R., et al. Changing femoral geometry in growing girls: a cross-sectional DEXA study. Bone 1996, 19(6):645-649.
36. Nieves J.W., Formica C., Ruffing J., et al. Males have larger skeletal size and bone mass than females, despite comparable body size. J Bone Miner Res 2005, 20(3):529-535.
37. Semanick L.M., Beck T.J., Cauley J.A., et al. Association of body composition and physical activity with proximal femur geometry in middle-aged and elderly Afro-Caribbean men: the Tobago bone health study. Calcif Tissue Int 2005, 77(3):160-166.
38. Lee J.S., Auyeung T.W., Leung J., et al. The effect of diabetes mellitus on age-associated lean mass loss in 3153 older adults. Diabet Med 2010, 27(12):1366-1371.
39. Park S.W., Goodpaster B.H., Strotmeyer E.S., et al. Decreased muscle strength and quality in older adults with type 2 diabetes: the health, aging, and body composition study. Diabetes 2006, 55(6):1813-1818.
40. Park S.W., Goodpaster B.H., Strotmeyer E.S., et al. Accelerated loss of skeletal muscle strength in older adults with type 2 diabetes: the health, aging, and body composition study. Diabetes Care 2007, 30(6):1507-1512.
41. Kontogianni M.D., Dafni U.G., Routsias J.G., Skopouli F.N. Blood leptin and adiponectin as possible mediators of the relation between fat mass and BMD in perimenopausal women. J Bone Miner Res 2004, 19(4):546-551.
42. Ducy P., Amling M., Takeda S., et al. Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell 2000, 100(2):197-207.
43. Verhaeghe J., Oloumi G., van Herck E., et al. Effects of long-term diabetes and/or high-dose 17 beta-estradiol on bone formation, bone mineral density, and strength in ovariectomized rats. Bone 1997, 20(5):421-428.
44. Thrailkill K.M., Lumpkin C.K., Bunn R.C., et al. Is insulin an anabolic agent in bone? Dissecting the diabetic bone for clues. Am J Physiol Endocrinol Metab 2005, 289(5):E735-E745.
45. Cheng S., Massaro J.M., Fox C.S., et al. Adiposity, cardiometabolic risk, and vitamin D status: the Framingham Heart Study. Diabetes 2010, 59(1):242-248.
46. Bailey R.L., Dodd K.W., Goldman J.A., et al. Estimation of total usual calcium and vitamin D intakes in the United States. J Nutr 2010, 140(4):817-822.
47. Jackson R.D., Wright N.C., Beck T.J., et al. Calcium plus vitamin D supplementation has limited effects on femoral geometric strength in older postmenopausal women: the Women's Health Initiative. Calcif Tissue Int 2011, 88(3):198-208.
48. Cauley J.A., Danielson M.E., Boudreau R.M., et al. Inflammatory markers and incident fracture risk in older men and women: the Health Aging and Body Composition Study. J Bone Miner Res 2007, 22(7):1088-1095.