Discovery of 1,2,4-thiadiazolidine-3,5-dione analogs that exhibit unusual and selective rapid cell death kinetics against acute myelogenous leukemia cells in culture

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 16, 2011, Pages 4879-4883

  Nasim, Shama ^a   Guzman, Monica L ^b   Jordan, Craig T ^c   Crooks, Peter A ^a  

^a University of Kentucky   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

1,2,4 Thiadiazolidine 3,5 diones; Acute myelogenous leukemia (AML); Antileukemic; Rapid cell death kinetics

Indexed keywords

1,2,4 THIADIAZOLIDINE 3,5 DIONE DERIVATIVE; ANTILEUKEMIC AGENT; THIAZOLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL DEATH; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENCY; HUMAN; HUMAN CELL; LEUKEMIA CELL;

CELL DEATH; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; HUMANS; KINETICS; LEUKEMIA, MYELOID, ACUTE; MOLECULAR STRUCTURE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIADIAZOLES; TUMOR CELLS, CULTURED;

EID: 79960903704     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.06.027     Document Type: Article

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