Activation of endothelial nitric oxide synthase is dependent on its interaction with globular actin in human umbilical vein endothelial cells

Journal of Molecular and Cellular Cardiology

Volumn 51, Issue 3, 2011, Pages 419-427

  Mi, Qiongyu ^a,b   Chen, Nan ^c   Shaifta, Yasin ^c   Xie, Liping ^a   Lu, Hui ^a   Liu, Zhen ^a   Chen, Qi ^a   Hamid, Colleen ^c   Becker, Silke ^c   Ji, Yong ^a   Ferro, Albert ^c  

^a NANJING MEDICAL UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Actin; Cytoskeleton; Endothelium; Nitric oxide; Nitric oxide synthase

Indexed keywords

ACTIN; ADENOSINE; CALCIUM ION; CYCLIC GMP; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HISTAMINE; SALBUTAMOL; SERINE; THROMBIN;

ACTIN FILAMENT; ARTICLE; CALCIUM CELL LEVEL; CELL CULTURE; CONTROLLED STUDY; EMBRYO; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; FEMALE; HUMAN; HUMAN CELL; MUTANT; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; UMBILICAL VEIN; WILD TYPE;

ACTINS; ADENOSINE; CELLS, CULTURED; CYTOCHALASIN D; ENZYME ACTIVATION; HEK293 CELLS; HISTAMINE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; NITRIC OXIDE SYNTHASE TYPE III; PHALLOIDINE; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTO-ONCOGENE PROTEINS C-AKT; SERINE; THROMBIN;

EID: 79960895575     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2011.06.017     Document Type: Article

References (30)

1. Anderson T.J. Nitric oxide, atherosclerosis and the clinical relevance of endothelial dysfunction. Heart Fail Rev 2003, 8:71-86.
2. Michel T., Feron O. Nitric oxide synthase: which, where, how, and why?. J Clin Invest 1997, 100:2146-2152.
3. Fulton D., Gratton J.P., Sessa W.C. Post-translational control of endothelial nitric oxide synthase: why isn't calcium/calmodulin enough?. J Pharmacol Exp Ther 2001, 299:818-824.
4. Kerem A., Yin J., Kaestle S.M., Hoffmann J., Schoene A.M., Singh B., et al. Lung endothelial dysfunction in congestive heart failure: role of impaired Ca2+ signaling and cytoskeletal reorganization. Circ Res 2010, 106:1103-1116.
5. Su Y., Edwards-Bennett S., Bubb M.R., Block E.R. Regulation of endothelial nitric oxide synthase by the actin cytoskeleton. Am J Physiol Cell Physiol 2003, 284:C1542-C1549.
6. Ji Y., Ferracci G., Warley A., Ward M., Leung K.Y., Samsuddin S., et al. beta-Actin regulates platelet nitric oxide synthase 3 activity through interaction with heat shock protein 90. Proc Natl Acad Sci USA 2007, 104:8839-8844.
7. Hutcheson I.R., Griffith T.M. Mechanotransduction through the endothelial cytoskeleton: mediation of flow- but not agonist-induced EDRF release. Br J Pharmacol 1996, 118:720-726.
8. Lane P., Gross S.S. Disabling a C-terminal autoinhibitory control element in endothelial nitric-oxide synthase by phosphorylation provides a molecular explanation for activation of vascular NO synthesis by diverse physiological stimuli. J Biol Chem 2002, 277:19087-19094.
9. Thors B., Halldórsson H., Thorgeirsson G. Thrombin and histamine stimulate endothelial nitric-oxide synthase phosphorylation at Ser1177 via an AMPK mediated pathway independent of PI3K-Akt. FEBS Lett 2004, 573:175-180.
10. Lantoine F., Iouzalen L., Devynck M.A., Millanvoye-Van Brussel E., David-Dufilho M. Nitric oxide production in human endothelial cells stimulated by histamine requires Ca2+ influx. Biochem J 1998, 330(Pt. 2):695-699.
11. Motley E.D., Eguchi K., Patterson M.M., Palmer P.D., Suzuki H., Eguchi S. Mechanism of endothelial nitric oxide synthase phosphorylation and activation by thrombin. Hypertension 2007, 49:577-583.
12. Xu Z., Park S.S., Mueller R.A., Bagnell R.C., Patterson C., Boysen P.G. Adenosine produces nitric oxide and prevents mitochondrial oxidant damage in rat cardiomyocytes. Cardiovasc Res 2005, 65:803-812.
13. Queen L.R., Ji Y., Xu B., Young L., Yao K., Wyatt A.W., et al. Mechanisms underlying beta2-adrenoceptor-mediated nitric oxide generation by human umbilical vein endothelial cells. J Physiol 2006, 576:585-594.
14. Ferro A., Queen L.R., Priest R.M., Xu B., Ritter J.M., Poston L., et al. Activation of nitric oxide synthase by beta 2-adrenoceptors in human umbilical vein endothelium in vitro. Br J Pharmacol 1999, 126:1872-1880.
15. Russo I., Doronzo G., Mattiello L., De Salve A., Trovati M., Anfossi G. The activity of constitutive nitric oxide synthase is increased by the pathway cAMP/cAMP-activated protein kinase in human platelets. New insights into the antiaggregating effects of cAMP-elevating agents. Thromb Res 2004, 114:265-273.
16. Varani K., Gessi S., Dalpiaz A., Borea P.A. Pharmacological and biochemical characterization of purified A2a adenosine receptors in human platelet membranes by [3H]-CGS 21680 binding. Br J Pharmacol 1996, 117:1693-1701.
17. Goeckeler Z.M., Wysolmerski R.B. Myosin phosphatase and cofilin mediate cAMP/cAMP-dependent protein kinase-induced decline in endothelial cell isometric tension and myosin II regulatory light chain phosphorylation. J Biol Chem 2005, 280:33083-33095.
18. Shabb J.B. Physiological substrates of cAMP-dependent protein kinase. Chem Rev 2001, 101:2381-2411.
19. Howe A.K. Regulation of actin-based cell migration by cAMP/PKA. Biochim Biophys Acta 2004, 1692:159-174.
20. Vouret-Craviari V., Boquet P., Pouysségur J., Van Obberghen-Schilling E. Regulation of the actin cytoskeleton by thrombin in human endothelial cells: role of Rho proteins in endothelial barrier function. Mol Biol Cell 1998, 9:2639-2653.
21. Cooper J.A. Effects of cytochalasin and phalloidin on actin. J Cell Biol 1987, 105:1473-1478.
22. Hirshman C.A., Zhu D., Panettieri R.A., Emala C.W. Actin depolymerization via the beta-adrenoceptor in airway smooth muscle cells: a novel PKA-independent pathway. Am J Physiol Cell Physiol 2001, 281:C1468-C1476.
23. Mount P.F., Kemp B.E., Power D.A. Regulation of endothelial and myocardial NO synthesis by multi-site eNOS phosphorylation. J Mol Cell Cardiol 2007, 42:271-279.
24. Ferro A., Coash M., Yamamoto T., Rob J., Ji Y., Queen L. Nitric oxide-dependent beta2-adrenergic dilatation of rat aorta is mediated through activation of both protein kinase A and Akt. Br J Pharmacol 2004, 143:397-403.
25. Smits P., Williams S.B., Lipson D.E., Banitt P., Rongen G.A., Creager M.A. Endothelial release of nitric oxide contributes to the vasodilator effect of adenosine in humans. Circulation 1995, 92:2135-2141.
26. Toda N. Mechanism of histamine actions in human coronary arteries. Circ Res 1987, 61:280-286.
27. Bosnjak J.J., Terata K., Miura H., Sato A., Nicolosi A.C., McDonald M., et al. Mechanism of thrombin-induced vasodilation in human coronary arterioles. Am J Physiol Heart Circ Physiol 2003, 284:H1080-H1086.
28. Venema V.J., Marrero M.B., Venema R.C. Bradykinin-stimulated protein tyrosine phosphorylation promotes endothelial nitric oxide synthase translocation to the cytoskeleton. Biochem Biophys Res Commun 1996, 226:703-710.
29. Kondrikov D., Fonseca F.V., Elms S., Fulton D., Black S.M., Block E.R., et al. Beta-actin association with endothelial nitric-oxide synthase modulates nitric oxide and superoxide generation from the enzyme. J Biol Chem 2010, 285:4319-4327.
30. Liu Y., Li H., Bubolz A.H., Zhang D.X., Gutterman D.D. Endothelial cytoskeletal elements are critical for flow-mediated dilation in human coronary arterioles. Med Biol Eng Comput 2008, 46:469-478.