Official Positions for FRAX® Clinical Regarding Falls and Frailty: Can Falls and Frailty be Used in FRAX®?. From Joint Official Positions Development Conference of the International Society for Clinical Densitometry and International Osteoporosis Foundation on FRAX®

Journal of Clinical Densitometry

Volumn 14, Issue 3, 2011, Pages 194-204

  Masud, Tahir ^a   Binkley, Neil ^b   Boonen, Steven ^c   Hannan, Marian T ^d  

^a NOTTINGHAM UNIVERSITY HOSPITALS NHS TRUST   (United Kingdom)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^c UNIVERSITY OF LEUVEN   (Belgium)

^d BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Falls; Fracture; Frailty; FRAX; Sarcopenia

Indexed keywords

AGE; ARTICLE; BONE MASS; CLINICAL DECISION MAKING; COMPUTER PROGRAM; FALLING; FRACTURE; FRAIL ELDERLY; FUNCTIONAL STATUS; HUMAN; MUSCLE ATROPHY; PRIORITY JOURNAL; RISK FACTOR;

ACCIDENTAL FALLS; AGED; ALGORITHMS; BONE DENSITY; DIAGNOSIS, COMPUTER-ASSISTED; FEMALE; FRACTURES, BONE; FRAIL ELDERLY; HUMANS; MALE; MODELS, STATISTICAL; OSTEOPOROTIC FRACTURES; RISK ASSESSMENT; RISK FACTORS;

EID: 79960895042     PISSN: 10946950     EISSN: 15590747     Source Type: Journal    
DOI: 10.1016/j.jocd.2011.05.010     Document Type: Article

References (63)

1. Allolio B. Risk factors for hip fracture not related to bone mass and their therapeutic implications. Osteoporos Int 1999, 9(Suppl 2):S9-S16.
2. Masud T., Morris R.O. Epidemiology of falls. Age Ageing 2001, 30(Suppl 4):3-7.
3. Austin N., Devine A., Dick I., et al. Fear of falling in older women: a longitudinal study of incidence, persistence, and predictors. J Am Geriatr Soc 2007, 55(10):1598-1603.
4. Deshpande N., Metter E.J., Lauretani F., et al. Activity restriction induced by fear of falling and objective and subjective measures of physical function: a prospective cohort study. J Am Geriatr Soc 2008, 56(4):615-620.
5. Salkeld G., Cameron I.D., Cumming R.G., et al. Quality of life related to fear of falling and hip fracture in older women: a time trade off study. BMJ 2000, 320(7231):341-346.
6. Berry S.D., Miller R.R. Falls: epidemiology, pathophysiology, and relationship to fracture. Current Osteoporosis Reports 2008, 6(4):149-154.
7. Tinetti M.E., Kumar C. The patient who falls: "It's always a trade-off" JAMA 2010, 303(3):258-266.
8. Woolcott J.C., Richardson K.J., Wiens M.O., et al. Meta-analysis of the impact of 9 medication classes on falls in elderly persons. Arch Intern Med 2009, 169(21):1952-1960.
9. Leveille S.G., Jones R.N., Kiely D.K., et al. Chronic musculoskeletal pain and the occurrence of falls in an older population. JAMA 2009, 302(20):2214-2221.
10. American Geriatrics Society BGS. AGS/BGS Clinical Practice Guideline: Prevention of falls in older persons. 2010 (December 12, 2010). http://www.americangeriatrics.org/education/prevention_of_falls.shtml.
11. Kelsey J.L., Berry S.D., Procter-Gray E., et al. Indoor and outdoor falls in older adults are different: the maintenance of balance, independent living, intellect, and Zest in the Elderly of Boston Study. J Am Geriatr Soc 2010, 58(11):2135-2141.
12. Nevitt M.C., Cummings S.R., Kidd S., Black D. Risk factors for recurrent nonsyncopal falls. A prospective study. JAMA 1989, 261(18):2663-2668.
13. Tinetti M.E., Ginter S.F. Identifying mobility dysfunctions in elderly patients. Standard neuromuscular examination or direct assessment?. JAMA 1988, 259(8):1190-1193.
14. Schott A.M., Cormier C., Hans D., et al. How hip and whole-body bone mineral density predict hip fracture in elderly women: the EPIDOS Prospective Study. Osteoporos Int 1998, 8(3):247-254.
15. Black D.M., Steinbuch M., Palermo L., et al. An assessment tool for predicting fracture risk in postmenopausal women. Osteoporos Int 2001, 12(7):519-528.
16. Lyles K.W., Colon-Emeric C., Magaziner J., et al. Zoledronic acid and clinical fractures and mortality after hip fracture. N Engl J Med 2007, 357:1799-1809.
17. Geusens P., Van Geel T., van den Bergh J. Can hip fracture prediction in women be estimated beyond bone mineral density measurement alone. Therapeutic Advances in Musculoskeletal Disease 2010, 2:63-67.
18. Albrand G., Munoz F., Sornay-Rendu E., et al. Independent predictors of all osteoporosis-related fractures in healthy postmenopausal women: The OFELY study. SO - Bone 2003, 32(1):78-85.
19. Cummings S.R., Nevitt M.C., Browner W.S., et al. Risk factors for hip fracture in white women. Study of Osteoporotic Fractures Research Group. N Engl J Med 1995, 332(12):767-773.
20. Wainwright S.A., Marshall L.M., Ensrud K.E., et al. Hip fracture in women without osteoporosis. J Clin Endocrinol Metab 2005, 90(5):2787-2793.
21. Gardsell P., Johnell O., Nilsson B.E., Nilsson J.A. The predictive value of fracture, disease, and falling tendency for fragility fractures in women. Calcif Tissue Int 1989, 45(6):327-330.
22. Kaptoge S., Benevolenskaya L.I., Bhalla A.K., et al. Low BMD is less predictive than reported falls for future limb fractures in women across Europe: results from the European Prospective Osteoporosis Study. Bone 2005, 36(3):387-398.
23. Dargent-Molina P., Favier F., Grandjean H., et al. Fall-related factors and risk of hip fracture: the EPIDOS prospective study. Lancet 1996, 348(9021):145-149. [Erratum appears in Lancet 1996 Aug 10;348(9024):416].
24. Clark E.M., Cuming M., Gould V.C., et al. Risk factors for fractures over aged 50 in a population-based cohort of older women from the UK. JBMR 2010.
25. Frost M., Abrahamsen B., Masud T., Brixen K. Risk factors for fracture in elderly men. A population-based prospective study 2010.
26. Rolland Y., Abellan van Kan G., Benetos A., et al. Frailty, osteoporosis and hip fracture: causes, consequences and therapeutic perspectives. Journal of Nutrition, Health & Aging 2008, 12(5):335-346.
27. Kiely D.K., Cupples L.A., Lipsitz L.A. Validation and comparison of two frailty indexes: The MOBILIZE Boston Study. J Am Geriatr Soc 2009, 57(9):1532-1539.
28. Lang T.F., Cauley J.A., Tylavsky F., et al. Computed tomographic measurements of thigh muscle cross-sectional area and attenuation coefficient predict hip fracture: The health, aging, and body composition study. J Bone Miner Res 2010, 25.
29. Robbins J.A., Schott A.M., Garnero P., et al. Risk factors for hip fracture in women with high BMD: EPIDOS study. Osteoporos Int 2005, 16(2):149-154.
30. Di Monaco M., Vallero F., Di Monaco R., Tappero R. Prevalence of sarcopenia and its association with osteoporosis in 313 older women following a hip fracture. Arch Gerontol Geriatr 2011, 52(1):71-74.
31. Gerdhem P., Ringsberg K.A., Akesson K., Obrant K.J. Clinical history and biologic age predicted falls better than objective functional tests. J Clin Epidemiol 2005, 58(3):226-232.
32. Sandhu S.K., Nguyen N.D., Center J.R., et al. Prognosis of fracture: evaluation of predictive accuracy of the FRAX algorithm and Garvan nomogram. Osteoporos Int 2010, 21:863-871.
33. Pluskiewicz W., Adamczyk P., Franek E., et al. Ten-year probability of osteoporotic fracture in 2012 Polish women assessed by FRAX and nomogram by Nguyen, et al. - Conformity between methods and their clinical utility. Bone 2010, 46:1661-1667.
34. Van Geel T., Huntjens K., Bours S., et al. Comparison of FRAX and Garvan case finding algorithms in patients presenting with a fracture. Bone 2010, 47:S188.
35. Hippisley-Cox J., Coupland C. Predicting risk of osteoporotic fracture in men and women in England and Wales: prospective derivation of validation of QFractureScores. BMJ 2009, 339:b4229.
36. Black D.M., Cummings S.R., Karpf D.B., et al. Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures. Fracture Intervention Trial Research Group. Lancet 1996, 348(9041):1535-1541.
37. Cummings S.R., Black D.M., Thompson D.E., et al. Effect of alendronate on risk of fracture in women with low bone density but without vertebral fractures: Results from the Fracture Intervention Trial. JAMA 1998, 280:2077-2082.
38. McClung M.R., Geusens P., Miller P.D., et al. Effect of risedronate on the risk of hip fracture in elderly women. N Engl J Med 2001, 344:333-340.
39. Black D.M., Delmas P.D., Eastell R., et al. Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis. N Engl J Med 2007, 356:1809-1822.
40. Cummings S.R., San Martin J., McClung M.R., et al. Denosumab for prevention of fractures in postmenopausal women with osteoporosis. N Engl J Med 2009, 361(8):756-765. [Erratum appears in N Engl J Med. 2009 Nov 5;361(19):1914].
41. Reginster J.Y., Seeman E., De Vernejoul M.C., et al. Strontium ranelate reduces the risk of nonvertebral fractures in postmenopausal women with osteoporosis: Treatment of Peripheral Osteoporosis (TROPOS) study. J Clin Endocrinol Metab 2005, 90(5):2816-2822.
42. McCloskey E.V., Beneton M., Charlesworth D., et al. Clodronate reduces the incidence of fractures in community-dwelling elderly women unselected for osteoporosis: results of a double-blind, placebo-controlled randomized study. J Bone Miner Res 2007, 22(1):135-141.
43. McCloskey E.V., Johansson H., Oden A., et al. Ten-year fracture probability identifies women who will benefit from clodronate therapy-additional results from a double-blind, placebo-controlled randomised study. Osteoporos Int 2009, 20(5):811-817.
44. Kayan K., Johansson H., Oden A., et al. Can fall risk be incorporated into fracture risk assessment algorithms: a pilot study of responsiveness to clodronate. Osteoporos Int 2009, 20(12):2055-2061.
45. van den Bergh J.P., van Geel T.A., Lems W.F., Geusens P.P. Assessment of individual fracture risk: FRAX and beyond. Current Osteoporosis Reports 2010, 8(3):131-137.
46. Berry S.D., Quach L., Procter-Gray E., et al. Poor adherence to medications may be associated with falls. Journals of Gerontology Series A-Biological Sciences & Medical Sciences 2010, 65(5):553-558.
47. Gillespie L.D., Robertson M.C., Gillespie W.J., et al. Interventions for preventing falls in older people living in the community. Cochrane Database of Systematic Reviews 2009, (2):CD007146.
48. Sherrington C., Whitney J.C., Lord S.R., et al. Effective exercise for the prevention of falls: a systematic review and meta-analysis. J Am Geriatr Soc 2008, 56(12):2234-2243.
49. Leipzig R.M., Cumming R.G., Tinetti M.E. Drugs and falls in older people: a systematic review and meta-analysis: II. Cardiac and analgesic drugs. J Am Geriatr Soc 1999, 47(1):40-50.
50. Pit S.W., Byles J.E., Henry D.A., et al. A Quality Use of Medicines program for general practitioners and older people: a cluster randomised controlled trial. Med J Aust 2007, 187(1):23-30.
51. Campbell A.J., Robertson M.C., Gardner M.M., et al. Psychotropic medication withdrawal and a home-based exercise program to prevent falls: A randomized, controlled trial. J Am Geriatr Soc 1999, 47:850-853.
52. Bischoff-Ferrari H.A., Dawson-Hughes B., Willett W.C., et al. Effect of vitamin D on falls: A meta-analysis. JAMA 2004, 291:1999-2006.
53. Dukas L., Bischoff H.A., Lindpaintner L.S., et al. Alfacalcidol reduces the number of fallers in a community-dwelling elderly population with a minimum calcium intake of more than 500 mg daily. J Am Geriatr Soc 2004, 52(2):230-236.
54. Gallagher J.C. The effects of calcitriol on falls and fractures and physical performance tests. J Steroid Biochem Mol Biol 2004, 89-90(1-5):497-501.
55. Cumming R.G., Ivers R., Clemson L., et al. Improving vision to prevent falls in frail older people: a randomized trial. J Am Geriatr Soc 2007, 55(2):175-181.
56. Harwood R.H., Foss A.J., Osborn F., et al. Falls and health status in elderly women following first eye cataract surgery: a randomised controlled trial. Br J Ophthalmol 2005, 89(1):53-59.
57. Kenny R.A., Richardson D.A., Steen N., et al. Carotid sinus syndrome: a modifiable risk factor for nonaccidental falls in older adults (SAFE PACE). J Am Coll Cardiol 2001, 38(5):1491-1496.
58. Day L., Fildes B., Gordon I., et al. Randomised factorial trial of falls prevention among older people living in their own homes. BMJ 2002, 325(7356):128.
59. Clemson L., Cumming R.G., Kendig H., et al. The effectiveness of a community-based program for reducing the incidence of falls in the elderly: a randomized trial. J Am Geriatr Soc 2004, 52(9):1487-1494.
60. Assantachai P., Praditsuwan R., Chatthanawaree W., et al. Strategy to prevent falls in the Thai elderly: A controlled study integrated health research program for the Thai elderly. J Med Assoc Thai 2002, 85:215-222.
61. Close J., Ellis M., Hooper R., et al. Prevention of falls in the elderly trial (PROFET): a randomised controlled trial. Lancet 1999, 353:93-97.
62. Tinetti M.E., Baker D.I., King M., et al. Effect of dissemination of evidence in reducing injuries from falls. N Engl J Med 2008, 359(3):252-261.
63. Johansson P.M., Sadigh S., Tillgren P.E., Rehnberg C. Non-Pharmaceutical prevention of hip fractures - a cost-effectiveness analysis of a community based elderly safety promotion programme in Sweden. Cost Effectiveness and Resource Allocation 2008, 6:11.