Structure tuning of pyrazolylpyrrole derivatives as ERK inhibitors utilizing dual tools; 3D-QSAR and side-chain hopping

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 16, 2011, Pages 4900-4904

  Kim, Mi Hyun ^a   Chung, Jae Yoon ^a   Ryu, Jae Sang ^b   Hah, Jung Mi ^a  

^a Hanyang University   (South Korea)

^b Ewha Womans University   (South Korea)

Author keywords

3D QSAR; Anticancer agent; ERK inhibitors; Pyrazolylpyrrole; Side chain hopping

Indexed keywords

ANTINEOPLASTIC AGENT; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PYRAZOLYLPYRROLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; ENZYME STRUCTURE; HUMAN; HUMAN CELL; PREDICTIVE VALUE; QUANTITATIVE STRUCTURE ACTIVITY RELATION; SIDE CHAIN HOPPING;

DOSE-RESPONSE RELATIONSHIP, DRUG; MITOGEN-ACTIVATED PROTEIN KINASE 1; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRROLES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; STEREOISOMERISM;

EID: 79960894788     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.06.016     Document Type: Article

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