Combinatorial administration of insulin and vitamin C alleviates the cerebral vasospasm after experimental subarachnoid hemorrhage in rabbit

BMC Neuroscience

Volumn 12, Issue , 2011, Pages

  Li, Shouchun ^a   Xue, Jinghui ^a   Shi, Jixin ^b   Yin, Hongxia ^b   Zhang, Zhiwen ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

^b NANJING GENERAL HOSPITAL OF NANJING MILITARY COMMAND   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ASCORBIC ACID; EOSIN; GLUCOSE; HEMATOXYLIN; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR ALPHA; NITRIC OXIDE; UNCLASSIFIED DRUG; ANTIDIABETIC AGENT; VITAMIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY SPASM; ARTICLE; BASILAR ARTERY; BRAIN VASOSPASM; CEREBROSPINAL FLUID; CONTROLLED STUDY; DOWN REGULATION; ENDOTHELIUM CELL; EXPERIMENTAL RAT; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; SUBARACHNOID HEMORRHAGE; ANIMAL; BLOOD; DISEASE MODEL; DRUG COMBINATION; RABBIT;

ANIMALS; ASCORBIC ACID; DISEASE MODELS, ANIMAL; DRUG THERAPY, COMBINATION; HYPOGLYCEMIC AGENTS; INSULIN; RABBITS; SUBARACHNOID HEMORRHAGE; VASOSPASM, INTRACRANIAL; VITAMINS;

EID: 79960875429     PISSN: None     EISSN: 14712202     Source Type: Journal    
DOI: 10.1186/1471-2202-12-77     Document Type: Article

References (15)

1. Zubkov AY, Nanda A, Zhang JH. Signal transduction pathways in cerebral vasospasm. Pathophysiol 2003, 9:47-61.
2. Montagnani M, Quon MJ. Insulin action in vascular endothelium: potential mechanisms linking insulin resistance with hypertension. Diabetes Obes Metab 2000, 2:285-292. 10.1046/j.1463-1326.2000.00092.x, 11225743.
3. King GL, Yamauchi T, Feener EP. Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo: a specific vascular action of insulin. Circulation 2000, 101:676-681.
4. Hirashima O, Kawano H, Motoyama T, Hirai N, Ohgushi M, Kugiyama K, Ogawa H, Yasue H. Improvement of endothelial function and insulin sensitivity with vitamin C in patients with coronary spastic angina: possible role of reactive oxygen species. J Am Coll Cardiol 2000, 35:1860-1866. 10.1016/S0735-1097(00)00616-1, 10841236.
5. Despres JP, Lamarche B, Mauriege P, Cantin B, Dagenais GR, Moorjani S, Lupien PJ. Hyperinsulinemia as an independent risk factor for ischemic heart disease. N Engl J Med 1996, 334:952-957. 10.1056/NEJM199604113341504, 8596596.
6. Reaven GM. Pathophysiology of insulin resistance in human disease. Physiol Rev 1995, 75:473-486.
7. Botker HE, Skjaerbaek C, Eriksen UH, Schmitz O, Orskov H. Insulin-like growth factor-I, insulin, and angina pectoris secondary to coronary atherosclerosis, vasospasm, and syndrome X. Am J Cardiol 1997, 79:961-963. 10.1016/S0002-9149(97)00021-0, 9104913.
8. Zhang S, Li X, Zhang L. Pathogenesis of insulin resistance. Insulin resistance syndrome 2001, 22-43. Beijing: People's Medical Publishing, Li X.
9. Huang D, Lu F. Defect in insulin signal transduction and formation of insulin resistance. Prog Physiol Sci 2003, 34:213-216.
10. Klaus F, Neal F, Kevin S. Cerebral vasospasm after subarachnoid hemorrhage putative role of inflammation. Neurosurgery 2003, 53:123-135. 10.1227/01.NEU.0000068863.37133.9E, 12823881.
11. Kim J, Montagnani M, Koh KK, Quon MJ. Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms. Circulation 2006, 113:1888-1904. 10.1161/CIRCULATIONAHA.105.563213, 16618833.
12. Scherrer U, Randin D, Vollenweider L, Nicod P. Nitric oxide release accounts for insulin's vascular effects in humans. J Clin Invest 1994, 94:2511-2515. 10.1172/JCI117621, 330085, 7989610.
13. Kawakami M, Kodama N, Toda N. Suppression of the cerebral vasospastic actions of oxyhemoglobin by ascorbic acid. Neurosurgery 1991, 28:33-39. 10.1227/00006123-199101000-00006, 1704491.
14. Spallone A, Pastore FS. Cerebral vasospasm in a double-injection model in rabbit. Surg Neurol 1989, 32:408-417. 10.1016/0090-3019(89)90002-5, 2636794.
15. Wang L, Shi JX, Yin HX, Ma CY, Zhang QR. The influence of subarachnoid hemorrhage on neurons: an animal model. Ann Clia Lab Sci 2005, 35:79-85.