Analgesic and anti-ulcer activities of ethanol and aqueous extracts of root of bauhinia variegata Linn

International Journal of Pharmacology

Volumn 7, Issue 5, 2011, Pages 616-622

  Kumar, Yamini R ^a   Rajani, G P ^a  

^a A Constituent Unit of KLE Academy of Higher Education Research   (India)

Author keywords

Analgesic; Anti ulcer; Aspirin; Bauhinia variegata Linn.; Eddy's hot plate; Ethanol; Pylorus ligation; Writhing test

Indexed keywords

ANALGESIC AGENT; ANTIULCER AGENT; BAUHINIA VARIEGATA EXTRACT; FLAVANOID; INDOMETACIN; PLANT EXTRACT; RANITIDINE; TRAMADOL; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIULCER ACTIVITY; ARTICLE; BAUHINIA; BAUHINIA VARIEGATA; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; DRUG SCREENING; LATENT PERIOD; NONHUMAN; PAIN; PHYTOCHEMISTRY; PLANT ROOT; PYLORUS LIGATION; RAT; STOMACH ULCER; TOXICITY TESTING;

EID: 79960866464     PISSN: 18117775     EISSN: 18125700     Source Type: Journal    
DOI: 10.3923/ijp.2011.616.622     Document Type: Article

References (26)

1. Abbott, F.V. and S.N. Young, 1988. Effect of 5-hydroxytryptamine precursors on morphine analgesia in the formalin test. Pharmacol. Biochem. Behav., 31: 855-860.
2. Bandyopadhyay, S.K., S.C. Pakrashi and A. Pakrashi, 2000. The role of antioxidant activity of Phyllanthus emblica fruits on prevention from indomethacin induced gastric ulcer. J. Ethnopharmacol., 70: 171-176.
3. Bentley, G.A., S.H. Newton and J. Starr, 1981. Evidence for an action of morphine and the enkephalins on sensory nerve endings in the mouse peritoneum. Br. J. Pharmacol., 73: 325-332.
4. Besra, S.E., R.M. Sharma and A. Gomes, 1996. Antiinflammatory effect of petroleum ether extract of leaves of Litchi chinensis Gaertn. (Sapindaceae). J. Ethnopharmacol., 54: 1-6.
5. Bodakhe, S.H. and A. Ram, 2007. Hepatoprotective properties of Bauhinia variegata bark extract. Yakugaku Zasshi, 127: 1503-1507.
6. Deshpande, S., G.B. Shah, I. Deshpande and N.S. Parmar, 2003. Antiulcer activity of aqueous extract of Basella rubra in albino rats. J. Nat. Remedies, 3: 212-214.
7. Dordevic, S., S. Petrovic, S. Dobric, M. Milenkovic, D. Vucicevic, S. Zizic and J. Kukie, 2007. Antimicrobial, anti-inflammatoiy, anti-ulcer and antioxidant activities of Carlina acanthifolia root essential oil. J. Ethnopharmacol., 109: 458-463.
8. Govindarajan, R., M. Vijayakumar, M. Singh, C.H.V. Rao, A. Shirwaikar, A.K.S. Rawat and P. Pushpangadan, 2006. Antiulcer and antimicrobial activity of Anogeissus Iatifolia. J. Ethnopharmacol., 106: 57-61.
9. Gupta, M., B.P. Shaw and A. Mukerjee, 2008. Studies of antipyretic-analgesic and ulcerogenic activity of polyherbal preparation in rats and mice. Int. J. Pharmacol., 4: 88-94.
10. Gupta, M., U.K. Mazumdar and P. Gomathi, 2007. Antiinflammatory and antinociceptive effects of Galega purpurea root. Int. J. Pharmacol., 3: 210-218.
11. Ibironke, G.F. and K.I. Ajiboye, 2007. Studies on antiinflammatory and analgesic properties of Chenopodium ambrosioides leaf extract in rats. Int. J. Pharmacol., 3: 111-115.
12. Karim, A., M. Nouman, S. Munir and S. Sattar, 2011. Pharmacology and phytochemistry of Pakistani herbs and herbal drugs used for treatement of diabetes. Int. J. Pharmacol., 7: 419-439.
13. Kokate, C.K., 2002. Practical Pharmacognosy-Techniques and Experiments. 9th Edn., Nirali Prakashan, Pune, pp: 149-153.
14. OECD, 2006. OECD guidelines for the testing of chemicals (Acute oral toxicity-up and down procedure), http://www.oecd.org/.
15. Odabasoglu, F., A. Cakir, H. Suleyman, A. Asian, Y. Bayir, M. Halici and C. Kazaz, 2006. Gastroprotective and antioxidant effects of usnic acid on indomethacin-induced gastric ulcer in rats. J. Ethnopharmacol. 103: 59-65.
16. Ojewole, J.A.O., 2007. Analgesic, anti-inflammatory and hypoglycemic effects of Rhus chirindensis (Baker F.) [Anacardiaceae] stem-bark aqueous extract in mice and rats. J. Ethnopharmacol., 113: 338-345.
17. Okokon, J.E., B.S. Antia and E. Umoh, 2008. Analgesic and anti-inflammatory effects of ethanolic root extract of Hippocratea africana. Int. J. Pharmacol., 4: 51-55.
18. Owolabi, O.J. and E.K.I. Omogbai, 2007. Analgesic and anti-inflammatory activities of the ethanolic stem bark extract of Kingelia africana (Bignoniaceae). Afr. J. Biotechnol., 6: 582-585.
19. Rajani, G.P. and P. Ashok, 2009. In vitro antioxidant and antihyperlipidemic activities of Bauhinia variegata Linn. Indian J. Pharmacol., 41: 227-232.
20. Rajkapoor, B., B. Jayakar, R. Anandan and S. Kavimani, 2003. Anti-Ulcer effect of Bauhinia variegata Linn in rats. J. Nat. Remedies., 3: 215-217.
21. Rao, C.V., S.K. Ojha, K. Radhakrishnan, R. Govindarajan, S. Rastogi, S. Mehrotra and P. Pushpangadan, 2004. Antiulcer activity of Utleria salicifolia rhizome extract. J. Ethnopharmacol., 91: 243-249.
22. Somchit, M.N., M.R. Sulaiman, A. Zuraini, L. Samsuddin and N. Somchit et al., 2004. Antinociceptive and anti-inflammatory effects of Centella asiatica. Indian. J. Pharmacol., 36: 377-380.
23. Sunilson, J.A.J., R. Varatharajan, P. Jayaraj, T. John, J. Jisha and P. Promwichit, 2008. Gastroprotective and antioxidant activities of the roots of Hibiscus aculeatus roxb in rats. Int. J. Pharmacol., 4: 252-257.
24. Umamaheswari, M., K. Asokkumar, R. Rathidevi, A.T. Sivashanmugam, V. Subhadradevi and T.K. Ravi, 2007. Antiulcer and in vitro antioxidant activities of Jasminum grandiflorum L. J. Ethnopharmacol., 110: 464-470.
25. Vogel, W.H., B.A. Scholkens, J. Sandow, G. Muller and W.F. Vogel, 2002. Drug Discovery and Evaluation. 2nd Edn., Springer, New York, ISBN-13: 978-3540423966, pp: 670-725.
26. Yadava, R.N. and V.M. Reddy, 2003. Anti-inflammatory activity of a novel flavonol glycoside from the Bauhinia variegata Linn. Nat. Prod. Res., 17: 165-169.