Impairment of cognitive function and reduced hippocampal cholinergic activity in a rat model of chronic intermittent hypoxia

Neural Regeneration Research

Volumn 6, Issue 17, 2011, Pages 1301-1305

  Zhao, Chunling ^a   Chen, Yan ^a   Zhang, Chunlai ^a   Lü, Linya ^b   Xu, Qian ^a  

^a SOUTHWEST MEDICAL UNIVERSITY   (China)

^b THE AFFILIATED HOSPITAL OF SOUTHWEST MEDICAL UNIVERSITY   (China)

Author keywords

Brain; Choline acetyl transferase; Chronic intermittent hypoxia; Hypoxia; Memory dysfunction; Neural regeneration; Nicotinic acetylcholine receptor; Rat

Indexed keywords

CHOLINE ACETYLTRANSFERASE; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR ALPHA4;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN HYPOXIA; BRAIN NERVE CELL; BRAIN REGION; CELL STRUCTURE; CHOLINERGIC ACTIVITY; CHOLINERGIC TRANSMISSION; CHRONIC INTERMITTENT HYPOXIA; COGNITIVE DEFECT; CONTROLLED STUDY; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MALE; MAZE TEST; NERVE CELL NECROSIS; NEUROPATHOLOGY; NONHUMAN; PROTEIN EXPRESSION; RAT; SLEEP APNEA SYNDROME;

EID: 79960849458     PISSN: 16735374     EISSN: None     Source Type: Journal    
DOI: 10.3969/j.issn.1673-5374.2011.17.004     Document Type: Article

References (23)

1. Young T, Palta M, Dempsey J, et al. The occurrence of sleep-disordered breathing among middle-aged adults. NEJM. 1993;328(17):1230-1235.
2. Decker MJ, Hue GE, Caudle WM, et al. Episodic neonatal hypoxia evokes executive dysfunction and regionally specific alterations in markers of dopamine signaling. Neuroscience. 2003;117(2): 417-425.
3. Li RC, Row BW, Kheirandish L, et al. Nitric oxide synthase and intermittent hypoxia-induced spatial learning deficits in the rat. Neurobiol Dis. 2004;17(1):44-53.
4. Debiec J, LeDoux JE, Nader K. Cellular and systems reconsolidation in the hippocampus. Neuron. 2002;36(3):340-343.
5. Geula C, Mesulam MM. Cortical cholinergic fibers in aging and Alzheimer's disease: a morphometric study. Neuroscience. 1989; 33(3):469-481.
6. Tian JZ, Yin JX, Shi J, et al. Changes of choline acetyltransferase and synaptophysin protein expression in hippocampus of rats with middle cerebral artery occlusion. Zhongguo Linchuang Kangfu. 2006;10(20):54-56.
7. Terry AV Jr, Buccafusco JJ. The cholinergic hypothesis of age and Alzheimer's disease-related cognitive deficits: recent challenges and their implications for novel drug development. J Pharmacol Exp Ther. 2003;306(3):821-827.
8. Deutsch JA. The cholinergic synapse and the site of memory. Science. 1971;174(11):788-795.
9. Drachman DA, Leavitt J. Human memory and the central cholinergic system: a relationship to aging? Arch Neurol. 1974; 30:113-121.
10. Pych JC, Chang Q, Colon-Rivera C, et al. Acetylcholine release in the hippocampus and striatum during place and response training. Learn Mem. 2005;12(6):564-572.
11. Muthuraju S, Maiti P, Solanki P, et al. Cholinesterase inhibitors ameliorate spatial learning deficits in rats following hypobaric hypoxia. Exp Brain Res. 2010;203(3):583-592.
12. Chung E, Iwasaki K, Mishima K, et al. Repeated cerebral ischemia induced hippocampal cell death and impairments of spatial cognition in the rat. Life Sci. 2002;72(4-5):609-619.
13. Fernandes C, Hoyle E, Dempster E, et al. Performance deficit of alpha7 nicotinic receptor knockout mice in a delayed matching-to-place task suggests a mild impairment of working/episodic-like memory. Genes Brain Behav. 2006; 5(6):433-440.
14. Pocivavsek A, Icenogle L, Levin ED. Ventral hippocampal alpha7 and alpha4beta2 nicotinic receptor blockade and clozapine effects on memory in female rats. Psychopharmacology (Berl). 2006; 188(4):597-604.
15. Sallette J, Pons S, Devillers-Thiery A, et al. Nicotine upregulates its own receptors through enhanced intracellular maturation. Neuron. 2005;46(4):595-607.
16. Kheirandish L, Row BW, Li RC, et al. Apolipoprotein E-deficient mice exhibit increased vulnerability to intermittent hypoxia-induced spatial learning deficits. Sleep. 2005;28(11):1355-1357.
17. Liu RY, Gu R, Qi XL, et al. Influence of beta-amyloid protein and cholesterol on the pathological changes of Alzheimer's disease and expression of nicotinic acetylcholine receptors in rats. Zhonghua Bing Li Xue Za Zhi. 2007;36(3):184-189.
18. Zhang YX, Guo HJ, Cui RY, et al. Expression of nAchR in brains of ovariectomized rats. Linchuang Junyi Zazhi. 2006;34(1):1-3.
19. Slotkin TA, Seidler FJ. Cholinergic receptor subtypes in the olfactory bulbectomy model of depression. Brain Res Bull. 2006; 68(5):341-345.
20. The Ministry of Science and Technology of the People's Republic Of China. Guidance Suggestions for the Care and Use of Laboratery Animals. 2006-09-30.
21. Xue QF, Xie JM, Hu CG, et al. A model of isobaric hypoxic pulmonary hypertension in rats. Zhonghua Jie He He Hu Xi Za Zhi. 1989;12(6):350-352, 381-382.
22. Yang Y, Tan SY, Zhang XM, et al. Effects of intermittent hypoxia on cognition and the ultrastructure in CA1 region of the hippocampus in rats. Zhongguo Shengjing Mianyixue he Shengjingbingxue Zazhi. 2007;3(14):157-163.
23. Qiu H, Jin WQ, Jin RF, et al. Analysis of variance of repeated data measured by water maze with SPSS. Zhong Xi Yi Jie He Xue Bao. 2007;5(1):101-105.