Cellular trafficking of low molecular weight heparin incorporated in layered double hydroxide nanoparticles in rat vascular smooth muscle cells

Biomaterials

Volumn 32, Issue 29, 2011, Pages 7234-7240

  Gu, Zi ^a   Rolfe, Barbara E ^a   Thomas, Anita C ^b   Campbell, Julie H ^a   Lu, G Q Max ^a   Xu, Zhi P ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Endocytosis; Layered double hydroxide (LDH); Low molecular weight heparin (LMWH); Mitogen activated protein kinase (MAPK) Signal transduction; Nanoparticle; Rat vascular smooth muscle cells

Indexed keywords

CELLULAR DELIVERY; CELLULAR UPTAKE; ENDOCYTOSIS; ENDOSOMES; FOETAL CALF SERUMS; INTRACELLULAR PATHWAYS; LATE ENDOSOMES; LAYERED DOUBLE HYDROXIDES; LOW-MOLECULAR WEIGHT HEPARINS; MITOGEN-ACTIVATED PROTEIN KINASE (MAPK) SIGNAL TRANSDUCTION; NANOHYBRIDS; VASCULAR SMOOTH MUSCLE CELLS;

CYTOLOGY; ENZYME ACTIVITY; FLOW CYTOMETRY; MEDICAL NANOTECHNOLOGY; MOLECULAR BIOLOGY; MOLECULAR WEIGHT; MUSCLE; NANOPARTICLES; POLYSACCHARIDES; RATS; SIGNAL TRANSDUCTION; TRANSMISSION ELECTRON MICROSCOPY;

CELLS;

HYDROXIDE; LOW MOLECULAR WEIGHT HEPARIN; MITOGEN ACTIVATED PROTEIN KINASE 1; NANOPARTICLE;

ANIMAL CELL; ARTICLE; CELL MIGRATION; CELL PROLIFERATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENDOCYTOSIS; ENDOSOME; FETAL CALF SERUM; FLOW CYTOMETRY; LYSOSOME; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; TRANSMISSION ELECTRON MICROSCOPY; VASCULAR SMOOTH MUSCLE;

ANIMALS; BIOCOMPATIBLE MATERIALS; CELLS, CULTURED; ENDOCYTOSIS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HEPARIN, LOW-MOLECULAR-WEIGHT; HYDROXIDES; MATERIALS TESTING; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; NANOPARTICLES; RATS;

RATTUS;

EID: 79960842017     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2011.05.083     Document Type: Article

References (35)

1. De M., Ghosh P.S., Rotello V.M. Applications of nanoparticles in biology. Adv Mater 2008, 20(22):4225-4241.
2. Peer D., Karp J.M., Hong S., FaroKhzad O.C., Margalit R., Langer R. Nanocarriers as an emerging platform for cancer therapy. Nat Nanotechnol 2007, 2(12):751-760.
3. Xing X.L., He X.X., Peng J.F., Wang K.M., Tan W.H. Uptake of silica-coated nanoparticles by HeLa cells. J Nanosci Nanotechnol 2005, 5(10):1688-1693.
4. Berry C.C. Possible exploitation of magnetic nanoparticle-cell interaction for biomedical applications. J Mater Chem 2005, 15(5):543-547.
5. Kam N.W.S., Liu Z.A., Dai H.J. Carbon nanotubes as intracellular transporters for proteins and DNA: an investigation of the uptake mechanism and pathway. Angew Chem Int Ed Engl 2006, 45(4):577-581.
6. Oh J.M., Choi S.J., Kim S.T., Choy J.H. Cellular uptake mechanism of an inorganic nanovehicle and its drug conjugates: enhanced efficacy due to clathrin-mediated endocytosis. Bioconjug Chem 2006, 17(6):1411-1417.
7. Xu Z.P., Niebert M., Porazik K., Walker T.L., Cooper H.M., Middelberg A.P.J., et al. Subcellular compartment targeting of layered double hydroxide nanoparticles. J Control Release 2008, 130(1):86-94.
8. Ladewig K., Xu Z.P., Lu G.Q. Layered double hydroxide nanoparticles in gene and drug delivery. Expert Opin Drug Deliv 2009, 6(9):907-922.
9. Braterman P.S., Xu Z.P., Yarberry F. Layered double hydroxides (LDHs). Handbook of layered materials 2004, 373-474. Marcel Dekker, New York. S.M. Auerbach, K.A. Carrado, P.K. Dutta (Eds.).
10. Xu Z.P., Lu G.Q. Layered double hydroxide nanomaterials as potential cellular drug delivery agents. Pure Appl Chem 2006, 78(9):1771-1779.
11. Kriven W.M., Kwak S.Y., Wallig M.A., Choy J.H. Bio-resorbable nanoceramics for gene and drug delivery. MRS Bull 2004, 29(1):33-37.
12. Khan A.I., Lei L.X., Norquist A.J., O'Hare D. Intercalation and controlled release of pharmaceutically active compounds from a layered double hydroxide. Chem Commun 2001, 22:2342-2343.
13. Zhang H., Zou K., Guo S.H., Duan X. Nanostructural drug-inorganic clay composites: structure, thermal property and in vitro release of captopril-intercalated Mg-Al-layered double hydroxides. J Solid State Chem 2006, 179(6):1792-1801.
14. Zhang H., Pan D.K., Zou K., He J., Duan X. A novel core-shell structured magnetic organic-inorganic nanohybrid involving drug-intercalated layered double hydroxides coated on a magnesium ferrite core for magnetically controlled drug release. J Mater Chem 2009, 19(19):3069-3077.
15. Zhang H., Pan D.K., Duan X. Synthesis, characterization, and magnetically controlled release behavior of novel core-shell structural magnetic ibuprofen-intercalated LDH nanohybrids. J Phys Chem C 2009, 113(28):12140-12148.
16. Choy J.H., Jung J.S., Oh J.M., Park M., Jeong J., Kang Y.K., et al. Layered double hydroxide as an efficient drug reservoir for folate derivatives. Biomaterials 2004, 25(15):3059-3064.
17. Choy J.H., Kwak S.Y., Jeong Y.J., Park J.S. Inorganic layered double hydroxides as nonviral vectors. Angew Chem Int Ed Engl 2000, 39(22):4042-4045.
18. Choy J.H., Kwak S.Y., Park J.S., Jeong Y.J. Cellular uptake behavior of [gamma-P-32] labeled ATP-LDH nanohybrids. J Mater Chem 2001, 11(6):1671-1674.
19. Choy J.H., Kwak S.Y., Park J.S., Jeong Y.J., Portier J. Intercalative nanohybrids of nucleoside monophosphates and DNA in layered metal hydroxide. J Am Chem Soc 1999, 121(6):1399-1400.
20. Kwak S.Y., Jeong Y.J., Park J.S., Choy J.H. Bio-LDH nanohybrid for gene therapy. Solid State Ionics 2002, 151(1-4):229-234.
21. Kwak S.Y., Kriven W.M., Wallig M.A., Choy J.H. Inorganic delivery vector for intravenous injection. Biomaterials 2004, 25(28):5995-6001.
22. Ladewig K., Niebert M., Xu Z.P., Gray P.P., Lu G.Q. Controlled preparation of layered double hydroxide nanoparticles and their application as gene delivery vehicles. Appl Clay Sci 2010, 48(1-2):280-289.
23. Wong Y.Y., Markham K., Xu Z.P., Chen M., Lu G.Q., Bartlett P.F., et al. Efficient delivery of siRNA to cortical neurons using layered double hydroxide nanoparticles. Biomaterials 2010, 31(33):8770-8779.
24. Gu Z., Thomas A.C., Xu Z.P., Campbell J.H., Lu G.Q. In vitro sustained release of LMWH from MgAl-layered double hydroxide nanohybrids. Chem Mater 2008, 20(11):3715-3722.
25. Gu Z., Rolfe B.E., Xu Z.P., Thomas A.C., Campbell J.H., Lu G.Q.M. Enhanced effects of low molecular weight heparin intercalated with layered double hydroxide nanoparticles on rat vascular smooth muscle cells. Biomaterials 2010, 31(20):5455-5462.
26. Zhang H., Xu Z.P., Lu G.Q., Smith S.C. Computer modeling study for intercalation of drug heparin into layered double hydroxide. J Phys Chem C 2010, 114(29):12618-12629.
27. Castellot J.J., Wong K., Herman B., Hoover R.L., Albertini D.F., Wright T.C., et al. Binding and internalization of heparin by vascular smooth muscle cells. J Cell Physiol 1985, 124(1):13-20.
28. Letourneur D., Caleb B.L., Castellot J.J. Heparin binding, internalization, and metabolism in vascular smooth muscle cell .2. Degradation and secretion in sensitive and resistant cells. J Cell Physiol 1995, 165(3):687-695.
29. Letourneur D., Caleb B.L., Castellot J.J. Heparin binding, internalization, and metabolism in vascular smooth muscle cell .1. Up regulation of heparin binding correlates with antiproliferative activity. J Cell Physiol 1995, 165(3):676-686.
30. Daum G., Hedin U., Wang Y.X., Wang T., Clowes A.W. Diverse effects of heparin on mitogen-activated protein kinase-dependent signal transduction in vascular smooth muscle cells. Circ Res 1997, 81(1):17-23.
31. Nelson P.R., Yamamura S., Mureebe L., Itoh H., Kent K.C. Smooth muscle cell migration and proliferation are mediated by distinct phases of activation of the intracellular messenger mitogen-activated protein kinase. J Vasc Surg 1998, 27(1):117-125.
32. Ottlinger M.E., Pukac L.A., Karnovsky M.J. Heparin inhibits mitogen-activated protein kinase activation in intact rat vascular smooth muscle cells. J Biol Chem 1993, 268(26):19173-19176.
33. Zhao Y., Xiao W.Q., Templeton D.M. Suppression of mitogen-activated protein kinase phosphatase-1 (MKP-1) by heparin in vascular smooth muscle cells. Biochem Pharmacol 2003, 66(5):769-776.
34. Parrales A., Palma-Nicolas J.P., Lopez E., Lopez-Colome A.M. Thrombin stimulates RPE cell proliferation by promoting c-Fos-mediated cyclin D1 expression. J Cell Physiol 2010, 222(2):302-312.
35. Seger R., Krebs E.G. Protein kinases .7. The MAPK signaling cascade. FASEB J 1995, 9(9):726-735.