Effect of chronic transfusion therapy on progression of neurovascular pathology in pediatric patients with sickle cell anemia

Blood Cells, Molecules, and Diseases

Volumn 47, Issue 2, 2011, Pages 125-128

  Bishop, Sarah ^a   Matheus, M Gisele ^a   Abboud, Miguel R ^b   Cane, Ian D ^a   Adams, Robert J ^a   Jackson, Sherron M ^a   Kalpatthi, Ram ^c  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b AMERICAN UNIVERSITY OF BEIRUT   (Lebanon)

^c CHILDREN S MERCY HOSPITAL   (United States)

Author keywords

Children; MRI; Stroke; Transcranial Doppler; Transfusion

Indexed keywords

ARTICLE; BLOOD TRANSFUSION; CEREBROVASCULAR ACCIDENT; CEREBROVASCULAR DISEASE; CHILD; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE COURSE; DOPPLER ECHOGRAPHY; FEMALE; FOLLOW UP; HUMAN; LONG TERM CARE; MAGNETIC RESONANCE ANGIOGRAPHY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; OUTCOME ASSESSMENT; PRESCHOOL CHILD; PRIORITY JOURNAL; RADIOLOGIST; SCHOOL CHILD; SICKLE CELL ANEMIA;

ADOLESCENT; ANEMIA, SICKLE CELL; BLOOD TRANSFUSION; BRAIN; CEREBROVASCULAR CIRCULATION; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; DISEASE PROGRESSION; FEMALE; FOLLOW-UP STUDIES; HEMOGLOBIN, SICKLE; HUMANS; MAGNETIC RESONANCE ANGIOGRAPHY; MAGNETIC RESONANCE IMAGING; MALE; PEDIATRICS; RETROSPECTIVE STUDIES; STROKE; ULTRASONOGRAPHY, DOPPLER, TRANSCRANIAL;

EID: 79960839271     PISSN: 10799796     EISSN: 10960961     Source Type: Journal    
DOI: 10.1016/j.bcmd.2011.06.002     Document Type: Article

References (16)

1. Switzer J.A., Hess D.C., Nichols F.T., et al. Pathophysiology and treatment of stroke in sickle-cell disease: present and future. Lancet Neurol. 2006, 5(6):501-512.
2. Wang W.C. The pathophysiology, prevention, and treatment of stroke in sickle cell disease. Curr. Opin. Hematol. 2007, 14(3):191-197.
3. Verduzco L.A., Nathan D.G. Sickle cell disease and stroke. Blood 2009, 114(25):5117-5125.
4. Ohene-Frempong K., Weiner S.J., Sleeper L.A., et al. Cerebrovascular accidents in sickle cell disease: rates and risk factors. Blood 1998, 91(1):288-294.
5. Adams R.J., McKie V.C., Hsu L., et al. Prevention of a first stroke by transfusions in children with sickle cell anemia and abnormal results on transcranial Doppler ultrasonography. N. Engl. J. Med. 1998, 339(1):5-11.
6. Adams R.J., Brambilla D. Discontinuing prophylactic transfusions used to prevent stroke in sickle cell disease. N. Engl. J. Med. 2005, 353(26):2769-2778.
7. Russell M.O., Goldberg H.I., Hodson A., et al. Effect of transfusion therapy on arteriographic abnormalities and on recurrence of stroke in sickle cell disease. Blood 1984, 63(1):162-169.
8. Abboud M.R., Cure J., Granger S., et al. Magnetic resonance angiography in children with sickle cell disease and abnormal transcranial Doppler ultrasonography findings enrolled in the STOP study. Blood 2004, 103(7):2822-2826.
9. Bader-Meunier B., Verlhac S., Elmaleh-Berges M., et al. Effect of transfusion therapy on cerebral vasculopathy in children with sickle-cell anemia. Haematologica 2009, 94(1):123-126.
10. Brousse V., Hertz-Pannier L., Consigny Y., et al. Does regular blood transfusion prevent progression of cerebrovascular lesions in children with sickle cell disease?. Ann. Hematol. 2009, 88(8):785-788.
11. Cohen A.R., Martin M.B., Silber J.H., et al. A modified transfusion program for prevention of stroke in sickle cell disease. Blood 1992, 79(7):1657-1661.
12. Hulbert M.L., Scothorn D.J., Panepinto J.A., et al. Exchange blood transfusion compared with simple transfusion for first overt stroke is associated with a lower risk of subsequent stroke: a retrospective cohort study of 137 children with sickle cell anemia. J. Pediatr. 2006, 149(5):710-712.
13. Walters M.C., Hardy K., Edwards S., et al. Pulmonary, gonadal, and central nervous system status after bone marrow transplantation for sickle cell disease. Biol. Blood Marrow Transplant. 2010, 16(2):263-272.
14. Ware R.E., Zimmerman S.A., Sylvestre P.B., et al. Prevention of secondary stroke and resolution of transfusional iron overload in children with sickle cell anemia using hydroxyurea and phlebotomy. J. Pediatr. 2004, 145(3):346-352.
15. Sumoza A., de Bisotti R., Sumoza D., et al. Hydroxyurea (HU) for prevention of recurrent stroke in sickle cell anemia (SCA). Am. J. Hematol. 2002, 71(3):161-165.
16. Helton K.J., Wang W.C., Wynn L.W., et al. The effect of hydroxyurea on vasculopathy in a child with sickle cell disease. AJNR. Am. J. Neuroradiol. 2002, 23(10):1692-1696.