Does regular blood transfusion prevent progression of cerebrovascular lesions in children with sickle cell disease?

Annals of Hematology

Volumn 88, Issue 8, 2009, Pages 785-788

  Brousse, Valentine ^a   Hertz Pannier, Lucie ^a,b   Consigny, Yann ^c   Bresson, Jean Louis ^a   Girot, Robert ^d   Mirre, Elsa ^a   Lenoir, Gérard ^a   de Montalembert, Mariane ^a  

^a HÔPITAL NECKER ENFANTS MALADES   (France)

^b INSERM   (France)

^c BEAUJON HOSPITAL   (France)

^d HÔPITAL TENON   (France)

Author keywords

Brain imaging; Sickle cell disease; Stroke; Transfusion

Indexed keywords

ANTERIOR CEREBRAL ARTERY; ARTICLE; BLOOD TRANSFUSION; BRAIN ATROPHY; CEREBROVASCULAR DISEASE; CHILD; CLINICAL ARTICLE; DISEASE COURSE; ENCEPHALOMALACIA; HUMAN; INTERNAL CAROTID ARTERY OCCLUSION; LEUKOENCEPHALOPATHY; LONG TERM CARE; MAGNETIC RESONANCE ANGIOGRAPHY; MIDDLE CEREBRAL ARTERY OCCLUSION; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIMARY PREVENTION; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SECONDARY PREVENTION; SICKLE CELL ANEMIA;

ANEMIA, SICKLE CELL; ANGIOGRAPHY; BLOOD TRANSFUSION; CEREBROVASCULAR DISORDERS; CHILD; CHILD, PRESCHOOL; DISEASE PROGRESSION; FEMALE; FOLLOW-UP STUDIES; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; RETROSPECTIVE STUDIES; STROKE;

EID: 67649404712     PISSN: 09395555     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00277-008-0670-x     Document Type: Article

References (13)

1. Steen RG, Emudianughe T, Hankins GM, Wynn LW, Wang WC, Xiong X, Helton KJ (2003) Brain imaging findings in pediatric patients with sickle cell disease. Radiology 228:216-225. doi: 10.1148/radiol.2281020943
2. Ohene-Frempong K, Weiner SJ, Sleeper LA, Miller ST, Embury S, Moohr JW, Wethers DL, Pegelow CH, Gill FM (1998) Cerebrovascular accidents in sickle cell disease: Rates and risk factors. Blood 91:288-294
3. Steen RG, Miles MA, Helton KJ, Strawn S, Wang W, Xiong X, Mulhern RK (2003) Cognitive impairment in children with hemoglobin SS sickle cell disease: Relationship to MR imaging findings and hematocrit. AJNR Am J Neuroradiol 24:382-389
4. Wang W, Enos L, Gallagher D, Thompson R, Guarini L, Vichinsky E, Wright E, Zimmerman R, Armstrong FD (2001) Neuropsychologic performance in school-aged children with sickle cell disease: A report from the Cooperative Study of Sickle Cell Disease. J Pediatr 139:391-397. doi: 10.1067/mpd.2001.116935
5. Bernaudin F, Verlhac S, Freard F, Roudot-Thoraval F, Benkerrou M, Thuret I, Mardini R, Vannier JP, Ploix E, Romero M, Casse-Perrot C, Helly M, Gillard E, Sebag G, Kchouk H, Pracros JP, Finck B, Dacher JN, Ickowicz V, Raybaud C, Poncet M, Lesprit E, Reinert PH, Brugieres P (2000) Multicenter prospective study of children with sickle cell disease: radiographic and psychometric correlation. J Child Neurol 15:333-343. doi: 10.1177/088307380001500510
6. Adams RJ, McKie VC, Hsu L, Files B, Vichinsky E, Pegelow C, Abboud M, Gallagher D, Kutlar A, Nichols FT, Bonds DR, Brambilla D (1998) Prevention of a first stroke by transfusions in children with sickle cell anemia and abnormal results on transcranial Doppler ultrasonography. N Engl J Med 339:5-11. doi: 10.1056/NEJM199807023390102
7. Pegelow CH, Adams RJ, McKie V, Abboud M, Berman B, Miller ST, Olivieri N, Vichinsky E, Wang W, Brambilla D (1995) Risk of recurrent stroke in patients with sickle cell disease treated with erythrocyte transfusions. J Pediatr 126:896-899. doi: 10.1016/S0022-3476(95)70204-0
8. Scothorn DJ, Price C, Schwartz D et al (2002) Risk of recurrent stroke in children with sickle cell disease receiving blood transfusion therapy for at least five years after initial stroke. J Pediatr 140:348-354. doi: 10.1067/mpd.2002.122498
9. Wang WC, Kovnar EH, Tonkin IL et al (1991) High risk of recurrent stroke after discontinuance of five to twelve years of transfusiont therapy in patients with sickle cell disease. J Pediatr 118:377-382. doi: 10.1016/ S0022-3476(05)82150-X
10. Adams RJ, Brambilla D (2005) Discontinuing prophylactic transfusions used to prevent stroke in sickle cell disease. N Engl J Med 353:2769-2778. doi: 10.1056/NEJMoa050460
11. Venketasubramanian N, Prohovnik I, Hurlet A, Mohr JP, Piomelli S (1994) Middle cerebral artery velocity changes during transfusion in sickle cell anemia. Stroke 25:2153-2158
12. Russell MO, Goldberg HI, Hodson A, Kim HC, Halus J, Reivich M, Schwartz E (1984) Effect of transfusion therapy on arteriographic abnormalities and on recurrence of stroke in sickle cell disease. Blood 63:162-169
13. Woodard P, Helton KJ, Khan RB et al (2005) Brain parenchymal damage after haematopoietic stem cell transplantation for severe sickle cell disease. Br J Haematol 129:550-552. doi: 10.1111/j.1365-2141.2005.05491.x