How prompt is prompt in daily practice? Earlier initiation of empirical antibacterial therapy for the febrile neutropenic patient

European Journal of Cancer Care

Volumn 20, Issue 5, 2011, Pages 679-685

  Van Vliet, M ^a   Potting, C M J ^a   Sturm, P D J ^a   Donnelly, J P ^a   Blijlevens, N M A ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Body temperature; Cancer; Infection; Neutropenia; Prompt antibiotic therapy; Sepsis

Indexed keywords

ANTIINFECTIVE AGENT;

ADULT; AGED; ARTICLE; CLINICAL PROTOCOL; FEMALE; FEVER; HEALTH CARE DELIVERY; HUMAN; MALE; MEDICAL AUDIT; MIDDLE AGED; NEOPLASM; NEUTROPENIA; STANDARD; TIME;

ADULT; AGED; ANTI-BACTERIAL AGENTS; CLINICAL AUDIT; CLINICAL PROTOCOLS; DELIVERY OF HEALTH CARE; FEMALE; FEVER; HUMANS; MALE; MIDDLE AGED; NEOPLASMS; NEUTROPENIA; TIME FACTORS; YOUNG ADULT;

EID: 79960835415     PISSN: 09615423     EISSN: 13652354     Source Type: Journal    
DOI: 10.1111/j.1365-2354.2011.01264.x     Document Type: Article

References (20)

1. Baron E.J., Wilson D.M., Weinstein M.P., Dunne W.M., Yagupsky P. & Welch D.F. (2005) Cumitech 1C: Blood Cultures IV. ASM Press, Washington, DC, USA.
2. Battleman D.S., Callahan M. & Thaler H.T. (2002) Rapid antibiotic delivery and appropriate antibiotic selection reduce length of hospital stay of patients with community-acquired pneumonia: link between quality of care and resource utilization. Archives of Internal Medicine 162, 682-688.
3. Bishara J., Hershkovitz D., Paul M., Rotenberg Z. & Pitlik S. (2007) Appropriateness of antibiotic therapy on weekends versus weekdays. The Journal of Antimicrobial Chemotherapy 60, 625-628.
4. Blijlevens N.M., Donnelly J.P. & de Pauw B.E. (2001) Empirical therapy of febrile neutropenic patients with mucositis: challenge of risk-based therapy. Clinical Microbiology and Infection 7 (Suppl. 4), 47-52.
5. Bone R.C., Balk R.A., Cerra F.B., Dellinger R.P., Fein A.M., Knaus W.A., Schein R.M. & Sibbald W.J. (1992) Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 101, 1644-1655.
6. Ciuraru N.B., Braunstein R., Sulkes A. & Stemmer S.M. (2008) The influence of mucositis on oral thermometry: when fever may not reflect infection. Clinical Infectious Diseases 46, 1859-1863.
7. Corey A.L. & Snyder S. (2008) Antibiotics in 30min or less for febrile neutropenic patients: a quality control measure in a new hospital. Journal of Pediatric Oncology Nursing 25, 208-212.
8. Dellinger R.P., Levy M.M., Carlet J.M., Bion J., Parker M.M., Jaeschke R., Reinhart K., Angus D.C., Brun-Buisson C., Beale R., Calandra T., Dhainaut J.F., Gerlach H., Harvey M., Marini J.J., Marshall J., Ranieri M., Ramsay G., Sevransky J., Thompson B.T., Townsend S., Vender J.S., Zimmerman J.L. & Vincent J.L. (2008) Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Critical Care Medicine 36, 296-327.
9. Feld R., DePauw B., Berman S., Keating A. & Ho W. (2000) Meropenem versus ceftazidime in the treatment of cancer patients with febrile neutropenia: a randomized, double-blind trial. Journal of Clinical Oncology 18, 3690-3698.
10. Hughes W.T., Armstrong D., Bodey G.P., Bow E.J., Brown A.E., Calandra T., Feld R., Pizzo P.A., Rolston K.V., Shenep J.L. & Young L.S. (2002) 2002 guidelines for the use of antimicrobial agents in neutropenic patients with cancer. Clinical Infectious Diseases 34, 730-751.
11. Lin M.Y., Weinstein R.A. & Hota B. (2008) Delay of active antimicrobial therapy and mortality among patients with bacteremia: impact of severe neutropenia. Antimicrobial Agents and Chemotherapy 52, 3188-3194.
12. MacArthur R.D., Miller M., Albertson T., Panacek E., Johnson D., Teoh L. & Barchuk W. (2004) Adequacy of early empiric antibiotic treatment and survival in severe sepsis: experience from the MONARCS trial. Clinical Infectious Diseases 38, 284-288.
13. Natsch S., Kullberg B.J., van der Meer J.W. & Meis J.F. (1998) Delay in administering the first dose of antibiotics in patients admitted to hospital with serious infections. European Journal of Clinical Microbiology and Infectious Diseases 17, 681-684.
14. O'Grady N.P., Barie P.S., Bartlett J.G., Bleck T., Carroll K., Kalil A.C., Linden P., Maki D.G., Nierman D., Pasculle W. & Masur H. (2008) Guidelines for evaluation of new fever in critically ill adult patients: 2008 update from the American College of Critical Care Medicine and the Infectious Diseases Society of America. Critical Care Medicine 36, 1330-1349.
15. Paul M., Soares-Weiser K. & Leibovici L. (2003) Beta lactam monotherapy versus beta lactam-aminoglycoside combination therapy for fever with neutropenia: systematic review and meta-analysis. BMJ (Clinical Research Ed.) 326, 1111.
16. de Pauw B.E., Kauw F., Muytjens H., Williams K.J. & Bothof T. (1983) Randomized study of ceftazidime versus gentamicin plus cefotaxime for infections in severe granulocytopenic patients. The Journal of Antimicrobial Chemotherapy 12 (Suppl. A), 93-99.
17. de Pauw B.E., Deresinski S.C., Feld R., Lane-Allman E.F. & Donnelly J.P. (1994) Ceftazidime compared with piperacillin and tobramycin for the empiric treatment of fever in neutropenic patients with cancer. A multicenter randomized trial. The Intercontinental Antimicrobial Study Group. Annals of Internal Medicine 120, 834-844.
18. Schimpff S., Satterlee W., Young V.M. & Serpick A. (1971) Empiric therapy with carbenicillin and gentamicin for febrile patients with cancer and granulocytopenia. The New England Journal of Medicine 284, 1061-1065.
19. The Meropenem Study Group of Leuven LaN (1995) Equivalent efficacies of meropenem and ceftazidime as empirical monotherapy of febrile neutropenic patients. The Journal of Antimicrobial Chemotherapy 36, 185-200.
20. van Vliet M., Donnelly J.P., Potting C.M. & Blijlevens N.M. (2010) Continuous non-invasive monitoring of the skin temperature of HSCT recipients. Supportive Care in Cancer 18, 37-42.