Increased muscular dehydroepiandrosterone levels are associated with improved hyperglycemia in obese rats

American Journal of Physiology - Endocrinology and Metabolism

Volumn 301, Issue 2, 2011, Pages

  Sato, Koji ^a   Iemitsu, Motoyuki ^a   Aizawa, Katsuji ^b   Mesaki, Noboru ^c   Fujita, Satoshi ^a  

^a RITSUMEIKAN UNIVERSITY   (Japan)

^b SENSHU UNIVERSITY   (Japan)

^c TEIKYO HEISEI UNIVERSITY   (Japan)

Author keywords

Exercise; Muscle glucose metabolism; Sex steroid hormone

Indexed keywords

ANDROSTANOLONE; CITRATE SYNTHASE; GLUCOSE; GLUCOSE TRANSPORTER 4; INSULIN; PRASTERONE; PROTEIN KINASE B; PROTEIN KINASE C DELTA; PROTEIN KINASE C GAMMA; STEROID 5ALPHA REDUCTASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG MUSCLE LEVEL; ENDURANCE TRAINING; ENZYME PHOSPHORYLATION; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; INSULIN BLOOD LEVEL; MALE; MUSCLE LEVEL; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; UPREGULATION;

ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; CHOLESTENONE 5 ALPHA-REDUCTASE; DEHYDROEPIANDROSTERONE; DIETARY SUCROSE; DIHYDROTESTOSTERONE; GLUCOSE TRANSPORTER TYPE 4; HYPERGLYCEMIA; ISOENZYMES; MALE; OBESITY; PHYSICAL CONDITIONING, ANIMAL; PROTEIN KINASE C; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION;

EID: 79960820601     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00564.2010     Document Type: Article

References (31)

1. Aizawa K, Iemitsu M, Maeda S, Jesmin S, Otsuki T, Mowa CN, Miyauchi T, Mesaki N. Expression of steroidogenic enzymes and synthesis of sex steroid hormones from DHEA in skeletal muscle. Am J Physiol Endocrinol Metab 292: E577-E584, 2007.
2. Aizawa K, Iemitsu M, Otsuki T, Maeda S, Miyauchi T, Mesaki N. Sex differences in steroidogenesis in skeletal muscle following a single bout of exercise in rats. J Appl Physiol 104: 67-74, 2008.
3. Aizawa K, Iemitsu M, Maeda S, Otsuki T, Sato K, Ushida T, Mesaki N, Akimoto T. Acute exercise activates local bioactive androgen metabolism in skeletal muscle. Steroids 75: 219-223, 2010.
4. Berdanier CD, Parente JA, Jr, McIntosh, MK. Is dehydroepiandrosterone an antiobesity agent? FASEB J 7: 414-419, 1993.
5. Cleary MP, Zisk JF. Anti-obesity effect of two different levels of dehydroepiandrosterone in lean and obese middle-aged female Zucker rats. Int J Obes 10: 193-204, 1986.
6. Coleman DL, Leiter EH, Schwizer RW. Therapeutic effects of dehydroepiandrosterone (DHEA) in diabetic mice. Diabetes 31: 830-833, 1982.
7. Coleman DL, Schwizer RW, Leiter EH. Effect of genetic background on the therapeutic effects of dehydroepiandrosterone (DHEA) in diabetesobesity mutants and in aged normal mice. Diabetes 33: 26-32, 1984.
8. Commerford SR, Ferniza JB, Bizeau ME, Thresher JS, Willis WT, Pagliassotti MJ. Diets enriched in sucrose or fat increase gluconeogenesis and G-6-Pase but not basal glucose production in rats. Am J Physiol Endocrinol Metab 283: E545-E555, 2002.
9. Everson SA, Goldberg DE, Helmrich SP, Lakka TA, Lynch JW, Kaplan GA, Salonen JT. Weight gain and the risk of developing insulin resistance syndrome. Diabetes Care 10: 1637-1643, 1998.
10. Garvey TM, Maianu L, Zhu JH, Brechtel-Hook G, Wallance P, Baron AD. Evidence for defects in the trafficking and translocation of GLUT4 glucose transporters in skeletal muscle as a cause of human insulin resistance. J Clin Invest 101: 2377-2386, 1998.
11. Iemitsu M, Miyauchi T, Maeda S, Tanabe T, Takanashi M, Irukayama-Tomobe Y, Sakai S, Ohmori H, Matsuda M, Yamaguchi I. Aging-induced decrease in the PPAR-α level in hearts is improved by exercise training. Am J Physiol Heart Circ Physiol 283: H1750-H1760, 2002.
12. Ivy JL, Young JC, Craig BW, Kohrt WM, Holloszy JO. Ageing, exercise and food restriction: effects on skeletal glucose uptake. Mech Ageing Dev 61: 123-133, 1991.
13. Jedrzejuk D, Medras M, Milewicz A, Demissie M. Dehydroepiandrosterone replacement in health men with age-related decline of DHEA-S: effects of fat distribution, insulin sensitivity and lipid metabolism. Aging Male 6: 151-156, 2003.
14. Jessen N, Pold R, Buhl ES, Jensen LS, Schmitz O, Lund S. Effects of AICAR and exercise on insulin-stimulated glucose uptake, signaling, and GLUT4 content in rat muscles. J Appl Physiol 94: 1373-1379, 2003.
15. Kapoor D, Malkin CJ, Channer KS, Jones TH. Androgens, insulin resistance and vascular disease in men. Clin Endocrinol 63: 239-250, 2005.
16. Kim Y, Inoue T, Nakajima R, Nakae K, Tamura T, Tokuyama K, Suzuki M. Effects of endurance training on gene expression of insulin signal transduction pathway. Biochem Biophys Res Commun 210: 766-773, 1995.
17. Lea-Currie YR, Wen P, McIntosh MK. Dehydroepiandrosterone-sulfate (DHEAS) reduces adipocyte hyperplasia associated with feeding rats a high-fat diet. Int J Obes Relat Metab Disord 21: 1058-1064, 1997.
18. Leighton B, Tagliaferro AR, Newsholme EA. The effect of DHEA acetate on liver peroxisomal enzyme activities of male and female rats. J Nutr 117: 1287-1290, 1987.
19. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and betacell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28: 412-419, 1985.
20. Mulle M, Grobbee DE, den Tonkelaar I, TLamberts SW, van der Schouw. Endogenous sex hormones and metabolic syndrome in aging men. J Clin Endcrinol Metab 90: 2618-2623, 1982.
21. Nair KS, Rizza RA, O'Brien P, Dhatariya K, Short KR, Nehra A, Vittone JL, Klee GG, Basu A, Basu R, Cobelli C, Toffolo G, Dalla Man C, Tindall DJ, Melton 3rd LJ, Smith GE, Khosla S, Jensen MD. DHEA in elderly women and DHEA or testosterone in elderly men. N Engl J Med 355: 1647-1659, 2006.
22. Nestler JE, Barlascini CO, Clore JN, Blackard G. Dehydroepiandrosterone reduces serum low density lipoprotein levels and body fat but does not alter insulin sensitivity in normal men. J Clin Endocrinol Metab 66: 57-61, 1988.
23. Orentreich N, Brind JL, Rizer RL, Vogelman JH. Age changes and sex differences in serum dehydroepiandrosterone sulfate concentrations throughout adulthood. J Clin Endocrinol Metab 59: 551-555, 1984.
24. Sanchez J, Heredia FP, Priego T, Portillo MP, Zamora S, Garaulet M, Palou A. Dehydroepiandrosterone prevents age-associated alterations, increasing insulin sensitivity. J Nutr Biochem 19: 809-818, 2008.
25. Sato K, Iemitsu M, Aizawa K, Ajisaka R. Testosterone and DHEA activate the glucose metabolism-related signaling pathway in skeletal muscle. Am J Physiol Endocrinol Metab 294: E961-E968, 2008.
26. Sato K, Iemitsu M, Aizawa K, Ajisaka R. DHEA improves impaired activation of Akt and PKC ζ/λ-GLUT4 pathway in skeletal muscle and improves hyperglycaemia in streptozotocin-induced diabetes rats. Acta Physiol 197: 217-225, 2009.
27. Sato Y, Nagasaki M, Nakai N, Fushimi T. Physical exercise improves glucose metabolism in lifestyle-related disease. Exp Biol Med 228: 1208-1212, 2003.
28. Shepherd A, Cleary MP. Metabolic alterations after dehydroepiandrosterone treatment in Zucker rats. Am J Physiol Endocrinol Metab 246: E123-E128, 1984.
29. Tagliaferro AR, Ronan AM, Payne J, Meeker LD, Tse S. Increased lipolysis to _-adrenergic stimulation after dehydroepiandrosterone treatment in rats. Am J Physiol Regul Integr Comp Physiol 268: R1374-R1380, 1995.
30. Villareal DT, Hollszy JO. Effect of DHEA on abdominal fat and insulin action in elderly women and men. JAMA 292: 2243-2248, 2004.
31. Zierath Invited review JR. Exercise training-induced changes in insulin signaling in skeletal muscle. J Appl Physiol 93: 773-781, 2002.