Stability study of steviol glycosides in mock beverages using fluorescent light exposure under ICH guidelines

International Journal of Pharmacy and Pharmaceutical Sciences

Volumn 3, Issue 3, 2011, Pages 316-323

  Chaturvedula, Venkata Sai Prakash ^a   Clos, John F ^a   Prakash, Indra ^a  

^a The Coca Cola Company   (United States)

Author keywords

Degradation products; Fluorescent light exposure; Stability; Steviol glycoside mixture

Indexed keywords

13 [(2 BETA DEXTRO GLUCOPYRANOSYL 3 BETA DEXTRO GLUCOPYRANOSYL BETA DEXTRO GLUCOPYRANOSYL)OXYL 16 HYDROXY ENT KAURAN 19 OIC ACID BETA DEXTRO GLUCOPYRANOSYL ESTER; 13 [2 ALPHA LEVO RHAMNOPYRANOSYL 3 BETA DEXTRO GLUCOPYRANOSYL BETA DEXTRO GLUCOPYRANOSYL)OXY] ENT KAUR 16 EN 19 OIC ACID (2 BETA DEXTRO GLUCOPYRANOSYL BETA DEXTRO GLUCOPYRANOSYL ESTER; 13 [2 BETA DEXTRO GLUCOPYRANOSYL BETA DEXTRO GLUCOPYRANOSYL)OXY] 17 HYDROXY ENT KAUR 15 EN 19 OIC ACID BETA DEXTRO GLUCOPYRANOSYL ESTER; DULCOSIDE A; ESTER DERIVATIVE; GLYCOSIDE; REBAUDIOSIDE; REBAUDIOSIDE B; REBAUDIOSIDE C; RUBUSOSIDE; STEVIOL; STEVIOLBIOSIDE; STEVIOSIDE; UNCLASSIFIED DRUG;

ARTICLE; BEVERAGE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DEGRADATION; DRUG DECOMPOSITION; FLUORESCENT LIGHTING; HETERONUCLEAR SINGLE QUANTUM COHERENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; MASS SPECTROMETRY; PH; PROTON NUCLEAR MAGNETIC RESONANCE;

EID: 79960815676     PISSN: None     EISSN: 09751491     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Mosettig E, Beglinger U, Dolder F, Lichiti H, Quitt P, Waters JA. The absolute configuration of steviol and isosteviol. J. Am. Chem. Soc. 1963; 85: 2305-2309.
2. Mosettig E, Nes WR. Stevioside. II. The structure of the aglucon. J. Org. Chem. 1955; 20: 884-899.
3. Wayne ES, Lin L. NMR studies of the conformation of the natural sweetener rebaudioside A. Carbohydr. Res. 2009; 344: 2533-2538.
4. Brandle JE, Starrratt AN, Gijen M. Stevia rebaudiana: its agricultural, biological and chemical properties. Can. J. Plant Sci. 1998; 78: 527-536.
5. Chaturvedula VSP, Mani U, Prakash I. Diterpene glycosides from Stevia rebaudiana. Molecules. 2011a; 16: 3552-3562.
6. Chaturvedula VSP, Prakash I. A new diterpenoid glycoside from Stevia rebaudiana. Molecules. 2011b; 16: 2937-2943.
7. Chaturvedula VSP, Prakash I. Structures of the novel diterpene glycosides from Stevia rebaudiana. Carbohydr. Res., 2011c; 346: 1057-1060.
8. Chaturvedula VSP, Rhea J, Milanowski D, Mocek U, Prakash I. Two minor diterpene glycosides from the leaves of Stevia rebaudiana. Nat. Prod. Commun. 2011d; 6: 175-178.
9. Chaturvedula VSP, Clos JF, Rhea J, Milanowski D, Mocek U, DuBois GE, Prakash I. Minor diterpene glycosides from the leaves of Stevia rebaudiana. Phytochemistry Lett. 2011e; (in press).
10. Clos JF, DuBois GE, Prakash I. Photostability of rebaudioside A and stevioside in beverages. J. Agric. Food Chem. 2008; 56: 8507-8513.
11. Tanaka T, Nakashima T, Ueda T, Tomii K, Kouno I. Facile discrimination of aldose enantiomers by reversed-phase HPLC. Chem. Pharm. Bull. 2007; 55: 899-901.
12. Ohtani K, Aikawa Y, Kasai R, Chou W, Yamasaki K, Tanaka O. Minor diterpene glycosides from sweet leaves of Rubus suavissimus. Phytochemistry, 1992; 31: 1553-1559.
13. ICH Harmonised Tripartite Guideline, Stability Testing: Photostability testing of new drug substances and products Q1B, Current Step 4 Version, 06 November 1996., [Online], Available: http://www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Quality/Q1B/Step4/Q1B_Guideline.pdf
14. Kobayashi M, Horikawa S, Degrandi IH, Ueno J, Mitsuhashi H. Dulcosides A and B, new diterpene glycosides from Stevia rebaudiana. Phytochemistry 1977; 16: 1405-1408.
15. Ohta M, Sasa S, Inoue A, Tamai T, Fujita I, Morita K, Matsuura F. Characterization of novel steviol glycosides from leaves of Stevia rebaudiana Morita. J. Appl. Glycosci. 2010; 57: 199-209.