Subcutaneous adipose tissue metabolism and pharmacology: A new investigative technique

Canadian Journal of Physiology and Pharmacology

Volumn 89, Issue 6, 2011, Pages 383-391

  Martin, Elizabeth ^a   Brassard, Pascal ^a   Gagnon Auger, Maude ^a   Yale, Philippe ^a   Carpentier, André C ^a   Ardilouze, Jean Luc ^a  

^a CENTRE HOSPITALIER UNIVERSITAIRE DE SHERBROOKE   (Canada)

Author keywords

133xenon washout; Adipose tissue; Blood flow; Microinfusion

Indexed keywords

ALCOHOL; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; INSULIN; N(G) METHYLARGININE; VASOACTIVE AGENT; XENON 133;

ABDOMINAL WALL; ADIPOSE TISSUE BLOOD FLOW; BRADYCARDIA; BRONCHOSPASM; FLOW RATE; GOLD STANDARD; HUMAN; HYPERTENSION; HYPOGLYCEMIA; HYPOTENSION; LASER DOPPLER FLOWMETRY; LIPID METABOLISM; MICRODIALYSIS; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RADIOACTIVITY; REVIEW; SUBCUTANEOUS FAT;

ABDOMINAL WALL; HUMANS; MICRODIALYSIS; REGIONAL BLOOD FLOW; SUBCUTANEOUS FAT; VASOCONSTRICTOR AGENTS; VASODILATOR AGENTS; XENON RADIOISOTOPES;

EID: 79960795877     PISSN: 00084212     EISSN: 12057541     Source Type: Journal    
DOI: 10.1139/y11-039     Document Type: Review

References (61)

1. Ardilouze, J.L. 2004. Regulation of adipose tissue blood flow in humans. Ph.D. thesis, University of Oxford, Oxford, UK. pp. 1-251.
2. Ardilouze, J.L., Fielding, B.A., Currie, J.M., Frayn, K.N., and Karpe, F. 2004a. Nitric oxide and beta-adrenergic stimulation are major regulators of preprandial and postprandial subcutaneous adipose tissue blood flow in humans. Circulation, 109(1): 47-52. doi:10.1161/01.CIR.0000105681.70455.73.
3. Ardilouze, J.L., Karpe, F., Currie, J.M., Frayn, K.N., and Fielding, B. A. 2004b. Subcutaneous adipose tissue blood flow varies between superior and inferior levels of the anterior abdominal wall. Int. J. Obes. Relat. Metab. Disord. 28(2): 228-233.
4. Arner, P., Kriegholm, E., Engfeldt, P., and Bolinder, J. 1990. Adrenergic regulation of lipolysis in situ at rest and during exercise. J. Clin. Invest. 85(3): 893-898. doi:10.1172/JCI114516.
5. Bartness, T.J., and Song, C.K. 2007. Brain-adipose tissue neural crosstalk. Physiol. Behav. 91(4): 343-351. doi:10.1016/j.physbeh.2007.04.002.
6. Blaak, E.E., van Baak, M.A., Kemerink, G.J., Pakbiers, M.T., Heidendal, G.A., and Saris, W.H. 1995. Beta-adrenergic stimulation and abdominal subcutaneous fat blood flow in lean, obese, and reduced-obese subjects. Metabolism, 44(2): 183-187. doi:10.1016/0026-0495(95)90262-7.
7. Bolinder, J., Kerckhoffs, D.A., Moberg, E., Hagström-Toft, E., and Arner, P. 2000. Rates of skeletal muscle and adipose tissue glycerol release in nonobese and obese subjects. Diabetes, 49(5): 797-802. doi:10.2337/diabetes.49.5.797.
8. Bülow, J. 1981. Human adipose tissue blood flow during prolonged exercise, III. Effect of beta-adrenergic blockade, nicotinic acid and glucose infusion. Scand. J. Clin. Lab. Invest. 41(4): 415-424. doi:10.3109/00365518109092065.
9. Bülow, J. 2001. Measurement of adipose tissue blood flow. Methods Mol. Biol. 155: 281-293.
10. Bülow, J., Jelnes, R., Astrup, A., Madsen, J., and Vilmann, P. 1987. Tissue/blood partition coefficients for xenon in various adipose tissue depots in man. Scand. J. Clin. Lab. Invest. 47(1): 1-3.
11. Campbell, P.J., Carlson, M.G., Hill, J.O., and Nurjhan, N. 1992. Regulation of free fatty acid metabolism by insulin in humans: role of lipolysis and reesterification. Am. J. Physiol. 263(6 Pt 1): E1063-E1069.
12. Canadian Nuclear Safety Commission. 2010. Radiation Protection Regulations (SOR/2000-203). Available from lois.justice.gc.ca/eng/SOR-2000-203/page-1.html.
13. Chen, R.Y., Fan, F.C., Kim, S., Jan, K.M., Usami, S., and Chien, S. 1980. Tissue-blood partition coefficient for xenon: temperature and hematocrit dependence. J. Appl. Physiol. 49(2): 178-183.
14. Clark, A.D., Youd, J.M., Rattigan, S., Barrett, E.J., and Clark, M.G. 2001. Heterogeneity of laser Doppler flowmetry in perfused muscle indicative of nutritive and nonnutritive flow. Am. J. Physiol. Heart Circ. Physiol. 280(3): H1324-H1333.
15. Coppack, S.W., Evans, R.D., Fisher, R.M., Frayn, K.N., Gibbons, G. F., Humphreys, S.M., et al. 1992. Adipose tissue metabolism in obesity: lipase action in vivo before and after a mixed meal. Metabolism, 41(3): 264-272. doi:10.1016/0026-0495(92)90269-G.
16. Crandall, D.L., Hausman, G.J., and Kral, J.G. 1997. A review of the microcirculation of adipose tissue: anatomic, metabolic, and angiogenic perspectives. Microcirculation, 4(2): 211-232. doi:10.3109/10739689709146786.
17. Dimitriadis, G., Lambadiari, V., Mitrou, P., Maratou, E., Boutati, E., Panagiotakos, D.B., et al. 2007. Impaired postprandial blood flow in adipose tissue may be an early marker of insulin resistance in type 2 diabetes. Diabetes Care, 30(12): 3128-3130. doi:10.2337/dc07-0699.
18. DiPiazza, H.J., and Harbert, J.C. 1983. Preparation of sterile xenon- 133 in saline for tissue perfusion studies. J. Nucl. Med. 24(11): 1070-1071.
19. Enevoldsen, L.H., Simonsen, L., Stallknecht, B., Galbo, H., and Bulow, J. 2001. In vivo human lipolytic activity in preperitoneal and subdivisions of subcutaneous abdominal adipose tissue. Am. J. Physiol. Endocrinol. Metab. 281(5): E1110-E1114.
20. Enoksson, S., Nordenstrom, J., Bolinder, J., and Arner, P. 1995. Influence of local blood flow on glycerol levels in human adipose tissue. Int. J. Obes. Relat. Metab. Disord. 19(5): 350-354.
21. Frayn, K.N., Karpe, F., Fielding, B.A., Macdonald, I.A., and Coppack, S.W. 2003. Integrative physiology of human adipose tissue. Int. J. Obes. Relat. Metab. Disord. 27(8): 875-888. doi:10.1038/sj.ijo.0802326.
22. Galitzky, J., Lafontan, M., Nordenstrom, J., and Arner, P. 1993. Role of vascular alpha-2 adrenoceptors in regulating lipid mobilization from human adipose tissue. J. Clin. Invest. 91(5): 1997-2003. doi:10.1172/JCI116421.
23. Goossens, G.H., McQuaid, S.E., Dennis, A.L., van Baak, M.A., Blaak, E.E., Frayn, K.N., et al. 2006. Angiotensin II: a major regulator of subcutaneous adipose tissue blood flow in humans. J. Physiol. 571(2): 451-460. doi:10.1113/jphysiol.2005.101352.
24. Hagström, E., Arner, P., Ungerstedt, U., and Bolinder, J. 1990. Subcutaneous adipose tissue: a source of lactate production after glucose ingestion in humans. Am. J. Physiol. 258(5 Pt. 1): E888-E893.
25. Hickner, R.C., Rosdahl, H., Borg, I., Ungerstedt, U., Jorfeldt, L., and Henriksson, J. 1992. The ethanol technique of monitoring local blood flow changes in rat skeletal muscle: implications for microdialysis. Acta Physiol. Scand. 146(1): 87-97. doi:10.1111/j.1748-1716.1992.tb09396.x.
26. Jansson, P.A., Larsson, A., and Lönnroth, P.N. 1998. Relationship between blood pressure, metabolic variables and blood flow in obese subjects with or without non-insulin-dependent diabetes mellitus. Eur. J. Clin. Invest. 28(10): 813-818. doi:10.1046/j.1365-2362.1998.00360.x.
27. Jansson, P.A., and Lönnroth, P. 1995. Comparison of two methods to assess the tissue/blood partition coefficient for xenon in subcutaneous adipose tissue in man. Clin. Physiol. 15(1): 47-55. doi:10.1111/j.1475-097X.1995.tb00429.x.
28. Jelnes, R., Astrup, A., and Bulow, J. 1985. The double isotope technique for in vivo determination of the tissue-to-blood partition coefficient for xenon in human subcutaneous adipose tissue-an evaluation. Scand. J. Clin. Lab. Invest. 45(6): 565-568. doi:10. 3109/00365518509155260.
29. Johnson, D., Cormack, G.C., Abrahams, P.H., and Dixon, A.K. 1996. Computed tomographic observations on subcutaneous fat: implications for liposuction. Plast. Reconstr. Surg. 97(2): 387-396. doi:10.1097/00006534-199602000-00017.
30. Kaplan, N.M. 1992. The appropriate goals of antihypertensive therapy: neither too much nor too little. Ann. Intern. Med. 116 (8): 686-690.
31. Karpe, F., Fielding, B.A., Ardilouze, J.L., Ilic, V., Macdonald, I.A., and Frayn, K.N. 2002a. Effects of insulin on adipose tissue blood flow in man. J. Physiol. 540(3): 1087-1093. doi:10.1113/jphysiol.2001.013358.
32. Karpe, F., Fielding, B.A., Ilic, V., Humphreys, S.M., and Frayn, K.N. 2002b. Monitoring adipose tissue blood flow in man: a comparison between the (133)xenon washout method and microdialysis. Int. J. Obes. Relat. Metab. Disord. 26(1): 1-5. doi:10.1038/sj.ijo.0801843.
33. Karpe, F., Fielding, B.A., Ilic, V., Macdonald, I.A., Summers, L.K., and Frayn, K.N. 2002c. Impaired postprandial adipose tissue blood flow response is related to aspects of insulin sensitivity. Diabetes, 51(8): 2467-2473. doi:10.2337/diabetes.51.8.2467.
34. 133Xenon washout technique and Laser Doppler flowmetry in the measurement of local vasoconstrictor effects on the microcirculation in subcutaneous tissue and skin. Clin. Physiol. 7(5): 403-409. doi:10.1111/j.1475-097X.1987.tb00182.x.
35. Kety, S.S. 1948. Quantitative measurement of regional circulation by the clearance of radioactive sodium. Am. J. Med. Sci. 215(3): 352.
36. Klassen, G.A., Janigan, D., Paton, B., Mathews, J., Perey, B., Macdonald, A.S., and Barclay, K.D. 1996. Body position, age and mass effect of adiposity on adipose tissue red cell flux in morbid obesity. Obes. Res. 4(2): 145-151.
37. Kotzerke, J., Glatting, G., van den Hoff, J., Höher, M., Neumaier, B., Wöhrle, J., and Reske, S.N. 2001. Validation of myocardial blood flow estimation with nitrogen-13 ammonia PET by the argon inert gas technique in humans. Eur. J. Nucl. Med. 28(3): 340-345. doi:10.1007/s002590000459.
38. Kreier, F., Fliers, E., Voshol, P.J., Van Eden, C.G., Havekes, L.M., Kalsbeek, A., et al. 2002. Selective parasympathetic innervation of subcutaneous and intra-abdominal fat-functional implications. J. Clin. Invest. 110(9): 1243-1250.
39. Laaksonen, D.E., Nuutinen, J., Lahtinen, T., Rissanen, A., and Niskanen, L.K. 2003. Changes in abdominal subcutaneous fat water content with rapid weight loss and long-term weight maintenance in abdominally obese men and women. Int. J. Obes. Relat. Metab. Disord. 27(6): 677-683. doi:10.1038/sj.ijo.0802296.
40. Lafontan, M., and Arner, P. 1996. Application of in situ microdialysis to measure metabolic and vascular responses in adipose tissue. Trends Pharmacol. Sci. 17(9): 309-313. doi:10.1016/0165-6147 (96)40002-5.
41. Larsen, O.A., Lassen, N.A., and Quaade, F. 1966. Blood flow through human adipose tissue determined with radioactive xenon. Acta Physiol. Scand. 66(3): 337-345. doi:10.1111/j.1748-1716.1966.tb03208.x.
42. Lassen, N.A. 1964. Muscle blood flow in normal man and in patients with intermittent claudication evaluated by simultaneous Xe-133 and Na24 clearances. J. Clin. Invest. 43(9): 1805-1812. doi:10.1172/JCI105054.
43. Lassen, N.A., Hoedt-Rasmussen, K., Lindbjerg, I., Pedersen, F., and Munck, O. 1963. Muscle blood flow determined by use of Xenon133. Scand. J. Clin. Lab. Invest. 15(Suppl. 76): 61.
44. Linde, B., and Hjemdahl, P. 1982. Effect of tilting on adipose tissue vascular resistance and sympathetic activity in humans. Am. J. Physiol. 242(2): H161-H167.
45. Lönnroth, P., Jansson, P.A., Fredholm, B.B., and Smith, U. 1989. Microdialysis of intercellular adenosine concentration in subcutaneous tissue in humans. Am. J. Physiol. 256(2 Pt. 1): E250-E255.
46. Ménard, S.L., Ci, X., Frisch, F., Normand-Lauzière, F., Cadorette, J., Ouellet, R., et al. 2009. Mechanism of reduced myocardial glucose utilization during acute hypertriglyceridemia in rats. Mol. Imaging Biol. 11(1): 6-14. doi:10.1007/s11307-008-0171-2.
47. Saha, G.B. 2003. Fundamentals of Nuclear Pharmacy. 5th ed. Springer, New York, N.Y. Chapter 7, p. 129.
48. Samra, J.S., Simpson, E.J., Clark, M.L., Forster, C.D., Humphreys, S. M., Macdonald, I.A., and Frayn, K.N. 1996. Effects of epinephrine infusion on adipose tissue: interactions between blood flow and lipid metabolism. Am. J. Physiol. 271(5 Pt. 1): E834-E839.
49. Sethi, J.K., and Vidal-Puig, A.J. 2007. Thematic review series: adipocyte biology. Adipose tissue function and plasticity orchestrate nutritional adaptation. J. Lipid Res. 48(6): 1253-1262. doi:10.1194/jlr.R700005-JLR200.
50. Simonsen, L., Bulow, J., Astrup, A., Madsen, J., and Christensen, N. J. 1990. Diet-induced changes in subcutaneous adipose tissue blood flow in man: effect of b-adrenoceptor inhibition. Acta Physiol. Scand. 139(2): 341-346. doi:10.1111/j.1748-1716.1990.tb08932.x.
51. 133Xe clearance. Evaluation of a new labelling technique. Clin. Physiol. Funct. Imaging, 23(6): 320-323. doi:10.1046/j.1475-0961.2003.00509.x.
52. Stallknecht, B., Lorentsen, J., Enevoldsen, L.H., Bulow, J., Biering-Sorensen, F., Galbo, H., and Kjaer, M. 2001. Role of the sympathoadrenergic system in adipose tissue metabolism during exercise in humans. J. Physiol. 536(1): 283-294. doi:10.1111/j.1469-7793.2001.00283.x.
53. Summers, L.K., Samra, J.S., and Frayn, K.N. 1999. Impaired postprandial tissue regulation of blood flow in insulin resistance: a determinant of cardiovascular risk? Atherosclerosis, 147(1): 11-15. doi:10.1016/S0021-9150(99)00172-0.
54. Summers, L.K., Samra, J.S., Humphreys, S.M., Morris, R.J., and Frayn, K.N. 1996. Subcutaneous abdominal adipose tissue blood flow: variation within and between subjects and relationship to obesity. Clin. Sci. (Lond.), 91(6): 679-683.
55. Tafeit, E., Moller, R., Pieber, T.R., Sudi, K., and Reibnegger, G. 2000. Differences of subcutaneous adipose tissue topography in type-2 diabetic (NIDDM) women and healthy controls. Am. J. Phys. Anthropol. 113(3): 381-388. doi:10.1002/1096-8644(200011)113:3<381::AID-AJPA8>3.0.CO;2-T.
56. Tan, G.D., Goossens, G.H., Humphreys, S.M., Vidal, H., and Karpe, F. 2004. Upper and lower body adipose tissue function: a direct comparison of fat mobilization in humans. Obes. Res. 12(1): 114-118. doi:10.1038/oby.2004.15.
57. van den Hoff, J., Burchert, W., Borner, A.R., Fricke, H., Kuhnel, G., Meyer, G.J., et al. 2001. [1-(11)C]Acetate as a quantitative perfusion tracer in myocardial PET. J. Nucl. Med. 42(8): 1174-1182.
58. Virtanen, K.A., Lönnroth, P., Parkkola, R., Peltoniemi, P., Asola, M., Viljanen, T., et al. 2002. Glucose uptake and perfusion in subcutaneous and visceral adipose tissue during insulin stimulation in nonobese and obese humans. J. Clin. Endocrinol. Metab. 87 (8): 3902-3910. doi:10.1210/jc.87.8.3902.
59. Virtanen, K.A., Peltoniemi, P., Marjamaki, P., Asola, M., Strindberg, L., Parkkola, R., et al. 2001. Human adipose tissue glucose uptake determined using [(18)F]-fluoro-deoxy-glucose ([(18)F]FDG) and PET in combination with microdialysis. Diabetologia, 44(12): 2171-2179. doi:10.1007/s001250100026.
60. Wellhöner, P., Rolle, D., Lonnroth, P., Strindberg, L., Elam, M., and Dodt, C. 2006. Laser-Doppler flowmetry reveals rapid perfusion changes in adipose tissue of lean and obese females. Am. J. Physiol. Endocrinol. Metab. 291(5): E1025-E1030. doi:10.1152/ajpendo.00120.2006.
61. Yeh, S.Y., and Peterson, R.E. 1965. Solubility of krypton and xenon in blood, protein solutions, and tissue homogenates. J. Appl. Physiol. 20(5): 1041-1047.