Histomorphometric changes in the perirenal adipocytes of adrenalectomized rats treated with dexamethasone

Clinics

Volumn 66, Issue 5, 2011, Pages 849-853

  Ahmad, Fairus ^a   Soelaiman, Ima Nirwana ^a   Ramli, Elvy Suhana Mohd ^a   Hooi, Tan Ming ^b   Suhaimi, Farihah H ^a  

^a UNIVERSITI KEBANGSAAN MALAYSIA   (Malaysia)

^b UNIVERSITI TUNKU ABDUL RAHMAN   (Malaysia)

Author keywords

11 hydroxysteroid dehydrogenase type 1; Adrenalectomized rat; Dexamethasone; Hyperplasia; Perirenal fat

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; DEXAMETHASONE; GLUCOCORTICOID;

ADIPOCYTE; ADIPOSE TISSUE; ADRENALECTOMY; ANIMAL; ARTICLE; CYTOLOGY; DRUG EFFECT; ENZYMOLOGY; IMMUNOHISTOCHEMISTRY; INTRAABDOMINAL FAT; KIDNEY; MALE; METABOLISM; RAT; SPRAGUE DAWLEY RAT;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; ADIPOCYTES; ADIPOSE TISSUE; ADRENALECTOMY; ANIMALS; DEXAMETHASONE; GLUCOCORTICOIDS; IMMUNOHISTOCHEMISTRY; INTRA-ABDOMINAL FAT; KIDNEY; MALE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 79960791226     PISSN: 18075932     EISSN: None     Source Type: Journal    
DOI: 10.1590/S1807-59322011000500023     Document Type: Article

References (21)

1. Reaven G. Metabolic syndrome: pathophysiology and implications for management of cardiovascular disease. Circulation. 2002;106:286-8 doi: 10.1161/01.CIR.0000019884.36724.D9.
2. Roberts SR, Mayer J, Heyman MB, editors. Dietary fat intake and regulation of energy balance: implications for obesity. Proceeding of the Dietary Composition and Obesity: Do We Need to Look Beyond Dietry Fat?; 2000 April 17 - 21; Washington, DC. J. Nutr. 2000;130:284-8.
3. Cinti S. The adipose organ. In: Fantuzzi G, Mazzone T, editors. Nutrition and health: adipose tissue and adipokines in health and disease. Totowa: Human Press Inc; 2007. p. 3-19.
4. Jernas M, Palming J, Sjoholm K, Jennische E, Svensson PA, Gabrielsson BG, et al. Separation of human adipocytes by sizes: hypertrophic fat cells display distinct gene expression. FASEB J. 2006;20:832-9.
5. Stimson RH, Walker BR. 11β-hydroxysteroid dehydrogenase Type 1 and obesity. In: Donohoue PA, editor. Contemporary endocrinology: energy metabolism and obesity: research and clinical applications. Totowa: Human Press Inc; 2007. p. 175-96.
6. Tomlinson JW, Walker EA, Bujalska IJ, Draper N, Lavery GG, Cooper MS, et al. 11β-hydroxysteroid dehydrogenase type 1: tissue specific regulator of glucocorticoid response. Endocr Rev. 2004;25:831-66 doi: 10.1210/er.2003-0031.
7. Stulnig TM, Waldhausl W. Review: 11β-Hydroxysteroid dehydrogenase type 1 obesity and type 2 diabetes. Diabetologia. 2004;47:1-11 doi: 10.1007/s00125-003-1284-4.
8. Makimura H, Mizuno TM, Roberts J, Silverstein J, Beasley J, Mobbs CV. Adrenalectomy reverses obese phenotype and restores hypothalamic melanocortin tone in leptin-deficient ob/ob mice. Diabetes. 2000;49:1917-23 doi: 10.2337/diabetes.49.11.1917.
9. Tung YL, Hewson AK, Dickson SL. Glucocorticoid-dependent stimula- tion of adiposity and appetite by a ghrelin mimetic in the rat. Eur J Endocrinol. 2004;150:905-11.
10. Ima-Nirwana S, Suhainiza S. Effects of tocopherols and tocotrienols on body composition and bone calcium content in adrenalectomized rats replaced with Dexamethasone. J Med Food. 2004;7:45-51 doi: 10.1089/ 109662004322984699.
11. Livingstone DEW, Kenyon CJ, Walker BR. Mechanisms of dysregulation of 11β-hydroxysteroid dehydrogenase type 1 in obese Zucker rats. J Endocrinol. 2000;167:533-9, doi: 10.1677/joe.0.1670533.
12. Ima-Nirwana S, Fakhrurazi H. Palm vitamin E protects bone against Dexamethasone-induced osteoporosis in male rats. Med J Malaysia. 2002;57:136-43.
13. Moison MP, Seckl JR, Edwards CRW. 11β-hydroxysteroid dehydrogen- ase bioactivity and messenger RNA expression in rat forebrain: localization in hypothalamus, hippocampus and cortex. Endocrinology. 1990;127:1450-5 doi: 10.1210/endo-127-3-1450.
14. Archer ZO, Rayner DV, Rozman J, Klingenspor M, Mercer JG. Normal distribution of body weight gain in male Spraque-Dawley rats fed a high-energy diet. Obes Res. 2003;11:1376-83 doi: 10.1038/oby.2003.186.
15. Ma K, Mallidis C, Bhasin S, Mahabadi V, Artaza J, Gonzalez-Cadavid N, et al. Glucocorticoid-induced skeletal muscle atrophy is associated with upregulation of myostatin gene expression. Am J Physiol Endocrinol Metab. 2003;285:363-71.
16. Rooman K, Koster JG, Bloemen R, Gresnigt R, van Buul-Offers SC. The effect of dexamethasone on body and organ growth of normal and IGF- II-transgenic mice. J Endocrinol. 1999;163:543-52 doi: 10.1677/joe.0. 1630543.
17. Freedman MR, Horwitz BA, Stern JS. Effect of adrenalectomy and glucocorticoid replacement on development of obesity. Am J Physiol. 1986;250:595-607.
18. DiGirolamo M, Fine JB, Tagra K, Rossmanith R. Qualitative regional differences in adipose tissue growth and cellularity in male Wistar rat fed ad libitum. Am J Physiol Regul Integr Comp Physiol. 1998;274:1460-7.
19. Ayida AW, Wan Nazaimoon WM, Farihah HS, Azian AL. Effect of ovariectomy, Labisia pumila var alata treatment and estrogen replace- ment therapy on the morphology of adipose tissue in ovariectomised Spraque Dawley rats. J Med. 2007;1:1.
20. Balachandran A, Guan H, Sellan M, van Uum S, Yang K. Insulin and Dexamethasone dynamically regulate adipocyte 11β-hydroxysteroid dehydrogenase type 1. Endocrinology. 2008;149:4069-79 doi: 10.1210/ en.2008-0088.
21. Bujalska IJ, Durrani OM, Abbott J, Onyimba CU, Khosla P, Moosavi AH, et al. Characterisation of 11β-hydroxysteroid dehydrogenase 1 in human orbital adipose tissue: a comparasion with subcutaneous and omental fat. J Endocrinol. 2007;192:279-88 doi: 10.1677/JOE-06-0042.