Anti-inflammatory treatment for contact dermatitis by topical leptomycin B: Inhibitory effects on the induced expression of matrix metalloproteinases (MMP)-9 and -3

European Journal of Dermatology

Volumn 21, Issue 3, 2011, Pages 438-439

  Kobayashi, Takashi ^a  

^a NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1 FLUORO 2,4 DINITROBENZENE; GELATINASE B; LEPTOMYCIN B; STROMELYSIN;

ACANTHOSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; CONTACT DERMATITIS; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; ERYTHEMA; HISTOPATHOLOGY; LETTER; MONONUCLEAR CELL; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PAPULE; PARAKERATOSIS; PROTEIN EXPRESSION; SKIN INFLAMMATION; ZYMOGRAPHY;

ADMINISTRATION, TOPICAL; ANIMALS; ANTIFUNGAL AGENTS; DERMATITIS, CONTACT; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FATTY ACIDS, UNSATURATED; MATRIX METALLOPROTEINASE 3; MATRIX METALLOPROTEINASE 9; MICE; MICE, HAIRLESS; TREATMENT OUTCOME;

EID: 79960786748     PISSN: 11671122     EISSN: 19524013     Source Type: Journal    
DOI: 10.1684/ejd.2011.1336     Document Type: Letter

References (6)

1. Kobayashi T. Is matrix metalloproteinase (MMP)-9 a culprit involved in dermatitis? Increased expression of gelatinolytic activity in allergic contact dermatitis. Contact Dermatitis 2011; 64: 171-2.
2. Kobayashi T, Shinkai H. Leptomycin B reduces matrix metalloproteinase-9 expression and suppresses cutaneous inflammation. J Invest Dermatol 2005; 124: 331-7.
3. Nosbaum A, Vocanson M, Rozieres A, Hennino A, Nicolas JF. Allergic and irritant contact dermatitis. Eur J Dermatol 2009; 19: 325-32.
4. Berth-Jones J. Topical therapy. In: Goodfield MJD, Jones SK, Veale DJ, Burns T, Breathnach S, Cox N, Griffiths C, eds. Textbook of Dermatology. 7th ed. Oxford: Blackwell Scientific Publications, 2004: 75: 1-52.
5. Nishi K, Yoshida M, Fujiwara D, Nishikawa M, Horinouchi S, Beppu T. Leptomycin B targets a regulatory cascade of crm1, a fission yeast nuclear protein, involved in control of higher order chromosome structure and gene expression. J Biol Chem 1994; 269: 6320-4.
6. Wang M, Qin X, Mudgett JS, Ferguson TA, Senior RM, Welgus HG. Matrix metalloproteinase deficiencies affect contact hypersensitivity: stromelysin-1 deficiency prevents the response and gelatinase B deficiency prolongs the response. Proc Natl Acad Sci USA 1999; 96: 6885-9.