The reduction in human motoneurone responsiveness during muscle fatigue is not prevented by increased muscle spindle discharge

Journal of Physiology

Volumn 589, Issue 15, 2011, Pages 3731-3738

  McNeil, Chris J ^a   Giesebrecht, Sabine ^a   Khan, Serajul I ^a   Gandevia, Simon C ^a   Taylor, Janet L ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; BICEPS BRACHII MUSCLE; CONTROLLED STUDY; EVOKED MUSCLE RESPONSE; FEMALE; FLEXOR MUSCLE; HUMAN; HUMAN EXPERIMENT; MALE; MASTOID; MOTONEURON; MOTOR CORTEX; MUSCLE CONTRACTION; MUSCLE FATIGUE; MUSCLE SPINDLE; MUSCLE SPINDLE AFFERENT NERVE; NERVE CELL EXCITABILITY; NEUROMUSCULAR FACILITATION; NORMAL HUMAN; PRIORITY JOURNAL; PYRAMIDAL TRACT; STIMULUS RESPONSE; TENDON; TRANSCRANIAL MAGNETIC STIMULATION; VIBRATION; VOLUNTEER;

ADULT; ELBOW JOINT; ELECTRIC STIMULATION; ELECTROMYOGRAPHY; EVOKED POTENTIALS, MOTOR; FEMALE; HUMANS; MALE; MOTOR CORTEX; MOTOR NEURONS; MUSCLE CONTRACTION; MUSCLE FATIGUE; MUSCLE SPINDLES; MUSCLE, SKELETAL; NEURONS, AFFERENT; PYRAMIDAL TRACTS; TENDONS; TRANSCRANIAL MAGNETIC STIMULATION; VIBRATION;

EID: 79960784880     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2011.210252     Document Type: Article

References (32)

1. Bigland-Ritchie BR, Dawson NJ, Johansson RS & Lippold OC (1986). Reflex origin for the slowing of motoneurone firing rates in fatigue of human voluntary contractions. J Physiol 379, 451-459.
2. Bongiovanni LG & Hagbarth KE (1990). Tonic vibration reflexes elicited during fatigue from maximal voluntary contractions in man. J Physiol 423, 1-14.
3. Butler JE, Taylor JL & Gandevia SC (2003). Responses of human motoneurons to corticospinal stimulation during maximal voluntary contractions and ischemia. J Neurosci 23, 10224-10230.
4. De Gail P, Lance JW & Neilson PD (1966). Differential effects on tonic and phasic reflex mechanisms produced by vibration of muscles in man. J Neurol Neurosurg Psychiatry 29, 1-11.
5. Eccles JC, Eccles RM & Lundberg A (1957). The convergence of monosynaptic excitatory afferents on to many different species of alpha motoneurones. J Physiol 137, 22-50.
6. Gandevia SC, Petersen N, Butler JE & Taylor JL (1999). Impaired response of human motoneurones to corticospinal stimulation after voluntary exercise. J Physiol 521, 749-759.
7. Garland SJ (1991). Role of small diameter afferents in reflex inhibition during human muscle fatigue. J Physiol 435, 547-558.
8. Heckman CJ & Binder MD (1988). Analysis of effective synaptic currents generated by homonymous Ia afferent fibers in motoneurons of the cat. J Neurophysiol 60, 1946-1966.
9. Holmgren H, Larsson LE & Pedersen S (1990). Late muscular responses to transcranial cortical stimulation in man. Electroencephalogr Clin Neurophysiol 75, 161-172.
10. Jackson A, Baker SN & Fetz EE (2006). Tests for presynaptic modulation of corticospinal terminals from peripheral afferents and pyramidal tract in the macaque. J Physiol 573, 107-120.
11. Kernell D & Monster AW (1982). Time course and properties of late adaptation in spinal motoneurones of the cat. Exp Brain Res 46, 191-196.
12. Kirkwood PA & Sears TA (1982). The effects of single afferent impulses on the probability of firing of external intercostal motoneurones in the cat. J Physiol 322, 315-336.
13. Kossev A, Siggelkow S, Schubert M, Wohlfarth K & Dengler R (1999). Muscle vibration: different effects on transcranial magnetic and electrical stimulation. Muscle Nerve 22, 946-948.
14. Macefield G, Hagbarth KE, Gorman R, Gandevia SC & Burke D (1991). Decline in spindle support to α-motoneurones during sustained voluntary contractions. J Physiol 440, 497-512.
15. Macefield VG, Gandevia SC, Bigland-Ritchie B, Gorman RB & Burke D (1993). The firing rates of human motoneurones voluntarily activated in the absence of muscle afferent feedback. J Physiol 471, 429-443.
16. McNeil CJ, Martin PG, Gandevia SC & Taylor JL (2009). The response to paired motor cortical stimuli is abolished at a spinal level during human muscle fatigue. J Physiol 587, 5601-5612.
17. Magladery JW, Porter WE, Park AM & Teasdall RD (1951). Electrophysiological studies of nerve and reflex activity in normal man. IV. The two-neurone reflex and identification of certain action potentials from spinal roots and cord. Bull Johns Hopkins Hosp 88, 499-519.
18. Martin PG, Smith JL, Butler JE, Gandevia SC & Taylor JL (2006). Fatigue-sensitive afferents inhibit extensor but not flexor motoneurons in humans. J Neurosci 26, 4796-4802.
19. Martin PG, Weerakkody N, Gandevia SC & Taylor JL (2008). Group III and IV muscle afferents differentially affect the motor cortex and motoneurones in humans. J Physiol 586, 1277-1289.
20. Nielsen J & Petersen N (1994). Is presynaptic inhibition distributed to corticospinal fibres in man? J Physiol 477, 47-58.
21. Petersen NT, Taylor JL, Butler JE & Gandevia SC (2003). Depression of activity in the corticospinal pathway during human motor behavior after strong voluntary contractions. J Neurosci 23, 7974-7980.
22. Petersen NT, Taylor JL & Gandevia SC (2002). The effect of electrical stimulation of the corticospinal tract on motor units of the human biceps brachii. J Physiol 544, 277-284.
23. Roll JP, Vedel JP & Ribot E (1989). Alteration of proprioceptive messages induced by tendon vibration in man: a microneurographic study. Exp Brain Res 76, 213-222.
24. Rosenkranz K & Rothwell JC (2003). Differential effect of muscle vibration on intracortical inhibitory circuits in humans. J Physiol 551, 649-660.
25. Rudomin P & Schmidt RF (1999). Presynaptic inhibition in the vertebrate spinal cord revisited. Exp Brain Res 129, 1-37.
26. Sacco P, Newberry R, McFadden L, Brown T & McComas AJ (1997). Depression of human electromyographic activity by fatigue of a synergistic muscle. Muscle Nerve 20, 710-717.
27. Stuart M, Butler JE, Collins DF, Taylor JL & Gandevia SC (2002). The history of contraction of the wrist flexors can change cortical excitability. J Physiol 545, 731-737.
28. Taylor JL, Butler JE, Allen GM & Gandevia SC (1996). Changes in motor cortical excitability during human muscle fatigue. J Physiol 490, 519-528.
29. Taylor JL, Petersen N, Butler JE & Gandevia SC (2000). Ischaemia after exercise does not reduce responses of human motoneurones to cortical or corticospinal tract stimulation. J Physiol 525, 793-801.
30. Todd G, Butler JE, Taylor JL & Gandevia SC (2005). Hyperthermia: a failure of the motor cortex and the muscle. J Physiol 563, 621-631.
31. Todd G, Taylor JL, Butler JE, Martin PG, Gorman RB & Gandevia SC (2007). Use of motor cortex stimulation to measure simultaneously the changes in dynamic muscle properties and voluntary activation in human muscles. J Appl Physiol 102, 1756-1766.
32. Ugawa Y, Rothwell JC, Day BL, Thompson PD & Marsden CD (1991). Percutaneous electrical stimulation of corticospinal pathways at the level of the pyramidal decussation in humans. Ann Neurol 29, 418-427.