The effect of a flavonoid fractions diosmin + hesperidin on radiation-induced acute proctitis in a rat model

Journal of Cancer Research and Therapeutics

Volumn 7, Issue 2, 2011, Pages 152-156

  Sezer, Atakan ^a   Usta, Ufuk ^a   Kocak, Zafer ^a   Yagci, Mehmet Ali ^a  

^a TRAKYA UNIVERSITY   (Turkey)

Author keywords

Acute radiation proctitis; Daflon; flavonoid fractions; radiotherapy

Indexed keywords

COBALT 60; DAFLON;

ANIMAL EUTHANASIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COBALT THERAPY; CONTROLLED STUDY; CRYPT CELL; DRUG EFFECT; DRUG EFFICACY; FEMALE; HISTOPATHOLOGY; INFLAMMATORY CELL; INFLAMMATORY INFILTRATE; IRRADIATION; MICROSCOPY; MUCOSA INFLAMMATION; NONHUMAN; PROCTITIS; RADIATION DOSE; RADIATION INJURY; RADIATION PROTECTION; RAT; SHAM PROCEDURE;

ACUTE DISEASE; ANIMALS; DIOSMIN; DISEASE MODELS, ANIMAL; FEMALE; INDOLES; INTESTINAL MUCOSA; PROCTITIS; RADIATION INJURIES, EXPERIMENTAL; RADIATION-PROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; RECTUM; SULFONAMIDES;

EID: 79960772713     PISSN: 09731482     EISSN: 19984138     Source Type: Journal    
DOI: 10.4103/0973-1482.82927     Document Type: Article

References (24)

1. Reis ED, Vine AJ, Heimann T. Radiation damage to the rectum and anus: Pathophysiology, clinical features and surgical implications. Colorectal Dis 2002;4:2-12. (Pubitemid 34285249)
2. th ed. New York: Lippincott-Raven Press; 1997. p. 307-21.
3. Hovdenak N, Fajardo LF, Hauer-Jensen M. Acute radiation proctitis: A sequential clinicopathologic study during pelvic radiotherapy. Int J Radiat Oncol Biol Phys 2000;48:1111-7.
4. Korkut C, Asoglu O, Aksoy M, Kapran Y, Bilge H, Kiremit-Korkut N, et al. Histopathological comparison of topical therapy modalities for acute radiation proctitis in an experimental rat model. World J Gastroenterol 2006;12:4879-83. (Pubitemid 44323216)
5. Gul YA, Prasannan S, Jabar FM, Shaker AR, Moissinac K. Pharmacotherapy for chronic hemorrhagic radiation proctitis. World J Surg 2002;26:1499-502. (Pubitemid 36920213)
6. Vernia P, Fracasso PL, Casale V, Villotti G, Marcheggiano A, Stigliano V, et al. Topical butyrate for acute radiation proctitis: Randomised, crossover trial. Lancet 2000;356;1232-5.
7. Cavcić J, Turcić J, Martinac P, Jelincić Z, Zupancić B, Panijan-Pezerović R, et al. Metronidazole in the treatment of chronic radiation proctitis: Clinical trial. Croat Med J 2000; 4: 314-8.
8. Kneebone A, Mameghan H, Bolin T, Berry M, Turner S, Kearsley J, et al. The effect of oral sucralfate on the acute proctitis associated with prostate radiotherapy: A double-blind, randomized trial. Int J Radiat Oncol Biol Phys 2001;5:628-35.
9. Al-Sabbagh R, Sinicrope FA, Sellin JH, Shen Y, Roubein L. Evaluation of short-chain fatty acid enemas: Treatment of radiation proctitis. Am J Gastroenterol 1996;91:1814-6. (Pubitemid 26307188)
10. Jones K, Evans AW, Bristow RG, Levin W Treatment of radiation proctitis with hyperbaric oxygen. Radiother Oncol 2006;78:91-4. (Pubitemid 43136540)
11. Freund U, Schölmerich J, Siems H, Kluge F, Schäfer HE, Wannenmacher M. Unwanted side-effects in using mesalazine (5-aminosalicylic acid) during radiotherapy. Strahlenther Onkol 1987;163:678-80. (Pubitemid 18075124)
12. Luna-Perez P, Rodriguez-Ramirez SE. Formalin instillation for refractory radiation-induced hemorrhagic proctitis. J Surg Oncol 2002;80:41-4. (Pubitemid 34477734)
13. Pickelmann S, Nolte D, Leiderer R, Möllmann M, Schütze E, Messmer K. Effects of the phlebotropic drug Daflon 500mg on postischemic microvascular disturbances in striated skin muscle: An intravital microscopic study in the hamster. J Lab Clin Med 1999;134:526-35. (Pubitemid 29530703)
14. Labrid C. Pharmacologic properties of Daflon 500 mg. Angiology 1994;45:524-30. (Pubitemid 24179188)
15. Buell MG, Hardins RK. Proinflammatory effects of local abdominal irradiation on rat gastrointestinal tract. Dig Dis Sci 1989;34:390-9. (Pubitemid 19088780)
16. Gelfand MD, Tepper M, Katz LA, Binder HJ, Yesner R, Floch MH. cute irradiation proctitis in man: Development of eosinophilic crypt abscesses. Gastroenterology 1968;54:401-11.
17. Zand RS, Jenkins DJ, Diamandis EP. Steroid hormone activity of Flavonoids and related compounds. Breast Cancer Res Treat 2000;62:35-49. (Pubitemid 30609562)
18. Launois R. At the crossroads of venous insufficiency and hemorrhoidal disease: Daflon 500 mg. repercussions of venous insufficiency on everyday life. Angiology 1994;45:495-504. (Pubitemid 24179185)
19. Lonchampt M, Guardiola B, Sicot N, Bertrand M, Perdrix L, Duhault J. Protective effect of a purified flavonoid fraction against reactive oxygen radicals. In vivo and in vitro study. Arzneimittelforschung 1989;39:882-5. (Pubitemid 19204691)
20. Jean T, Bodinier MC. Mediators involved in inflammation: Effects of Daflon 500 mg on their release. Angiology 1994;45:554-9. (Pubitemid 24179193)
21. Brown MS, Buchanan RB, Karran SJ. Clinical observations on the effects of elemental diet supplementation during irradiation. Clin Radiol 1980;31:19-20. (Pubitemid 10166655)
22. Kochhar R, Patel F, Dhar A, Sharma SC, Ayyagari S, Aggarwal R, et al. Radiation-induced proctosigmoiditis. Prospective, randomized, double-blind controlled trial of oral sulfasalazine plus rectal steroids versus rectal sucralfate. Dig Dis Sci 1991;36:103-7.
23. Rougier P, Zimmerman P, Pignon JP, Kac J, Crespon B, Zrihen E, et al. Rectites radiques: Efficate comparee de deux types de corticoides adminstre localement. Med Chir Dig 1992;21:91-3.
24. Simone NL, Ménard C, Soule BP, Albert PS, Guion P, Smith S, et al. Intrarectal amifostine during external beam radiation therapy for prostate cancer produces significant improvements in Quality of Life measured by EPIC score. Int J Radiat Oncol Biol Phys 2008;70:90-5. (Pubitemid 350258596)