Genomic biomarkers and clinical outcomes of physical activity

Annals of the New York Academy of Sciences

Volumn 1229, Issue 1, 2011, Pages 103-114

  Izzotti, Alberto ^a  

^a UNIVERSITY OF GENOA   (Italy)

Author keywords

DNA damage; Gene expression; Gene polymorphisms; Molecular biomarkers; Physical activity

Indexed keywords

BIOLOGICAL MARKER; CELL NUCLEUS DNA; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE M1; GLUTATHIONE TRANSFERASE T1; MICRORNA; MITOCHONDRIAL DNA;

AGE DISTRIBUTION; ARTICLE; ATHEROSCLEROSIS; DNA ADDUCT; DNA DAMAGE; DYSLIPIDEMIA; EXERCISE; GENE DELETION; GENE EXPRESSION; GENETIC MARKER; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HUMAN; LIFE EXPECTANCY; LIPID PEROXIDATION; LIPID STORAGE; MITOCHONDRION; MODULATION; MUSCLE BIOPSY; OUTCOME ASSESSMENT; PHYSICAL ACTIVITY; SEDENTARY LIFESTYLE; SURVIVAL;

EID: 79960766108     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2011.06091.x     Document Type: Article

References (29)

1. Izzotti, A. et al 2007. Survival of atherosclerotic patients as related to oxidative stress and gene polymorphisms. Mutat. Res. 621: 119-128.
2. Izzotti, A. et al 2001. Increased DNA alterations in atherosclerotic lesions of individuals lacking theGSTM1genotype. FASEB J. 15: 752-757.
3. De Flora, S. et al. 1997. Molecular epidemiology of atherosclerosis. FASEB J. 11: 1021-1031.
4. Bogliolo, M. et al 1999. Detection of the "4977 bp" mitochondrial DNA deletion in human atherosclerotic lesions. Mutagenesis 14: 77-82.
5. Izzotti, A. et al 1999. Age-related increases of 8-hydroxy-2'-deoxyguanosine and DNA protein cross-link in mouse organs. Mutat. Res. 446: 215-223.
6. Neubauer, O. et al 2010. Antioxidant responses to an acute ultra-endurance exercise: impact on DNA stability and indications for an increased need for nutritive antioxidants in the early recovery phase. Br. J. Nutr. 104: 1129-1138.
7. Reichhold, S. et al 2009. Endurance exercise and DNA stability: is there a link to duration and intensity Mutat. Res. Rev. 682: 28-38.
8. Ramel, A. et al 2004. Correlations between plasma noradrenaline concentrations, antioxidants, and neutrophil counts after submaximal resistance exercise in men. Br. J. Sports Med. 38: E22.
9. Ramel, A. et al 2004. Plasma antioxidants and lipid oxidation after submaximal resistance exercise in men. Eur. J. Nutr. 43: 2-6.
10. Izzotti, A. 2009. Gene environment interactions in noncancer degenerative diseases. Mutat. Res. 667: 1-3.
11. Stepto, N.K. et al 2009. Global gene expression in skeletal muscle from well-trained strength and endurance athletes. Med. Sci. Sports Exerc. 41: 546-565.
12. Melov, S. et al 2007. Resistance exercise reverses aging in human skeletal muscle. PLoS One 23: e465.
13. Timmons, J.A. et al 2006. Expression profiling following local muscle inactivity in humans provides new perspective on diabetes-related genes. Genomics 87 165-172.
14. Simonsen, M.L. et al 2010. Acute physical activity effects on cardiac gene expression. Exp. Physiol. 95: 1071-1080.
15. Izzotti, A. et al 2009. Downregulation of microRNA expression in the lung of rats exposed to cigarette smoke. FASEB J. 23: 806-812.
16. Aoi, W. et al 2010. The microRNA miR-696 regulates PGC-1{alpha} in mouse skeletal muscle in response to physical activity. Am. J. Physiol. Endocrinol. Metab. 298: 799-806.
17. Shiroma, E.J. et al 2010. Physical activity and cardiovascular health: lessons learned from epidemiological studies across age, gender, and race/ethnicity. Circulation 122: 743-752.
18. Bray, M.S. et al 2009. The human gene map for performance and health-related fitness phenotypes: the 2006-2007 update. Med. Sci. Sports Exerc. 41: 35-73.
19. Myerson, S. et al 1999. Human angiotensin I-converting enzyme gene and endurance performance. J. Appl. Physiol. 87: 1313-1316.
20. Williams, A.G. et al 2000. The ACE gene and muscle performance. Nature 403: 614.
21. Alvarez, R. et al 2000. Genetic variation in the renin-angiotensin system and athletic performance. Eur. J. Appl. Physiol. 82: 117-120.
22. Folland, J. et al 2000. Angiotensin-converting enzyme genotype affects the response of human skeletal muscle to functional overload. Exp. Physiol. 85: 575-579.
23. Druzhevskaya, A.M. et al 2008. Association of the ACTN3 R577X polymorphism with power athlete status in Russians. Eur. J. Appl. Physiol. 103: 631-634.
24. He, Z. et al 2008. Association between HMOX-1 genotype and cardiac function during exercise. Appl. Physiol. Nutr. Metab. 33: 450-460.
25. Döring, F. et al 2010. A common haplotype and the Pro582Ser polymorphism of the hypoxia-inducible factor-1alpha (HIF1A) gene in elite endurance athletes. J. Appl. Physiol. 108: 1497-1500.
26. Karlowatz, R.J. et al 2011. Polymorphisms in the IGF1 signalling pathway including the myostatin gene are associated with left ventricular mass in male athletes. Br. J. Sports Med. 45: 36-41.
27. Castro, M.G. et al 2007. Mitochondrial haplogroup T is negatively associated with the status of elite endurance athlete. Mitochondrion 7: 354-357.
28. Eynon, N. et al 2010. Interaction between SNPs in the NRF2 gene and elite endurance performance. Physiol. Genomics. 42: 78-81.
29. Gómez-Gallego, F. et al 2009. The -786 T/C polymorphism of the NOS3 gene is associated with elite performance in power sports. Eur. J. Appl. Physiol. 107: 565-569.