The -786 T/C polymorphism of the NOS3 gene is associated with elite performance in power sports

European Journal of Applied Physiology

Volumn 107, Issue 5, 2009, Pages 565-569

  Gómez Gallego, Félix ^a   Ruiz, Jonatan R ^b   Buxens, Amaya ^c   Artieda, Marta ^c   Arteta, David ^a   Santiago, Catalina ^a   Rodríguez Romo, Gabriel ^d   Lao, José I ^e   Lucia, Alejandro ^a  

^a UNIVERSIDAD EUROPEA DE MADRID   (Spain)

^b KAROLINSKA INSTITUTE   (Sweden)

^c IMG Pharma Biotech S L Parque Tecnologico de Zamudio   (Spain)

^d UNIVERSIDAD POLITÉCNICA DE MADRID   (Spain)

^e Sabiobbi SL   (Spain)

Author keywords

Endurance; Exercise; NOS3; Performance; Power

Indexed keywords

CYTOSINE; DNA; ENDOTHELIAL NITRIC OXIDE SYNTHASE; THYMINE;

ADULT; ARTICLE; ATHLETE; CAUCASIAN; CONTROLLED STUDY; CYCLING; DNA POLYMORPHISM; ENDURANCE SPORT; GENE FREQUENCY; GENOTYPE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RUNNING; SPORT; TASK PERFORMANCE;

ADULT; ATHLETES; ATHLETIC PERFORMANCE; CASE-CONTROL STUDIES; DNA MUTATIONAL ANALYSIS; GENE FREQUENCY; GENOTYPE; HUMANS; MALE; NITRIC OXIDE SYNTHASE TYPE III; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; RESISTANCE TRAINING; SPORTS; YOUNG ADULT;

EID: 70350671294     PISSN: 14396319     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00421-009-1166-7     Document Type: Article

References (36)

1. Bray MS, Hagberg JM, Perusse L, Rankinen T, Roth SM, Wolfarth B, Bouchard C (2009) The human gene map for performance and health-related fitness phenotypes: The 2006-2007 update. Med Sci Sports Exerc 41:35-73
2. Cooke JP, Rossitch E Jr, Andon NA, Loscalzo J, Dzau VJ (1991) Flow activates an endothelial potassium channel to release an endogenous nitrovasodilator. J Clin Invest 88:1663-1671
3. Garland TJ, Bernnet AF, Daniels CB (1990) Heritability of locomotor performance and its correlates in a natural population. Experientia 46:530-533
4. Hambrecht R, Fiehn E, Weigl C, Gielen S, Hamann C, Kaiser R, Yu J, Adams V, Niebauer J, Schuler G (1998) Regular physical exercise corrects endothelial dysfunction and improves exercise capacity in patients with chronic heart failure. Circulation 98:2709-2715
5. Hand BD, McCole SD, Brown MD, Park JJ, Ferrell RE, Huberty A, Douglass LW, Hagberg JM (2006) NOS3 gene polymorphisms and exercise hemodynamics in postmenopausal women. Int J Sports Med 27:951-958
6. Heydemann A, McNally E (2009) NO more muscle fatigue. J Clin Invest 119:448-450
7. Hickner RC, Fisher JS, Ehsani AA, Kohrt WM (1997) Role of nitric oxide in skeletal muscle blood flow at rest and during dynamic exercise in humans. Am J Physiol 273:H405-H410
8. Higashi Y, Sasaki S, Sasaki N, Nakagawa K, Ueda T, Yoshimizu A, Kurisu S, Matsuura H, Kajiyama G, Oshima T (1999) Daily aerobic exercise improves reactive hyperemia in patients with essential hypertension. Hypertension 33:591-597
9. Hyndman ME, Parsons HG, Verma S, Bridge PJ, Edworthy S, Jones C, Lonn E, Charbonneau F, Anderson TJ (2002) The T-786 → C mutation in endothelial nitric oxide synthase is associated with hypertension. Hypertension 39:919-922
10. Le Gouill E, Jimenez M, Binnert C, Jayet PY, Thalmann S, Nicod P, Scherrer U, Vollenweider P (2007) Endothelial nitric oxide synthase (eNOS) knockout mice have defective mitochondrial beta-oxidation. Diabetes 56:2690-2696
11. Loke KE, Laycock SK, Mital S, Wolin MS, Bernstein R, Oz M, Addonizio L, Kaley G, Hintze TH (1999a) Nitric oxide modulates mitochondrial respiration in failing human heart. Circulation 100:1291-1297
12. Loke KE, McConnell PI, Tuzman JM, Shesely EG, Smith CJ, Stackpole CJ, Thompson CI, Kaley G, Wolin MS, Hintze TH (1999b) Endogenous endothelial nitric oxide synthase-derived nitric oxide is a physiological regulator of myocardial oxygen consumption. Circ Res 84:840-845
13. Long JH, Lira VA, Soltow QA, Betters JL, Sellman JE, Criswell DS (2006) Arginine supplementation induces myoblast fusion via augmentation of nitric oxide production. J Muscle Res Cell Motil 27:577-584
14. McConell GK, Kingwell BA (2006) Does nitric oxide regulate skeletal muscle glucose uptake during exercise? Exerc Sport Sci Rev 34:36-41
15. McNamara DM, Tam SW, Sabolinski ML, Tobelmann P, Janosko K, Venkitachalam L, Ofili E, Yancy C, Feldman AM, Ghali JK, Taylor AL, Cohn JN, Worcel M (2009) Endothelial nitric oxide synthase (NOS3) polymorphisms in African Americans with heart failure: Results from the A-HeFT trial. J Card Fail 15:191-198
16. Moncada S, Palmer RM, Higgs EA (1991) Nitric oxide: Physiology, pathophysiology, and pharmacology. Pharmacol Rev 43:109-142
17. Nakayama M, Yasue H, Yoshimura M, Shimasaki Y, Kugiyama K, Ogawa H, Motoyama T, Saito Y, Ogawa Y, Miyamoto Y, Nakao K (1999) T-786 → C mutation in the 5′-flanking region of the endothelial nitric oxide synthase gene is associated with coronary spasm. Circulation 99:2864-2870
18. Nakayama M, Yasue H, Yoshimura M, Shimasaki Y, Ogawa H, Kugiyama K, Mizuno Y, Harada E, Nakamura S, Ito T, Saito Y, Miyamoto Y, Ogawa Y, Nakao K (2000) T(-786) → C mutation in the 5′-flanking region of the endothelial nitric oxide synthase gene is associated with myocardial infarction, especially without coronary organic stenosis. Am J Cardiol 86:628-634
19. Otani H (2009) The role of nitric oxide in myocardial repair and remodeling. Antioxid Redox Signal [Epub ahead of print]
20. Quyyumi AA, Dakak N, Andrews NP, Gilligan DM, Panza JA, Cannon RO 3rd (1995) Contribution of nitric oxide to metabolic coronary vasodilation in the human heart. Circulation 92:320-326
21. Rankinen T, Rice T, Perusse L, Chagnon YC, Gagnon J, Leon AS, Skinner JS, Wilmore JH, Rao DC, Bouchard C (2000) NOS3 Glu298Asp genotype and blood pressure response to endurance training: The HERITAGE family study. Hypertension 36:885-889
22. Robinson LJ, Weremowicz S, Morton CC, Michel T (1994) Isolation and chromosomal localization of the human endothelial nitric oxide synthase (NOS3) gene. Genomics 19:350-357
23. Ruiz JR, Gomez-Gallego F, Santiago C, Gonzalez-Freire M, Verde Z, Foster C, Lucia A (2009) Is there an optimum endurance polygenic profile? J Physiol 587:1527-1534
24. Salanova M, Schiffl G, Puttmann B, Schoser BG, Blottner D (2008) Molecular biomarkers monitoring human skeletal muscle fibres and microvasculature following long-term bed rest with and without countermeasures. J Anat 212:306-318
25. Santiago C, Ruiz JR, Muniesa CA, González-Freire M, Gómez-Gallego F, Lucia A (2009) Does the polygenic profile determine the potential for becoming a world-class athlete? Insights from the sport of rowing. Scand J Med Sci Sports [Epub ahead of print]
26. Saunders CJ, Xenophontos SL, Cariolou MA, Anastassiades LC, Noakes TD, Collins M (2006) The bradykinin beta 2 receptor (BDKRB2) and endothelial nitric oxide synthase 3 (NOS 3) genes and endurance performance during Ironman Triathlons. Hum Mol Genet 15:979-987
27. Sellman JE, DeRuisseau KC, Betters JL, Lira VA, Soltow QA, Selsby JT, Criswell DS (2006) In vivo inhibition of nitric oxide synthase impairs upregulation of contractile protein mRNA in overloaded plantaris muscle. J Appl Physiol 100:258-265
28. Smith LW, Smith JD, Criswell DS (2002) Involvement of nitric oxide synthase in skeletal muscle adaptation to chronic overload. J Appl Physiol 92:2005-2011
29. Tejedor D, Castillo S, Mozas P, Jimenez E, Lopez M, Tejedor MT, Artieda M, Alonso R, Mata P, Simon L, Martinez A, Pocovi M (2005) Reliable low-density DNA array based on allele-specific probes for detection of 118 mutations causing familial hypercholesterolemia. Clin Chem 51:1137-1144
30. Van Damme R, Wilson RS, Vanhooydonck B, Aerts P (2002) Performance constraints in decathletes. Nature 415:755-756
31. 2 max. Exerc Sport Sci Rev 28:10-14
32. Wang XL, Sim AS, Wang MX, Murrell GA, Trudinger B, Wang J (2000) Genotype dependent and cigarette specific effects on endothelial nitric oxide synthase gene expression and enzyme activity. FEBS Lett 471:45-50
33. Wilkerson DP, Campbell IT, Jones AM (2004) Influence of nitric oxide synthase inhibition on pulmonary O2 uptake kinetics during supra-maximal exercise in humans. J Physiol 561:623-635
34. Wolfarth B, Rankinen T, Muhlbauer S, Ducke M, Rauramaa R, Boulay MR, Perusse L, Bouchard C (2008) Endothelial nitric oxide synthase gene polymorphism and elite endurance athlete status: The Genathlete study. Scand J Med Sci Sports 18:485-490
35. Yang N, MacArthur DG, Gulbin JP, Hahn AG, Beggs AH, Easteal S, North K (2003) ACTN3 genotype is associated with human elite athletic performance. Am J Hum Genet 73:627-631
36. Yoshimura M, Yasue H, Nakayama M, Shimasaki Y, Sumida H, Sugiyama S, Kugiyama K, Ogawa H, Ogawa Y, Saito Y, Miyamoto Y, Nakao K (1998) A missense Glu298Asp variant in the endothelial nitric oxide synthase gene is associated with coronary spasm in the Japanese. Hum Genet 103:65-69