Systematic polymorphism discovery after genome-wide identification of potential susceptibility loci in a hereditary rodent model of human hypertension

Blood Pressure

Volumn 20, Issue 4, 2011, Pages 222-231

  Friese, Ryan S ^a,b   Schmid Schönbein, Geert W ^a   O'Connor, Daniel T ^b,c,d  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

Author keywords

Essential hypertension; Polymorphism; Sequencing; SHR rat strain; WKY rat strain

Indexed keywords

CATECHOL METHYLTRANSFERASE; CHROMOGRANIN A; DOPAMINE BETA MONOOXYGENASE; ELECTRON TRANSFERRING FLAVOPROTEIN; ENDOTHELIN RECEPTOR; NEUROPEPTIDE Y; PHENYLETHANOLAMINE N METHYLTRANSFERASE;

ADRENAL GLAND; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; DATA MINING; DNA POLYMORPHISM; GENE; GENE EXPRESSION; GENE IDENTIFICATION; GENE LOCUS; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC DATABASE; GENETIC SUSCEPTIBILITY; HYPERTENSION; MALE; MICROARRAY ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; RAT;

ANIMALS; CHROMOSOME MAPPING; DATA MINING; DISEASE MODELS, ANIMAL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; HYPERTENSION; MALE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYMORPHISM, GENETIC; QUANTITATIVE TRAIT LOCI; RATS; RATS, INBRED SHR; RATS, INBRED WKY;

EID: 79960751573     PISSN: 08037051     EISSN: 16511999     Source Type: Journal    
DOI: 10.3109/08037051.2011.566012     Document Type: Article

References (54)

1. Okamoto K, Aoki K. Development of a strain of spontaneously hypertensive rats. Jpn Circ J. 1963;27:282-293.
2. Jacob HJ Lindpaintner K, Lincoln SE, Kusumi K, Bunker RK, Mao YP, et al. Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat. Cell. 1991;67:213-224. (Pubitemid 121001437)
3. Graham D, McBride MW, Brain NJ, Dominiczak AF. Congenic/consomic models of hypertension. Methods Mol Med. 2005;108:3-15.
4. Printz MP, Jirout M, Jaworski R, Alemayehu A, Kren V. Genetic models in applied physiology. HXB/BXH rat recombinant inbred strain platform: A newly enhanced tool for cardiovascular, behavioral, and developmental genetics and genomics. J Appl Physiol. 2003;94:2510-2522. (Pubitemid 36605316)
5. Jirout ML, Friese RS, Mahapatra NR, Mahata M, Taupenot L, Mahata SK, et al. Genetic regulation of catecholamine synthesis, storage and secretion in the spontaneously hypertensive rat. Hum Mol Genet. 2010;19:2567-2580.
6. Twigger SN, Shimoyama M, Bromberg S, Kwitek AE, Jacob HJ. The Rat Genome Database, update 2007 - Easing the path from disease to data and back again. Nucleic Acids Res. 2007;35:D658-D662. (Pubitemid 46056287)
7. Woon PY, Kaisaki PJ, Bragança J, Bihoreau MT, Levy JC, Farrall M, et al. Aryl hydrocarbon receptor nuclear translocator-like (BMAL1) is associated with susceptibility to hypertension and type 2 diabetes. Proc Natl Acad Sci USA. 2007;104:14412-14417. (Pubitemid 350003275)
8. Yagisawa, H., Tanase, H., Nojima, H. Phospholipase C-delta gene of the spontaneously hypertensive rat harbors point mutations causing amino acid substitutions in a catalytic domain. J Hypertens. 1999;9:997-1004.
9. Klett CP, Printz MP. Is the M1-muscarinic receptor a candidate gene for hypertension in the spontaneously hypertensive rat? Clin Exp Pharmacol Physiol Suppl. 1995;22:S4-S6. (Pubitemid 26064463)
10. Huang H, Pravenec M, Wang JM, Kren V, St Lezin E, Szpirer C, et al. Mapping and sequence analysis of the gene encoding the beta subunit of the epithelial sodium channel in experimental models of hypertension. J Hypertens. 1995;13: 1247-1251. (Pubitemid 26003261)
11. Pausova Z, Sedova L, Berube J, Hamet P, Tremblay J, Dumont M, et al. Segment of rat chromosome 20 regulates dietinduced augmentations in adiposity, glucose intolerance, and blood pressure. Hypertension. 2003;41:1047-1055. (Pubitemid 36548602)
12. McBride MW, Brosnan MJ, Mathers J, McLellan LI, Miller WH, Graham D, et al. Reduction of Gstm1 expression in the stroke-prone spontaneously hypertension rat contributes to increased oxidative stress. Hypertension. 2005;45:786-792. (Pubitemid 40418382)
13. Clemitson JR, Dixon RJ, Haines S, Bingham AJ, Patel BR, Hall L, et al. Genetic dissection of a blood pressure quantitative trait locus on rat chromosome 1 and gene expression analysis identifi es SPON1 as a novel candidate hypertension gene. Circ Res. 2007;100:992-999. (Pubitemid 46598923)
14. Graham D, McBride MW, Gaasenbeek M, Gilday K, Beattie E, Miller WH, et al. Candidate genes that determine response to salt in the stroke-prone spontaneously hypertensive rat: Congenic analysis. Hypertension. 2007;50:1134-1141. (Pubitemid 350172937)
15. Johnson MD, He L, Herman D, Wakimoto H, Wallace CA, Zidek V, et al. Dissection of chromosome 18 blood pressure and salt-sensitivity quantitative trait loci in the spontaneouslyhypertensive rat. Hypertension. 2009;54:639-645.
16. Koike G, Jacob HJ, Krieger JE, Szpirer C, Hoehe MR, Horiuchi M, et al. Investigation of the phenylethanolamine N-methyltransferase gene as a candidate gene for hypertension. Hypertension. 1995;26:595-601.
17. Atanur SS, Birol I, Guryev V, Hirst M, Hummel O, Morrissey C, et al. The genome sequence of the spontaneously hypertensive rat: Analysis and functional signifi cance. Genome Res. 2010;20:791-803.
18. Mashimo T, Voigt B, Tsurumi T, Naoi K, Nakanishi S, Yamasaki K, et al. A set of highly informative rat simple sequence length polymorphism (SSLP) markers and genetically defi ned rat strains. BMC Genet. 2006;7:19.
19. Friese RS, Mahboubi P, Mahapatra NR, Mahata SK, Schork NJ, Schmid-Sch ö nbein GW, et al. Common genetic mechanisms of blood pressure elevation in two independent rodent models of human essential hypertension. Am J Hypertens. 2005;18:633-652. (Pubitemid 40692431)
20. Brazma A, Hingamp P, Quackenbush J, Sherlock G, Spellman P, Stoeckert C, et al. Minimum information about a microarray experiment (MIAME)-toward standards for microarray data. Nat Genet. 2001;29:365-371. (Pubitemid 34326681)
21. Fries RS, Mahboubi P, Mahapatra NR, Mahata SK, Schork NJ, Schmid-Schoenbein GW, et al. Neuroendocrine transcriptome in genetic hypertension: multiple changes in diverse adrenal physiological systems. Hypertension. 2004;43: 1301-1311. (Pubitemid 38691754)
22. Kent WJ, Sugnet CW, Furey TS, Roskin KM, Pringle TH, Zahler AM, et al. The human genome browser at UCSC. Genome Res. 2002;12:996-1006. (Pubitemid 34662293)
23. Rozen S, Skaletsky H. Primer3 on the WWW for general users and for biologist programmers. Methods Mol Biol. 2000;132:365-386.
24. O' C onnor DT, Takiyyuddin MA, Printz MP, Dinh TQ, Barbosa JA, Rozansky DJ, et al. Catecholamine storage vesicle protein expression in genetic hypertension. Blood Press. 1999;8:285-295. (Pubitemid 30220292)
25. Sahu BS, Sonawane PJ, Mahapatra NR. Chromogranin A: A novel susceptibility gene for essential hypertension. Cell Mol Life Sci. 2010;67:861-874.
26. Kloting I, Kovacs P, van den Brandt J. Quantitative trait loci for body weight, blood pressure, blood glucose, and serum lipids: linkage analysis with wild rats ( Rattus norvegicus ). Biochem Biophys Res Commun. 2001;284:1126-1133. (Pubitemid 32917955)
27. Clark JS, Jeffs B, Davidson AO, Lee WK, Anderson NH, Bihoreau MT, et al. Quantitative trait loci in genetically hypertensive rats. Possible sex specifi city. Hypertension. 1996; 28:898-906. (Pubitemid 26365538)
28. Kato N, Mashimo T, Nabika T, Cui ZH, Ikeda K, Yamori Y. Genome-wide searches for blood pressure quantitative trait loci in the stroke-prone spontaneously hypertensive rat of a Japanese colony. J Hypertens. 2003;21:295-303. (Pubitemid 36269700)
29. Katsuya T, Higaki J, Zhao Y, Miki T, Mikami H, Serikawa T, et al. A neuropeptide Y locus on chromosome 4 cosegregates with blood pressure in the spontaneously hypertensive rat. Biochem Biophys Res Commun. 1993;192:261-267. (Pubitemid 23205295)
30. Suematsu M, Suzuki H, Delano FA, Schmid-Schonbein GW. The infl ammatory aspect of the microcirculation in hypertension: Oxidative stress, leukocytes/endothelial interaction, apoptosis. Microcirculation. 2002;9:259-276. (Pubitemid 135685862)
31. Taupenot L, Harper KL, O' C onnor DT. The chromog raninsecretogranin family. N Engl J Med. 2003;348:1134-1149.
32. Mahapatra NR, O'Connor DT, Vaingankar SM, Hikim AP, Mahata M, Ray S, et al. Hypertension from targeted ablation of chromogranin A can be rescued by the human ortholog. J Clin Invest. 2005;115:1942-1952. (Pubitemid 40979734)
33. Mahata SK, Mahata M, Fung MM, O' C onnor DT. Catestatin: A multifunctional peptide from chromogranin A. Regul Pept. 2010;162:33-43.
34. Zhang K, Rao F, Wen G, Salem RM, Vaingankar S, Mahata M, et al. Catecholamine storage vesicles and the metabolic syndrome: The role of the chromogranin A fragment pancreastatin. Diabetes Obes Metab. 2006;8:621-633. (Pubitemid 44515559)
35. Helle KB. Chromogranins A and B and secretogranin II as prohormones for regulatory peptides from the diffuse neuroendocrine system. Results Probl Cell Differ. 2010;50: 21-44.
36. Pons J, Lee EW, Li L, Kitlinska J. Neuropeptide Y: Multiple receptors and multiple roles in cardiovascular diseases. Curr Opin Investig Drugs. 2004;5:957-962.
37. Abe M, Wu Z, Yamamoto M, Jin JJ, Tabara Y, Mogi M, et al. Association of dopamine beta-hydroxylase polymorphism with hypertension through interaction with fasting plasma glucose in Japanese. Hypertens Res. 2005;28:215-221. (Pubitemid 40812605)
38. Chen Y, Wen G, Rao F, Zhang K, Wang L, Rodriguez-Flores JL, et al. Human dopamine beta-hydroxylase (DBH) regulatory polymorphism that infl uences enzymatic activity, autonomic function, and blood pressure. J Hypertens. 2010; 28: 76-86.
39. Rodriguez-Flores JL, Zhang K, Kang SW, Wen G, Ghosh S, Friese RS, et al. Conserved regulatory motifs at phenylethanolamine N-methyltransferase (PNMT) are disrupted by common functional genetic variation: An integrated computational/experimental approach. Mamm Genome. 2010;21:195-204.
40. Cui J, Zhou X, Chazaro I, DeStefano AL, Manolis AJ, Baldwin CT, et al. Association of polymorphisms in the promoter region of the PNMT gene with essential hypertension in African Americans but not in whites. Am J Hypertens. 2003;16: 859-863. (Pubitemid 37204684)
41. Chen A, Chen X, Shi R, Guo Y, Chen L, Xie M, et al. [Association of genetic polymorphism in phenylethanolamine- N -methyl transferase with essential hypertension in Changsha Han people]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2009;34:1120-1125.
42. Teitelman G, Ross RA, Joh TH, Reis DJ. Differences in utero in activities of catecholamine biosynthetic enzymes in adrenals of spontaneously hypertensive rats. Clin Sci (Lond).1981;61 Suppl 7:227s - 230s. (Pubitemid 12222736)
43. Nagatsu T, Kato T, Numata Y, Ikuta K, Sano M. Norepinephrine-synthesizing enzymes in brain, adrenals and peripheral sympathetic nerves of spontaneously hypertensive rats. Jpn J Pharmacol. 1977;27:531-535. (Pubitemid 8206551)
44. Reja V, Goodchild AK, Pilowsky PM. Catecholamine-related gene expression correlates with blood pressures in SHR. Hypertension. 2002;40:342-347. (Pubitemid 35006721)
45. Nguyen P, Peltsch H, de Wit J, Crispo J, Ubriaco G, Eibl J, et al. Regulation of the phenylethanolamine N -methyltransferase gene in the adrenal gland of the spontaneous hypertensive rat. Neurosci Lett. 2009;461:280-284.
46. Axelrod J, Tomchick R. Enzymatic O-methylation of epinephrine and other catechols. J Biol Chem. 1958;233: 702-705.
47. Guldberg HC, Marsden CA. Catechol- O -methyl transferase: pharmacological aspects and physiological role. Pharmacol Rev. 1975;27:135-206.
48. Yasuda H, Kamide K, Takiuchi S, Matayoshi T, Hanada H, Kada A, et al. Association of single nucleotide polymorphisms in endothelin family genes with the progression of atherosclerosis in patients with essential hypertension. J Hum Hypertens. 2007;21:883-892. (Pubitemid 350020340)
49. Goodman SI, Binard RJ, Woontner MR, Frerman FE. Glutaric acidemia type II: gene structure and mutations of the electron transfer fl avoprotein:ubiquinone oxidoreductase (ETF:QO) gene. Mol Genet Metab. 2002;77:86-90. (Pubitemid 35178519)
50. Kamide K, Kokubo Y, Yang J, Matayoshi T, Inamoto N, Takiuchi S, et al. Association of genetic polymorphisms of ACADSB and COMT with human hypertension. J Hypertens. 2007;25:103-110. (Pubitemid 44885670)
51. Hagen K, Pettersen E, Stovner LJ, Skorpen F, Holmen J, Zwart JA. High systolic blood pressure is associated with Val/Val genotype in the catechol- O -methyltransferase gene. The Nord-Trondelag Health Study (HUNT).Am J Hypertens. 2007;20:21-26. (Pubitemid 46014058)
52. Annerbrink K, Westberg L, Nilsson S, Rosmond R, Holm G, Eriksson E. Catechol O-methyltransferase val158-met polymorphism is associated with abdominal obesity and blood pressure in men. Metabolism. 2008;57:708-711. (Pubitemid 351608233)
53. Caprioli J, Mele C, Mossali C, Gallizioli L, Giacchetti G, Noris M, et al. Polymorphisms of EDNRB, ATG, and ACE genes in salt-sensitive hypertension. Can J Physiol Pharmacol. 2008;86:505-510.
54. Bhaskar LV, Thangaraj K, Non AL, Praveen Kumar K, Pardhasaradhi G, Singh L, et al. Neuropeptide Y gene functional polymorphism infl uences susceptibility to hypertension in Indian population. J Hum Hypertens. 2010;24: 617-622.