Kinesin-3 KLP-6 regulates intraflagellar transport in male-specific cilia of caenorhabditis elegans

Current Biology

Volumn 21, Issue 14, 2011, Pages 1239-1244

  Morsci, Natalia S ^a,b   Barr, Maureen M ^a  

^a RUTGERS UNIVERSITY   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAENORHABDITIS ELEGANS PROTEIN; KINESIN; KLP 6 PROTEIN, C ELEGANS; KLP-6 PROTEIN, C ELEGANS; OSM 3 PROTEIN, C ELEGANS; OSM-3 PROTEIN, C ELEGANS;

ANIMAL; ARTICLE; CAENORHABDITIS ELEGANS; CYTOLOGY; EUKARYOTIC FLAGELLUM; MALE; METABOLISM; PHYSIOLOGY; PROTEIN TRANSPORT; SENSORY RECEPTOR;

ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CILIA; KINESIN; MALE; PROTEIN TRANSPORT; SENSORY RECEPTOR CELLS;

CAENORHABDITIS ELEGANS; EUKARYOTA;

EID: 79960747090     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cub.2011.06.027     Document Type: Article

References (27)

1. M. Fliegauf, T. Benzing, and H. Omran When cilia go bad: Cilia defects and ciliopathies Nat. Rev. Mol. Cell Biol. 8 2007 880 893 (Pubitemid 47622564)
2. S. Mukhopadhyay, Y. Lu, H. Qin, A. Lanjuin, S. Shaham, and P. Sengupta Distinct IFT mechanisms contribute to the generation of ciliary structural diversity in C. elegans EMBO J. 26 2007 2966 2980 (Pubitemid 46975773)
3. J. Burghoorn, M.P. Dekkers, S. Rademakers, T. de Jong, R. Willemsen, P. Swoboda, and G. Jansen Dauer pheromone and G-protein signaling modulate the coordination of intraflagellar transport kinesin motor proteins in C. elegans J. Cell Sci. 123 2010 2077 2084
4. J. Burghoorn, M.P. Dekkers, S. Rademakers, T. de Jong, R. Willemsen, and G. Jansen Mutation of the MAP kinase DYF-5 affects docking and undocking of kinesin-2 motors and reduces their speed in the cilia of Caenorhabditis elegans Proc. Natl. Acad. Sci. USA 104 2007 7157 7162 (Pubitemid 47186025)
5. K.G. Kozminski, K.A. Johnson, P. Forscher, and J.L. Rosenbaum A motility in the eukaryotic flagellum unrelated to flagellar beating Proc. Natl. Acad. Sci. USA 90 1993 5519 5523 (Pubitemid 23176192)
6. G.J. Pazour, B.L. Dickert, Y. Vucica, E.S. Seeley, J.L. Rosenbaum, G.B. Witman, and D.G. Cole Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella J. Cell Biol. 151 2000 709 718
7. G.J. Pazour, S.A. Baker, J.A. Deane, D.G. Cole, B.L. Dickert, J.L. Rosenbaum, G.B. Witman, and J.C. Besharse The intraflagellar transport protein, IFT88, is essential for vertebrate photoreceptor assembly and maintenance J. Cell Biol. 157 2002 103 113 (Pubitemid 34847833)
8. L.A. Perkins, E.M. Hedgecock, J.N. Thomson, and J.G. Culotti Mutant sensory cilia in the nematode Caenorhabditis elegans Dev. Biol. 117 1986 456 487
9. D.G. Cole, D.R. Diener, A.L. Himelblau, P.L. Beech, J.C. Fuster, and J.L. Rosenbaum Chlamydomonas kinesin-II-dependent intraflagellar transport (IFT): IFT particles contain proteins required for ciliary assembly in Caenorhabditis elegans sensory neurons J. Cell Biol. 141 1998 993 1008 (Pubitemid 28243966)
10. S. Nonaka, Y. Tanaka, Y. Okada, S. Takeda, A. Harada, Y. Kanai, M. Kido, and N. Hirokawa Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein Cell 95 1998 829 837 (Pubitemid 29014462)
11. L.B. Pedersen, S. Geimer, and J.L. Rosenbaum Dissecting the molecular mechanisms of intraflagellar transport in chlamydomonas Curr. Biol. 16 2006 450 459 (Pubitemid 43343705)
12. Y. Cao, A. Park, and Z. Sun Intraflagellar transport proteins are essential for cilia formation and for planar cell polarity J. Am. Soc. Nephrol. 21 2010 1326 1333
13. Y.G. Han, B.H. Kwok, and M.J. Kernan Intraflagellar transport is required in Drosophila to differentiate sensory cilia but not sperm Curr. Biol. 13 2003 1679 1686 (Pubitemid 37216245)
14. J.J. Snow, G. Ou, A.L. Gunnarson, M.R. Walker, H.M. Zhou, I. Brust-Mascher, and J.M. Scholey Two anterograde intraflagellar transport motors cooperate to build sensory cilia on C. elegans neurons Nat. Cell Biol. 6 2004 1109 1113 (Pubitemid 39468012)
15. J.E. Evans, J.J. Snow, A.L. Gunnarson, G. Ou, H. Stahlberg, K.L. McDonald, and J.M. Scholey Functional modulation of IFT kinesins extends the sensory repertoire of ciliated neurons in Caenorhabditis elegans J. Cell Biol. 172 2006 663 669
16. Y.K. Bae, H. Qin, K.M. Knobel, J. Hu, J.L. Rosenbaum, and M.M. Barr General and cell-type specific mechanisms target TRPP2/PKD-2 to cilia Development 133 2006 3859 3870 (Pubitemid 44650964)
17. E.M. Peden, and M.M. Barr The KLP-6 kinesin is required for male mating behaviors and polycystin localization in Caenorhabditis elegans Curr. Biol. 15 2005 394 404 (Pubitemid 40323524)
18. H. Miki, Y. Okada, and N. Hirokawa Analysis of the kinesin superfamily: Insights into structure and function Trends Cell Biol. 15 2005 467 476 (Pubitemid 41253466)
19. W. Dentler Intraflagellar transport (IFT) during assembly and disassembly of Chlamydomonas flagella J. Cell Biol. 170 2005 649 659 (Pubitemid 41186939)
20. W.F. Marshall, and J.L. Rosenbaum Intraflagellar transport balances continuous turnover of outer doublet microtubules: Implications for flagellar length control J. Cell Biol. 155 2001 405 414 (Pubitemid 34289331)
21. J. Pan, and W.J. Snell Chlamydomonas shortens its flagella by activating axonemal disassembly, stimulating IFT particle trafficking, and blocking anterograde cargo loading Dev. Cell 9 2005 431 438 (Pubitemid 41235812)
22. G. Ou, O.E. Blacque, J.J. Snow, M.R. Leroux, and J.M. Scholey Functional coordination of intraflagellar transport motors Nature 436 2005 583 587 (Pubitemid 41112934)
23. M. Imanishi, N.F. Endres, A. Gennerich, and R.D. Vale Autoinhibition regulates the motility of the C. elegans intraflagellar transport motor OSM-3 J. Cell Biol. 174 2006 931 937 (Pubitemid 44455182)
24. X. Pan, G. Ou, G. Civelekoglu-Scholey, O.E. Blacque, N.F. Endres, L. Tao, A. Mogilner, M.R. Leroux, R.D. Vale, and J.M. Scholey Mechanism of transport of IFT particles in C. elegans cilia by the concerted action of kinesin-II and OSM-3 motors J. Cell Biol. 174 2006 1035 1045 (Pubitemid 44455191)
25. P.M. Jenkins, T.W. Hurd, L. Zhang, D.P. McEwen, R.L. Brown, B. Margolis, K.J. Verhey, and J.R. Martens Ciliary targeting of olfactory CNG channels requires the CNGB1b subunit and the kinesin-2 motor protein, KIF17 Curr. Biol. 16 2006 1211 1216 (Pubitemid 43867290)
26. B. Huang, M.R. Rifkin, and D.J. Luck Temperature-sensitive mutations affecting flagellar assembly and function in Chlamydomonas reinhardtii J. Cell Biol. 72 1977 67 85 (Pubitemid 8007650)
27. K.G. Kozminski, P.L. Beech, and J.L. Rosenbaum The Chlamydomonas kinesin-like protein FLA10 is involved in motility associated with the flagellar membrane J. Cell Biol. 131 1995 1517 1527 (Pubitemid 26001755)