Liver regeneration is promoted by increasing serotonin content in rat liver with secondary biliary cirrhosis

Hepatology Research

Volumn 41, Issue 8, 2011, Pages 784-794

  Nagao, Yoshihiro ^a,b   Akahoshi, Tomohiko ^a   Kamori, Masahiro ^a   Uehara, Hideo ^a   Hashimoto, Naotaka ^a   Kinjo, Nao ^a   Shirabe, Ken ^a   Taketomi, Akinobu ^a   Tomikawa, Morimasa ^b   Hashizume, Makoto ^b   Maehara, Yoshihiko ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY HOSPITAL   (Japan)

Author keywords

Ketanserin; Liver regeneration; Secondary biliary cirrhosis; Serotonin; Splenectomy

Indexed keywords

KETANSERIN; KI 67 ANTIGEN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; SEROTONIN 2A RECEPTOR; SEROTONIN RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE DUCT LIGATION; BILIARY CIRRHOSIS; CONTROLLED STUDY; FIBROGENESIS; HEMODYNAMICS; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; LIVER CELL; LIVER REGENERATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SECONDARY BILIARY CIRRHOSIS; SPLENECTOMY; SPRAGUE DAWLEY RAT; THROMBOCYTE COUNT; THROMBOCYTOSIS;

EID: 79960744515     PISSN: 13866346     EISSN: 1872034X     Source Type: Journal    
DOI: 10.1111/j.1872-034X.2011.00828.x     Document Type: Article

References (40)

1. Bataller R, Brenner DA. Liver fibrosis. J Clin Invest 2005; 115: 209-18.
2. Garcia-Tsao G, Sanyal AJ, Grace ND, Carey W. Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis. Hepatology 2007; 46: 922-38.
3. Krowka MJ. Hepatopulmonary syndrome and portopulmonary hypertension: implications for liver transplantation. Clin Chest Med 2005; 26: 587-97. vi.
4. Hassab MA. Gastroesophageal decongestion and splenectomy in the treatment of esophageal varices in bilharzial cirrhosis: further studies with a report on 355 operations. Surgery 1967; 61: 169-76.
5. Hashizume M, Tanoue K, Morita M, Ohta M, Tomikawa M, Sugimachi K. Laparoscopic gastric devascularization and splenectomy for sclerotherapy-resistant esophagogastric varices with hypersplenism. J Am Coll Surg 1998; 187: 263-70.
6. Kamal SM, El Kamary SS, Shardell MD etal. Pegylated interferon alpha-2b plus ribavirin in patients with genotype 4 chronic hepatitis C: the role of rapid and early virologic response. Hepatology 2007; 46: 1732-40.
7. Rosemurgy AS, Zervos EE, Goode SE, Black TJ, Zwiebel BR. Differential effects on portal and effective hepatic blood flow. A comparison between transjugular intrahepatic portasystemic shunt and small-diameter H-graft portacaval shunt. Ann Surg 1997; 225: 601-7; discussion 7-8.
8. Shimada M, Hashizume M, Shirabe K, Takenaka K, Sugimachi K. A new surgical strategy for cirrhotic patients with hepatocellular carcinoma and hypersplenism. Performing a hepatectomy after a laparoscopic splenectomy. Surg Endosc 2000; 14: 127-30.
9. Tanoue K, Okita K, Akahoshi T etal. Laparoscopic splenectomy for hematologic diseases. Surgery 2002; 131: S318-23.
10. Akahoshi T, Tomikawa M, Korenaga D, Ikejiri K, Saku M, Takenaka K. Laparoscopic splenectomy with peginterferon and ribavirin therapy for patients with hepatitis C virus cirrhosis and hypersplenism. Surg Endosc 2010; 24: 680-5.
11. Hayashi PH, Mehia C, Joachim Reimers H, Solomon HS, Bacon BR. Splenectomy for thrombocytopenia in patients with hepatitis C cirrhosis. J Clin Gastroenterol 2006; 40: 740-4.
12. Watanabe M, Murata S, Hashimoto I etal. Platelets contribute to the reduction of liver fibrosis in mice. J Gastroenterol Hepatol 2009; 24: 78-89.
13. Tomikawa M, Hashizume M, Highashi H, Ohta M, Sugimachi K. The role of the spleen, platelets, and plasma hepatocyte growth factor activity on hepatic regeneration in rats. J Am Coll Surg 1996; 182: 12-16.
14. Murata K, Shiraki K, Sugimoto K etal. Splenectomy enhances liver regeneration through tumor necrosis factor (TNF)-alpha following dimethylnitrosamine-induced cirrhotic rat model. Hepatogastroenterology 2001; 48: 1022-7.
15. Murata K, Ito K, Yoneda K, Shiraki K, Sakurai H, Ito M. Splenectomy improves liver function in patients with liver cirrhosis. Hepatogastroenterology 2008; 55: 1407-11.
16. Akahoshi T, Hashizume M, Tanoue K etal. Role of the spleen in liver fibrosis in rats may be mediated by transforming growth factor beta-1. J Gastroenterol Hepatol 2002; 17: 59-65.
17. Sugawara Y, Yamamoto J, Shimada K etal. Splenectomy in patients with hepatocellular carcinoma and hypersplenism. J Am Coll Surg 2000; 190: 446-50.
18. Chen XP, Wu ZD, Huang ZY, Qiu FZ. Use of hepatectomy and splenectomy to treat hepatocellular carcinoma with cirrhotic hypersplenism. Br J Surg 2005; 92: 334-9.
19. Michel K, Zeller F, Langer R etal. Serotonin excites neurons in the human submucous plexus via 5-HT3 receptors. Gastroenterology 2005; 128: 1317-26.
20. Balasubramanian S, Paulose CS. Induction of DNA synthesis in primary cultures of rat hepatocytes by serotonin: possible involvement of serotonin S2 receptor. Hepatology 1998; 27: 62-6.
21. Battaglino R, Fu J, Spate U etal. Serotonin regulates osteoclast differentiation through its transporter. J Bone Miner Res 2004; 19: 1420-31.
22. Lesurtel M, Graf R, Aleil B etal. Platelet-derived serotonin mediates liver regeneration. Science 2006; 312: 104-7.
23. Culafic DM, Mirkovic DS, Vukcevic MD, Rudic JS. Plasma and platelet serotonin levels in patients with liver cirrhosis. World J Gastroenterol 2007; 13: 5750-3.
24. Ruddell RG, Oakley F, Hussain Z etal. A role for serotonin (5-HT) in hepatic stellate cell function and liver fibrosis. Am J Pathol 2006; 169: 861-76.
25. Kercher KW, Carbonell AM, Heniford BT, Matthews BD, Cunningham DM, Reindollar RW. Laparoscopic splenectomy reverses thrombocytopenia in patients with hepatitis C cirrhosis and portal hypertension. J Gastrointest Surg 2004; 8: 120-6.
26. Imura S, Shimada M, Utsunomiya T etal. Impact of splenectomy in patients with liver cirrhosis: results from 18 patients in a single center experience. Hepatol Res 2010; 40: 894-900.
27. Anegawa G, Kawanaka H, Yoshida D etal. Defective endothelial nitric oxide synthase signaling is mediated by rho-kinase activation in rats with secondary biliary cirrhosis. Hepatology 2008; 47: 966-77.
28. Papadimas GK, Tzirogiannis KN, Panoutsopoulos GI etal. Effect of serotonin receptor 2 blockage on liver regeneration after partial hepatectomy in the rat liver. Liver Int 2006; 26: 352-61.
29. Persson B, Heykants J, Hedner T. Clinical pharmacokinetics of ketanserin. Clin Pharmacokinet 1991; 20: 263-79.
30. Brogden RN, Sorkin EM. Ketanserin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in hypertension and peripheral vascular disease. Drugs 1990; 40: 903-49.
31. Yamaguchi S, Kawanaka H, Yoshida D, Maehara Y, Hashizume M. Splenic hemodynamics and decreased endothelial nitric oxide synthase in the spleen of rats with liver cirrhosis. Life Sci 2007; 80: 2036-44.
32. Lee CM, Leung TK, Wang HJ etal. Evaluation of the effect of partial splenic embolization on platelet values for liver cirrhosis patients with thrombocytopenia. World J Gastroenterol 2007; 13: 619-22.
33. Liu Q, Ma K, Song Y, Zhou N, He Z. Two-year follow-up of splenic radiofrequency ablation in patients with cirrhotic hypersplenism: does increased hepatic arterial flow induce liver regeneration? Surgery 2008; 143: 509-18.
34. Zhang Y, Wen T, Yan L etal. The changes of hepatic hemodynamics and functional hepatic reserve after splenectomy with periesophagogastric devascularization. Hepatogastroenterology 2009; 56: 835-9.
35. Palmes D, Spiegel HU. Animal models of liver regeneration. Biomaterials 2004; 25: 1601-11.
36. Johnson GL, Lapadat R. Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 2002; 298: 1911-12.
37. Fausto N. Liver regeneration. J Hepatol 2000; 32: 19-31.
38. Shimabukuro R, Kawanaka H, Tomikawa M etal. Effect of thrombopoietin on platelet counts and liver regeneration after partial hepatectomy in a rat model. Surg Today 2009; 39: 1054-9.
39. Hong JY, Sato E F, Hiramoto K, Nishikawa M, Inoue M. Mechanism of liver injury during obstructive jaundice: role of nitric oxide, splenic cytokines, and intestinal flora. J Clin Biochem Nutr 2007; 40: 184-93.
40. Huston JM, Wang H, Ochani M etal. Splenectomy protects against sepsis lethality and reduces serum HMGB1 levels. J Immunol 2008; 181: 3535-9.