Influence of the use of functional foods enriched with phytosterols/-stanols on adherence to statin therapy

Pharmacoepidemiology and Drug Safety

Volumn 20, Issue 8, 2011, Pages 830-837

  Eussen, Simone R B M ^a   Bouvy, Marcel L ^a   Rompelberg, Cathy J M ^a   van der Elst, Menno E ^b   Garssen, Johan ^a   Oosterveld, Marco H ^c   de Boer, Anthonius ^a   de Gier, Johan J ^d   van Kranen, Henk J ^a   Klungel, Olaf H ^a  

^a NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^b MEDICINES EVALUATION BOARD   (Netherlands)

^c Waldeck Pharmacy   (Netherlands)

^d UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

Adherence; Lipid lowering treatment; Phytosterols stanols; Statins

Indexed keywords

ATORVASTATIN; FLUINDOSTATIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; PHYTOSTEROL; PRAVASTATIN; ROSUVASTATIN; SIMVASTATIN; STANOZOLOL;

ADULT; ARTICLE; DRUG WITHDRAWAL; FEMALE; FUNCTIONAL FOOD; GENERAL PRACTITIONER; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL PRACTICE; MEDICAL RESEARCH; PATIENT CARE; PATIENT COMPLIANCE; PHARMACEUTICAL CARE; PHARMACIST; PHARMACY; PRIORITY JOURNAL; QUESTIONNAIRE; TREATMENT WITHDRAWAL;

AGED; DIRECTIVE COUNSELING; FEMALE; FOOD, FORTIFIED; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MALE; MEDICATION ADHERENCE; MIDDLE AGED; PHARMACEUTICAL SERVICES; PHARMACISTS; PHYTOSTEROLS; QUESTIONNAIRES;

EID: 79960708714     PISSN: 10538569     EISSN: 10991557     Source Type: Journal    
DOI: 10.1002/pds.2168     Document Type: Article

References (25)

1. World Health Organization (WHO). World Health Organization, World health report [23 July 2010].
2. Law MR, Wald NJ, Rudnicka AR. Quantifying effect of statins on low density lipoprotein cholesterol, ischaemic heart disease, and stroke: systematic review and meta-analysis. BMJ 2003; 326: 1423.
3. Baigent C, Keech A, Kearney PM, et al. Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90, 056 participants in 14 randomised trials of statins. Lancet 2005; 366: 1267-1278.
4. Howlett J. Functional Foods From Science to Health and Claims. ILSI Europe Concise Monograph Series. ILSI Europe: Brussels, Belgium, 2008; 1-36.
5. Scholle J, Baker W, Talati R, Coleman C. The effect of adding plant sterols or stanols to statin therapy in hypercholesterolemic patients: systematic review and meta-analysis. J Am Coll Nutr 2009; 28: 517-524.
6. Eussen S, Klungel O, Garssen J, et al. Support of drug therapy using functional foods and dietary supplements: focus on statin therapy. Br J Nutr 2010; 103: 1260-1277.
7. Cramer JA, Roy A, Burrell A, et al. Medication compliance and persistence: terminology and definitions. Value Health 2008; 11: 44-47.
8. Liberopoulos EN, Florentin M, Mikhailidis DP, Elisaf MS. Compliance with lipid-lowering therapy and its impact on cardiovascular morbidity and mortality. Expert Opin Drug Saf 2008; 7: 717-725.
9. Alevizos A, Mihas C, Mariolis A. Advertising campaigns of sterol-enriched food. An often neglected cause of reduced compliance to lipid lowering drug therapy. Cardiovasc Drugs Ther 2007; 21: 133-134.
10. Eussen SR, de Jong N, Rompelberg CJ, Garssen J, Verschuren WM, Klungel OH. Effects of the use of phytosterol/-stanol-enriched margarines on adherence to statin therapy. Pharmacoepidemiol Drug Saf 2010; 19: 1225-1232.
11. Eussen SRBM, van der Elst M, Klungel O, Rompelberg CJM, et al. A pharmaceutical care program to improve adherence to statin therapy: a randomized controlled trial. Ann Pharmacother 2010; 44: 1905-1913.
12. Ocké MC, Buurma-Rethans EJM, Fransen HP. Dietary supplement use in the Netherlands-Current data and recommendations for future assessment. 2005; RIVM report 350100001: 1-113.
13. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972; 18: 499-502.
14. Lekkerkerker F, Kanis JA, Alsayed N, et al. Adherence to treatment of osteoporosis: a need for study. Osteoporos Int 2007; 18: 1311-1317.
15. Van Wijk BL, Klungel OH, Heerdink ER, de Boer A. Refill persistence with chronic medication assessed from a pharmacy database was influenced by method of calculation. J Clin Epidemiol 2006; 59: 11-17.
16. Gardarsdottir H, Souverein PC, Egberts TC, Heerdink ER. Construction of drug treatment episodes from drug-dispensing histories is influenced by the gap length. J Clin Epidemiol 2010; 63: 422-427.
17. Penning-van Beest FJ, Termorshuizen F, Goettsch WG, Klungel OH, Kastelein JJ, Herings RM. Adherence to evidence-based statin guidelines reduces the risk of hospitalizations for acute myocardial infarction by 40%: a cohort study. Eur Heart J 2007; 28: 154-159.
18. WHO Collaborating Centre for Drug Statistics Methodology Guidelines for ATC classification and DDD assignment. 2010 [Accessed on 10 November 2010].
19. Greenland S. Modeling and variable selection in epidemiologic analysis. Am J Public Health 1989; 79: 340-349.
20. Bouvy ML, Heerdink ER, Urquhart J, Grobbee DE, Hoes AW, Leufkens HG. Effect of a pharmacist-led intervention on diuretic compliance in heart failure patients: a randomized controlled study. J Card Fail 2003; 9: 404-411.
21. Hamann GF, Weimar C, Glahn J, Busse O, Diener HC. Adherence to secondary stroke prevention strategies-results from the German Stroke Data Bank. Cerebrovasc Dis 2003; 15: 282-288.
22. Petty DR, Zermansky AG, Raynor DK, et al. "No thank you": why elderly patients declined to participate in a research study. Pharm World Sci 2001; 23: 22-27.
23. Eussen S, de Jong N, Rompelberg C, Garssen J, Verschuren W, Klungel O. Dose-dependent cholesterol-lowering effects of phytosterol/phytostanol-enriched margarine in statin users and statin non-users under free-living conditions. Public Health Nutr 2011; 1-10.
24. Demonty I, Ras RT, van der Knaap HC, et al. Continuous dose-response relationship of the LDL-cholesterol-lowering effect of phytosterol intake. J Nutr 2009; 139: 271-284.
25. de Jong N, Zuur A, Wolfs MC, Wendel-Vos GC, van Raaij JM, Schuit AJ. Exposure and effectiveness of phytosterol/-stanol-enriched margarines. Eur J Clin Nutr 2007; 61: 1407-1415.