Estrogen receptors do not influence angiogenesis after myocardial infarction

Scandinavian Cardiovascular Journal

Volumn 45, Issue 4, 2011, Pages 215-222

  Broberg, Agneta Månsson ^a   Siddiqui, Anwar J ^a   Fischer, Helene ^a   Grinnemo, Karl Henrik ^a   Wardell, Eva ^a   Andersson, Agneta B ^a   Inzunza, José ^b   Sylvén, Christer ^a   Gustafsson, Jan Åke ^b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Angiogenesis; Estrogen receptor; Myocardial infarction; Myocardium

Indexed keywords

ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; MESSENGER RNA;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; HEART INFARCTION; IMMUNOHISTOCHEMISTRY; KNOCKOUT MOUSE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION;

ANIMALS; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FEMALE; GENE EXPRESSION REGULATION; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYOCARDIAL INFARCTION; NEOVASCULARIZATION, PATHOLOGIC; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 79960703520     PISSN: 14017431     EISSN: 16512006     Source Type: Journal    
DOI: 10.3109/14017431.2011.569941     Document Type: Article

References (30)

1. Grodstein F, Stampfer M. The epidemiology of coronary heart disease and estrogen replacement in postmenopausal women. Prog Cardiovasc Dis. 1995;38:199-210.
2. Hulley S, Grady D, Bush T, Furberg C, Herrington D, Riggs B, et al. Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. JAMA. 1998;280:605-13. (Pubitemid 28502636)
3. Hulley S, Grady D, Bush T, Furberg C, Herrington D, Riggs B, et al. Postmenopausal hormone treatment. JAMA. 2009;301:2493-5.
4. Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML, et al. Risks and benefi ts of estrogen plus progestin in healthy postmenopausal women: Principal results From the Women?s Health Initiative randomized controlled trial. JAMA. 2002;288:321-33. (Pubitemid 34761611)
5. Chen D-B, Bird IM, Zheng J, Magness RR. Membrane estrogen receptor - dependent extracellular signal-regulated kinase pathway mediates acute activation of endothelial nitric oxide synthase by estrogen in uterine artery endothelial cells. Endocrinology. 2004;145:113-25. (Pubitemid 38094507)
6. Traupe T, Stettler CD, Li H, Haas E, Bhattacharya I, Minotti R, et al. Distinct roles of estrogen receptor á and â mediating acute vasodilation of epicardial coronary arteries. Hypertension. 2007;49:1364-70. (Pubitemid 46809381)
7. Taylor AH, Al-Azzawi F. Immunolocalisation of oestrogen receptor beta in human tissues. J Mole Endocrin. 2000;24: 145-55. (Pubitemid 30117668)
8. Grohé C, Kahlert S, Löb bert K, Stimpel M, Karas RH, Vetter H, et al. Cardiomyocytes and fi broblast contain functional estrogen receptors. FEBS Lett. 1997;416:107-12. (Pubitemid 27470812)
9. Karas RH, Baur WE, van Eickels M, Mendelsohn ME. Human vascular smooth muscle cells express an estrogen receptor isoform. FEBS Lett. 1995;377:103-8. (Pubitemid 26018519)
10. Patten RD, Pourati I, Aronovitz MJ, Baur J, Celestin F, Chen X, et al. 17-beta estradiol reduces cardiomyocyte apopotosis in vivo and in vitro via activation of phosphoinositide- 3 kinase/Akt signaling. Circ Res. 2004;95:692-9. (Pubitemid 39331929)
11. Babiker FA, Lips D, Meyer R, Delvaux E, Zandberg P, Janssen B, et al. Estrogen receptor â protects the murine heart against left ventricular hypertrophy. Arterioscler Thromb Vasc Biol. 2006;26:1524-30. (Pubitemid 44288978)
12. Pedram A, Razandi M, Aitkenhead M, Levin ER. Estrogen inhibits cardiomyocyte hypertrophy in vitro. J Biol Chem. 2005;280:26339-48.
13. Groten T, Pierce AA, Huen AC, Schnaper HW. 17â -estradiol transiently disrupts adherens junctions in endothelial cells. FASEB J. 2005;19:1368-70. (Pubitemid 41113752)
14. Mahmoodzadeh S, Eder S, Nordmeyer J, Ehler E, Huber O, Martus P, et al. Estrogen receptor alpha up-regulation and redistribution in human heart failure. FASEB J. 2006;20:926-34. (Pubitemid 44943950)
15. Mancino A, Mancino MG, Glaser SS, Alpini G, Bolognese L, Izzo A, et al. Estrogens stimulate the proliferation of human cholangiocarcinoma by inducing the expression and secretion of vascular endothelial growth factor. Dig Liver Dis. 2009;41:156-63.
16. Gargett CE, Zaitseva M, Bucak K, Chu S, Fuller PJ, Rogers PA. 17Beta-estradiol up-regulates vascular endothelial growth factor receptor-2 expression in human myometrial microvascular endothelial cells: Role of estrogen receptoralpha and -beta. J Clin Endocrinol Metab. 2002;87:4341-9.
17. Lizotte E, Grandy SA, Tremblay A, Allen BG, Fiset C. Expression, distribution and regulation of sex steroid hormone receptors in mouse heart. Cell Physiol Biochem. 2009;23:75-86.
18. Wang M, Wang Y, Weil B, Abarbanell A, Herrmann J, Tan J, et al. Estrogen receptor â mediates increased activation of PI3K/Akt signalling and improved myocardial function in female hearts following acute ischemia. Am J Physiol Regul Integr Comp Physiol. 2009;296:R972 - 8.
19. Smith PJW, Ornatsky O, Stewart DJ, Picard P, Dawood F, Wen WH, et al. Effects of estrogen replacement on infarct size, cardiac remodeling, and the endothelin system after myocardial infarction in ovariectomized rats. Circulation. 2000;102:2983-9.
20. van Eickels M, Patten RD, Aronovitz MJ, Alsheikh-Ali A, Gostyla K, Celestin F, et al. 17-beta-estradiol increases cardiac remodelling and mortality in mice with myocardial infarction. J Am Coll Cardiol. 2003;41:2048 - 92; (published correction in J AM Coll Cardiol. 2003;42:143.
21. Fö r ster C, Kietz S, Hultenby K, Warner M, Gustafsson JÅ . Characterization of the ER â -/- mouse heart. PNAS. 2004; 101:14234-9.
22. Lubahn DB, Moyer JS, Golding TS, Couse JF, Korach KS, Smithies O. Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene. PNAS. 1993;90:11162-6. (Pubitemid 23354389)
23. Krege JH, Hodgin JB, Couse JF, Enmark E, Warner M, Mahler JF, et al. Generation and reproductive phenotypes of mice lacking estrogen receptor â . PNAS. 1998;95:15677-82. (Pubitemid 29018759)
24. W iner J, Jung CKS, Shackel I, Williams PM. Development and validation of real-time quantitative reverse transcriptasepolymerase chain reaction for monitoring gene expression in cardiac myocytes in vitro. Analyt Biochem. 1999;270: 41-9. (Pubitemid 29230718)
25. Cheng G, Weihua Z, Warner M, Gustafsson JÅ . Estrogen receptors ER alpha and ER beta in proliferation in the rodent mammary gland. PNAS. 2004;101:3739-46. (Pubitemid 38386631)
26. Siddiqui AJ, Mansson-Broberg A, Gusafsson T, Grinnemo KH, Dellgren G, Hao X, et al. Antagonism of the renin-angiotensinsystem can counteract cardiac angiogenic vascular endothelial growth factor gene therapy and myocardial angiogenesis in the normal heart. AJH. 2005;18:1347-52. (Pubitemid 41400206)
27. Grinnemo KH, Genead R, Kumagai-Braesh M, Andersson A, Danielsson C, M å nsson-Broberg A, et al. Costimulation blockade induces tolerance to HESC transplanted to the testis and induces regulatory T-cells to HESC transplanted into the heart. Stem Cells. 2008;26:1850 - 7.
28. Arias-Loza PA, Jazbutyte V, Pelzer T. Genetic and pharmacologic strategies to determine the function of estrogen receptor á and estrogen receptor â in the cardiovascular system. Gender Med. 2008;5(Suppl A):34-45.
29. Byers MJ, Zangl A, Phernetton TM, Lopez G, Chen D-B, Magness RR. Endothelial vasodilator production by ovine uterine and systemic arteries: Ovarian steroid and pregnancy control of ER á and ER â levels. J Physiol. 2005;565:85-99. (Pubitemid 40723693)
30. Cutolo M, Sulli A, Capellino S, Villaggio B, Montagna P, Seriolo B, et al. Sex hormones infl uence on the immune system: Basic and clinical aspects in autoimmunity. Lupus. 2004;13:635-8. (Pubitemid 39279773)