The syntheses and in vitro biotransformation studies of [ 14C]apixaban, a highly potent, selective, efficacious and orally bioavailable inhibitor of blood coagulation Factor Xa

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 54, Issue 8, 2011, Pages 418-425

  Maxwell, Brad D ^a   Tran, Scott B ^a   Chen, Shiang Yuan ^a   Zhang, Donglu ^a   Chen, Bang Chi ^a   Zhang, Huiping ^a   Bonacorsi, Samuel J ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

ADME; apixaban; Factor Xa; hepatocytes; microsomes

Indexed keywords

BLOOD; COAGULATION;

ADME; APIXABAN; BIOAVAILABLE; BLOOD COAGULATION; COAGULATION FACTOR; FACTOR XA; HEPATOCYTES; IN-VITRO; MICROSOME; POTENT INHIBITOR;

SYNTHESIS (CHEMICAL);

1 (4 METHOXYPHENYL) 6 [4 (2 OXOPIPERIDIN 1 YL)PHENYL] 4,5,6,7 TETRAHYDRO 1H PYRAZOLO[3,4 C]PYRIDINE 3 CARBOXAMIDE C 14; 1 (4 METHOXYPHENYL) 7 OXO 6 [4 (2 OXOPIPERIDIN 1 YL)PHENYL] 4,5,6,7 TETRAHYDRO 1H PYRAZOLO[3,4 C]PYRIDINE 3 CARBOXAMIDE C 14; APIXABAN; APIXABAN C 14; BLOOD CLOTTING FACTOR 10A INHIBITOR; CARBON 14; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG METABOLISM; DRUG POTENCY; DRUG PURIFICATION; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TRANSFORMATION; HUMAN; HUMAN CELL; IN VITRO STUDY; ISOTOPE LABELING; LIVER CELL; LIVER MICROSOME; NONHUMAN; RAT; REPRODUCIBILITY; TECHNIQUE;

RATTUS;

EID: 79960676834     PISSN: 03624803     EISSN: 10991344     Source Type: Journal    
DOI: 10.1002/jlcr.1890     Document Type: Article

References (5)

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2. This research was partially presented as an oral paper at the 10th International Symposium on the Synthesis and Applications of Isotopes and Isotopically Labelled Compounds held June 14-18, 2009 in Chicago, Illinois, USA and published as an abstract in the Proceedings of the Symposium. See B. D. Maxwell, S. B. Tran, S. Y. Chen, D. Zhang, B. C. Chen, H. Zhang, S. J. Bonacorsi Jr. J. Label Comp. Radiopharm 2010, 53, 363-367.
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5. L. Wang, D. Zhang, N. Raghavan, M. Yao, M. Li, C. A. Frost, B. D. Maxwell, S. Y. Chen, K. He, T. C. Goosen, W. G. Humphreys, S. J. Grossman, Drug Metab. Dispos. 2010, 38, 448-458. DOI: 10.1124/dmd.109.029694.